The Experts below are selected from a list of 34455 Experts worldwide ranked by ideXlab platform
Dan R Littman - One of the best experts on this subject based on the ideXlab platform.
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gpr15 mediated homing controls immune homeostasis in the Large Intestine mucosa muc9p 817
Journal of Immunology, 2014Co-Authors: Wenkai Xiang, Changsoo Kwak, Ruliang Xu, Umut Sarpel, Daniel B. Rifkin, Dan R Littman, Yi YangAbstract:The Large Intestine is the site most commonly affected in inflammatory bowel diseases. However, the mechanism of T cell homing to the Large Intestine, which contributes to inflammation, had remained unclear. We show here that an orphan G-protein coupled receptor GPR15 controls the specific homing of T cells, particularly FOXP3+ regulatory T cells (Tregs), to the Large Intestine lamina propria (LILP). GPR15 expression is promoted by gut microbiota and TGF-β1, but not by retinoic acid. GPR15-deficient mice had fewer Tregs in LILP and were prone to develop more severe inflammation in the Large Intestine, which was rescued by the transfer of GPR15-sufficient Tregs. Our findings thus indicate that GPR15 is a T cell homing receptor for LILP and that GPR15 plays a key role in maintaining gut immune homeostasis, Largely by regulating the influx of Tregs. Our study also demonstrates that adaptive immune responses in the gut are functionally compartmentalized through the differential requirements for T cell homing to the small and Large bowel.
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gpr15 mediated homing controls immune homeostasis in the Large Intestine mucosa
Science, 2013Co-Authors: Wenkai V Xiang, Changsoo Kwak, Ruliang Xu, Umut Sarpel, Daniel B. Rifkin, Yi Yang, Dan R LittmanAbstract:Lymphocyte homing, which contributes to inflammation, has been studied extensively in the small Intestine, but there is little known about homing to the Large Intestine, the site most commonly affected in inflammatory bowel disease. GPR15, an orphan heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptor, controlled the specific homing of T cells, particularly FOXP3 + regulatory T cells (T regs ), to the Large Intestine lamina propria (LILP). GPR15 expression was modulated by gut microbiota and transforming growth factor–β1, but not by retinoic acid. GPR15-deficient mice were prone to develop more severe Large Intestine inflammation, which was rescued by the transfer of GPR15-sufficient T regs . Our findings thus describe a T cell–homing receptor for LILP and indicate that GPR15 plays a role in mucosal immune tolerance Largely by regulating the influx of T regs .
Wenkai Xiang - One of the best experts on this subject based on the ideXlab platform.
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gpr15 mediated homing controls immune homeostasis in the Large Intestine mucosa muc9p 817
Journal of Immunology, 2014Co-Authors: Wenkai Xiang, Changsoo Kwak, Ruliang Xu, Umut Sarpel, Daniel B. Rifkin, Dan R Littman, Yi YangAbstract:The Large Intestine is the site most commonly affected in inflammatory bowel diseases. However, the mechanism of T cell homing to the Large Intestine, which contributes to inflammation, had remained unclear. We show here that an orphan G-protein coupled receptor GPR15 controls the specific homing of T cells, particularly FOXP3+ regulatory T cells (Tregs), to the Large Intestine lamina propria (LILP). GPR15 expression is promoted by gut microbiota and TGF-β1, but not by retinoic acid. GPR15-deficient mice had fewer Tregs in LILP and were prone to develop more severe inflammation in the Large Intestine, which was rescued by the transfer of GPR15-sufficient Tregs. Our findings thus indicate that GPR15 is a T cell homing receptor for LILP and that GPR15 plays a key role in maintaining gut immune homeostasis, Largely by regulating the influx of Tregs. Our study also demonstrates that adaptive immune responses in the gut are functionally compartmentalized through the differential requirements for T cell homing to the small and Large bowel.
Qiu Yan - One of the best experts on this subject based on the ideXlab platform.
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application of multi slice spiral ct in advanced carcinoma of Large Intestine
Journal of Modern Oncology, 2007Co-Authors: Qiu YanAbstract:Objective:To investigate the application of multi-slice spiral CT in diagnosing advanced carcinoma of Large Intestine and appraising its curative effect.Methods:Total of 165 patients with advanced carcinoma of colon or rectum were examined with 16-slice spiral CT and colonofibroscope before operations.Among them,42 patients also were examined with 16-slice spiral CT again after a course of neoadjuvant chemothearapy.Then all the patients accepted operations.The CT results of judging Borrmann typing,T-stage and chemical treatment effect were compared with surgical and pathological findings.Results:In diagnosing advanced carcinoma of Large Intestine by multi-slice spiral CT,the accuracy of judging Borrmann typing was 95.8%(P0.01);the accuracy of judging T-[HK]stage was 82.4%(P0.05);the accuracy of judging neoadjuvant chemotherapy effect was 88.1%(P0.05).Conclusion:Some CT findings reflecting biological behavior of advanced carcinoma of Large Intestine were correlative to its pathological findings.multi-slice spiral CT is valuable in detecting advanced carcinoma of Large Intestine with Borrmann typing,T-stage and chemical treatment effect and also valuable to surgical intervention and treatment planning.
