The Experts below are selected from a list of 2013 Experts worldwide ranked by ideXlab platform
Ilkka Immonen - One of the best experts on this subject based on the ideXlab platform.
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Transcleral contact Krypton-Laser photocoagulation of the retina in rabbits.
Acta ophthalmologica, 2009Co-Authors: Veli-pekka Suomalainen, E. Viherkoski, Ilkka ImmonenAbstract:Transcleral contact retinal Krypton Laser photocoagulation of the retina was studied in rabbit eyes. The Laser application was performed under indirect ophthalmoscope visual control with indentation of the sclera by the Laser probe. Retinal lesions were produced with powers ranging from 0.2 to 0.3 W and application times between 1 and 2 sec. The lesions were studied histologically 2, 5, 10, 12, 20, 30 and 70 days after treatment. Histopathological examination of the lesions showed damage of mainly the outer retinal layers in light lesions, and to all layers of the retina in the more intense lesions. No scleral damage was observed in the light lesions, whereas transient oedema of the inner sclera was seen in the intense lesions. Studies with enucleated rabbit eyes showed that indentation of the sclera by the Laser probe substantially decreased the power needed to produce a retinal lesion. It is concluded, that when used with scleral indentation, transscleral Krypton Laser photocoagulation of the retina can be performed with minimal damage to the sclera.
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Transscleral contact Krypton Laser cyclophotocoagulation for treatment of posttraumatic glaucoma.
Journal of glaucoma, 2001Co-Authors: Virpi Raivio, Ilkka Immonen, Päivi PuskaAbstract:PURPOSE: To evaluate the usefulness of the Krypton Laser for transscleral contact cyclophotocoagulation in the treatment of posttraumatic glaucoma. PATIENTS AND METHODS: A total of 18 eyes of 18 patients with therapy-resistant posttraumatic glaucoma treated with Krypton Laser cyclophotocoagulation from 1991 to 1996 were included in this review. The Krypton Laser was delivered by a fiberoptic probe with simultaneous compression of the sclera. The energy used was 3 to 5 J per application at the tip of the probe, with an exposure time of 10 seconds. The treatment covered 90 to 360 degrees of the ciliary body with approximately 10 applications per quadrant. RESULTS: With one or more cyclophotocoagulation treatments, the intraocular pressure decreased from the baseline mean (+/- standard deviation) of 32.6 +/- 12.8 mm Hg to 23.6 +/- 10.3 mm Hg (n = 17) at 1 month, to 21.8 +/- 7.5 mm Hg (n = 13) at 3 months, to 22.5 +/- 7.6 mm Hg (n = 13) at 6 months, and to 19.6 +/- 10.5 mm Hg (n = 18) at the last control visit (mean, 19.4 months; range, 3 weeks to 73 months) after cyclophotocoagulation but no other glaucoma procedure. At baseline, 17 (94%) of 18 patients were taking glaucoma medication, as were 15 (83%) of 18 patients at the last control visit. One (6%) case of phthisis occurred. CONCLUSIONS: Krypton Laser cyclophotocoagulation is an effective and reasonably well tolerated means of lowering intraocular pressure in posttraumatic glaucoma. Because of the refractory nature of the disease, repeated treatments may be needed.
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Transscleral contact Krypton Laser cyclophotocoagulation for treatment of glaucoma in children and young adults.
