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Johannes G Ramaekers - One of the best experts on this subject based on the ideXlab platform.
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a pooled analysis of on the road highway driving studies in actual traffic measuring standard deviation of Lateral Position i e weaving while driving at a blood alcohol concentration of 0 5 g l
Psychopharmacology, 2017Co-Authors: Stefan Jongen, A Vermeeren, N N J J M Van Der Sluiszen, Markus Schumacher, Eef L Theunissen, Kim P C Kuypers, E F P M Vuurman, Johannes G RamaekersAbstract:Introduction The on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of Lateral Position (SDLP), a measure of road tracking error or “weaving”. The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study.
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a pooled analysis of on the road highway driving studies in actual traffic measuring standard deviation of Lateral Position i e weaving while driving at a blood alcohol concentration of 0 5 g l
Psychopharmacology, 2017Co-Authors: Stefan Jongen, A Vermeeren, N N J J M Van Der Sluiszen, Markus Schumacher, Eef L Theunissen, Kim P C Kuypers, E F P M Vuurman, Johannes G RamaekersAbstract:The on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of Lateral Position (SDLP), a measure of road tracking error or “weaving”. The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study. The present study pooled data of 182 participants from nine placebo-controlled crossover studies who performed the highway driving test, while their BAC was at or just below the legal limit for drivers (i.e., 0.5 g/L). Overall, mean SDLP increased with 2.5 cm (95% CI 2.0–2.9 cm). Equivalence testing showed that the clinical relevance criterion value of 2.4 cm fell well within the 95% CI in each individual study. Gender did not affect alcohol-induced changes in SDLP. These results demonstrate the robustness and validity of the clinical relevance criterion for SDLP as measured during on-the-road driving.
R E Collis - One of the best experts on this subject based on the ideXlab platform.
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hypotension following combined spinal epidural anaesthesia for caesarean section left Lateral Position vs tilted supine Position
Anaesthesia, 2003Co-Authors: C Mendonca, J Griffiths, B Ateleanu, R E CollisAbstract:Summary Eighty-seven pregnant mothers undergoing elective Caesarean section were randomly allocated either to the full left Lateral Position (n = 45) or to the supine Position with 12° left Lateral tilt (n = 42) after a combined spinal–epidural (CSE) in the sitting Position and an initial 2 min in the full right Lateral Position. Fewer mothers were hypotensive while in the study Position [29 (64%) in Lateral group vs. 38 (90%) in the tilted supine group; p = 0.03]. Mothers in the Lateral group tended to become hypotensive after turning them back to the tilted supine Position immediately before surgery; hence the number of mothers who were hypotensive from the insertion of the CSE until delivery were similar [36 (80%) vs. 38 (90%)]. Mothers in the Lateral group needed a lower dose of ephedrine to treat their hypotension while in their study Position {median (interquartile range [range]) 6 (0–12 [0–36]) mg vs. 12 (6–18 [0–36]) mg, respectively; p = 0.04} but ephedrine requirements were similar overall {12 (6–12 [0–36]) mg vs. 12 (6–18 [0–36]) mg}, respectively. The full left Lateral Position reduces the incidence of early hypotension compared with the tilted supine Position with tilt, and makes it easier to treat.
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hypotension following combined spinal epidural anaesthesia for caesarean section left Lateral Position vs tilted supine Position
Anaesthesia, 2003Co-Authors: C Mendonca, J Griffiths, B Ateleanu, R E CollisAbstract:Eighty-seven pregnant mothers undergoing elective Caesarean section were randomly allocated either to the full left Lateral Position (n = 45) or to the supine Position with 12 degrees left Lateral tilt (n = 42) after a combined spinal-epidural (CSE) in the sitting Position and an initial 2 min in the full right Lateral Position. Fewer mothers were hypotensive while in the study Position [29 (64%) in Lateral group vs. 38 (90%) in the tilted supine group; p = 0.03]. Mothers in the Lateral group tended to become hypotensive after turning them back to the tilted supine Position immediately before surgery; hence the number of mothers who were hypotensive from the insertion of the CSE until delivery were similar [36 (80%) vs. 38 (90%)]. Mothers in the Lateral group needed a lower dose of ephedrine to treat their hypotension while in their study Position (median (interquartile range [range]) 6 (0-12 [0-36]) mg vs. 12 (6-18 [0-36]) mg, respectively; p = 0.04) but ephedrine requirements were similar overall (12 (6-12 [0-36]) mg vs. 12 (6-18 [0-36]) mg), respectively. The full left Lateral Position reduces the incidence of early hypotension compared with the tilted supine Position with tilt, and makes it easier to treat.
Stefan Jongen - One of the best experts on this subject based on the ideXlab platform.
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a pooled analysis of on the road highway driving studies in actual traffic measuring standard deviation of Lateral Position i e weaving while driving at a blood alcohol concentration of 0 5 g l
Psychopharmacology, 2017Co-Authors: Stefan Jongen, A Vermeeren, N N J J M Van Der Sluiszen, Markus Schumacher, Eef L Theunissen, Kim P C Kuypers, E F P M Vuurman, Johannes G RamaekersAbstract:Introduction The on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of Lateral Position (SDLP), a measure of road tracking error or “weaving”. The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study.
