The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform
Erol Egeli - One of the best experts on this subject based on the ideXlab platform.
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Histopathological effects of estrogen deficiency on Larynx Mucosa in ovariectomised rats.
European Archives of Oto-rhino-laryngology, 2010Co-Authors: Mehmet Surmeli, Tulay Erden Habesoglu, Mehmet Habesoglu, Ildem Deveci, Murat Eriman, Vefa Kinis, Pembegul Gunes, Erol EgeliAbstract:Laryngeal manifestations due to estrogen deficiency have been studied in the literature. But to date, the possible histopathological changes of laryngeal Mucosa due to estrogen deficiency have not been studied. Therefore, our objective was to determine the histopathological changes of laryngeal Mucosa in ovariectomised rats in order to clarify effects of estrogen deficiency on laryngeal tissue. The study is a randomized trial and was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Twenty-one Wistar rats were used throughout the experiment. There were six rats in the sham-operated control group. And others were divided into two groups (4, 8 weeks) according to follow-up time after ovariectomy. We observed significant changes 4 weeks after ovariectomy when we assessed subepithelial edema, inflammation, cilia and goblet cell loss (p < 0.01). It was shown that estrogen deficiency after ovariectomy in rats caused changes in laryngeal tissue when it was studied histopathologically.
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histopathological changes of rat Larynx Mucosa with exposure to chronic thinner inhalation
Otolaryngology-Head and Neck Surgery, 2009Co-Authors: Seyla Bolukbasi, Tulay Erden Habesoglu, Mehmet Habesoglu, Baver Samanci, Yesim Erol, Gulistan Gumrukcu, Erol EgeliAbstract:Abstract Objective Histopathological changes in nasal Mucosa, trachea, and pulmonary system with exposure to chronic thinner inhalation have been studied in the literature. However, the possible changes in Larynx Mucosa, which is a part of the upper airway tract, have not been studied yet. The aim of this study is to determine the histopathological changes of rat Larynx Mucosa with exposure to chronic thinner inhalation. Study Design and Setting Randomized trial. The study was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Subjects and Methods Fifty-one Sprague-Dawley rats were used throughout the experiment. Four groups of rats inhaled thinner in a glass cage for 2, 4, 8, and 12 weeks respectively. Seven rats inhaled only the air in the room as the control group. Results The comparison of inflammation and exocytosis in the control and 2 week groups revealed no significant difference ( P > 0.05), but from the beginning of 4 weeks of thinner inhalation, statistically significant differences were observed ( P P Conclusion On the basis of histopathological evaluations, it was shown that the harmful effect of inhalation of thinner in high concentrations to Larynx Mucosa is similar to the effect on other organs of the respiratory system.
M. Wierzbicka - One of the best experts on this subject based on the ideXlab platform.
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the role of intraoperative narrow band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer
Revista Brasileira De Otorrinolaringologia, 2019Co-Authors: H. Klimza, Cesare Piazza, J. Jackowska, Jacek Banaszewski, M. WierzbickaAbstract:Abstract Introduction Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer. Objective The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the Larynx Mucosa in terms of specifying surgical margins. Methods Forty-four consecutive T1–T2 glottic cancers treated with trans-oral laser microsurgery Type I–VI cordectomy were presented. Suspected areas (90 samples/44 patients) were biopsied under the guidance of narrow-band imaging and white light and sent for frozen section. Results Our study revealed that 75 of 90 (83.3%) white light and narrow-band imaging-guided samples were histopathologically positive: 30 (40%) were confirmed as carcinoma in situ or invasive carcinoma and 45 (60%) as moderate to severe dysplasia. In 6 patients Mucosa was suspected only in narrow-band imaging, with no suspicion under white light. Thus, in these 6 patients 18/90 (20%) samples were taken. In 5/6 patients 16/18 (88.8%) samples were positive in frozen section: in 6/18 (33.3%) carcinoma (2 patients), 10/18 (66.6%) severe dysplasia was confirmed (3 patients). In 1 patient 2/18 (11.1%) samples were negative in frozen section. Presented analysis showed, that sensitivity, specificity and accuracy of white light was 79.5%, 20% and 71.1% respectively, while narrow-band imaging was 100%, 0.0% and 85.7%, respectively. Conclusion The intraoperative use of narrow-band imaging proved to be valuable in the visualization of suspect areas of the Mucosa. Narrow-band imaging confirms the suspicions undertaken in white light and importantly, it showed microlesions beyond the scope of white light.