Ophthalmology, 2001Co-Authors: Virpi Raivio, Ilkka Immonen, Päivi PuskaAbstract:Abstract Purpose To evaluate the usefulness of the Krypton Laser for transscleral contact cyclophotocoagulation (CPC) in the treatment of glaucoma in young patients. Design Retrospective noncomparative interventional case series. Participants Transscleral contact Krypton Laser CPC was performed in 27 glaucomatous eyes of 22 young patients (mean age, 10.5 ± 5.6 years; range, 11 months–19.4 years). Methods The treatment was delivered by means of a fiberoptic probe with compression of the sclera by the probe. The power used was 300 to 500 W per application at the tip of the probe with an exposure time of 10 seconds. Main outcome measures The primary outcome measure is a change in intraocular pressure (IOP). Results Of the patients who received CPC in both eyes, one eye was randomly chosen for statistical analysis. The mean overall follow-up time was 43.3 ± 25.3 (median, 36.5; range, 1–82) months after the initial CPC. Preoperatively, the mean intraocular pressure was 35.0 ± 7.9 mmHg (n = 22). After one or more CPCs, the mean IOP was decreased to 21.5 ± 8.7 mmHg (n = 22) at 1 month ( P P P P P Conclusions Krypton Laser CPC is a well-tolerated means of lowering IOP in young patients with glaucoma, but repeated treatments may be needed.
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Clinically Successful Contact Transscleral Krypton Laser Cyclophotocoagulation: Long-term Histopathologic and Immunohistochemical Autopsy Findings
Archives of ophthalmology (Chicago Ill. : 1960), 1995Co-Authors: Tero Kivelä, Ilkka Immonen, Päivi Puska, Christina Raitta, Ahti TarkkanenAbstract:Objective: To report long-term histopathologic findings 10 months after contact transscleral Krypton cyclophotocoagulation. Methods: The tissue response in a successfully treated eye was analyzed by light microscopy and a panel of 11 antibodies to epithelial, mesenchymal, and inflammatory cells. Results: A 75-year-old man with uncontrolled angle recession glaucoma was treated with transscleral contact Krypton cyclophotocoagulation (17 burns, 3.5 J each) 10 months before his death. The intraocular pressure fell from 28 to 17 mm Hg 6 months after therapy. Confluent scars straddled the posterior pars plicata and the anterior pars plana. The ciliary processes were destroyed, but the sclera and zonules were intact. Vimentin and cytokeratin 8 and 18 persisted in the degenerated ciliary epithelium. The inner connective-tissue layer and the ciliary muscle had atrophied, as shown with antibodies to the HNK-1 epitope, desmin, and α—smooth-muscle actin. Macrophages with phagocytized pigment and single T cells were present instead. No unusual inflammatory infiltrate was present in the choroid of either eye. Conclusions: Clinically effective ablation of ciliary processes is achieved with contact Krypton Laser. Little chronic inflammation and no signs of sympathetic ophthalmia were present. Atrophy of the ciliary muscle may reduce accommodative capacity in younger patients undergoing cyclophotocoagulation.
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Transscleral Contact Krypton Laser Cyclophotocoagulation for Treatment of Glaucoma
Ophthalmology, 1994Co-Authors: Ilkka Immonen, Päivi Puska, Christina RaittaAbstract:Purpose: To evaluate the usefulness of the Krypton Laser for transscleral contact cyclophotocoagulation. Methods: Transscleral contact Krypton Laser cyclophotocoagulation was performed in 62 eyes of 57 patients with therapy-resistant glaucoma. A minimum follow-up for 6 months was obtained for 59 eyes. The Krypton Laser was delivered via a fiberoptic probe with compression of the sclera by the probe. The energy used was 4 to 5 J per application at the tip of the probe with an exposure time of 10 seconds. Results: The intraocular pressure (IOP) decreased from the baseline mean of 34.8 ± 11.0 mmHg to 20.4 ± 8.3 mmHg within 10 days, to 22.6 ± 12.5 mmHg at 1 month, to 21.3 ± 11.3 mmHg at 3 months, and to 20.9 ± 9.1 mmHg at 6 months postoperatively. Intraocular pressures of 8 to 24 mmHg were obtained in 62% of the eyes at 1 month, 60% at 3 months, and 73% at 6 months postoperatively with one or more cyclophotocoagulations but no other hypotensive procedures. The corresponding success rates after 6 months were 82% for eyes in which the procedure was performed to preserve vision and 50% for eyes in which the procedure was performed to relieve pain. No clinical signs of scleral injury or cyclodestruction-related loss of vision were detected. Conclusions: Krypton Laser cyclophotocoagulation appears to be an effective and well-tolerated means of lowering IOP in therapy-resistant glaucoma. An advantage of the method is that standard retinal Krypton photocoagulators can be used for the procedure.