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appraisal of t stage and neoadjuvant chemothearapy effect of advanced carcinoma of Large Intestine by multi slice computed tomography
China Modern Doctor, 2007Co-Authors: Qiu YanAbstract:Objective To investigate the application values of multi-slice spiral CT in diagnosing T-stage of advanced carcinoma of Large Intestine and appraising its neoadjuvant chemothearapy effect. Methods 165 patients with advanced carcinoma of colon or rectum were examined with 16-slice spiral CT and colonofibroscope before operations. In the group, 42 patients also were examined with 16-slice spiral CT again after a course of neoadjuvant chemothearapy. Then all the patients accepted operations. The CT results of judging T-stage and chemical treatment effect were compared with surgical and pathological findings. Results In diagnosing advanced carcinoma of Large Intestine by multi-slice spiral CT, the accuracy of judging T-stage was 82.4%%(P0.05); The accuracy of judging neoadjuvant chemotherapying effect was 88.1%(P0.05). Conclusion Some CT findings reflecting biological behavior of advanced carcinoma of Large Intestine were correlated to its pathological findings. Multi-slice spiral CT is valuable in detecting advanced carcinoma of Large Intestine with T-stage and chemical treatment effect and also valuable in surgical intervention and treatment planning.
Ruliang Xu - One of the best experts on this subject based on the ideXlab platform.
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gpr15 mediated homing controls immune homeostasis in the Large Intestine mucosa muc9p 817
Journal of Immunology, 2014Co-Authors: Wenkai Xiang, Changsoo Kwak, Ruliang Xu, Umut Sarpel, Daniel B. Rifkin, Dan R Littman, Yi YangAbstract:The Large Intestine is the site most commonly affected in inflammatory bowel diseases. However, the mechanism of T cell homing to the Large Intestine, which contributes to inflammation, had remained unclear. We show here that an orphan G-protein coupled receptor GPR15 controls the specific homing of T cells, particularly FOXP3+ regulatory T cells (Tregs), to the Large Intestine lamina propria (LILP). GPR15 expression is promoted by gut microbiota and TGF-β1, but not by retinoic acid. GPR15-deficient mice had fewer Tregs in LILP and were prone to develop more severe inflammation in the Large Intestine, which was rescued by the transfer of GPR15-sufficient Tregs. Our findings thus indicate that GPR15 is a T cell homing receptor for LILP and that GPR15 plays a key role in maintaining gut immune homeostasis, Largely by regulating the influx of Tregs. Our study also demonstrates that adaptive immune responses in the gut are functionally compartmentalized through the differential requirements for T cell homing to the small and Large bowel.
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gpr15 mediated homing controls immune homeostasis in the Large Intestine mucosa
Science, 2013Co-Authors: Wenkai V Xiang, Changsoo Kwak, Ruliang Xu, Umut Sarpel, Daniel B. Rifkin, Yi Yang, Dan R LittmanAbstract:Lymphocyte homing, which contributes to inflammation, has been studied extensively in the small Intestine, but there is little known about homing to the Large Intestine, the site most commonly affected in inflammatory bowel disease. GPR15, an orphan heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptor, controlled the specific homing of T cells, particularly FOXP3 + regulatory T cells (T regs ), to the Large Intestine lamina propria (LILP). GPR15 expression was modulated by gut microbiota and transforming growth factor–β1, but not by retinoic acid. GPR15-deficient mice were prone to develop more severe Large Intestine inflammation, which was rescued by the transfer of GPR15-sufficient T regs . Our findings thus describe a T cell–homing receptor for LILP and indicate that GPR15 plays a role in mucosal immune tolerance Largely by regulating the influx of T regs .
Umut Sarpel - One of the best experts on this subject based on the ideXlab platform.
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gpr15 mediated homing controls immune homeostasis in the Large Intestine mucosa muc9p 817
Journal of Immunology, 2014Co-Authors: Wenkai Xiang, Changsoo Kwak, Ruliang Xu, Umut Sarpel, Daniel B. Rifkin, Dan R Littman, Yi YangAbstract:The Large Intestine is the site most commonly affected in inflammatory bowel diseases. However, the mechanism of T cell homing to the Large Intestine, which contributes to inflammation, had remained unclear. We show here that an orphan G-protein coupled receptor GPR15 controls the specific homing of T cells, particularly FOXP3+ regulatory T cells (Tregs), to the Large Intestine lamina propria (LILP). GPR15 expression is promoted by gut microbiota and TGF-β1, but not by retinoic acid. GPR15-deficient mice had fewer Tregs in LILP and were prone to develop more severe inflammation in the Large Intestine, which was rescued by the transfer of GPR15-sufficient Tregs. Our findings thus indicate that GPR15 is a T cell homing receptor for LILP and that GPR15 plays a key role in maintaining gut immune homeostasis, Largely by regulating the influx of Tregs. Our study also demonstrates that adaptive immune responses in the gut are functionally compartmentalized through the differential requirements for T cell homing to the small and Large bowel.
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gpr15 mediated homing controls immune homeostasis in the Large Intestine mucosa
Science, 2013Co-Authors: Wenkai V Xiang, Changsoo Kwak, Ruliang Xu, Umut Sarpel, Daniel B. Rifkin, Yi Yang, Dan R LittmanAbstract:Lymphocyte homing, which contributes to inflammation, has been studied extensively in the small Intestine, but there is little known about homing to the Large Intestine, the site most commonly affected in inflammatory bowel disease. GPR15, an orphan heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptor, controlled the specific homing of T cells, particularly FOXP3 + regulatory T cells (T regs ), to the Large Intestine lamina propria (LILP). GPR15 expression was modulated by gut microbiota and transforming growth factor–β1, but not by retinoic acid. GPR15-deficient mice were prone to develop more severe Large Intestine inflammation, which was rescued by the transfer of GPR15-sufficient T regs . Our findings thus describe a T cell–homing receptor for LILP and indicate that GPR15 plays a role in mucosal immune tolerance Largely by regulating the influx of T regs .
