The Experts below are selected from a list of 2409 Experts worldwide ranked by ideXlab platform
M G Roccia - One of the best experts on this subject based on the ideXlab platform.
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uncommon clinical presentation of Kimuras Disease as bilateral retroauricular masses in a young malian male successful surgical approach
Journal of Biological Regulators and Homeostatic Agents, 2016Co-Authors: Fausto Fama, A Sindoni, Georgi Tchernev, A A Chokoeva, Uwe Wollina, Torello Lotti, G K Maximov, James W Patterson, Massimo Fioranelli, M G RocciaAbstract:We present a case of a 27 year-old Malian male referred to our hospital for two large, painless retroauricolar masses that had appeared two years earlier. Bilateral cervical painless lymphadenopathy was present at physical examination, without any other systemic symptoms. His history was relevant for bilateral Kimuras Disease lesions resected 5 years earlier in the same locations. Lymphocytosis and a mild hypereosinophilia were found in routine blood tests, together with increased total IgE levels. After surgery, histology showed lymphoid infiltrates with reactive prominent germinal centres containing eosinophils, suggesting relapse of Kimuras Disease, in the context of nonencapsulated fibrous proliferation with discontinuous collagen fibers, consistent with keloid. Three months after removal of retroauricular masses, abnormal laboratory findings reverted to normal. To the best our knowledge, this is the first case in literature of bilateral keloid lesions developed after surgery for Kimura Disease and harbouring its histopathologic features. Clinicians should be aware of these unusual reactive phenomena and their possible simulators.
Fausto Fama - One of the best experts on this subject based on the ideXlab platform.
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uncommon clinical presentation of Kimuras Disease as bilateral retroauricular masses in a young malian male successful surgical approach
Journal of Biological Regulators and Homeostatic Agents, 2016Co-Authors: Fausto Fama, A Sindoni, Georgi Tchernev, A A Chokoeva, Uwe Wollina, Torello Lotti, G K Maximov, James W Patterson, Massimo Fioranelli, M G RocciaAbstract:We present a case of a 27 year-old Malian male referred to our hospital for two large, painless retroauricolar masses that had appeared two years earlier. Bilateral cervical painless lymphadenopathy was present at physical examination, without any other systemic symptoms. His history was relevant for bilateral Kimuras Disease lesions resected 5 years earlier in the same locations. Lymphocytosis and a mild hypereosinophilia were found in routine blood tests, together with increased total IgE levels. After surgery, histology showed lymphoid infiltrates with reactive prominent germinal centres containing eosinophils, suggesting relapse of Kimuras Disease, in the context of nonencapsulated fibrous proliferation with discontinuous collagen fibers, consistent with keloid. Three months after removal of retroauricular masses, abnormal laboratory findings reverted to normal. To the best our knowledge, this is the first case in literature of bilateral keloid lesions developed after surgery for Kimura Disease and harbouring its histopathologic features. Clinicians should be aware of these unusual reactive phenomena and their possible simulators.
Ronit Nesher - One of the best experts on this subject based on the ideXlab platform.
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Vasculitis of the Temporal Arteries in the Young
Seminars in Arthritis and Rheumatism, 2008Co-Authors: Gideon Nesher, Shirly Oren, Graciela Lijovetzky, Ronit NesherAbstract:Objective Temporal artery vasculitis (TAV) in patients younger than 50 years is extremely rare. A case of TAV in an 18-year-old man is described here, followed by a literature review regarding cases of all types of vasculitic involvement of the temporal arteries in the young. Methods Review of the English literature on vasculitis involving the temporal arteries in young patients, based on a PubMed search. Results Less than 40 cases of vasculitic involvement of temporal arteries in the young have been described. TAV in the young may be divided into 3 groups: juvenile temporal arteritis, a localized eosinophilic arteritis confined to the temporal arteries, seems unique to this age group. Fifteen patients with juvenile temporal arteritis were described. Other vasculitides, such as polyarteritis nodosa, Churg–Strauss syndrome, and thrombangiitis obliterans may involve the temporal arteries in young patients. The literature search revealed 12 such cases. The least common group is arteritis in young patients, histologically resembling elderly type temporal arteritis, featuring 5 cases. In addition, other conditions such as Kimura Disease and angiolymphoid hyperplasia with eosinophilia may resemble temporal arteritis in the young. Conclusions TAV in the young is rare and differs from the classical temporal arteritis of older adults. There is an apparent overlap among several vasculitic conditions involving the temporal arteries in the young, and histological distinction may be difficult at times. The final diagnosis of the different conditions causing TAV in the young is based on a combination of clinical findings, relevant laboratory data, imaging studies, and histological findings.
Ilhan Kılınc - One of the best experts on this subject based on the ideXlab platform.
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Thrombosis of temporal artery and renal vein in Kimura Disease related nephrotic syndrome
Journal of Thrombosis and Thrombolysis, 2009Co-Authors: Ramazan Danis, Sehmus Ozmen, Davut Akin, Selver Ozekinci, Abdullah Altintas, Timucin Cil, Semir Pasa, Ilhan KılıncAbstract:Kimura Disease (KD) is an angiolymphoid proliferative disorder of unknown etiology, occurs mainly in Asian patients, presenting with subcutaneous slowly growing masses, with a predilection for preauricular and submandibular regions . The clinical course of the Disease is thought to be benign. Concomitant peripheral blood eosinophilia and elevated serum immunoglobulin E levels are often observed. Main systemic manifestation of the KD is renal involvement. Renal abnormalities, notably proteinuria and nephrotic syndrome have been found to be associated with KD. We report a 42-year-old man with KD and a steroid-sensitive membraneous nephrotic syndrome with bilaterally temporal artery and renal vein thrombosis. This is the first reported case of KD associated nephrotic syndrome complicated with wide arterial and venous thrombosis from Anatolia.
Colin Hopper - One of the best experts on this subject based on the ideXlab platform.
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treatment of Kimura Disease with photodynamic therapy a case study
Photodiagnosis and Photodynamic Therapy, 2012Co-Authors: Syedda Abbas, Waseem Jerjes, Tahwinder Upile, A Vincent, Colin HopperAbstract:Summary We report on the application of photodynamic therapy (PDT) in the management of Kimura Disease. A 58-year-old Asian male was offered this modality to assess the possibility to control Disease progression. The patient was managed with surgery and the Disease recurred and caused facial disfigurement. PDT was offered after careful discussion at UCLH multidiscipline meeting. The photosensitiser “mTHPC” was introduced intravenously 96 h prior to delivering the light under ultrasound guidance. Magnetic resonance images showed moderate-significant reduction of the Disease volume. Fourteen months post-PDT, the Disease started re-growing and the patient subsequently underwent one further round of PDT which was as successful as the first round in reducing the facial disfigurement. Photodynamic therapy was very effective in controlling Disease progression in this patient who suffers from Kimura Disease.
