The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform
Andrea Bishopmarbury - One of the best experts on this subject based on the ideXlab platform.
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identifying native Language difficulties among foreign Language learners in college a foreign Language learning Disability
Journal of Learning Disabilities, 1991Co-Authors: Leonore Ganschow, Richard L Sparks, James Javorsky, Jane Pohlman, Andrea BishopmarburyAbstract:The present study compared successful and unsuccessful college foreign Language learners on measures of intelligence, foreign Language aptitude, native oral and written Language, and math. Unsuccessful students had received petitions to waive the foreign Language requirement. No significant differences between groups were found on intelligence and reading comprehension. Significant differences were found on the Modern Language Aptitude Test, on tests of written and oral Language in the syntactic and phonological domains, and on math calculation. Authors suggest that students with foreign Language learning difficulties may have underlying native Language problems manifested especially in the areas of syntax and phonology. Suggestions for diagnosing a foreign Language Disability are made.
Melanie A. Manning - One of the best experts on this subject based on the ideXlab platform.
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22q13 3 deletion syndrome a recognizable malformation syndrome associated with marked speech and Language delay
American Journal of Medical Genetics Part C-seminars in Medical Genetics, 2007Co-Authors: Kristina Cusmanoozog, Melanie A. Manning, Eugene H HoymeAbstract:The 22q13.3 deletion syndrome is a recognizable malformation syndrome associated with developmental delay, hypotonia, delayed or absent speech, autistic-like behavior, normal to accelerated growth and dysmorphic facies. The prevalence of this disorder is unknown, but it is likely under-diagnosed. Age at diagnosis has varied widely, from cases diagnosed prenatally to 46 years. Males and females are equally affected. The distal 22q deletion can be detected occasionally by routine or high resolution chromosome analysis; however, the majority of cases are detected by FISH analysis, associated with deletion of the ARSA (control) probe when performing a FISH analysis for the velocardiofacial syndrome (del 22q11.2). The 22q13.3 deletion syndrome can accompany a simple chromosome deletion, an unbalanced translocation, or a ring chromosome. Primary care physicians, in addition to numerous specialists, play an important role in caring for patients with this disorder. Although the dysmorphic features observed in this condition are nonspecific, it is an important consideration in the differential diagnosis of children with developmental delay, hypotonia, marked speech and Language Disability, autistic-like features, multiple minor anomalies, and normal growth and head circumference.
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Terminal 22q Deletion Syndrome: A Newly Recognized Cause of Speech and Language Disability in the Autism Spectrum
Pediatrics, 2004Co-Authors: Melanie A. Manning, Suzanne B. Cassidy, Carol L. Clericuzio, Athena M. Cherry, Stuart Schwartz, Louanne Hudgins, Gregory M. Enns, H. Eugene HoymeAbstract:Objective. Cryptic subtelomeric chromosome rearrangements account for 6% to 10% of idiopathic mental retardation. As cytogenetic and molecular techniques have become more sophisticated, the number of genetic syndromes attributed to these microdeletions has increased. To date, 64 patients have been described in the literature with a more recently recognized microdeletion syndrome, del 22q13.3. The purpose of this study is to present 11 new cases of this recently described syndrome to delineate further the phenotype and to alert the clinician to another genetic condition that should be considered in the differential diagnosis of early hypotonia, delayed speech acquisition, and autistic behavior. Methods. Eleven patients were evaluated in 3 academic institutions. Clinical features and results of cytogenetic testing were recorded and tabulated. Reasons for referral for genetic evaluation included developmental delay, severe expressive speech and Language delay, and dysmorphic features. Results. Age of presentation ranged from 5 months to 46 years. There were 10 female patients and 1 male patient. All of the patients exhibited delayed motor development, some degree of hypotonia, and severe expressive speech and Language delay. Dysmorphic facial features included epicanthal folds, large cupped ears, underdeveloped philtrum, loss of cupid9s bow, and full supraorbital ridges. Six patients exhibited autistic-like behaviors. Microscopically visible chromosome deletions were observed in 6 patients. In the remainder, the deletion was detected with the use of fluorescence in situ hybridization. Conclusions. Hypotonia and developmental delay are nonspecific findings observed in many malformation and genetic syndromes. However, in association with severe speech and Language delay and autistic-like behavior, this phenotype may be a significant indication to consider the 22q13 deletion syndrome as a potential cause.
