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Jason M Lazar - One of the best experts on this subject based on the ideXlab platform.
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assessment of arterial stiffness from pedal artery Korotkoff Sound recordings in heart failure patients
Journal of The American Society of Hypertension, 2016Co-Authors: Arismendy Nunez Nunez, Muhammad Ihsan, Louis Salciccioli, Syed Haidry, Firehiwot Achamyeleh, Ghazal Javaid, Sophia Russ, Jason M LazarAbstract:Introduction: Statin therapy is widely used to treat dyslipidemia. However, recent reports suggest that statin therapy increases the risk for type 2 diabetes mellitus (DM). Fitness lowers the risk of developing DM. The interaction between fitness, statin therapy and the risk of DM has not been investigated. Methods: We identified 3,161 hypertensive individuals on statin therapy for at least 6 months (mean age: 59.0 10.7) and no evidence of type 2 diabetes mellitus (DM) prior to initiation of statin therapy. All completed an exercise stress test at two VA Medical Centers (Washington, DC and Palo Alto, CA. We established five age-adjusted fitness categories based on peak metabolic equivalents (METs) achieved: Least-Fit ( 20%; 4.6 0.98 METs; n1⁄4733); Low-Fit (20.1%-40%; 6.2 0.80 METs; n1⁄4807); Moderate-Fit (40.1%-60%; 7.6 0.70 METs; n1⁄4799), Fit (60.1%-80%; 8.7 0.64; n1⁄4450) and High-Fit (>75%; 9.6 1.0 METs; n1⁄4377). Multivariable Cox proportional hazard model, adjusted for age, BMI, cardiac risk factors, and cardiac medications was used to assess the association between exercise capacity and the risk for developing DM2. The Least-Fit category was used as the referent. P-values <0.05 using two sided tests were considered statistically significant. Results: During a median follow-up period of 8.9 years, 1,172 developed DM2 (41.9/1,000 person-years). Exercise capacity was inversely related to DM2 incidence. The risk was 6% lower (hazard ratio, 0.94; 95% CI, 0.91-0.98) for every 1-MET increase in exercise capacity. Compared with the Least-Fit individuals, hazard ratios were: 0.78 (95% CI: 0.63-0.96) for Fit and 0.73 (95% CI: 0.58-0.93) for HighFit individuals. Conclusion: Moderate and high levels of cardiorespiratory fitness attenuated the risk of developing DM in hypertensive patients on statin therapy.
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differential effects of hyperemia and passive leg raising on qrs to Korotkoff Sound time intervals in hypertensive patients
Journal of The American Society of Hypertension, 2016Co-Authors: Arismendy Nunez, Muhammad Ihsan, Louis Salciccioli, Sarah Gaballah, Attiya Haque, Oleg Yurevich, Sukhpreet Ahluwalia, Mark G Stewart, Jason M LazarAbstract:Introduction: Statin therapy is widely used to treat dyslipidemia. However, recent reports suggest that statin therapy increases the risk for type 2 diabetes mellitus (DM). Fitness lowers the risk of developing DM. The interaction between fitness, statin therapy and the risk of DM has not been investigated. Methods: We identified 3,161 hypertensive individuals on statin therapy for at least 6 months (mean age: 59.0 10.7) and no evidence of type 2 diabetes mellitus (DM) prior to initiation of statin therapy. All completed an exercise stress test at two VA Medical Centers (Washington, DC and Palo Alto, CA. We established five age-adjusted fitness categories based on peak metabolic equivalents (METs) achieved: Least-Fit ( 20%; 4.6 0.98 METs; n1⁄4733); Low-Fit (20.1%-40%; 6.2 0.80 METs; n1⁄4807); Moderate-Fit (40.1%-60%; 7.6 0.70 METs; n1⁄4799), Fit (60.1%-80%; 8.7 0.64; n1⁄4450) and High-Fit (>75%; 9.6 1.0 METs; n1⁄4377). Multivariable Cox proportional hazard model, adjusted for age, BMI, cardiac risk factors, and cardiac medications was used to assess the association between exercise capacity and the risk for developing DM2. The Least-Fit category was used as the referent. P-values <0.05 using two sided tests were considered statistically significant. Results: During a median follow-up period of 8.9 years, 1,172 developed DM2 (41.9/1,000 person-years). Exercise capacity was inversely related to DM2 incidence. The risk was 6% lower (hazard ratio, 0.94; 95% CI, 0.91-0.98) for every 1-MET increase in exercise capacity. Compared with the Least-Fit individuals, hazard ratios were: 0.78 (95% CI: 0.63-0.96) for Fit and 0.73 (95% CI: 0.58-0.93) for HighFit individuals. Conclusion: Moderate and high levels of cardiorespiratory fitness attenuated the risk of developing DM in hypertensive patients on statin therapy.
