The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Tsega Teshale - One of the best experts on this subject based on the ideXlab platform.
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pre Lacteal feeding practice and associated factors among mothers having children less than two years of age in aksum town tigray ethiopia 2017 a cross sectional study
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p-value < 0.05 at 95% CI in multivariate logistic regression were considered statistically significant. The prevalence of pre-Lacteal feeding in Aksum town was 10.1% (95% CI: 7.3%, 13%). Mothers with no previous birth (AOR: 2.93(95% CI:1.21,7.09)), birth spacing less than 24 (AOR: 2.88(95% CI: 1.15,7.25)), colostrum discarding (AOR: 6.72 (95% CI: 2.49,18.12)), less than four anti natal care follow up (AOR: 10.55 (95% CI: 4.78,23.40)), those who underwent cesarean section (AOR: 4.38 (95% CI:1.72,11.12)) and maternal believe on purported advantage of pre-Lacteal feeding (AOR: 3.36 (95%CI: 1.62,6.96)) were more likely to practice pre-Lacteal feeding to their infants. Pre-Lacteal feeding is still practiced in the study area. Childbirth spacing, colostrum discarding, antenatal Care follow up, maternal belief in pre-Lacteal feeding was contributing factors for practicing of pre-Lacteal feeding. Coordination and sustaining the existing strategies and approaches are recommended to give emphasis on the nutritional value of colostrum and anti-natal care follow up.
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Pre-Lacteal feeding practice and associated factors among mothers having children less than two years of age in Aksum town, Tigray, Ethiopia, 2017: a cross-sectional study
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Background Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. Methods A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p -value
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Pre-Lacteal feeding practice and associated factors among mothers having children less than two years of age in Aksum town, Tigray, Ethiopia, 2017: a cross-sectional study.
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p-value
Joohye Song - One of the best experts on this subject based on the ideXlab platform.
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gut microbiota regulates Lacteal integrity by inducing vegf c in intestinal villus macrophages
EMBO Reports, 2019Co-Authors: Kibaek Choe, Seon Pyo Hong, Seunghwan Jeong, Taija Makinen, Kari Alitalo, Charles D Surh, Joohye SongAbstract:Abstract A Lacteal is a blunt‐ended, long, tube‐like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining Lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates Lacteal integrity. Germ depletion by antibiotic treatment triggers Lacteal regression during adulthood and delays Lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button‐like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into Lacteals, is significantly reduced in Lacteals of germ‐depleted mice. Lacteal defects are also found in germ‐free mice, but conventionalization of germ‐free mice leads to normalization of Lacteals. Mechanistically, VEGF‐C secreted from villus macrophages upon MyD88‐dependent recognition of microbes and their products is a main factor in Lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for Lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.
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Gut microbiota regulates Lacteal integrity by inducing VEGF‐C in intestinal villus macrophages
EMBO Reports, 2019Co-Authors: Kibaek Choe, Seon Pyo Hong, Seunghwan Jeong, Taija Makinen, Kari Alitalo, Charles D Surh, Joohye SongAbstract:Abstract A Lacteal is a blunt‐ended, long, tube‐like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining Lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates Lacteal integrity. Germ depletion by antibiotic treatment triggers Lacteal regression during adulthood and delays Lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button‐like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into Lacteals, is significantly reduced in Lacteals of germ‐depleted mice. Lacteal defects are also found in germ‐free mice, but conventionalization of germ‐free mice leads to normalization of Lacteals. Mechanistically, VEGF‐C secreted from villus macrophages upon MyD88‐dependent recognition of microbes and their products is a main factor in Lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for Lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.
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morphological analysis of Lacteal structure in the small intestine of adult mice
Methods of Molecular Biology, 2018Co-Authors: Seon Pyo Hong, Intae Park, Joohye SongAbstract:: The Lacteal is a blunt-ended lymphatic capillary located at the center of a villus in the small intestine that plays multifaceted roles under both physiologic and pathologic conditions. However, studies of its biology are limited by the lack of a feasible method to visualize all the relevant components for its regulation. Here, we describe an efficient whole-mount protocol to visualize the intact structure of Lacteals and surrounding cells in villi of the small intestine of adult mouse.