Päivi Puska - One of the best experts on this subject based on the ideXlab platform.
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Transscleral contact Krypton Laser cyclophotocoagulation for treatment of glaucoma in children and young adults.
Ophthalmology, 2001Co-Authors: Virpi Raivio, Ilkka Immonen, Päivi PuskaAbstract:Abstract Purpose To evaluate the usefulness of the Krypton Laser for transscleral contact cyclophotocoagulation (CPC) in the treatment of glaucoma in young patients. Design Retrospective noncomparative interventional case series. Participants Transscleral contact Krypton Laser CPC was performed in 27 glaucomatous eyes of 22 young patients (mean age, 10.5 ± 5.6 years; range, 11 months–19.4 years). Methods The treatment was delivered by means of a fiberoptic probe with compression of the sclera by the probe. The power used was 300 to 500 W per application at the tip of the probe with an exposure time of 10 seconds. Main outcome measures The primary outcome measure is a change in intraocular pressure (IOP). Results Of the patients who received CPC in both eyes, one eye was randomly chosen for statistical analysis. The mean overall follow-up time was 43.3 ± 25.3 (median, 36.5; range, 1–82) months after the initial CPC. Preoperatively, the mean intraocular pressure was 35.0 ± 7.9 mmHg (n = 22). After one or more CPCs, the mean IOP was decreased to 21.5 ± 8.7 mmHg (n = 22) at 1 month ( P P P P P Conclusions Krypton Laser CPC is a well-tolerated means of lowering IOP in young patients with glaucoma, but repeated treatments may be needed.
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Transscleral contact Krypton Laser cyclophotocoagulation for treatment of posttraumatic glaucoma.
Journal of glaucoma, 2001Co-Authors: Virpi Raivio, Ilkka Immonen, Päivi PuskaAbstract:PURPOSE: To evaluate the usefulness of the Krypton Laser for transscleral contact cyclophotocoagulation in the treatment of posttraumatic glaucoma. PATIENTS AND METHODS: A total of 18 eyes of 18 patients with therapy-resistant posttraumatic glaucoma treated with Krypton Laser cyclophotocoagulation from 1991 to 1996 were included in this review. The Krypton Laser was delivered by a fiberoptic probe with simultaneous compression of the sclera. The energy used was 3 to 5 J per application at the tip of the probe, with an exposure time of 10 seconds. The treatment covered 90 to 360 degrees of the ciliary body with approximately 10 applications per quadrant. RESULTS: With one or more cyclophotocoagulation treatments, the intraocular pressure decreased from the baseline mean (+/- standard deviation) of 32.6 +/- 12.8 mm Hg to 23.6 +/- 10.3 mm Hg (n = 17) at 1 month, to 21.8 +/- 7.5 mm Hg (n = 13) at 3 months, to 22.5 +/- 7.6 mm Hg (n = 13) at 6 months, and to 19.6 +/- 10.5 mm Hg (n = 18) at the last control visit (mean, 19.4 months; range, 3 weeks to 73 months) after cyclophotocoagulation but no other glaucoma procedure. At baseline, 17 (94%) of 18 patients were taking glaucoma medication, as were 15 (83%) of 18 patients at the last control visit. One (6%) case of phthisis occurred. CONCLUSIONS: Krypton Laser cyclophotocoagulation is an effective and reasonably well tolerated means of lowering intraocular pressure in posttraumatic glaucoma. Because of the refractory nature of the disease, repeated treatments may be needed.
