The Experts below are selected from a list of 78 Experts worldwide ranked by ideXlab platform
A. Fletcher - One of the best experts on this subject based on the ideXlab platform.
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counts of s 100 positive epidermal dendritic cells in Kveim Test skin biopsies
Histopathology, 1991Co-Authors: P.a.v. Shaw, A. FletcherAbstract:S-100 positive epidermal dendritic cells were counted in skin biopsies from 48 Kveim Tests and four known foreign-body reactions. Counts in histologically positive Kveim biopsies (mean 11.3 per 200 basal cells) were significantly higher than in either negative biopsies (5.1; P less than 0.001) or foreign-body reactions (4.7; P less than 0.05). A similar difference was found, irrespective of the histological appearances, between biopsies from patients diagnosed clinically as having sarcoidosis (10.5) and those in which another diagnosis had been made (4.1; P less than 0.001). In biopsies from patients with sarcoidosis 70% had a positive Kveim Test, 70% had a raised epidermal dendritic cell count and one or the other was positive in 90%. All cases in which both the Kveim Test was positive and the dendritic cell count was raised had a final clinical diagnosis of sarcoidosis. Counts of S-100 positive epidermal dendritic cells are useful in differentiating positive reactions to Kveim suspension from non-specific reactions to foreign material and increase the diagnostic confidence of the Kveim Test.
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Counts of S‐100 positive epidermal dendritic cells in Kveim Test skin biopsies
Histopathology, 1991Co-Authors: P.a.v. Shaw, A. FletcherAbstract:S-100 positive epidermal dendritic cells were counted in skin biopsies from 48 Kveim Tests and four known foreign-body reactions. Counts in histologically positive Kveim biopsies (mean 11.3 per 200 basal cells) were significantly higher than in either negative biopsies (5.1; P less than 0.001) or foreign-body reactions (4.7; P less than 0.05). A similar difference was found, irrespective of the histological appearances, between biopsies from patients diagnosed clinically as having sarcoidosis (10.5) and those in which another diagnosis had been made (4.1; P less than 0.001). In biopsies from patients with sarcoidosis 70% had a positive Kveim Test, 70% had a raised epidermal dendritic cell count and one or the other was positive in 90%. All cases in which both the Kveim Test was positive and the dendritic cell count was raised had a final clinical diagnosis of sarcoidosis. Counts of S-100 positive epidermal dendritic cells are useful in differentiating positive reactions to Kveim suspension from non-specific reactions to foreign material and increase the diagnostic confidence of the Kveim Test.
Tuncer Karayel - One of the best experts on this subject based on the ideXlab platform.
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seasonality of the onset of symptoms tuberculin Test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis
Respirology, 2007Co-Authors: Sevtap Sipahi Demirkok, Metin Basaranoglu, Elif Coker, Tuncer KarayelAbstract:Background and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim Test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger’s Test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P < 0.001). For patients with Tuberculin anergy (n = 364) the onset of symptoms was most frequent in spring and least frequent in autumn (P < 0.001); there was no seasonal variation among Tuberculin positive patients (n = 128). Of those patients with a Kveim Test result (n = 248), the onset of symptoms was most frequent in spring and least frequent in summer (P < 0.001); there was no seasonal variation for patients with a negative Kveim results (n = 50 patients). Conclusions: The onset of the symptoms was most frequent in spring and least frequent in the second half of the year (summer or autumn) in patients with sarcoidosis, Tuberculin anergy and a positive Kveim reaction. The significance of this finding in relation to aetiology and clinical utility needs to be further assessed.
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Seasonality of the onset of symptoms, tuberculin Test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis.
Respirology (Carlton Vic.), 2007Co-Authors: Sevtap Sipahi Demirkok, Metin Basaranoglu, Elif Coker, Tuncer KarayelAbstract:Background and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim Test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger’s Test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P
P.a.v. Shaw - One of the best experts on this subject based on the ideXlab platform.
