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Guido Sotti - One of the best experts on this subject based on the ideXlab platform.
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Assessment of radiation-induced xerostomia: validation of the Italian version of the xerostomia questionnaire in head and neck cancer patients
Supportive Care in Cancer, 2015Co-Authors: Federica Pellegrino, Elena Groff, Bruno Fattori, Luca Bastiani, Guido SottiAbstract:Purpose Xerostomia is the most common acute and Late Side Effect of radiation treatment for head and neck cancer. Affecting taste perception, chewing, swallowing and speech, xerostomia is also the major cause of decreased quality of life. The aims of this study were to validate the Italian translation of the self-reported eight-item xerostomia questionnaire (XQ) and determine its psychometric properties in patients treated with radiotherapy for head and neck cancer. Methods An observational cross-sectional study was conducted in the Radiotherapy Unit of the Veneto Institute of Oncology – IOV in Padua. The XQ was transLated according to international guidelines and filled out by 102 patients. Construct validity was assessed using principal component analysis, internal consistency using Cronbach’s α coefficient and test-retest reliability at 1-month interval using the intraclass correlation coefficient (ICC). Criterion-reLated validity was evaluated to compare the Italian version of XQ with the European Organization for Research and Treatment of Cancer (EORTC) Core Quality-of-Life Questionnaire (QLQ-C30) and its Head and Neck Cancer Module (QLQ-H&N35). Results Cronbach’s α for the Italian version of XQ was strong at α = 0.93, test-retest reliability was also strong (0.79) and factor analysis confirmed that the questionnaire was one-dimensional. Criterion-reLated validity was excellent with high association with the EORTC QLQ-H&N35 xerostomia and sticky saliva scales. Conclusions The Italian version of XQ has excellent psychometric properties and can be used to evaluate the impact of emerging radiation delivery techniques aiming at preventing xerostomia.
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Assessment of radiation-induced xerostomia: validation of the Italian version of the xerostomia questionnaire in head and neck cancer patients.
Supportive Care in Cancer, 2014Co-Authors: Federica Pellegrino, Elena Groff, Bruno Fattori, Luca Bastiani, Guido SottiAbstract:Purpose Xerostomia is the most common acute and Late Side Effect of radiation treatment for head and neck cancer. Affecting taste perception, chewing, swallowing and speech, xerostomia is also the major cause of decreased quality of life. The aims of this study were to validate the Italian translation of the self-reported eight-item xerostomia questionnaire (XQ) and determine its psychometric properties in patients treated with radiotherapy for head and neck cancer.
Hideo Sugama - One of the best experts on this subject based on the ideXlab platform.
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Bifurcation and Metamorphosis of Plasma Turbulence‐Shear Flow Dynamics: the Path to the Top of the Hill
AIP Conference Proceedings, 2003Co-Authors: Rowena Ball, Robert L. Dewar, Hideo SugamaAbstract:The structural properties of an economical model for a confined plasma turbulence governor are investigated through bifurcation and stability analyses. Two types of discontinuous low to high confinement transition are found. One involves classical hysteresis, governed by viscous dissipation. The other is intrinsically oscillatory and non‐hysteretic, and thus provides a model for observed “dithering” transitions. This metamorphosis of the system dynamics is an important Late Side‐Effect of symmetry‐breaking, which manifests as an unusual non‐symmetric transcritical bifurcation induced by a significant shear flow drive.
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metamorphosis of plasma turbulence shear flow dynamics through a transcritical bifurcation
Physical Review E, 2002Co-Authors: Rowena Ball, Robert L. Dewar, Hideo SugamaAbstract:The structural properties of an economical model for a confined plasma turbulence governor are investigated through bifurcation and stability analyses. A close relationship is demonstrated between the underlying bifurcation framework of the model and typical behavior associated with low- to high-confinement transitions such as shear-flow stabilization of turbulence and oscillatory collective action. In particular, the analysis evinces two types of discontinuous transition that are qualitatively distinct. One involves classical hysteresis, governed by viscous dissipation. The other is intrinsically oscillatory and nonhysteretic, and thus provides a model for the so-called dithering transitions that are frequently observed. This metamorphosis, or transformation, of the system dynamics is an important Late Side-Effect of symmetry breaking, which manifests as an unusual nonsymmetric transcritical bifurcation induced by a significant shear-flow drive.