Girmay Tekaly - One of the best experts on this subject based on the ideXlab platform.
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pre Lacteal feeding practice and associated factors among mothers having children less than two years of age in aksum town tigray ethiopia 2017 a cross sectional study
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p-value < 0.05 at 95% CI in multivariate logistic regression were considered statistically significant. The prevalence of pre-Lacteal feeding in Aksum town was 10.1% (95% CI: 7.3%, 13%). Mothers with no previous birth (AOR: 2.93(95% CI:1.21,7.09)), birth spacing less than 24 (AOR: 2.88(95% CI: 1.15,7.25)), colostrum discarding (AOR: 6.72 (95% CI: 2.49,18.12)), less than four anti natal care follow up (AOR: 10.55 (95% CI: 4.78,23.40)), those who underwent cesarean section (AOR: 4.38 (95% CI:1.72,11.12)) and maternal believe on purported advantage of pre-Lacteal feeding (AOR: 3.36 (95%CI: 1.62,6.96)) were more likely to practice pre-Lacteal feeding to their infants. Pre-Lacteal feeding is still practiced in the study area. Childbirth spacing, colostrum discarding, antenatal Care follow up, maternal belief in pre-Lacteal feeding was contributing factors for practicing of pre-Lacteal feeding. Coordination and sustaining the existing strategies and approaches are recommended to give emphasis on the nutritional value of colostrum and anti-natal care follow up.
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Pre-Lacteal feeding practice and associated factors among mothers having children less than two years of age in Aksum town, Tigray, Ethiopia, 2017: a cross-sectional study
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Background Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. Methods A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p -value
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Pre-Lacteal feeding practice and associated factors among mothers having children less than two years of age in Aksum town, Tigray, Ethiopia, 2017: a cross-sectional study.
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p-value
Kibaek Choe - One of the best experts on this subject based on the ideXlab platform.
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gut microbiota regulates Lacteal integrity by inducing vegf c in intestinal villus macrophages
EMBO Reports, 2019Co-Authors: Kibaek Choe, Seon Pyo Hong, Seunghwan Jeong, Taija Makinen, Kari Alitalo, Charles D Surh, Joohye SongAbstract:Abstract A Lacteal is a blunt‐ended, long, tube‐like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining Lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates Lacteal integrity. Germ depletion by antibiotic treatment triggers Lacteal regression during adulthood and delays Lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button‐like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into Lacteals, is significantly reduced in Lacteals of germ‐depleted mice. Lacteal defects are also found in germ‐free mice, but conventionalization of germ‐free mice leads to normalization of Lacteals. Mechanistically, VEGF‐C secreted from villus macrophages upon MyD88‐dependent recognition of microbes and their products is a main factor in Lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for Lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.
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Gut microbiota regulates Lacteal integrity by inducing VEGF‐C in intestinal villus macrophages
EMBO Reports, 2019Co-Authors: Kibaek Choe, Seon Pyo Hong, Seunghwan Jeong, Taija Makinen, Kari Alitalo, Charles D Surh, Joohye SongAbstract:Abstract A Lacteal is a blunt‐ended, long, tube‐like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining Lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates Lacteal integrity. Germ depletion by antibiotic treatment triggers Lacteal regression during adulthood and delays Lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button‐like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into Lacteals, is significantly reduced in Lacteals of germ‐depleted mice. Lacteal defects are also found in germ‐free mice, but conventionalization of germ‐free mice leads to normalization of Lacteals. Mechanistically, VEGF‐C secreted from villus macrophages upon MyD88‐dependent recognition of microbes and their products is a main factor in Lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for Lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.