Louis Salciccioli - One of the best experts on this subject based on the ideXlab platform.
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assessment of arterial stiffness from pedal artery Korotkoff Sound recordings in heart failure patients
Journal of The American Society of Hypertension, 2016Co-Authors: Arismendy Nunez Nunez, Muhammad Ihsan, Louis Salciccioli, Syed Haidry, Firehiwot Achamyeleh, Ghazal Javaid, Sophia Russ, Jason M LazarAbstract:Introduction: Statin therapy is widely used to treat dyslipidemia. However, recent reports suggest that statin therapy increases the risk for type 2 diabetes mellitus (DM). Fitness lowers the risk of developing DM. The interaction between fitness, statin therapy and the risk of DM has not been investigated. Methods: We identified 3,161 hypertensive individuals on statin therapy for at least 6 months (mean age: 59.0 10.7) and no evidence of type 2 diabetes mellitus (DM) prior to initiation of statin therapy. All completed an exercise stress test at two VA Medical Centers (Washington, DC and Palo Alto, CA. We established five age-adjusted fitness categories based on peak metabolic equivalents (METs) achieved: Least-Fit ( 20%; 4.6 0.98 METs; n1⁄4733); Low-Fit (20.1%-40%; 6.2 0.80 METs; n1⁄4807); Moderate-Fit (40.1%-60%; 7.6 0.70 METs; n1⁄4799), Fit (60.1%-80%; 8.7 0.64; n1⁄4450) and High-Fit (>75%; 9.6 1.0 METs; n1⁄4377). Multivariable Cox proportional hazard model, adjusted for age, BMI, cardiac risk factors, and cardiac medications was used to assess the association between exercise capacity and the risk for developing DM2. The Least-Fit category was used as the referent. P-values <0.05 using two sided tests were considered statistically significant. Results: During a median follow-up period of 8.9 years, 1,172 developed DM2 (41.9/1,000 person-years). Exercise capacity was inversely related to DM2 incidence. The risk was 6% lower (hazard ratio, 0.94; 95% CI, 0.91-0.98) for every 1-MET increase in exercise capacity. Compared with the Least-Fit individuals, hazard ratios were: 0.78 (95% CI: 0.63-0.96) for Fit and 0.73 (95% CI: 0.58-0.93) for HighFit individuals. Conclusion: Moderate and high levels of cardiorespiratory fitness attenuated the risk of developing DM in hypertensive patients on statin therapy.
