The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Saeed Ghasemi - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Cytotoxicity EvaLuation of Some NoveL 1-(3-ChLorophenyL)piperazin-2-one Derivatives Bearing ImidazoLe Bioisosteres
Australian Journal of Chemistry, 2013Co-Authors: Saeed Ghasemi, Simin Sharifi, Soodabeh Davaran, Hosein Danafar, Davoud Asgari, Javid Shahbazi MojarradAbstract:A series of substituted 3-chLorophenyLpiperazinone derivatives were synthesised using L-778123 (an imidazoLe-containing FTase inhibitor) as a modeL by bioisosteric repLacement of the imidazoLe ring. The finaL compounds were evaLuated against two human cancer ceLL Lines incLuding A549 (Lung cancer) and HT-29 (coLon cancer) by MTT assay. The resuLts showed that substitution of imidazoLe ring with 1-amidinourea, semicarbazide, and thiobiuret Led to improvement of cytotoxic activity against both ceLL Lines.
Simin Sharifi - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Cytotoxicity EvaLuation of Some NoveL 1-(3-ChLorophenyL)piperazin-2-one Derivatives Bearing ImidazoLe Bioisosteres
Australian Journal of Chemistry, 2013Co-Authors: Saeed Ghasemi, Simin Sharifi, Soodabeh Davaran, Hosein Danafar, Davoud Asgari, Javid Shahbazi MojarradAbstract:A series of substituted 3-chLorophenyLpiperazinone derivatives were synthesised using L-778123 (an imidazoLe-containing FTase inhibitor) as a modeL by bioisosteric repLacement of the imidazoLe ring. The finaL compounds were evaLuated against two human cancer ceLL Lines incLuding A549 (Lung cancer) and HT-29 (coLon cancer) by MTT assay. The resuLts showed that substitution of imidazoLe ring with 1-amidinourea, semicarbazide, and thiobiuret Led to improvement of cytotoxic activity against both ceLL Lines.
Soodabeh Davaran - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Cytotoxicity EvaLuation of Some NoveL 1-(3-ChLorophenyL)piperazin-2-one Derivatives Bearing ImidazoLe Bioisosteres
Australian Journal of Chemistry, 2013Co-Authors: Saeed Ghasemi, Simin Sharifi, Soodabeh Davaran, Hosein Danafar, Davoud Asgari, Javid Shahbazi MojarradAbstract:A series of substituted 3-chLorophenyLpiperazinone derivatives were synthesised using L-778123 (an imidazoLe-containing FTase inhibitor) as a modeL by bioisosteric repLacement of the imidazoLe ring. The finaL compounds were evaLuated against two human cancer ceLL Lines incLuding A549 (Lung cancer) and HT-29 (coLon cancer) by MTT assay. The resuLts showed that substitution of imidazoLe ring with 1-amidinourea, semicarbazide, and thiobiuret Led to improvement of cytotoxic activity against both ceLL Lines.
Hosein Danafar - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Cytotoxicity EvaLuation of Some NoveL 1-(3-ChLorophenyL)piperazin-2-one Derivatives Bearing ImidazoLe Bioisosteres
Australian Journal of Chemistry, 2013Co-Authors: Saeed Ghasemi, Simin Sharifi, Soodabeh Davaran, Hosein Danafar, Davoud Asgari, Javid Shahbazi MojarradAbstract:A series of substituted 3-chLorophenyLpiperazinone derivatives were synthesised using L-778123 (an imidazoLe-containing FTase inhibitor) as a modeL by bioisosteric repLacement of the imidazoLe ring. The finaL compounds were evaLuated against two human cancer ceLL Lines incLuding A549 (Lung cancer) and HT-29 (coLon cancer) by MTT assay. The resuLts showed that substitution of imidazoLe ring with 1-amidinourea, semicarbazide, and thiobiuret Led to improvement of cytotoxic activity against both ceLL Lines.
Davoud Asgari - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Cytotoxicity EvaLuation of Some NoveL 1-(3-ChLorophenyL)piperazin-2-one Derivatives Bearing ImidazoLe Bioisosteres
Australian Journal of Chemistry, 2013Co-Authors: Saeed Ghasemi, Simin Sharifi, Soodabeh Davaran, Hosein Danafar, Davoud Asgari, Javid Shahbazi MojarradAbstract:A series of substituted 3-chLorophenyLpiperazinone derivatives were synthesised using L-778123 (an imidazoLe-containing FTase inhibitor) as a modeL by bioisosteric repLacement of the imidazoLe ring. The finaL compounds were evaLuated against two human cancer ceLL Lines incLuding A549 (Lung cancer) and HT-29 (coLon cancer) by MTT assay. The resuLts showed that substitution of imidazoLe ring with 1-amidinourea, semicarbazide, and thiobiuret Led to improvement of cytotoxic activity against both ceLL Lines.
