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Yasuhiro Kon - One of the best experts on this subject based on the ideXlab platform.
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bxsb mpj yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger rnas in the Lacrimal Fluid
Clinical and Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
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BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the Lacrimal Fluid.
Clinical & Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
Keigo Kosenda - One of the best experts on this subject based on the ideXlab platform.
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bxsb mpj yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger rnas in the Lacrimal Fluid
Clinical and Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
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BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the Lacrimal Fluid.
Clinical & Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
Osamu Ichii - One of the best experts on this subject based on the ideXlab platform.
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bxsb mpj yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger rnas in the Lacrimal Fluid
Clinical and Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
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BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the Lacrimal Fluid.
Clinical & Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
Yoshiharu Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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bxsb mpj yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger rnas in the Lacrimal Fluid
Clinical and Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
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BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the Lacrimal Fluid.
Clinical & Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
Saori Otsuka - One of the best experts on this subject based on the ideXlab platform.
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bxsb mpj yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger rnas in the Lacrimal Fluid
Clinical and Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
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BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the Lacrimal Fluid.
Clinical & Experimental Ophthalmology, 2013Co-Authors: Keigo Kosenda, Osamu Ichii, Saori Otsuka, Yoshiharu Hashimoto, Yasuhiro KonAbstract:BACKGROUND Dacryoadenitis is characteristic of an autoimmune exocrinopathy, e.g. Sjogren syndrome. We pathologically examined the Lacrimal glands of autoimmune-prone BXSB/MpJ-Yaa mice for the appearance of pathological signs of dacryoadenitis progression in autoimmune dacryoadenitis models, particularly focusing on messenger RNAs in the Lacrimal Fluid. METHODS The Lacrimal glands of the BXSB/MpJ-Yaa and C57BL/6 mice were histopathologically analyzed in parallel with the evaluation of lacrimation and messenger RNA expression of water channels (Aqp3, Aqp4 and Aqp5). In addition, autoimmune model mice (MRL/MpJ-lpr/lpr and NZB/NZWF1) were used for evaluating cell infiltration and detecting inflammatory cell marker messenger RNAs (Cd68, Ptprc and Cd3e) in the Lacrimal Fluids by polymerase chain reaction-based methods. RESULTS B-cell predominant lymphocytic infiltrations and the destruction of acini were observed in the Lacrimal glands of BXSB/MpJ-Yaa mice. There was no significant difference in the quantity of Lacrimal Fluid between the BXSB/MpJ-Yaa and C57BL/6 mice. In the BXSB/MpJ-Yaa mice, Aqp3 expression increased significantly with the cell infiltration score, whereas expression of Aqp4 and Aqp5 tended to decrease. Aqp3 expression increased significantly with the cell infiltration score in BXSB/MpJ-Yaa mice. Among inflammatory cell markers, Cd68 was more frequently detected in the Lacrimal Fluid of the BXSB/MpJ-Yaa, MRL/MpJ-lpr/lpr and NZB/NZWF1 mice than in that of the C57BL/6 mice. CONCLUSION BXSB/MpJ-Yaa mice clearly developed autoimmune dacryoadenitis. The altered expression of water channels in Lacrimal glands might be associated with the preservation of Lacrimal Fluid excretion in BXSB/MpJ-Yaa mice. The detection of inflammatory cell markers in Lacrimal Fluid could be used as a diagnostic marker for autoimmune dacryoadenitis.