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Clinically Successful Contact Transscleral Krypton Laser Cyclophotocoagulation: Long-term Histopathologic and Immunohistochemical Autopsy Findings
Archives of ophthalmology (Chicago Ill. : 1960), 1995Co-Authors: Tero Kivelä, Ilkka Immonen, Päivi Puska, Christina Raitta, Ahti TarkkanenAbstract:Objective: To report long-term histopathologic findings 10 months after contact transscleral Krypton cyclophotocoagulation. Methods: The tissue response in a successfully treated eye was analyzed by light microscopy and a panel of 11 antibodies to epithelial, mesenchymal, and inflammatory cells. Results: A 75-year-old man with uncontrolled angle recession glaucoma was treated with transscleral contact Krypton cyclophotocoagulation (17 burns, 3.5 J each) 10 months before his death. The intraocular pressure fell from 28 to 17 mm Hg 6 months after therapy. Confluent scars straddled the posterior pars plicata and the anterior pars plana. The ciliary processes were destroyed, but the sclera and zonules were intact. Vimentin and cytokeratin 8 and 18 persisted in the degenerated ciliary epithelium. The inner connective-tissue layer and the ciliary muscle had atrophied, as shown with antibodies to the HNK-1 epitope, desmin, and α—smooth-muscle actin. Macrophages with phagocytized pigment and single T cells were present instead. No unusual inflammatory infiltrate was present in the choroid of either eye. Conclusions: Clinically effective ablation of ciliary processes is achieved with contact Krypton Laser. Little chronic inflammation and no signs of sympathetic ophthalmia were present. Atrophy of the ciliary muscle may reduce accommodative capacity in younger patients undergoing cyclophotocoagulation.
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Transscleral Contact Krypton Laser Cyclophotocoagulation for Treatment of Glaucoma
Ophthalmology, 1994Co-Authors: Ilkka Immonen, Päivi Puska, Christina RaittaAbstract:Purpose: To evaluate the usefulness of the Krypton Laser for transscleral contact cyclophotocoagulation. Methods: Transscleral contact Krypton Laser cyclophotocoagulation was performed in 62 eyes of 57 patients with therapy-resistant glaucoma. A minimum follow-up for 6 months was obtained for 59 eyes. The Krypton Laser was delivered via a fiberoptic probe with compression of the sclera by the probe. The energy used was 4 to 5 J per application at the tip of the probe with an exposure time of 10 seconds. Results: The intraocular pressure (IOP) decreased from the baseline mean of 34.8 ± 11.0 mmHg to 20.4 ± 8.3 mmHg within 10 days, to 22.6 ± 12.5 mmHg at 1 month, to 21.3 ± 11.3 mmHg at 3 months, and to 20.9 ± 9.1 mmHg at 6 months postoperatively. Intraocular pressures of 8 to 24 mmHg were obtained in 62% of the eyes at 1 month, 60% at 3 months, and 73% at 6 months postoperatively with one or more cyclophotocoagulations but no other hypotensive procedures. The corresponding success rates after 6 months were 82% for eyes in which the procedure was performed to preserve vision and 50% for eyes in which the procedure was performed to relieve pain. No clinical signs of scleral injury or cyclodestruction-related loss of vision were detected. Conclusions: Krypton Laser cyclophotocoagulation appears to be an effective and well-tolerated means of lowering IOP in therapy-resistant glaucoma. An advantage of the method is that standard retinal Krypton photocoagulators can be used for the procedure.
Veli-pekka Suomalainen - One of the best experts on this subject based on the ideXlab platform.
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Comparison of retinal lesions produced by transscleral Krypton Laser photocoagulation, transpupillar Krypton Laser photocoagulation and cryocoagulation.
