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Ochuko L. Erukainure - One of the best experts on this subject based on the ideXlab platform.
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the antidiabetic properties of the hot water extract of Kola Nut cola nitida vent schott endl in type 2 diabetic rats
Journal of Ethnopharmacology, 2019Co-Authors: Ochuko L. Erukainure, Omamuyovwi M Ijomone, Collins U Ibeji, Chika I Chukwuma, Olakunle Sanni, Shahidul IslamAbstract:Abstract Ethnopharmacological relevance Cola nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes. Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. nitida seeds in type 2 diabetic rats. Methods Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 wk and thereafter, blood glucose, insulin level, lipid profile, pancreatic β-cell function, perfusion and morphology, redox imbalance, glycolytic and cholinergic enzymes, as well as of caspase-3 and Nrf2 expressions were measured. Results Treatment with the extract led to significant depletion of blood glucose, serum triglycerides, LDL-cholesterol, fructosamine, ALT, and uric acids, while elevating serum insulin and HDL-cholesterol levels. The infusion also significantly (p Conclusion These results insinuate the antidiabetic activities of C. nitida hot water extract and may be attributed to the NMR-identified compounds.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:Abstract The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at 50 °C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p 0.05) scavenging 2,2′-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p L -Arginine, L -tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127 mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at <50°C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p<0.05) scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p<0.05) inhibited α-glucosidase and α-amylase activities. Treatment of Fe2+ induced oxidative hepatic tissues with the infusion led to increase Superoxide Dismutase (SOD) and catalase activities, and glutathione (GSH) level as well as decreased malondialdehyde (MDA) level. FTIR spectroscopy of hepatic metabolite revealed restoration of oxidative-induced depleted functional groups by the infusion. LC-MS analysis of the metabolite also revealed restoration of most depleted metabolites with concomitant generation of 4-O-Methylgallic, (-)-Epicatechin sulfate, L-Arginine, L-tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
Md. Shahidul Islam - One of the best experts on this subject based on the ideXlab platform.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:Abstract The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at 50 °C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p 0.05) scavenging 2,2′-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p L -Arginine, L -tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127 mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at <50°C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p<0.05) scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p<0.05) inhibited α-glucosidase and α-amylase activities. Treatment of Fe2+ induced oxidative hepatic tissues with the infusion led to increase Superoxide Dismutase (SOD) and catalase activities, and glutathione (GSH) level as well as decreased malondialdehyde (MDA) level. FTIR spectroscopy of hepatic metabolite revealed restoration of oxidative-induced depleted functional groups by the infusion. LC-MS analysis of the metabolite also revealed restoration of most depleted metabolites with concomitant generation of 4-O-Methylgallic, (-)-Epicatechin sulfate, L-Arginine, L-tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
Mxolisi K Sokhela - One of the best experts on this subject based on the ideXlab platform.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:Abstract The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at 50 °C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p 0.05) scavenging 2,2′-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p L -Arginine, L -tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127 mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at <50°C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p<0.05) scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p<0.05) inhibited α-glucosidase and α-amylase activities. Treatment of Fe2+ induced oxidative hepatic tissues with the infusion led to increase Superoxide Dismutase (SOD) and catalase activities, and glutathione (GSH) level as well as decreased malondialdehyde (MDA) level. FTIR spectroscopy of hepatic metabolite revealed restoration of oxidative-induced depleted functional groups by the infusion. LC-MS analysis of the metabolite also revealed restoration of most depleted metabolites with concomitant generation of 4-O-Methylgallic, (-)-Epicatechin sulfate, L-Arginine, L-tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
Neil A. Koorbanally - One of the best experts on this subject based on the ideXlab platform.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:Abstract The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at 50 °C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p 0.05) scavenging 2,2′-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p L -Arginine, L -tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127 mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at <50°C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p<0.05) scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p<0.05) inhibited α-glucosidase and α-amylase activities. Treatment of Fe2+ induced oxidative hepatic tissues with the infusion led to increase Superoxide Dismutase (SOD) and catalase activities, and glutathione (GSH) level as well as decreased malondialdehyde (MDA) level. FTIR spectroscopy of hepatic metabolite revealed restoration of oxidative-induced depleted functional groups by the infusion. LC-MS analysis of the metabolite also revealed restoration of most depleted metabolites with concomitant generation of 4-O-Methylgallic, (-)-Epicatechin sulfate, L-Arginine, L-tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
Olajumoke A Oyebode - One of the best experts on this subject based on the ideXlab platform.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:Abstract The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at 50 °C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p 0.05) scavenging 2,2′-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p L -Arginine, L -tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127 mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
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caffeine rich infusion from cola nitida Kola Nut inhibits major carbohydrate catabolic enzymes abates redox imbalance and modulates oxidative dysregulated metabolic pathways and metabolites in fe2 induced hepatic toxicity
Biomedicine & Pharmacotherapy, 2017Co-Authors: Ochuko L. Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A. Koorbanally, Md. Shahidul IslamAbstract:The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at <50°C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p<0.05) scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p<0.05) inhibited α-glucosidase and α-amylase activities. Treatment of Fe2+ induced oxidative hepatic tissues with the infusion led to increase Superoxide Dismutase (SOD) and catalase activities, and glutathione (GSH) level as well as decreased malondialdehyde (MDA) level. FTIR spectroscopy of hepatic metabolite revealed restoration of oxidative-induced depleted functional groups by the infusion. LC-MS analysis of the metabolite also revealed restoration of most depleted metabolites with concomitant generation of 4-O-Methylgallic, (-)-Epicatechin sulfate, L-Arginine, L-tyrosine, Citric acid and Decanoic acid in infusion-treated tissues. Pathway analysis of the identified metabolites revealed the presence of 21 metabolic pathways involved in normal hepatic tissues, 12 in oxidative injured tissues and 17 in the treated tissues. Treatment with the infusion restored 4 metabolic pathways common to the normal tissue and further activated 4 additional pathways. Prediction of oral toxicity of caffeine showed it to belong to class 3, with a LD50 of 127mg/kg. Its toxicity target was predicted as Adenosine Receptor A2a. It was also predicted to be an inhibitor of CYP1A2. These results suggest the antioxidative and antidiabetic properties of C. nitida infusion, with caffeine as the major constituent.