Howran Guo - One of the best experts on this subject based on the ideXlab platform.
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gender and geographic differences in the prevalence of reportable childhood speech and Language Disability in taiwan
Research in Developmental Disabilities, 2015Co-Authors: Yen Cheng Tseng, Der Chung Lai, Howran GuoAbstract:Speech and Language Disability (SLD) is not uncommon in children. However, data at the national level are limited, and geographic differences are seldom evaluated. Starting from 1980, the local governments in Taiwan has begun to certify disabled residents for providing various services and report cases to the central government according to the law, and the central government maintains a registry of reported cases, which provides a unique opportunity for studying SLD at the national level. Using the registry data from 2004 to 2010, we calculated the prevalence of SLD by age, gender, and geographic area and assessed the changes over time. Because the government discourages the certification under 3 years of age, we excluded cases under 3 years old from the analyses. We found that from 2004 to 2010 the registered cases between 3 and 17 years old increased from 1418 to 1637 per year, and the prevalence generally increased every year in all age groups except in 12-14 years of age. In each year there were more boy cases than girl cases, and the prevalence rate ratio increased from 1.50 to 1.83 (p < 0.05 in all years), with an increasing trend over time (p < 0.01). A higher prevalence was observed in the rural areas over the years, and the prevalence rate ratio increased from 1.35 to 1.71 (p < 0.05 in all years), with an increasing trend over time (p < 0.01). Further studies identifying the risk factors contributed to the increases might help the prevention of SLD in the future.
H. Eugene Hoyme - One of the best experts on this subject based on the ideXlab platform.
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Terminal 22q Deletion Syndrome: A Newly Recognized Cause of Speech and Language Disability in the Autism Spectrum
Pediatrics, 2004Co-Authors: Melanie A. Manning, Suzanne B. Cassidy, Carol L. Clericuzio, Athena M. Cherry, Stuart Schwartz, Louanne Hudgins, Gregory M. Enns, H. Eugene HoymeAbstract:Objective. Cryptic subtelomeric chromosome rearrangements account for 6% to 10% of idiopathic mental retardation. As cytogenetic and molecular techniques have become more sophisticated, the number of genetic syndromes attributed to these microdeletions has increased. To date, 64 patients have been described in the literature with a more recently recognized microdeletion syndrome, del 22q13.3. The purpose of this study is to present 11 new cases of this recently described syndrome to delineate further the phenotype and to alert the clinician to another genetic condition that should be considered in the differential diagnosis of early hypotonia, delayed speech acquisition, and autistic behavior. Methods. Eleven patients were evaluated in 3 academic institutions. Clinical features and results of cytogenetic testing were recorded and tabulated. Reasons for referral for genetic evaluation included developmental delay, severe expressive speech and Language delay, and dysmorphic features. Results. Age of presentation ranged from 5 months to 46 years. There were 10 female patients and 1 male patient. All of the patients exhibited delayed motor development, some degree of hypotonia, and severe expressive speech and Language delay. Dysmorphic facial features included epicanthal folds, large cupped ears, underdeveloped philtrum, loss of cupid9s bow, and full supraorbital ridges. Six patients exhibited autistic-like behaviors. Microscopically visible chromosome deletions were observed in 6 patients. In the remainder, the deletion was detected with the use of fluorescence in situ hybridization. Conclusions. Hypotonia and developmental delay are nonspecific findings observed in many malformation and genetic syndromes. However, in association with severe speech and Language delay and autistic-like behavior, this phenotype may be a significant indication to consider the 22q13 deletion syndrome as a potential cause.
Shilpa Shamapant - One of the best experts on this subject based on the ideXlab platform.
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abstract 42 validation of an ordinal 6 item functional outcome scale for speech and Language Disability in stroke the austin speech labs communication Disability scale
Stroke, 2018Co-Authors: Steven Warach, Ben King, Shilpa ShamapantAbstract:Introduction: Assessment of stroke outcomes specific to speech and Language typically depends on lengthy batteries yielding a derived score that has little functional meaning to patients. Our aim w...