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The role of intraoperative narrow-band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer
Elsevier, 2019Co-Authors: H. Klimza, Cesare Piazza, J. Jackowska, Jacek Banaszewski, M. WierzbickaAbstract:Introduction: Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer. Objective: The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the Larynx Mucosa in terms of specifying surgical margins. Methods: Forty-four consecutive T1–T2 glottic cancers treated with trans-oral laser microsurgery Type I–VI cordectomy were presented. Suspected areas (90 samples/44 patients) were biopsied under the guidance of narrow-band imaging and white light and sent for frozen section. Results: Our study revealed that 75 of 90 (83.3%) white light and narrow-band imaging-guided samples were histopathologically positive: 30 (40%) were confirmed as carcinoma in situ or invasive carcinoma and 45 (60%) as moderate to severe dysplasia. In 6 patients Mucosa was suspected only in narrow-band imaging, with no suspicion under white light. Thus, in these 6 patients 18/90 (20%) samples were taken. In 5/6 patients 16/18 (88.8%) samples were positive in frozen section: in 6/18 (33.3%) carcinoma (2 patients), 10/18 (66.6%) severe dysplasia was confirmed (3 patients). In 1 patient 2/18 (11.1%) samples were negative in frozen section. Presented analysis showed, that sensitivity, specificity and accuracy of white light was 79.5%, 20% and 71.1% respectively, while narrow-band imaging was 100%, 0.0% and 85.7%, respectively. Conclusion: The intraoperative use of narrow-band imaging proved to be valuable in the visualization of suspect areas of the Mucosa. Narrow-band imaging confirms the suspicions undertaken in white light and importantly, it showed microlesions beyond the scope of white light. Resumo: Introdução: A microcirurgia transoral a laser é uma técnica bem estabelecida para o tratamento de câncer de laringe inicial e moderadamente avançado. Objetivo: Verificar a utilidade da imagem de banda estreita na avaliação intraoperatória da Mucosa laríngea na especificação das margens cirúrgicas. Método: Foram avaliados 44 cânceres glóticos T1-T2 consecutivos, tratados com cordectomia Tipo I-VI, por microcirurgia transoral a laser. As áreas suspeitas (90 amostras/44 pacientes) foram submetidas a biopsia e avaliadas através de imagens de banda estreita e luz branca e enviadas para cortes por congelação. Resultados: Nosso estudo revelou que 75 (83,3%) das 90 amostras, apresentaram histopatologia positiva na análise com luz branca e imagens de banda estreita: 30 (40%) foram confirmadas como carcinoma in situ ou carcinoma invasivo e 45 (60%) como displasia moderada a grave. Em seis pacientes, a Mucosa apresentou-se suspeita apenas na imagem de banda estreita, sem nenhuma suspeita sob luz branca. Assim, nesses seis pacientes 18/90 (20%) amostras foram colhidas. Em 5/6 pacientes, 16/18 (88,8%) amostras mostraram resultado positivo na análise de congelação: em 6/18 (33,3%) amostras foi confirmado carcinoma (dois pacientes) e em 10/18 (66,6%) foi confirmada displasia grave (três pacientes). Em um paciente, 2/18 (11,1%) as amostras mostraram resultado negativo na congelação. A análise apresentada mostrou que a sensibilidade, a especificidade e a acurácia da luz branca foram de 79,5%, 20% e 71,1%, respectivamente, enquanto a imagem de banda estreita apresentou como resultados 100%, 0,0% e 85,7%, respectivamente. Conclusão: O uso intraoperatório de imagem de banda estreita provou ser valioso na identificação de áreas suspeitas da Mucosa, confirmou as suspeitas verificadas na análise com luz branca e, o que é mais importante, identificou microlesões além do alcance da luz branca. Keywords: Laser CO2, Early, Moderately advanced glottic cancer, Narrow-band imaging, Safe margins, Frozen sections, Palavras-chave: Laser CO2, Inicial, Câncer glótico moderadamente avançado, Imagens de banda estreita, Margens seguras, Cortes por congelaçã