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differential effects of hyperemia and passive leg raising on qrs to Korotkoff Sound time intervals in hypertensive patients
Journal of The American Society of Hypertension, 2016Co-Authors: Arismendy Nunez, Muhammad Ihsan, Louis Salciccioli, Sarah Gaballah, Attiya Haque, Oleg Yurevich, Sukhpreet Ahluwalia, Mark G Stewart, Jason M LazarAbstract:Introduction: Statin therapy is widely used to treat dyslipidemia. However, recent reports suggest that statin therapy increases the risk for type 2 diabetes mellitus (DM). Fitness lowers the risk of developing DM. The interaction between fitness, statin therapy and the risk of DM has not been investigated. Methods: We identified 3,161 hypertensive individuals on statin therapy for at least 6 months (mean age: 59.0 10.7) and no evidence of type 2 diabetes mellitus (DM) prior to initiation of statin therapy. All completed an exercise stress test at two VA Medical Centers (Washington, DC and Palo Alto, CA. We established five age-adjusted fitness categories based on peak metabolic equivalents (METs) achieved: Least-Fit ( 20%; 4.6 0.98 METs; n1⁄4733); Low-Fit (20.1%-40%; 6.2 0.80 METs; n1⁄4807); Moderate-Fit (40.1%-60%; 7.6 0.70 METs; n1⁄4799), Fit (60.1%-80%; 8.7 0.64; n1⁄4450) and High-Fit (>75%; 9.6 1.0 METs; n1⁄4377). Multivariable Cox proportional hazard model, adjusted for age, BMI, cardiac risk factors, and cardiac medications was used to assess the association between exercise capacity and the risk for developing DM2. The Least-Fit category was used as the referent. P-values <0.05 using two sided tests were considered statistically significant. Results: During a median follow-up period of 8.9 years, 1,172 developed DM2 (41.9/1,000 person-years). Exercise capacity was inversely related to DM2 incidence. The risk was 6% lower (hazard ratio, 0.94; 95% CI, 0.91-0.98) for every 1-MET increase in exercise capacity. Compared with the Least-Fit individuals, hazard ratios were: 0.78 (95% CI: 0.63-0.96) for Fit and 0.73 (95% CI: 0.58-0.93) for HighFit individuals. Conclusion: Moderate and high levels of cardiorespiratory fitness attenuated the risk of developing DM in hypertensive patients on statin therapy.
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Research Article Assessment of arterial stiffness from pedal artery Korotkoff Sound recordings: feasibility and potential utility
2016Co-Authors: Muhammad Ihsan, Arismendy Nunez, Yang Liu, Faraz Ahmed, Harsh Patel, Navneet Sharma, Marco Diaz, Mark Stewart, Isaac Naggar, Louis SalciccioliAbstract:Brachial artery (BA) Korotkoff Sound (KS) timing reflects arterial stiffness. We recorded pedal artery (PA) KS in 68 healthy subjects using an electronic stethoscope and electrocardiography. Intervals between QRS complex of the electrocardiogram and KS waveform peaks (termed the QKD interval) were measured for 60 seconds, averaged, and QKD velocity (v) calculated. Carotid‐BA and carotid‐PA pulse wave velocities (PWVs) were measured by applanation tonometry. Analyzable KS recordings were obtained from BA and PA in 100% and 92% subjects. PA QKDv decreased less than BA QKDv with progressive cuff inflation. At diastolic blood pressure þ 20 mm Hg (maximal yield), BA QKDv was independently associated with weight and pulse pressure, whereas PA QKDv was related to weight and age. PA QKDv correlated with its corresponding PWV stronger than BA QKDv. In conclusion, PA KS is optimally recorded at diastolic blood pressure þ 20 mm Hg; PA QKDv is correlated with age and better correlates with PWV than does BA QKDv. This technique may provide a simple arterial stiffness measure. J Am Soc Hypertens 2016;10(1):34‐40. Published by Elsevier Inc. on behalf of American Society of Hypertension.
