The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Sung Ho Jang - One of the best experts on this subject based on the ideXlab platform.
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Injury of the Lateral vestibulospinal tract in a patient with the Lateral Medullary Syndrome: Case report.
Medicine, 2020Co-Authors: Sung Ho Jang, Ga Young Park, In Hee Cho, Sang Seok YeoAbstract:Rationale Lateral Medullary Syndrome is a central vestibular disorder characterized by vertigo and ataxia. We report on a patient with injury of the Lateral vestibulospinal tract (VST) following Lateral Medullary Syndrome, detected on diffusion tensor tractography (DTT). Patient concerns A 56-year-old male patient was diagnosed with Lateral Medullary Syndrome due to an infarction in the posterior inferior cerebellar artery area. Diagnoses Two weeks following the infarction, he was transferred to the rehabilitation department of the same university hospital with severe vertigo, ataxia (Berg balance scale: 16 point), and dysphasia. In contrast, he maintained good motor power and cognitive function (Mini-mental state test: 26 points). Interventions N/A OUTCOMES:: Both the patient's medial VSTs and left Lateral VST were well-reconstructed. In contrast, the right Lateral VST was not reconstructed. On DTT parameters of the VST, the patient's medial VSTs and left Lateral VST did not differ significantly from the control subjects. Lessons An injury of the right Lateral VST was demonstrated in a patient with Lateral Medullary Syndrome. We believe that the result will be helpful in clinical management and research for patients with Lateral Medullary Syndrome.
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Lateral Medullary Syndrome Following Injury of Lateral Vestibulospinal Tract: Diffusion Tensor Imaging Study.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020Co-Authors: Sung Ho Jang, Sang Seok YeoAbstract:Abstract Background UniLateral lesions of vestibular nucleus can cause Lateral Medullary Syndrome. Little is known about injury of medial and Lateral vestibulospinal tract (VST) after dorsoLateral Medullary infarct. We investigated injury of the Lateral VST in patients with typical central vestibular disorder using diffusion tensor tractography (DTT). Methods Seven patients with Lateral Medullary Syndrome and ten control subjects were recruited. For the medial VST, we determined seed region of interest (ROI) as medial vestibular nuclei of pons and target ROI on posteromedial medulla. For the Lateral VST, the seed ROI was placed on Lateral vestibular nuclei of pons, and the target ROI on posteroLateral medulla. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. Result Reconstructed Lateral VST on both sides had significantly lower FA values in patients than controls (p 0.05). Conclusion Injury of the Lateral VST was demonstrated in patients with Lateral vestibular Syndrome following dorsoLateral Medullary infarct. Analysis of the Lateral VST using DTT would be helpful in evaluation of patients with Lateral Medullary Syndrome.
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Dysphagia in Lateral Medullary Syndrome: A Narrative Review
Dysphagia, 2020Co-Authors: Sung Ho Jang, Min Son KimAbstract:Dysphagia is a common clinical feature of Lateral Medullary Syndrome (LMS) and is clinically relevant because it is related to aspiration pneumonia, malnutrition, increased mortality, and prolonged hospital stay. Herein, the pathophysiology, prognosis, and treatment of dysphagia in LMS are reviewed. The pathophysiology, prognosis, and treatment of dysphagia in LMS are closely interconnected. Although the pathophysiology of dysphagia in LMS has not been fully elucidated, previous studies have suggested that the Medullary central pattern generators coordinate the pharyngeal phases of swallowing. Investigation of the extensive neural connections of the medulla oblongata is important in understanding the pathophysiologic mechanism of dysphagia in LMS. Previous studies have reported that most patients with dysphagia in LMS have a relatively good prognosis. However, some patients require tube feeding for several months, even years, due to severe dysphagia, and little has been reported about conditions associated with a poor prognosis of dysphagia in LMS. Concerning specific therapeutic modalities for dysphagia in LMS, in addition to general modalities used for dysphagia treatment in stroke patients, non-invasive modalities, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation, as well as invasive modalities, such as botulinum toxin injection, balloon catheter dilatation, and myotomy for relaxation of the cricopharyngeal muscle, have been applied. For the appropriate application of therapeutic modalities, clinicians should be aware of the recovery mechanisms and prognosis of dysphagia in LMS. Further studies on this topic, as well as studies involving large numbers of subjects on specific therapeutic modalities, should be encouraged.
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Lateral Medullary Syndrome following injury of the vestibular pathway to the core vestibular cortex: Diffusion tensor imaging study.