H. Klimza - One of the best experts on this subject based on the ideXlab platform.
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the role of intraoperative narrow band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer
Revista Brasileira De Otorrinolaringologia, 2019Co-Authors: H. Klimza, Cesare Piazza, J. Jackowska, Jacek Banaszewski, M. WierzbickaAbstract:Abstract Introduction Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer. Objective The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the Larynx Mucosa in terms of specifying surgical margins. Methods Forty-four consecutive T1–T2 glottic cancers treated with trans-oral laser microsurgery Type I–VI cordectomy were presented. Suspected areas (90 samples/44 patients) were biopsied under the guidance of narrow-band imaging and white light and sent for frozen section. Results Our study revealed that 75 of 90 (83.3%) white light and narrow-band imaging-guided samples were histopathologically positive: 30 (40%) were confirmed as carcinoma in situ or invasive carcinoma and 45 (60%) as moderate to severe dysplasia. In 6 patients Mucosa was suspected only in narrow-band imaging, with no suspicion under white light. Thus, in these 6 patients 18/90 (20%) samples were taken. In 5/6 patients 16/18 (88.8%) samples were positive in frozen section: in 6/18 (33.3%) carcinoma (2 patients), 10/18 (66.6%) severe dysplasia was confirmed (3 patients). In 1 patient 2/18 (11.1%) samples were negative in frozen section. Presented analysis showed, that sensitivity, specificity and accuracy of white light was 79.5%, 20% and 71.1% respectively, while narrow-band imaging was 100%, 0.0% and 85.7%, respectively. Conclusion The intraoperative use of narrow-band imaging proved to be valuable in the visualization of suspect areas of the Mucosa. Narrow-band imaging confirms the suspicions undertaken in white light and importantly, it showed microlesions beyond the scope of white light.
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The role of intraoperative narrow-band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer
Elsevier, 2019Co-Authors: H. Klimza, Cesare Piazza, J. Jackowska, Jacek Banaszewski, M. WierzbickaAbstract:Introduction: Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer. Objective: The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the Larynx Mucosa in terms of specifying surgical margins. Methods: Forty-four consecutive T1–T2 glottic cancers treated with trans-oral laser microsurgery Type I–VI cordectomy were presented. Suspected areas (90 samples/44 patients) were biopsied under the guidance of narrow-band imaging and white light and sent for frozen section. Results: Our study revealed that 75 of 90 (83.3%) white light and narrow-band imaging-guided samples were histopathologically positive: 30 (40%) were confirmed as carcinoma in situ or invasive carcinoma and 45 (60%) as moderate to severe dysplasia. In 6 patients Mucosa was suspected only in narrow-band imaging, with no suspicion under white light. Thus, in these 6 patients 18/90 (20%) samples were taken. In 5/6 patients 16/18 (88.8%) samples were positive in frozen section: in 6/18 (33.3%) carcinoma (2 patients), 10/18 (66.6%) severe dysplasia was confirmed (3 patients). In 1 patient 2/18 (11.1%) samples were negative in frozen section. Presented analysis showed, that sensitivity, specificity and accuracy of white light was 79.5%, 20% and 71.1% respectively, while narrow-band imaging was 100%, 0.0% and 85.7%, respectively. Conclusion: The intraoperative use of narrow-band imaging proved to be valuable in the visualization of suspect areas of the Mucosa. Narrow-band imaging confirms the suspicions