The Experts below are selected from a list of 102 Experts worldwide ranked by ideXlab platform

Madhulika Kabra - One of the best experts on this subject based on the ideXlab platform.

  • detection of fetomaternal hemorrhage following chorionic villus sampling by kleihauer betke Test and rise in maternal serum alpha feto protein
    Prenatal Diagnosis, 2007
    Co-Authors: Richa Katiyar, Alka Kriplani, N Agarwal, Neerja Bhatla, Madhulika Kabra
    Abstract:

    Objectives To assess incidence and volume of fetomaternal hemorrhage (FMH) after chorionic villus sampling (CVS) by Kleihauer Betke Test (KBT) and rise in maternal protein (MSAFP). Methods A prospective study was conducted on 61 cases requiring CVS. FMH due to CVS was assessed by KBT and MSAFP. Results Out of 61 cases, 60 (98.36%) cases showed FMH by MSAFP while all showed FMH by KBT. Median volume of FMH detected by MSAFP was 0.06 mL (25 to 75th interquartile (IQR) 0.01 to 0.12 mL) and by KBT was 0.45 mL (25 to 75th IQR 0.09 to 0.90). Mean volume of FMH detected by MSAFP was 0.1 + 0.1424 mL and by KBT was 0.58 + 0.637 mL. Significant FMH up to 0.1 mL was found in 20 (32.8%) and 45 (60.6%) by MSAFP and KBT respectively. Conclusion MSAFP and KBT are sensitive to detect FMH. KBT estimates more FMH than MSAFP. Fifty micrograms of anti-D is sufficient to cover FMH during CVS. Copyright © 2006 John Wiley & Sons, Ltd.

Ahmet Baschat - One of the best experts on this subject based on the ideXlab platform.

  • Persistent fetal hemoglobin in maternal circulation complicating the diagnosis of fetomaternal hemorrhage.
    Obstetrics & Gynecology, 2005
    Co-Authors: Michelle Kush, Michael V. Muench, Christopher Harman, Ahmet Baschat
    Abstract:

    BACKGROUND: Transplacental hemorrhage can be life threatening to a fetus and has important maternal treatment implications. In contrast, hereditary persistence of fetal hemoglobin is a condition that has little consequence. The Kleihauer-Betke Test, which is routinely used to document transplacental hemorrhage, will be positive in either case. CASES: We report two cases in which maternal persistence of fetal hemoglobin was unknown and led to the erroneous diagnosis of fetomaternal hemorrhage. These cases highlight both the limitations of the Kleihauer-Betke Test and the role of flow cytometry in diagnosing fetomaternal hemorrhage. CONCLUSION: The use of flow cytometry can clarify Kleihauer-Betke Test results when there is known maternal persistence of fetal hemoglobin and can more precisely quantify a fetomaternal hemorrhage for accurate Rh immune globulin dosing.

Anne Cortey - One of the best experts on this subject based on the ideXlab platform.

  • reduced fetal movement during pregnancy is the kleihauer betke Test really useful
    Journal of gynecology obstetrics and human reproduction, 2020
    Co-Authors: Yoann Athiel, Emeline Maisonneuve, Cecile Bleas, Paul Maurice, Anne Cortey, Cecile Tolyndour, Stephanie Huguetjacquot, Agnes Mailloux, Jeanmarie Jouannic
    Abstract:

    Abstract Introduction Reduced fetal movement (rFM) is a frequent cause of consultation during the pregnancy and can reveal feto-maternal hemorrhage (FMH) that is sometimes responsible of severe fetal anemia. Our primary objective was to evaluate the contribution of the KBT in case of rFM. Our secondary objective was to compare it with ultrasound examination including peak systolic velocity of the middle cerebral artery (MCA-PSV) to predict neonatal anemia. Materials and methods We conducted a retrospective study from January 2016 to December 2017 at Armand-Trousseau Hospital in Paris. We analyzed all patients consulting for rFM from 18 to 41 weeks of gestation. We compared the performance of KBT and MCA-PSV to predict neonatal anemia (Hemoglobin at birth under 13.5 g/dL) and severe neonatal anemia (Hb  Results Among the 338 patients, 327 KBT (96.7%) were performed. KBT was found positive in three cases (0.9%). Only one neonate (0.3%) presented with severe anemia requiring a postnatal transfusion. MCA-PSV was performed in 166 cases (49.1%). KBT and MCA-PSV were significantly correlated with neonatal hemoglobin at birth. KBT was better than MCA-PSV to predict neonatal anemia, while MCA-PSV was better than KBT to predict moderate to severe anemia. The KBT and MCA-PSV Doppler had excellent sensitivity and predictive negative values (100%), but they had poor predictive positive values for severe neonatal anemia. Conclusion In case of decreased fetal movement, we suggest performing fetal cerebral Doppler. MCA-PSV could suffice in first approach. KBT may be performed if there is suspicion of fetal anemia in order to confirm FMH.