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Assessment of arterial stiffness from pedal artery Korotkoff Sound recordings: feasibility and potential utility
Journal of the American Society of Hypertension : JASH, 2015Co-Authors: Muhammad Ihsan, Arismendy Nunez, Yang Liu, Faraz Ahmed, Harsh Patel, Navneet Sharma, Marco Diaz, Mark Stewart, Isaac Naggar, Louis SalciccioliAbstract:Brachial artery (BA) Korotkoff Sound (KS) timing reflects arterial stiffness. We recorded pedal artery (PA) KS in 68 healthy subjects using an electronic stethoscope and electrocardiography. Intervals between QRS complex of the electrocardiogram and KS waveform peaks (termed the QKD interval) were measured for 60 seconds, averaged, and QKD velocity (v) calculated. Carotid-BA and carotid-PA pulse wave velocities (PWVs) were measured by applanation tonometry. Analyzable KS recordings were obtained from BA and PA in 100% and 92% subjects. PA QKDv decreased less than BA QKDv with progressive cuff inflation. At diastolic blood pressure + 20 mm Hg (maximal yield), BA QKDv was independently associated with weight and pulse pressure, whereas PA QKDv was related to weight and age. PA QKDv correlated with its corresponding PWV stronger than BA QKDv. In conclusion, PA KS is optimally recorded at diastolic blood pressure + 20 mm Hg; PA QKDv is correlated with age and better correlates with PWV than does BA QKDv. This technique may provide a simple arterial stiffness measure.
Muhammad Ihsan - One of the best experts on this subject based on the ideXlab platform.
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assessment of arterial stiffness from pedal artery Korotkoff Sound recordings in heart failure patients
Journal of The American Society of Hypertension, 2016Co-Authors: Arismendy Nunez Nunez, Muhammad Ihsan, Louis Salciccioli, Syed Haidry, Firehiwot Achamyeleh, Ghazal Javaid, Sophia Russ, Jason M LazarAbstract:Introduction: Statin therapy is widely used to treat dyslipidemia. However, recent reports suggest that statin therapy increases the risk for type 2 diabetes mellitus (DM). Fitness lowers the risk of developing DM. The interaction between fitness, statin therapy and the risk of DM has not been investigated. Methods: We identified 3,161 hypertensive individuals on statin therapy for at least 6 months (mean age: 59.0 10.7) and no evidence of type 2 diabetes mellitus (DM) prior to initiation of statin therapy. All completed an exercise stress test at two VA Medical Centers (Washington, DC and Palo Alto, CA. We established five age-adjusted fitness categories based on peak metabolic equivalents (METs) achieved: Least-Fit ( 20%; 4.6 0.98 METs; n1⁄4733); Low-Fit (20.1%-40%; 6.2 0.80 METs; n1⁄4807); Moderate-Fit (40.1%-60%; 7.6 0.70 METs; n1⁄4799), Fit (60.1%-80%; 8.7 0.64; n1⁄4450) and High-Fit (>75%; 9.6 1.0 METs; n1⁄4377). Multivariable Cox proportional hazard model, adjusted for age, BMI, cardiac risk factors, and cardiac medications was used to assess the association between exercise capacity and the risk for developing DM2. The Least-Fit category was used as the referent. P-values <0.05 using two sided tests were considered statistically significant. Results: During a median follow-up period of 8.9 years, 1,172 developed DM2 (41.9/1,000 person-years). Exercise capacity was inversely related to DM2 incidence. The risk was 6% lower (hazard ratio, 0.94; 95% CI, 0.91-0.98) for every 1-MET increase in exercise capacity. Compared with the Least-Fit individuals, hazard ratios were: 0.78 (95% CI: 0.63-0.96) for Fit and 0.73 (95% CI: 0.58-0.93) for HighFit individuals. Conclusion: Moderate and high levels of cardiorespiratory fitness attenuated the risk of developing DM in hypertensive patients on statin therapy.