Federica Pellegrino - One of the best experts on this subject based on the ideXlab platform.
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Assessment of radiation-induced xerostomia: validation of the Italian version of the xerostomia questionnaire in head and neck cancer patients
Supportive Care in Cancer, 2015Co-Authors: Federica Pellegrino, Elena Groff, Bruno Fattori, Luca Bastiani, Guido SottiAbstract:Purpose Xerostomia is the most common acute and Late Side Effect of radiation treatment for head and neck cancer. Affecting taste perception, chewing, swallowing and speech, xerostomia is also the major cause of decreased quality of life. The aims of this study were to validate the Italian translation of the self-reported eight-item xerostomia questionnaire (XQ) and determine its psychometric properties in patients treated with radiotherapy for head and neck cancer. Methods An observational cross-sectional study was conducted in the Radiotherapy Unit of the Veneto Institute of Oncology – IOV in Padua. The XQ was transLated according to international guidelines and filled out by 102 patients. Construct validity was assessed using principal component analysis, internal consistency using Cronbach’s α coefficient and test-retest reliability at 1-month interval using the intraclass correlation coefficient (ICC). Criterion-reLated validity was evaluated to compare the Italian version of XQ with the European Organization for Research and Treatment of Cancer (EORTC) Core Quality-of-Life Questionnaire (QLQ-C30) and its Head and Neck Cancer Module (QLQ-H&N35). Results Cronbach’s α for the Italian version of XQ was strong at α = 0.93, test-retest reliability was also strong (0.79) and factor analysis confirmed that the questionnaire was one-dimensional. Criterion-reLated validity was excellent with high association with the EORTC QLQ-H&N35 xerostomia and sticky saliva scales. Conclusions The Italian version of XQ has excellent psychometric properties and can be used to evaluate the impact of emerging radiation delivery techniques aiming at preventing xerostomia.
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Assessment of radiation-induced xerostomia: validation of the Italian version of the xerostomia questionnaire in head and neck cancer patients.
Supportive Care in Cancer, 2014Co-Authors: Federica Pellegrino, Elena Groff, Bruno Fattori, Luca Bastiani, Guido SottiAbstract:Purpose Xerostomia is the most common acute and Late Side Effect of radiation treatment for head and neck cancer. Affecting taste perception, chewing, swallowing and speech, xerostomia is also the major cause of decreased quality of life. The aims of this study were to validate the Italian translation of the self-reported eight-item xerostomia questionnaire (XQ) and determine its psychometric properties in patients treated with radiotherapy for head and neck cancer.
D Pang - One of the best experts on this subject based on the ideXlab platform.
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SU‐FF‐T‐72: Absolute Rectal Volumetric Dose as a Meaningful Predictor to Its Late Side Effect in Prostate IMRT
Medical Physics, 2006Co-Authors: C Shang, T Williams, D PangAbstract:Purpose: To investigate a meaningful correlation between rectal volumetric doses and the rectal Late Side Effect in prostate IMRT.Method and Materials: Six cases with complaints of prolonged rectal bleeding after one year of prostate IMRT course were analyzed. The DVH's were compared with the control group comprised of 14 similar IMRT cases without Late rectal Side Effects. The follow‐up time was 24–45 months. In each case, a total of 75.6 Gy radiation dose was delivered in 32 fractions using 7‐field 18 MV photon beams. All CTV's were delineated on fused MR/CT images. The posterior margins of PTV's were 7 mm for initial 45 Gy and 4 mm for the 30.6 Gy reduction dose. Nonexclusively, PTV protruded into the anterior portion of rectal wall. During patient daily setup, an ultrasound targeting system was employed to ensure the accuracy. Results: There were no significant deviations seen in relative volumetric DVH's between the two groups for rectal D5 through D50 (p> 0.05). However, DVH's for absolute rectal volume indicated significant higher values (p< 0.01) in the group with Late rectal Side Effect, as seen in table1. Conclusions: No statistical meaningful correlation was found in our data between relative volumetric DVH and the occurrence of Late rectal Side Effect. Rectal DVH using absolute volume is suggested by this study to be a more sensitive indicator to predict Late rectal Side Effect in prostate IMRT. This study is valuable for future follow‐ups and investigations.