  • massive fetomaternal hemorrhage secondary to intrauterine intravascular transfusion
    Obstetrics & Gynecology, 2011
    Co-Authors: Yael Levyzauberman, Anne Cortey, Agnes Mailloux, Aminata Kane, Vanina Castaigne, Bruno Carbonne
    Abstract:

    BACKGROUND: Small-volume fetomaternal hemorrhage is frequently observed after intrauterine transfusion. The Kleihauer-Betke Test, the reference method for identifying fetomaternal hemorrhage, cannot be used after intrauterine transfusion, because the adult red blood cells used for transfusion cannot be distinguished from maternal red blood cells. CASE: Massive fetomaternal hemorrhage secondary to intrauterine transfusion led to fetal hemorrhagic stroke. We used a method based on blood group identification in the maternal blood to confirm and to quantify fetomaternal hemorrhage. CONCLUSION: Fetal stroke may result from severe hypovolemia and low cerebral blood flow caused by fetomaternal hemorrhage, rather than from fetal anemia itself.

Agnes Mailloux - One of the best experts on this subject based on the ideXlab platform.

  • reduced fetal movement during pregnancy is the kleihauer betke Test really useful
    Journal of gynecology obstetrics and human reproduction, 2020
    Co-Authors: Yoann Athiel, Emeline Maisonneuve, Cecile Bleas, Paul Maurice, Anne Cortey, Cecile Tolyndour, Stephanie Huguetjacquot, Agnes Mailloux, Jeanmarie Jouannic
    Abstract:

    Abstract Introduction Reduced fetal movement (rFM) is a frequent cause of consultation during the pregnancy and can reveal feto-maternal hemorrhage (FMH) that is sometimes responsible of severe fetal anemia. Our primary objective was to evaluate the contribution of the KBT in case of rFM. Our secondary objective was to compare it with ultrasound examination including peak systolic velocity of the middle cerebral artery (MCA-PSV) to predict neonatal anemia. Materials and methods We conducted a retrospective study from January 2016 to December 2017 at Armand-Trousseau Hospital in Paris. We analyzed all patients consulting for rFM from 18 to 41 weeks of gestation. We compared the performance of KBT and MCA-PSV to predict neonatal anemia (Hemoglobin at birth under 13.5 g/dL) and severe neonatal anemia (Hb  Results Among the 338 patients, 327 KBT (96.7%) were performed. KBT was found positive in three cases (0.9%). Only one neonate (0.3%) presented with severe anemia requiring a postnatal transfusion. MCA-PSV was performed in 166 cases (49.1%). KBT and MCA-PSV were significantly correlated with neonatal hemoglobin at birth. KBT was better than MCA-PSV to predict neonatal anemia, while MCA-PSV was better than KBT to predict moderate to severe anemia. The KBT and MCA-PSV Doppler had excellent sensitivity and predictive negative values (100%), but they had poor predictive positive values for severe neonatal anemia. Conclusion In case of decreased fetal movement, we suggest performing fetal cerebral Doppler. MCA-PSV could suffice in first approach. KBT may be performed if there is suspicion of fetal anemia in order to confirm FMH.

  • massive fetomaternal hemorrhage secondary to intrauterine intravascular transfusion
    Obstetrics & Gynecology, 2011
    Co-Authors: Yael Levyzauberman, Anne Cortey, Agnes Mailloux, Aminata Kane, Vanina Castaigne, Bruno Carbonne
    Abstract:

    BACKGROUND: Small-volume fetomaternal hemorrhage is frequently observed after intrauterine transfusion. The Kleihauer-Betke Test, the reference method for identifying fetomaternal hemorrhage, cannot be used after intrauterine transfusion, because the adult red blood cells used for transfusion cannot be distinguished from maternal red blood cells. CASE: Massive fetomaternal hemorrhage secondary to intrauterine transfusion led to fetal hemorrhagic stroke. We used a method based on blood group identification in the maternal blood to confirm and to quantify fetomaternal hemorrhage. CONCLUSION: Fetal stroke may result from severe hypovolemia and low cerebral blood flow caused by fetomaternal hemorrhage, rather than from fetal anemia itself.

Richa Katiyar - One of the best experts on this subject based on the ideXlab platform.

  • detection of fetomaternal hemorrhage following chorionic villus sampling by kleihauer betke Test and rise in maternal serum alpha feto protein
    Prenatal Diagnosis, 2007
    Co-Authors: Richa Katiyar, Alka Kriplani, N Agarwal, Neerja Bhatla, Madhulika Kabra
    Abstract:

    Objectives To assess incidence and volume of fetomaternal hemorrhage (FMH) after chorionic villus sampling (CVS) by Kleihauer Betke Test (KBT) and rise in maternal protein (MSAFP). Methods A prospective study was conducted on 61 cases requiring CVS. FMH due to CVS was assessed by KBT and MSAFP. Results Out of 61 cases, 60 (98.36%) cases showed FMH by MSAFP while all showed FMH by KBT. Median volume of FMH detected by MSAFP was 0.06 mL (25 to 75th interquartile (IQR) 0.01 to 0.12 mL) and by KBT was 0.45 mL (25 to 75th IQR 0.09 to 0.90). Mean volume of FMH detected by MSAFP was 0.1 + 0.1424 mL and by KBT was 0.58 + 0.637 mL. Significant FMH up to 0.1 mL was found in 20 (32.8%) and 45 (60.6%) by MSAFP and KBT respectively. Conclusion MSAFP and KBT are sensitive to detect FMH. KBT estimates more FMH than MSAFP. Fifty micrograms of anti-D is sufficient to cover FMH during CVS. Copyright © 2006 John Wiley & Sons, Ltd.