undertaken in white light and importantly, it showed microlesions beyond the scope of white light. Resumo: Introdução: A microcirurgia transoral a laser é uma técnica bem estabelecida para o tratamento de câncer de laringe inicial e moderadamente avançado. Objetivo: Verificar a utilidade da imagem de banda estreita na avaliação intraoperatória da Mucosa laríngea na especificação das margens cirúrgicas. Método: Foram avaliados 44 cânceres glóticos T1-T2 consecutivos, tratados com cordectomia Tipo I-VI, por microcirurgia transoral a laser. As áreas suspeitas (90 amostras/44 pacientes) foram submetidas a biopsia e avaliadas através de imagens de banda estreita e luz branca e enviadas para cortes por congelação. Resultados: Nosso estudo revelou que 75 (83,3%) das 90 amostras, apresentaram histopatologia positiva na análise com luz branca e imagens de banda estreita: 30 (40%) foram confirmadas como carcinoma in situ ou carcinoma invasivo e 45 (60%) como displasia moderada a grave. Em seis pacientes, a Mucosa apresentou-se suspeita apenas na imagem de banda estreita, sem nenhuma suspeita sob luz branca. Assim, nesses seis pacientes 18/90 (20%) amostras foram colhidas. Em 5/6 pacientes, 16/18 (88,8%) amostras mostraram resultado positivo na análise de congelação: em 6/18 (33,3%) amostras foi confirmado carcinoma (dois pacientes) e em 10/18 (66,6%) foi confirmada displasia grave (três pacientes). Em um paciente, 2/18 (11,1%) as amostras mostraram resultado negativo na congelação. A análise apresentada mostrou que a sensibilidade, a especificidade e a acurácia da luz branca foram de 79,5%, 20% e 71,1%, respectivamente, enquanto a imagem de banda estreita apresentou como resultados 100%, 0,0% e 85,7%, respectivamente. Conclusão: O uso intraoperatório de imagem de banda estreita provou ser valioso na identificação de áreas suspeitas da Mucosa, confirmou as suspeitas verificadas na análise com luz branca e, o que é mais importante, identificou microlesões além do alcance da luz branca. Keywords: Laser CO2, Early, Moderately advanced glottic cancer, Narrow-band imaging, Safe margins, Frozen sections, Palavras-chave: Laser CO2, Inicial, Câncer glótico moderadamente avançado, Imagens de banda estreita, Margens seguras, Cortes por congelaçã
Tulay Erden Habesoglu - One of the best experts on this subject based on the ideXlab platform.
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Histopathological effects of estrogen deficiency on Larynx Mucosa in ovariectomised rats.
European Archives of Oto-rhino-laryngology, 2010Co-Authors: Mehmet Surmeli, Tulay Erden Habesoglu, Mehmet Habesoglu, Ildem Deveci, Murat Eriman, Vefa Kinis, Pembegul Gunes, Erol EgeliAbstract:Laryngeal manifestations due to estrogen deficiency have been studied in the literature. But to date, the possible histopathological changes of laryngeal Mucosa due to estrogen deficiency have not been studied. Therefore, our objective was to determine the histopathological changes of laryngeal Mucosa in ovariectomised rats in order to clarify effects of estrogen deficiency on laryngeal tissue. The study is a randomized trial and was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Twenty-one Wistar rats were used throughout the experiment. There were six rats in the sham-operated control group. And others were divided into two groups (4, 8 weeks) according to follow-up time after ovariectomy. We observed significant changes 4 weeks after ovariectomy when we assessed subepithelial edema, inflammation, cilia and goblet cell loss (p < 0.01). It was shown that estrogen deficiency after ovariectomy in rats caused changes in laryngeal tissue when it was studied histopathologically.