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differential effects of hyperemia and passive leg raising on qrs to Korotkoff Sound time intervals in hypertensive patients
Journal of The American Society of Hypertension, 2016Co-Authors: Arismendy Nunez, Muhammad Ihsan, Louis Salciccioli, Sarah Gaballah, Attiya Haque, Oleg Yurevich, Sukhpreet Ahluwalia, Mark G Stewart, Jason M LazarAbstract:Introduction: Statin therapy is widely used to treat dyslipidemia. However, recent reports suggest that statin therapy increases the risk for type 2 diabetes mellitus (DM). Fitness lowers the risk of developing DM. The interaction between fitness, statin therapy and the risk of DM has not been investigated. Methods: We identified 3,161 hypertensive individuals on statin therapy for at least 6 months (mean age: 59.0 10.7) and no evidence of type 2 diabetes mellitus (DM) prior to initiation of statin therapy. All completed an exercise stress test at two VA Medical Centers (Washington, DC and Palo Alto, CA. We established five age-adjusted fitness categories based on peak metabolic equivalents (METs) achieved: Least-Fit ( 20%; 4.6 0.98 METs; n1⁄4733); Low-Fit (20.1%-40%; 6.2 0.80 METs; n1⁄4807); Moderate-Fit (40.1%-60%; 7.6 0.70 METs; n1⁄4799), Fit (60.1%-80%; 8.7 0.64; n1⁄4450) and High-Fit (>75%; 9.6 1.0 METs; n1⁄4377). Multivariable Cox proportional hazard model, adjusted for age, BMI, cardiac risk factors, and cardiac medications was used to assess the association between exercise capacity and the risk for developing DM2. The Least-Fit category was used as the referent. P-values <0.05 using two sided tests were considered statistically significant. Results: During a median follow-up period of 8.9 years, 1,172 developed DM2 (41.9/1,000 person-years). Exercise capacity was inversely related to DM2 incidence. The risk was 6% lower (hazard ratio, 0.94; 95% CI, 0.91-0.98) for every 1-MET increase in exercise capacity. Compared with the Least-Fit individuals, hazard ratios were: 0.78 (95% CI: 0.63-0.96) for Fit and 0.73 (95% CI: 0.58-0.93) for HighFit individuals. Conclusion: Moderate and high levels of cardiorespiratory fitness attenuated the risk of developing DM in hypertensive patients on statin therapy.
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Research Article Assessment of arterial stiffness from pedal artery Korotkoff Sound recordings: feasibility and potential utility
2016Co-Authors: Muhammad Ihsan, Arismendy Nunez, Yang Liu, Faraz Ahmed, Harsh Patel, Navneet Sharma, Marco Diaz, Mark Stewart, Isaac Naggar, Louis SalciccioliAbstract:Brachial artery (BA) Korotkoff Sound (KS) timing reflects arterial stiffness. We recorded pedal artery (PA) KS in 68 healthy subjects using an electronic stethoscope and electrocardiography. Intervals between QRS complex of the electrocardiogram and KS waveform peaks (termed the QKD interval) were measured for 60 seconds, averaged, and QKD velocity (v) calculated. Carotid‐BA and carotid‐PA pulse wave velocities (PWVs) were measured by applanation tonometry. Analyzable KS recordings were obtained from BA and PA in 100% and 92% subjects. PA QKDv decreased less than BA QKDv with progressive cuff inflation. At diastolic blood pressure þ 20 mm Hg (maximal yield), BA QKDv was independently associated with weight and pulse pressure, whereas PA QKDv was related to weight and age. PA QKDv correlated with its corresponding PWV stronger than BA QKDv. In conclusion, PA KS is optimally recorded at diastolic blood pressure þ 20 mm Hg; PA QKDv is correlated with age and better correlates with PWV than does BA QKDv. This technique may provide a simple arterial stiffness measure. J Am Soc Hypertens 2016;10(1):34‐40. Published by Elsevier Inc. on behalf of American Society of Hypertension.