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su ff t 72 absolute rectal volumetric dose as a meaningful predictor to its Late Side Effect in prostate imrt
Medical Physics, 2006Co-Authors: C Shang, T Williams, D PangAbstract:Purpose: To investigate a meaningful correlation between rectal volumetric doses and the rectal Late Side Effect in prostate IMRT.Method and Materials: Six cases with complaints of prolonged rectal bleeding after one year of prostate IMRT course were analyzed. The DVH's were compared with the control group comprised of 14 similar IMRT cases without Late rectal Side Effects. The follow‐up time was 24–45 months. In each case, a total of 75.6 Gy radiation dose was delivered in 32 fractions using 7‐field 18 MV photon beams. All CTV's were delineated on fused MR/CT images. The posterior margins of PTV's were 7 mm for initial 45 Gy and 4 mm for the 30.6 Gy reduction dose. Nonexclusively, PTV protruded into the anterior portion of rectal wall. During patient daily setup, an ultrasound targeting system was employed to ensure the accuracy. Results: There were no significant deviations seen in relative volumetric DVH's between the two groups for rectal D5 through D50 (p> 0.05). However, DVH's for absolute rectal volume indicated significant higher values (p< 0.01) in the group with Late rectal Side Effect, as seen in table1. Conclusions: No statistical meaningful correlation was found in our data between relative volumetric DVH and the occurrence of Late rectal Side Effect. Rectal DVH using absolute volume is suggested by this study to be a more sensitive indicator to predict Late rectal Side Effect in prostate IMRT. This study is valuable for future follow‐ups and investigations.
Michel Van Agthoven - One of the best experts on this subject based on the ideXlab platform.
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cost analysis comparing brachytherapy versus surgery for primary carcinoma of the tonsillar fossa and or soft paLate
International Journal of Radiation Oncology Biology Physics, 2004Co-Authors: Wietze Nijdam, Carin Uylde A Groot, Peter C Levendag, Inge Noever, Michel Van AgthovenAbstract:Abstract Purpose Locoregional control rates, Late normal tissue sequelae, and functional outcome scores have not been different for tonsillar fossa and/or soft paLate tumors treated by either brachytherapy (BT) or surgery in an organ function preservation protocol. For additional prioritizing in clinical decision-making, we focused on a comparison of the full hospital costs of the different treatment options. Methods and materials Between 1986 and 2001, tonsillar fossa and/or soft paLate tumors were treated by external beam radiotherapy (EBRT) to the primary tumor and neck, followed by fractionated BT to the primary. Neck dissection (ND) was performed for node-positive disease (BT group; 104 patients). If BT was not feasible, resection combined with postoperative EBRT was executed (surgery group; 86 patients). Locoregional control, disease-free survival, and overall survival were calcuLated according to the Kaplan-Meier method. The performance status scales, Late Side Effects, and degree of xerostomia have been previously reported. This paper focused on the hospital and follow-up costs for the treatment groups EBRT and BT with or without ND compared with surgery followed by postoperative RT (PORT). Finally, these costs were also computed for future treatment strategies (e.g., better sparing of normal tissues by intensity-moduLated RT [IMRT]). Results Locoregional control, disease-free survival, and overall survival rate at 5 years for patients treated with EBRT and BT with or without ND vs. surgery plus PORT was 80% vs. 78%, 58% vs. 55%, and 67% vs. 57%, respectively. The major Late Side Effect was xerostomia. Dry mouth syndrome affected the BT group and surgery