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histopathological changes of rat Larynx Mucosa with exposure to chronic thinner inhalation
Otolaryngology-Head and Neck Surgery, 2009Co-Authors: Seyla Bolukbasi, Tulay Erden Habesoglu, Mehmet Habesoglu, Baver Samanci, Yesim Erol, Gulistan Gumrukcu, Erol EgeliAbstract:Abstract Objective Histopathological changes in nasal Mucosa, trachea, and pulmonary system with exposure to chronic thinner inhalation have been studied in the literature. However, the possible changes in Larynx Mucosa, which is a part of the upper airway tract, have not been studied yet. The aim of this study is to determine the histopathological changes of rat Larynx Mucosa with exposure to chronic thinner inhalation. Study Design and Setting Randomized trial. The study was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Subjects and Methods Fifty-one Sprague-Dawley rats were used throughout the experiment. Four groups of rats inhaled thinner in a glass cage for 2, 4, 8, and 12 weeks respectively. Seven rats inhaled only the air in the room as the control group. Results The comparison of inflammation and exocytosis in the control and 2 week groups revealed no significant difference ( P > 0.05), but from the beginning of 4 weeks of thinner inhalation, statistically significant differences were observed ( P P Conclusion On the basis of histopathological evaluations, it was shown that the harmful effect of inhalation of thinner in high concentrations to Larynx Mucosa is similar to the effect on other organs of the respiratory system.
Mehmet Habesoglu - One of the best experts on this subject based on the ideXlab platform.
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Histopathological effects of estrogen deficiency on Larynx Mucosa in ovariectomised rats.
European Archives of Oto-rhino-laryngology, 2010Co-Authors: Mehmet Surmeli, Tulay Erden Habesoglu, Mehmet Habesoglu, Ildem Deveci, Murat Eriman, Vefa Kinis, Pembegul Gunes, Erol EgeliAbstract:Laryngeal manifestations due to estrogen deficiency have been studied in the literature. But to date, the possible histopathological changes of laryngeal Mucosa due to estrogen deficiency have not been studied. Therefore, our objective was to determine the histopathological changes of laryngeal Mucosa in ovariectomised rats in order to clarify effects of estrogen deficiency on laryngeal tissue. The study is a randomized trial and was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Twenty-one Wistar rats were used throughout the experiment. There were six rats in the sham-operated control group. And others were divided into two groups (4, 8 weeks) according to follow-up time after ovariectomy. We observed significant changes 4 weeks after ovariectomy when we assessed subepithelial edema, inflammation, cilia and goblet cell loss (p < 0.01). It was shown that estrogen deficiency after ovariectomy in rats caused changes in laryngeal tissue when it was studied histopathologically.
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histopathological changes of rat Larynx Mucosa with exposure to chronic thinner inhalation
Otolaryngology-Head and Neck Surgery, 2009Co-Authors: Seyla Bolukbasi, Tulay Erden Habesoglu, Mehmet Habesoglu, Baver Samanci, Yesim Erol, Gulistan Gumrukcu, Erol EgeliAbstract:Abstract Objective Histopathological changes in nasal Mucosa, trachea, and pulmonary system with exposure to chronic thinner inhalation have been studied in the literature. However, the possible changes in Larynx Mucosa, which is a part of the upper airway tract, have not been studied yet. The aim of this study is to determine the histopathological changes of rat Larynx Mucosa with exposure to chronic thinner inhalation. Study Design and Setting Randomized trial. The study was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Subjects and Methods Fifty-one Sprague-Dawley rats were used throughout the experiment. Four groups of rats inhaled thinner in a glass cage for 2, 4, 8, and 12 weeks respectively. Seven rats inhaled only the air in the room as the control group. Results The comparison of inflammation and exocytosis in the control and 2 week groups revealed no significant difference ( P > 0.05), but from the beginning of 4 weeks of thinner inhalation, statistically significant differences were observed ( P P Conclusion On the basis of histopathological evaluations, it was shown that the harmful effect of inhalation of thinner in high concentrations to Larynx Mucosa is similar to the effect on other organs of the respiratory system.