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Assessment of arterial stiffness from pedal artery Korotkoff Sound recordings: feasibility and potential utility
Journal of the American Society of Hypertension : JASH, 2015Co-Authors: Muhammad Ihsan, Arismendy Nunez, Yang Liu, Faraz Ahmed, Harsh Patel, Navneet Sharma, Marco Diaz, Mark Stewart, Isaac Naggar, Louis SalciccioliAbstract:Brachial artery (BA) Korotkoff Sound (KS) timing reflects arterial stiffness. We recorded pedal artery (PA) KS in 68 healthy subjects using an electronic stethoscope and electrocardiography. Intervals between QRS complex of the electrocardiogram and KS waveform peaks (termed the QKD interval) were measured for 60 seconds, averaged, and QKD velocity (v) calculated. Carotid-BA and carotid-PA pulse wave velocities (PWVs) were measured by applanation tonometry. Analyzable KS recordings were obtained from BA and PA in 100% and 92% subjects. PA QKDv decreased less than BA QKDv with progressive cuff inflation. At diastolic blood pressure + 20 mm Hg (maximal yield), BA QKDv was independently associated with weight and pulse pressure, whereas PA QKDv was related to weight and age. PA QKDv correlated with its corresponding PWV stronger than BA QKDv. In conclusion, PA KS is optimally recorded at diastolic blood pressure + 20 mm Hg; PA QKDv is correlated with age and better correlates with PWV than does BA QKDv. This technique may provide a simple arterial stiffness measure.
Arismendy Nunez - One of the best experts on this subject based on the ideXlab platform.
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differential effects of hyperemia and passive leg raising on qrs to Korotkoff Sound time intervals in hypertensive patients
Journal of The American Society of Hypertension, 2016Co-Authors: Arismendy Nunez, Muhammad Ihsan, Louis Salciccioli, Sarah Gaballah, Attiya Haque, Oleg Yurevich, Sukhpreet Ahluwalia, Mark G Stewart, Jason M LazarAbstract:Introduction: Statin therapy is widely used to treat dyslipidemia. However, recent reports suggest that statin therapy increases the risk for type 2 diabetes mellitus (DM). Fitness lowers the risk of developing DM. The interaction between fitness, statin therapy and the risk of DM has not been investigated. Methods: We identified 3,161 hypertensive individuals on statin therapy for at least 6 months (mean age: 59.0 10.7) and no evidence of type 2 diabetes mellitus (DM) prior to initiation of statin therapy. All completed an exercise stress test at two VA Medical Centers (Washington, DC and Palo Alto, CA. We established five age-adjusted fitness categories based on peak metabolic equivalents (METs) achieved: Least-Fit ( 20%; 4.6 0.98 METs; n1⁄4733); Low-Fit (20.1%-40%; 6.2 0.80 METs; n1⁄4807); Moderate-Fit (40.1%-60%; 7.6 0.70 METs; n1⁄4799), Fit (60.1%-80%; 8.7 0.64; n1⁄4450) and High-Fit (>75%; 9.6 1.0 METs; n1⁄4377). Multivariable Cox proportional hazard model, adjusted for age, BMI, cardiac risk factors, and cardiac medications was used to assess the association between exercise capacity and the risk for developing DM2. The Least-Fit category was used as the referent. P-values <0.05 using two sided tests were considered statistically significant. Results: During a median follow-up period of 8.9 years, 1,172 developed DM2 (41.9/1,000 person-years). Exercise capacity was inversely related to DM2 incidence. The risk was 6% lower (hazard ratio, 0.94; 95% CI, 0.91-0.98) for every 1-MET increase in exercise capacity. Compared with the Least-Fit individuals, hazard ratios were: 0.78 (95% CI: 0.63-0.96) for Fit and 0.73 (95% CI: 0.58-0.93) for HighFit individuals. Conclusion: Moderate and high levels of cardiorespiratory fitness attenuated the risk of developing DM in hypertensive patients on statin therapy.
