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Zuyuan He - One of the best experts on this subject based on the ideXlab platform.

  • ultra high resolution large dynamic range optical fiber static strain sensor using pound drever hall technique
    Optics Letters, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He
    Abstract:

    We report the realization of a fiber-optic static strain sensor with ultrahigh resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber-Bragg-grating-based Fabry–Perot interferometers as sensor heads for strain sensing and reference, respectively. The Pound–Drever–Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 5.8 nanostrains is demonstrated. The dynamic range can be extended up to hundreds of microstrains, and the measuring period is a few tens of seconds.

  • Ultra-high-resolution large-dynamic-range optical fiber static strain sensor using Pound–Drever–Hall technique
    Optics Letters, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He
    Abstract:

    We report the realization of a fiber-optic static strain sensor with ultrahigh resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber-Bragg-grating-based Fabry–Perot interferometers as sensor heads for strain sensing and reference, respectively. The Pound–Drever–Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 5.8 nanostrains is demonstrated. The dynamic range can be extended up to hundreds of microstrains, and the measuring period is a few tens of seconds.

  • An ultra-high-resolution large-dynamic-range fiber optic static strain sensor using Pound-Drever-Hall technique
    2011 Int. Quantum Electron. Conf. IQEC 2011 and Conf. Lasers and Electro-Optics CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics Lase, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He, Kazuo Hotate
    Abstract:

    In this paper we report the realization of a fiber optic static strain sensor with ultra-high resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber Bragg grating based Fabry-Perot interferometers for strain sensing and reference, respectively. Pound-Drever-Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 4.5 nε was demonstrated. The dynamic range can be extended up to hundreds of με, and the measuring period is a few tens of seconds. View full abstract

Qingwen Liu - One of the best experts on this subject based on the ideXlab platform.

  • ultra high resolution large dynamic range optical fiber static strain sensor using pound drever hall technique
    Optics Letters, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He
    Abstract:

    We report the realization of a fiber-optic static strain sensor with ultrahigh resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber-Bragg-grating-based Fabry–Perot interferometers as sensor heads for strain sensing and reference, respectively. The Pound–Drever–Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 5.8 nanostrains is demonstrated. The dynamic range can be extended up to hundreds of microstrains, and the measuring period is a few tens of seconds.

  • Ultra-high-resolution large-dynamic-range optical fiber static strain sensor using Pound–Drever–Hall technique
    Optics Letters, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He
    Abstract:

    We report the realization of a fiber-optic static strain sensor with ultrahigh resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber-Bragg-grating-based Fabry–Perot interferometers as sensor heads for strain sensing and reference, respectively. The Pound–Drever–Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 5.8 nanostrains is demonstrated. The dynamic range can be extended up to hundreds of microstrains, and the measuring period is a few tens of seconds.

  • An ultra-high-resolution large-dynamic-range fiber optic static strain sensor using Pound-Drever-Hall technique
    2011 Int. Quantum Electron. Conf. IQEC 2011 and Conf. Lasers and Electro-Optics CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics Lase, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He, Kazuo Hotate
    Abstract:

    In this paper we report the realization of a fiber optic static strain sensor with ultra-high resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber Bragg grating based Fabry-Perot interferometers for strain sensing and reference, respectively. Pound-Drever-Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 4.5 nε was demonstrated. The dynamic range can be extended up to hundreds of με, and the measuring period is a few tens of seconds. View full abstract

Tomochika Tokunaga - One of the best experts on this subject based on the ideXlab platform.

  • ultra high resolution large dynamic range optical fiber static strain sensor using pound drever hall technique
    Optics Letters, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He
    Abstract:

    We report the realization of a fiber-optic static strain sensor with ultrahigh resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber-Bragg-grating-based Fabry–Perot interferometers as sensor heads for strain sensing and reference, respectively. The Pound–Drever–Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 5.8 nanostrains is demonstrated. The dynamic range can be extended up to hundreds of microstrains, and the measuring period is a few tens of seconds.

  • Ultra-high-resolution large-dynamic-range optical fiber static strain sensor using Pound–Drever–Hall technique
    Optics Letters, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He
    Abstract:

    We report the realization of a fiber-optic static strain sensor with ultrahigh resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber-Bragg-grating-based Fabry–Perot interferometers as sensor heads for strain sensing and reference, respectively. The Pound–Drever–Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 5.8 nanostrains is demonstrated. The dynamic range can be extended up to hundreds of microstrains, and the measuring period is a few tens of seconds.