Neuroscience letters, 2017Co-Authors: Sang Seok Yeo, Sung Ho Jang, Jung Won KwonAbstract:Abstract Objective The parieto-insular vestibular cortex (PIVC) is a core region of vestibular input into regions of the cortex. The vestibular nuclei have reciprocal connections with the PIVC. However, little is known about injury of the core vestibular pathway to the PIVC in patients with dorsoLateral Medullary infarctions. In this study, using diffusion tensor tractography (DTT), we investigated injury of the neural connections between the vestibular nuclei and the PIVC in patients with typical central vestibular disorder. Methods Eight consecutive patients with Lateral Medullary Syndrome and 10 control subjects were recruited for this study. To reconstruct the core vestibular pathway to the PIVC, we defined the seed region of interest (ROI) as the vestibular nuclei of the pons and the target ROI as the PIVC. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. Result The core vestibular pathway to the PIVC showed significantly lower tract volume in patients compared with the control group (p 0.05). Conclusion In conclusion, injury of the core vestibular pathway to the PIVC was demonstrated in patients with Lateral vestibular Syndrome following dorsoLateral Medullary infarcts. We believe that analysis of the core vestibular pathway to the PIVC using DTT would be helpful in evaluating patients with Lateral Medullary Syndrome.
Sang Seok Yeo - One of the best experts on this subject based on the ideXlab platform.
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Injury of the Lateral vestibulospinal tract in a patient with the Lateral Medullary Syndrome: Case report.
Medicine, 2020Co-Authors: Sung Ho Jang, Ga Young Park, In Hee Cho, Sang Seok YeoAbstract:Rationale Lateral Medullary Syndrome is a central vestibular disorder characterized by vertigo and ataxia. We report on a patient with injury of the Lateral vestibulospinal tract (VST) following Lateral Medullary Syndrome, detected on diffusion tensor tractography (DTT). Patient concerns A 56-year-old male patient was diagnosed with Lateral Medullary Syndrome due to an infarction in the posterior inferior cerebellar artery area. Diagnoses Two weeks following the infarction, he was transferred to the rehabilitation department of the same university hospital with severe vertigo, ataxia (Berg balance scale: 16 point), and dysphasia. In contrast, he maintained good motor power and cognitive function (Mini-mental state test: 26 points). Interventions N/A OUTCOMES:: Both the patient's medial VSTs and left Lateral VST were well-reconstructed. In contrast, the right Lateral VST was not reconstructed. On DTT parameters of the VST, the patient's medial VSTs and left Lateral VST did not differ significantly from the control subjects. Lessons An injury of the right Lateral VST was demonstrated in a patient with Lateral Medullary Syndrome. We believe that the result will be helpful in clinical management and research for patients with Lateral Medullary Syndrome.
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Lateral Medullary Syndrome Following Injury of Lateral Vestibulospinal Tract: Diffusion Tensor Imaging Study.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020Co-Authors: Sung Ho Jang, Sang Seok YeoAbstract:Abstract Background UniLateral lesions of vestibular nucleus can cause Lateral Medullary Syndrome. Little is known about injury of medial and Lateral vestibulospinal tract (VST) after dorsoLateral Medullary infarct. We investigated injury of the Lateral VST in patients with typical central vestibular disorder using diffusion tensor tractography (DTT). Methods Seven patients with Lateral Medullary Syndrome and ten control subjects were recruited. For the medial VST, we determined seed region of interest (ROI) as medial vestibular nuclei of pons and target ROI on posteromedial medulla. For the Lateral VST, the seed ROI was placed on Lateral vestibular nuclei of pons, and the target ROI on posteroLateral medulla. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. Result Reconstructed Lateral VST on both sides had significantly lower FA values in patients than controls (p 0.05). Conclusion Injury of the Lateral VST was demonstrated in patients with Lateral vestibular Syndrome following dorsoLateral Medullary infarct. Analysis of the Lateral VST using DTT would be helpful in evaluation of patients with Lateral Medullary Syndrome.
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Lateral Medullary Syndrome following injury of the vestibular pathway to the core vestibular cortex: Diffusion tensor imaging study.