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counts of s 100 positive epidermal dendritic cells in Kveim Test skin biopsies
Histopathology, 1991Co-Authors: P.a.v. Shaw, A. FletcherAbstract:S-100 positive epidermal dendritic cells were counted in skin biopsies from 48 Kveim Tests and four known foreign-body reactions. Counts in histologically positive Kveim biopsies (mean 11.3 per 200 basal cells) were significantly higher than in either negative biopsies (5.1; P less than 0.001) or foreign-body reactions (4.7; P less than 0.05). A similar difference was found, irrespective of the histological appearances, between biopsies from patients diagnosed clinically as having sarcoidosis (10.5) and those in which another diagnosis had been made (4.1; P less than 0.001). In biopsies from patients with sarcoidosis 70% had a positive Kveim Test, 70% had a raised epidermal dendritic cell count and one or the other was positive in 90%. All cases in which both the Kveim Test was positive and the dendritic cell count was raised had a final clinical diagnosis of sarcoidosis. Counts of S-100 positive epidermal dendritic cells are useful in differentiating positive reactions to Kveim suspension from non-specific reactions to foreign material and increase the diagnostic confidence of the Kveim Test.
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Counts of S‐100 positive epidermal dendritic cells in Kveim Test skin biopsies
Histopathology, 1991Co-Authors: P.a.v. Shaw, A. FletcherAbstract:S-100 positive epidermal dendritic cells were counted in skin biopsies from 48 Kveim Tests and four known foreign-body reactions. Counts in histologically positive Kveim biopsies (mean 11.3 per 200 basal cells) were significantly higher than in either negative biopsies (5.1; P less than 0.001) or foreign-body reactions (4.7; P less than 0.05). A similar difference was found, irrespective of the histological appearances, between biopsies from patients diagnosed clinically as having sarcoidosis (10.5) and those in which another diagnosis had been made (4.1; P less than 0.001). In biopsies from patients with sarcoidosis 70% had a positive Kveim Test, 70% had a raised epidermal dendritic cell count and one or the other was positive in 90%. All cases in which both the Kveim Test was positive and the dendritic cell count was raised had a final clinical diagnosis of sarcoidosis. Counts of S-100 positive epidermal dendritic cells are useful in differentiating positive reactions to Kveim suspension from non-specific reactions to foreign material and increase the diagnostic confidence of the Kveim Test.
Sevtap Sipahi Demirkok - One of the best experts on this subject based on the ideXlab platform.
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seasonality of the onset of symptoms tuberculin Test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis
Respirology, 2007Co-Authors: Sevtap Sipahi Demirkok, Metin Basaranoglu, Elif Coker, Tuncer KarayelAbstract:Background and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim Test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger’s Test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P < 0.001). For patients with Tuberculin anergy (n = 364) the onset of symptoms was most frequent in spring and least frequent in autumn (P < 0.001); there was no seasonal variation among Tuberculin positive patients (n = 128). Of those patients with a Kveim Test result (n = 248), the onset of symptoms was most frequent in spring and least frequent in summer (P < 0.001); there was no seasonal variation for patients with a negative Kveim results (n = 50 patients). Conclusions: The onset of the symptoms was most frequent in spring and least frequent in the second half of the year (summer or autumn) in patients with sarcoidosis, Tuberculin anergy and a positive Kveim reaction. The significance of this finding in relation to aetiology and clinical utility needs to be further assessed.
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Seasonality of the onset of symptoms, tuberculin Test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis.
Respirology (Carlton Vic.), 2007Co-Authors: Sevtap Sipahi Demirkok, Metin Basaranoglu, Elif Coker, Tuncer KarayelAbstract:Background and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim Test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger’s Test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P
Elif Coker - One of the best experts on this subject based on the ideXlab platform.
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seasonality of the onset of symptoms tuberculin Test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis
Respirology, 2007Co-Authors: Sevtap Sipahi Demirkok, Metin Basaranoglu, Elif Coker, Tuncer KarayelAbstract:Background and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim Test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger’s Test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P < 0.001). For patients with Tuberculin anergy (n = 364) the onset of symptoms was most frequent in spring and least frequent in autumn (P < 0.001); there was no seasonal variation among Tuberculin positive patients (n = 128). Of those patients with a Kveim Test result (n = 248), the onset of symptoms was most frequent in spring and least frequent in summer (P < 0.001); there was no seasonal variation for patients with a negative Kveim results (n = 50 patients). Conclusions: The onset of the symptoms was most frequent in spring and least frequent in the second half of the year (summer or autumn) in patients with sarcoidosis, Tuberculin anergy and a positive Kveim reaction. The significance of this finding in relation to aetiology and clinical utility needs to be further assessed.
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Seasonality of the onset of symptoms, tuberculin Test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis.
Respirology (Carlton Vic.), 2007Co-Authors: Sevtap Sipahi Demirkok, Metin Basaranoglu, Elif Coker, Tuncer KarayelAbstract:Background and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim Test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger’s Test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P