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Research Article Assessment of arterial stiffness from pedal artery Korotkoff Sound recordings: feasibility and potential utility
2016Co-Authors: Muhammad Ihsan, Arismendy Nunez, Yang Liu, Faraz Ahmed, Harsh Patel, Navneet Sharma, Marco Diaz, Mark Stewart, Isaac Naggar, Louis SalciccioliAbstract:Brachial artery (BA) Korotkoff Sound (KS) timing reflects arterial stiffness. We recorded pedal artery (PA) KS in 68 healthy subjects using an electronic stethoscope and electrocardiography. Intervals between QRS complex of the electrocardiogram and KS waveform peaks (termed the QKD interval) were measured for 60 seconds, averaged, and QKD velocity (v) calculated. Carotid‐BA and carotid‐PA pulse wave velocities (PWVs) were measured by applanation tonometry. Analyzable KS recordings were obtained from BA and PA in 100% and 92% subjects. PA QKDv decreased less than BA QKDv with progressive cuff inflation. At diastolic blood pressure þ 20 mm Hg (maximal yield), BA QKDv was independently associated with weight and pulse pressure, whereas PA QKDv was related to weight and age. PA QKDv correlated with its corresponding PWV stronger than BA QKDv. In conclusion, PA KS is optimally recorded at diastolic blood pressure þ 20 mm Hg; PA QKDv is correlated with age and better correlates with PWV than does BA QKDv. This technique may provide a simple arterial stiffness measure. J Am Soc Hypertens 2016;10(1):34‐40. Published by Elsevier Inc. on behalf of American Society of Hypertension.
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Assessment of arterial stiffness from pedal artery Korotkoff Sound recordings: feasibility and potential utility
Journal of the American Society of Hypertension : JASH, 2015Co-Authors: Muhammad Ihsan, Arismendy Nunez, Yang Liu, Faraz Ahmed, Harsh Patel, Navneet Sharma, Marco Diaz, Mark Stewart, Isaac Naggar, Louis SalciccioliAbstract:Brachial artery (BA) Korotkoff Sound (KS) timing reflects arterial stiffness. We recorded pedal artery (PA) KS in 68 healthy subjects using an electronic stethoscope and electrocardiography. Intervals between QRS complex of the electrocardiogram and KS waveform peaks (termed the QKD interval) were measured for 60 seconds, averaged, and QKD velocity (v) calculated. Carotid-BA and carotid-PA pulse wave velocities (PWVs) were measured by applanation tonometry. Analyzable KS recordings were obtained from BA and PA in 100% and 92% subjects. PA QKDv decreased less than BA QKDv with progressive cuff inflation. At diastolic blood pressure + 20 mm Hg (maximal yield), BA QKDv was independently associated with weight and pulse pressure, whereas PA QKDv was related to weight and age. PA QKDv correlated with its corresponding PWV stronger than BA QKDv. In conclusion, PA KS is optimally recorded at diastolic blood pressure + 20 mm Hg; PA QKDv is correlated with age and better correlates with PWV than does BA QKDv. This technique may provide a simple arterial stiffness measure.
Petros Nihoyannopoulos - One of the best experts on this subject based on the ideXlab platform.
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the effect of age on vascular compliance in man which are the appropriate measures
Journal of Human Hypertension, 1999Co-Authors: C J Bulpitt, James D Cameron, Chakravarthi Rajkumar, S Armstrong, M Connor, J Joshi, D Lyons, O Moioli, Petros NihoyannopoulosAbstract:Vascular compliance declines rapidly with age and measures of arterial compliance may help understanding of the aging process. Of the different measures of vascular compliance, those more closely related to chronological age need to be identified. These measures may help in the estimation of 'biological age'. We measured pulse wave velocity as the carotid-finger interval, carotid-toe interval and QKD interval (time between the Q wave and the arrival of the diastolic Korotkoff Sound (K) over the brachial artery in diastoly (D)); central aortic compliance (CAC) and SV/PP (the stroke volume divided by pulse pressure in the brachial artery). Thirty-six volunteers were studied (30 men), ages 20 to 84, mean 49 years, to give the relationship of these measurements with age. CAC, the QKD interval and the carotid-toe interval were most closely related to age (r = - 0.51, -0.60 and -0.58 respectively). After adjustment for age, the only measure related to blood pressure was the carotid-finger interval; b for diastolic blood pressure = -0.83 (P = 0.01), the higher the pressure the shorter the interval. Measurements of CAC, QKD interval and carotid-toe interval may be employed to assess the impact of age on vascular compliance. Measures of peripheral vascular compliance, such as the carotid-finger interval, may prove useful in assessing the relationship between blood pressure and vascular compliance.