  • An ultra-high-resolution large-dynamic-range fiber optic static strain sensor using Pound-Drever-Hall technique
    2011 Int. Quantum Electron. Conf. IQEC 2011 and Conf. Lasers and Electro-Optics CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics Lase, 2011
    Co-Authors: Qingwen Liu, Tomochika Tokunaga, Zuyuan He, Kazuo Hotate
    Abstract:

    In this paper we report the realization of a fiber optic static strain sensor with ultra-high resolution and large dynamic range for the applications of geophysical research. The sensor consists of a pair of fiber Bragg grating based Fabry-Perot interferometers for strain sensing and reference, respectively. Pound-Drever-Hall technique is employed to interrogate the sensor heads, and a cross-correlation algorithm is used to figure out the strain information with high precision. Static strain resolution down to 4.5 nε was demonstrated. The dynamic range can be extended up to hundreds of με, and the measuring period is a few tens of seconds. View full abstract

Maria Esperanza Teresarodrigo - One of the best experts on this subject based on the ideXlab platform.

  • de novo heterozygous mutations in smc3 cause a range of cornelia de Lange syndrome overlapping phenotypes
    Human Mutation, 2015
    Co-Authors: Maria Concepcion Gilrodriguez, Matthew A Deardorff, Morad Ansari, Ilaria Parenti, Carolina Baqueromontoya, Lilian Bomme Ousager, Beatriz Puisac, Maria Hernandezmarcos, Maria Esperanza Teresarodrigo
    Abstract:

    Cornelia de Lange syndrome (CdLS) is characterized by facial dysmorphism, growth failure, intellectual disability, limb malformations, and multiple organ involvement. Mutations in five genes, encoding subunits of the cohesin complex (SMC1A, SMC3, RAD21) and its regulators (NIPBL, HDAC8), account for at least 70% of patients with CdLS or CdLS-like phenotypes. To date, only the clinical features from a single CdLS patient with SMC3 mutation has been published. Here, we report the efforts of an international research and clinical collaboration to provide clinical comparison of 16 patients with CdLS-like features caused by mutations in SMC3. Modeling of the mutation effects on protein structure suggests a dominant-negative effect on the multimeric cohesin complex. When compared with typical CdLS, many SMC3-associated phenotypes are also characterized by postnatal microcephaly but with a less distinctive craniofacial appearance, a milder prenatal growth retardation that worsens in childhood, few congenital heart defects, and an absence of limb deficiencies. While most mutations are unique, two unrelated affected individuals shared the same mutation but presented with different phenotypes. This work confirms that de novo SMC3 mutations account for approximate to 1%-2% of CdLS-like phenotypes.

Matthew A Deardorff - One of the best experts on this subject based on the ideXlab platform.

  • de novo heterozygous mutations in smc3 cause a range of cornelia de Lange syndrome overlapping phenotypes
    Human Mutation, 2015
    Co-Authors: Maria Concepcion Gilrodriguez, Matthew A Deardorff, Morad Ansari, Ilaria Parenti, Carolina Baqueromontoya, Lilian Bomme Ousager, Beatriz Puisac, Maria Hernandezmarcos, Maria Esperanza Teresarodrigo
    Abstract:

    Cornelia de Lange syndrome (CdLS) is characterized by facial dysmorphism, growth failure, intellectual disability, limb malformations, and multiple organ involvement. Mutations in five genes, encoding subunits of the cohesin complex (SMC1A, SMC3, RAD21) and its regulators (NIPBL, HDAC8), account for at least 70% of patients with CdLS or CdLS-like phenotypes. To date, only the clinical features from a single CdLS patient with SMC3 mutation has been published. Here, we report the efforts of an international research and clinical collaboration to provide clinical comparison of 16 patients with CdLS-like features caused by mutations in SMC3. Modeling of the mutation effects on protein structure suggests a dominant-negative effect on the multimeric cohesin complex. When compared with typical CdLS, many SMC3-associated phenotypes are also characterized by postnatal microcephaly but with a less distinctive craniofacial appearance, a milder prenatal growth retardation that worsens in childhood, few congenital heart defects, and an absence of limb deficiencies. While most mutations are unique, two unrelated affected individuals shared the same mutation but presented with different phenotypes. This work confirms that de novo SMC3 mutations account for approximate to 1%-2% of CdLS-like phenotypes.