Acta ophthalmologica, 2009Co-Authors: Veli-pekka SuomalainenAbstract:We compared the retinal lesions produced by transscleral and transpupillar Krypton Lasers and cryocoagulation. Transscleral Laser photocoagulation was applied under indirect ophthalmoscope visual control with indentation of the sclera by the Laser probe. Transpupillar Laser was performed with a Volk 90D lens. The power and the spot size were adjusted to create lesions of similar size and intensity as in transscleral photocoagulation. The output power needed for transscleral photocoagulation was 0.2W with exposure time of 3-5 sec. In the transpupillar photocoagulation the output power was 0.3W and the exposure time 2-3 sec, respectively. The lesions were studied histologically 1h, 1, 3, 7, 30 and 60 days after treatment. Histopathological studies of the Krypton Laser lesions revealed destruction and scarring of the outer layers of the retina and the choroid. The lesions produced by transpupillar and transscleral Laser appeared to be rather similar. These results indicate that, in the rabbit eye, there is no difference between the lesions produced by the transpupillar or transscleral route of Laser application. Transscleral Laser application may have clinical advantages over transpupillary Laser in the eyes with hazy media or in other cases when transpupillar Laser is not possible.
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Transcleral contact Krypton-Laser photocoagulation of the retina in rabbits.
Acta ophthalmologica, 2009Co-Authors: Veli-pekka Suomalainen, E. Viherkoski, Ilkka ImmonenAbstract:Transcleral contact retinal Krypton Laser photocoagulation of the retina was studied in rabbit eyes. The Laser application was performed under indirect ophthalmoscope visual control with indentation of the sclera by the Laser probe. Retinal lesions were produced with powers ranging from 0.2 to 0.3 W and application times between 1 and 2 sec. The lesions were studied histologically 2, 5, 10, 12, 20, 30 and 70 days after treatment. Histopathological examination of the lesions showed damage of mainly the outer retinal layers in light lesions, and to all layers of the retina in the more intense lesions. No scleral damage was observed in the light lesions, whereas transient oedema of the inner sclera was seen in the intense lesions. Studies with enucleated rabbit eyes showed that indentation of the sclera by the Laser probe substantially decreased the power needed to produce a retinal lesion. It is concluded, that when used with scleral indentation, transscleral Krypton Laser photocoagulation of the retina can be performed with minimal damage to the sclera.
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Energy levels needed for cyclophotocoagulation: a comparison of transscleral contact cw-YAG and Krypton Lasers in the rabbit eye.
Ophthalmic surgery, 1993Co-Authors: Ilkka Immonen, Veli-pekka Suomalainen, Tero Kivelä, E. ViherkoskiAbstract:The energy levels needed for cyclophotocoagulation using either transscleral contact Krypton or cw-YAG Lasers were compared in pigmented rabbits. The same transscleral Laser probe was used for both Lasers. With the Krypton Laser, 0.25 J of energy caused macroscopically detectable lesions, and 1.5 J led to widespread destruction of the ciliary body. With the cw-YAG Laser, the first detectable lesions were produced at 0.5 J. Similarly, at higher energies, twice as much energy was required using the cw-YAG as compared with using the Krypton Laser to produce comparable lesions. Histologically, lesions of the same macroscopic severity made with the two Lasers were similar. We conclude that the transscleral contact Krypton Laser is an efficient instrument for cyclophotocoagulation. Although these results may not be directly applied to human eyes, it appears that the poorer scleral transmission of the Krypton beam is offset by its higher level of absorption in the pigmented epithelium of the ciliary body.
Guo Jian-hui - One of the best experts on this subject based on the ideXlab platform.
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Krypton yellow Laser photocoagulation treatment of branch retinal vein occlusion
Journal of Shanxi Medical University, 2003Co-Authors: Guo Jian-huiAbstract:Objective To investigate the effect of Krypton Laser photocoagulation on branch retinal vein occlusion. Methods All of 56 patients with branch retinal vein occlusion were photocoagulated by Krypton Laser. The patients were followed up for 5 to 32 months. The fundus changes and complications were observed by fundus fluorescein angiography after photocoagulation. Results The visual acuity improved in 35 eyes(62 5%). The visual acuity surpassed 0 5 in 29 eyes(51 78%) after photocoagulation. Macular edema disappeared completely or reduced in 39 eyes(76 42%) after photocoagulation. Conclusion Krypton Laser photocoagulation is obviously effective on treatment of branch retinal vein occlusion.