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Intravital imaging of intestinal Lacteals unveils lipid drainage through contractility
Journal of Clinical Investigation, 2015Co-Authors: Kibaek Choe, Jeon Yeob Jang, Intae Park, Daeyoung Park, Young-kwon Hong, Kari AlitaloAbstract:Lacteals are lymphatic vessels located at the center of each intestinal villus and provide essential transport routes for lipids and other lipophilic molecules. However, it is unclear how absorbed molecules are transported through the Lacteal. Here, we used reporter mice that express GFP under the control of the lymphatic-specific promoter Prox1 and a custom-built confocal microscope and performed intravital real-time visualization of the absorption and transport dynamics of fluorescence-tagged fatty acids (FAs) and various exogenous molecules in the intestinal villi in vivo. These analyses clearly revealed transepithelial absorption of these molecules via enterocytes, diffusive distribution over the lamina propria, and subsequent transport through Lacteals. Moreover, we observed active contraction of Lacteals, which seemed to be directly involved in dietary lipid drainage. Our analysis revealed that the smooth muscles that surround each Lacteal are responsible for contractile dynamics and that Lacteal contraction is ultimately controlled by the autonomic nervous system. These results indicate that the Lacteal is a unique organ-specific lymphatic system and does not merely serve as a passive conduit but as an active pump that transports lipids. Collectively, using this efficient imaging method, we uncovered drainage of absorbed molecules in small intestinal villus Lacteals and the involvement of Lacteal contractibility.
Mekuria Kassa - One of the best experts on this subject based on the ideXlab platform.
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pre Lacteal feeding practice and associated factors among mothers having children less than two years of age in aksum town tigray ethiopia 2017 a cross sectional study
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p-value < 0.05 at 95% CI in multivariate logistic regression were considered statistically significant. The prevalence of pre-Lacteal feeding in Aksum town was 10.1% (95% CI: 7.3%, 13%). Mothers with no previous birth (AOR: 2.93(95% CI:1.21,7.09)), birth spacing less than 24 (AOR: 2.88(95% CI: 1.15,7.25)), colostrum discarding (AOR: 6.72 (95% CI: 2.49,18.12)), less than four anti natal care follow up (AOR: 10.55 (95% CI: 4.78,23.40)), those who underwent cesarean section (AOR: 4.38 (95% CI:1.72,11.12)) and maternal believe on purported advantage of pre-Lacteal feeding (AOR: 3.36 (95%CI: 1.62,6.96)) were more likely to practice pre-Lacteal feeding to their infants. Pre-Lacteal feeding is still practiced in the study area. Childbirth spacing, colostrum discarding, antenatal Care follow up, maternal belief in pre-Lacteal feeding was contributing factors for practicing of pre-Lacteal feeding. Coordination and sustaining the existing strategies and approaches are recommended to give emphasis on the nutritional value of colostrum and anti-natal care follow up.
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Pre-Lacteal feeding practice and associated factors among mothers having children less than two years of age in Aksum town, Tigray, Ethiopia, 2017: a cross-sectional study
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Background Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. Methods A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p -value
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Pre-Lacteal feeding practice and associated factors among mothers having children less than two years of age in Aksum town, Tigray, Ethiopia, 2017: a cross-sectional study.
BMC Pediatrics, 2018Co-Authors: Girmay Tekaly, Mekuria Kassa, Tilahun Belete, Hagos Tasew, Tekelwoini Mariye, Tsega TeshaleAbstract:Pre-Lacteal feeding has continued as a deep-rooted nutritional malpractice in developing countries. Pre-Lacteal feeding is a barrier to the implementation of optimal breastfeeding practices and increases the risk of neonatal early-life diseases and mortality. Therefore, the aim of this study was to assess pre-Lacteal feeding practice and associated factors among mothers having children less than 2 years of age in Aksum town, central Tigray, Ethiopia. A community-based cross-sectional study was conducted to interview 477 mother-child pairs by systematic random sampling technique. Data were collected through interviewer-administered semi-structured questionnaires. Data were coded, entered, cleaned and edited using EPIDATA version 3.1 and export to SPSS Version 22.0 for analysis. To identify the significant variables binary logistic regression were employed. Variables with p-value