Neuroscience letters, 2017Co-Authors: Sang Seok Yeo, Sung Ho Jang, Jung Won KwonAbstract:Abstract Objective The parieto-insular vestibular cortex (PIVC) is a core region of vestibular input into regions of the cortex. The vestibular nuclei have reciprocal connections with the PIVC. However, little is known about injury of the core vestibular pathway to the PIVC in patients with dorsoLateral Medullary infarctions. In this study, using diffusion tensor tractography (DTT), we investigated injury of the neural connections between the vestibular nuclei and the PIVC in patients with typical central vestibular disorder. Methods Eight consecutive patients with Lateral Medullary Syndrome and 10 control subjects were recruited for this study. To reconstruct the core vestibular pathway to the PIVC, we defined the seed region of interest (ROI) as the vestibular nuclei of the pons and the target ROI as the PIVC. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. Result The core vestibular pathway to the PIVC showed significantly lower tract volume in patients compared with the control group (p 0.05). Conclusion In conclusion, injury of the core vestibular pathway to the PIVC was demonstrated in patients with Lateral vestibular Syndrome following dorsoLateral Medullary infarcts. We believe that analysis of the core vestibular pathway to the PIVC using DTT would be helpful in evaluating patients with Lateral Medullary Syndrome.
Enrique C. Leira - One of the best experts on this subject based on the ideXlab platform.
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Paroxysmal sneezing at the onset of Lateral Medullary Syndrome: cause or consequence?
European journal of neurology, 2007Co-Authors: Andrea Swenson, Enrique C. LeiraAbstract:Sneezing is known to precede Lateral Medullary Syndrome (LMS). It is usually interpreted as the precipitating cause for a vertebral artery dissection that subsequently causes LMS. Through two case reports and a literature review, we aim to challenge the concept that sneezing at the onset of LMS implies that a dissection is the underlying cause. An 82-year-old man and a 54-year-old man both reported unprovoked explosive pathological sneezing at the onset of the LMS without any delay between sneezing and the other LMS symptoms. Both denied neck trauma or neck pain. There was no conclusive evidence for vertebral artery dissection in either case. Paroxysmal sneezing can be an initial manifestation of Lateral Medullary ischemia and may not necessarily indicate an underlying vertebral artery dissection as the cause.
Jin-woo Park - One of the best experts on this subject based on the ideXlab platform.
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Clinical course and outcome in patients with severe dysphagia after Lateral Medullary Syndrome.
Therapeutic advances in neurological disorders, 2018Co-Authors: Hyojun Kim, Ho Jun Lee, Jin-woo ParkAbstract:BackgroundThe objective of this study was to investigate the clinical course and final outcome in patients afflicted with severe dysphagia following a diagnosis of Lateral Medullary Syndrome (LMS)....
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Clinical course and outcome in patients with severe dysphagia after Lateral Medullary Syndrome
SAGE Publishing, 2018Co-Authors: Hyojun Kim, Ho Jun Lee, Jin-woo ParkAbstract:Background The objective of this study was to investigate the clinical course and final outcome in patients afflicted with severe dysphagia following a diagnosis of Lateral Medullary Syndrome (LMS). Methods The patients with severe dysphagia after LMS admitted to a rehabilitation unit were included and their respective clinical data were prospectively collected. The criteria of ‘severe dysphagia’ was defined as the condition that showed decreased pharyngeal constriction with no esophageal passage in a videofluoroscopic swallowing study (VFSS) and initially required enteral tube feeding. The data included VFSS findings, types of diet and postural modification, penetration-aspiration scale (PAS) and functional oral intake scale (FOIS). Results A total of 11 patients were included and VFSS was performed every 2 weeks after stroke onset. Esophageal passage began to show at an average 34.7 ± 18.3 days, and the patients were able to begin consuming a partial oral diet with postural modification. It was 52.2 ± 21.8 days till they were advanced to a full oral diet. PAS and FOIS were significantly improved over time. Conclusions Patients with severe dysphagia after LMS were able to tolerate a partial oral diet at about 5 weeks following onset, and they were advanced to a normal diet after 10 weeks. This clinical course might help in predicting the prognosis, as well as assist in making practical decisions regarding a rehabilitation program
Mark Hersch - One of the best experts on this subject based on the ideXlab platform.
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Loss of ability to sneeze in Lateral Medullary Syndrome.
Neurology, 2000Co-Authors: Mark HerschAbstract:Four consecutive patients with Lateral Medullary Syndrome reported reversible inability to complete a reflex sneeze, despite retaining the urge to do so and the ability to mimic the motor act. This previously undescribed feature of a relatively common Syndrome is in keeping with the known location of a "sneeze center" in the Lateral medulla of cat. In man, uniLateral brainstem lesion is sufficient to abolish the sneeze reflex temporarily.