group equally. The total costs for all treatment groups were €14,262 (BT group), €16,628 (BT plus ND group), €18,782 (surgery plus PORT group), €14,532 (IMRT group), and €16,897 (IMRT plus ND group). Conclusion Excellent locoregional tumor control was observed with either modality, with no statistically significant differences in the incidence of the most noted Side Effect xerostomia. The total costs for BT were less than for surgery: €16,628 ($19,452) for EBRT plus BT plus ND vs. €18,782 ($22,074) for surgery plus PORT. To reduce the morbidity of xerostomia, we propose further optimizing our organ function preservation protocol by implementing IMRT as a more conformal, tissue-sparing, RT technique. This is of particular interest because the costs of IMRT plus ND (€16,897; $19,767) were not very different from those for BT plus ND (€16,628; $19,452) and were far less than the costs for surgery.
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Cost analysis comparing brachytherapy versus surgery for primary carcinoma of the tonsillar fossa and/or soft paLate.
International Journal of Radiation Oncology Biology Physics, 2004Co-Authors: Wietze Nijdam, Peter C Levendag, Carin A. Uyl-de Groot, Inge Noever, Michel Van AgthovenAbstract:Abstract Purpose Locoregional control rates, Late normal tissue sequelae, and functional outcome scores have not been different for tonsillar fossa and/or soft paLate tumors treated by either brachytherapy (BT) or surgery in an organ function preservation protocol. For additional prioritizing in clinical decision-making, we focused on a comparison of the full hospital costs of the different treatment options. Methods and materials Between 1986 and 2001, tonsillar fossa and/or soft paLate tumors were treated by external beam radiotherapy (EBRT) to the primary tumor and neck, followed by fractionated BT to the primary. Neck dissection (ND) was performed for node-positive disease (BT group; 104 patients). If BT was not feasible, resection combined with postoperative EBRT was executed (surgery group; 86 patients). Locoregional control, disease-free survival, and overall survival were calcuLated according to the Kaplan-Meier method. The performance status scales, Late Side Effects, and degree of xerostomia have been previously reported. This paper focused on the hospital and follow-up costs for the treatment groups EBRT and BT with or without ND compared with surgery followed by postoperative RT (PORT). Finally, these costs were also computed for future treatment strategies (e.g., better sparing of normal tissues by intensity-moduLated RT [IMRT]). Results Locoregional control, disease-free survival, and overall survival rate at 5 years for patients treated with EBRT and BT with or without ND vs. surgery plus PORT was 80% vs. 78%, 58% vs. 55%, and 67% vs. 57%, respectively. The major Late Side Effect was xerostomia. Dry mouth syndrome affected the BT group and surgery group equally. The total costs for all treatment groups were €14,262 (BT group), €16,628 (BT plus ND group), €18,782 (surgery plus PORT group), €14,532 (IMRT group), and €16,897 (IMRT plus ND group). Conclusion Excellent locoregional tumor control was observed with either modality, with no statistically significant differences in the incidence of the most noted Side Effect xerostomia. The total costs for BT were less than for surgery: €16,628 ($19,452) for EBRT plus BT plus ND vs. €18,782 ($22,074) for surgery plus PORT. To reduce the morbidity of xerostomia, we propose further optimizing our organ function preservation protocol by implementing IMRT as a more conformal, tissue-sparing, RT technique. This is of particular interest because the costs of IMRT plus ND (€16,897; $19,767) were not very different from those for BT plus ND (€16,628; $19,452) and were far less than the costs for surgery.