Christina Raitta - One of the best experts on this subject based on the ideXlab platform.
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Clinically Successful Contact Transscleral Krypton Laser Cyclophotocoagulation: Long-term Histopathologic and Immunohistochemical Autopsy Findings
Archives of ophthalmology (Chicago Ill. : 1960), 1995Co-Authors: Tero Kivelä, Ilkka Immonen, Päivi Puska, Christina Raitta, Ahti TarkkanenAbstract:Objective: To report long-term histopathologic findings 10 months after contact transscleral Krypton cyclophotocoagulation. Methods: The tissue response in a successfully treated eye was analyzed by light microscopy and a panel of 11 antibodies to epithelial, mesenchymal, and inflammatory cells. Results: A 75-year-old man with uncontrolled angle recession glaucoma was treated with transscleral contact Krypton cyclophotocoagulation (17 burns, 3.5 J each) 10 months before his death. The intraocular pressure fell from 28 to 17 mm Hg 6 months after therapy. Confluent scars straddled the posterior pars plicata and the anterior pars plana. The ciliary processes were destroyed, but the sclera and zonules were intact. Vimentin and cytokeratin 8 and 18 persisted in the degenerated ciliary epithelium. The inner connective-tissue layer and the ciliary muscle had atrophied, as shown with antibodies to the HNK-1 epitope, desmin, and α—smooth-muscle actin. Macrophages with phagocytized pigment and single T cells were present instead. No unusual inflammatory infiltrate was present in the choroid of either eye. Conclusions: Clinically effective ablation of ciliary processes is achieved with contact Krypton Laser. Little chronic inflammation and no signs of sympathetic ophthalmia were present. Atrophy of the ciliary muscle may reduce accommodative capacity in younger patients undergoing cyclophotocoagulation.
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Transscleral Contact Krypton Laser Cyclophotocoagulation for Treatment of Glaucoma
Ophthalmology, 1994Co-Authors: Ilkka Immonen, Päivi Puska, Christina RaittaAbstract:Purpose: To evaluate the usefulness of the Krypton Laser for transscleral contact cyclophotocoagulation. Methods: Transscleral contact Krypton Laser cyclophotocoagulation was performed in 62 eyes of 57 patients with therapy-resistant glaucoma. A minimum follow-up for 6 months was obtained for 59 eyes. The Krypton Laser was delivered via a fiberoptic probe with compression of the sclera by the probe. The energy used was 4 to 5 J per application at the tip of the probe with an exposure time of 10 seconds. Results: The intraocular pressure (IOP) decreased from the baseline mean of 34.8 ± 11.0 mmHg to 20.4 ± 8.3 mmHg within 10 days, to 22.6 ± 12.5 mmHg at 1 month, to 21.3 ± 11.3 mmHg at 3 months, and to 20.9 ± 9.1 mmHg at 6 months postoperatively. Intraocular pressures of 8 to 24 mmHg were obtained in 62% of the eyes at 1 month, 60% at 3 months, and 73% at 6 months postoperatively with one or more cyclophotocoagulations but no other hypotensive procedures. The corresponding success rates after 6 months were 82% for eyes in which the procedure was performed to preserve vision and 50% for eyes in which the procedure was performed to relieve pain. No clinical signs of scleral injury or cyclodestruction-related loss of vision were detected. Conclusions: Krypton Laser cyclophotocoagulation appears to be an effective and well-tolerated means of lowering IOP in therapy-resistant glaucoma. An advantage of the method is that standard retinal Krypton photocoagulators can be used for the procedure.