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a pooled analysis of on the road highway driving studies in actual traffic measuring standard deviation of Lateral Position i e weaving while driving at a blood alcohol concentration of 0 5 g l
Psychopharmacology, 2017Co-Authors: Stefan Jongen, A Vermeeren, N N J J M Van Der Sluiszen, Markus Schumacher, Eef L Theunissen, Kim P C Kuypers, E F P M Vuurman, Johannes G RamaekersAbstract:The on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of Lateral Position (SDLP), a measure of road tracking error or “weaving”. The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study. The present study pooled data of 182 participants from nine placebo-controlled crossover studies who performed the highway driving test, while their BAC was at or just below the legal limit for drivers (i.e., 0.5 g/L). Overall, mean SDLP increased with 2.5 cm (95% CI 2.0–2.9 cm). Equivalence testing showed that the clinical relevance criterion value of 2.4 cm fell well within the 95% CI in each individual study. Gender did not affect alcohol-induced changes in SDLP. These results demonstrate the robustness and validity of the clinical relevance criterion for SDLP as measured during on-the-road driving.
Ruwen Wang - One of the best experts on this subject based on the ideXlab platform.
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one surgeon s learning curve for video assisted thoracoscopic esophagectomy for esophageal cancer with the patient in Lateral Position how many cases are needed to reach competence
Surgical Endoscopy and Other Interventional Techniques, 2013Co-Authors: Wei Guo, Yingbo Zou, Huijun Niu, Yaoguang Jiang, Yunping Zhao, Taiqian Gong, Ruwen WangAbstract:Background Minimally invasive esophagectomy is a feasible technique shown to be safe and oncologically adequate for the treatment of esophageal cancer. This study aimed to describe one surgeon’s learning curve for video-assisted thoracoscopic esophagectomy with the patient in Lateral Position.
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one surgeon s learning curve for video assisted thoracoscopic esophagectomy for esophageal cancer with the patient in Lateral Position how many cases are needed to reach competence
Surgical Endoscopy and Other Interventional Techniques, 2013Co-Authors: Wei Guo, Yingbo Zou, Huijun Niu, Yaoguang Jiang, Yunping Zhao, Taiqian Gong, Ruwen WangAbstract:Minimally invasive esophagectomy is a feasible technique shown to be safe and oncologically adequate for the treatment of esophageal cancer. This study aimed to describe one surgeon’s learning curve for video-assisted thoracoscopic esophagectomy with the patient in Lateral Position. From May 2010 to June 2012, 89 thoracoscopic esophagectomies for esophageal cancer were performed by one surgeon. The patients were divided into three groups. Group A included the first 30 cases. Group B comprised cases 31 to 60, and group C included the final 29 cases. The demographic characteristics and the intra- and postoperative variables were collected retrospectively and analyzed. One postoperative death occurred. Eight patients required conversion. No significant difference in background or clinicopathologic factors among the three groups was observed. Compared with group A, a significant decrease in intrathoracic operative time (107.7 ± 16.2 min; P = 0.0000), total operative time (326.3 ± 40.7 min; P = 0.0002), and blood loss (290.8 ± 114.3 ml; P = 0.0129) was observed in group B, whereas more retrieved nodes were harvested (20.1 ± 9.5; P = 0.0002). The last 29 patients (group C) involved significantly less intrathoracic operative time (82.8 ± 18.4 min; P = 0.0386), total operative time (294.7 ± 37.4 min; P = 0.0009), and blood loss (234.7 ± 87.8 ml; P = 0.0125) as well as a shorter postoperative hospital stay (12.4 ± 3.7 days; P = 0.0125) compared with group B. A significant decline in the overall morbidity from group A to group C (P = 0.0005) also was observed. The results of this study suggest that at least 30 cases were needed to reach the plateau of thoracoscopic esophagectomy. After more than 60 cases of thoracoscopic esophagectomies had been managed, lower morbidity could be obtained.
C Mendonca - One of the best experts on this subject based on the ideXlab platform.
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hypotension following combined spinal epidural anaesthesia for caesarean section left Lateral Position vs tilted supine Position
Anaesthesia, 2003Co-Authors: C Mendonca, J Griffiths, B Ateleanu, R E CollisAbstract:Summary Eighty-seven pregnant mothers undergoing elective Caesarean section were randomly allocated either to the full left Lateral Position (n = 45) or to the supine Position with 12° left Lateral tilt (n = 42) after a combined spinal–epidural (CSE) in the sitting Position and an initial 2 min in the full right Lateral Position. Fewer mothers were hypotensive while in the study Position [29 (64%) in Lateral group vs. 38 (90%) in the tilted supine group; p = 0.03]. Mothers in the Lateral group tended to become hypotensive after turning them back to the tilted supine Position immediately before surgery; hence the number of mothers who were hypotensive from the insertion of the CSE until delivery were similar [36 (80%) vs. 38 (90%)]. Mothers in the Lateral group needed a lower dose of ephedrine to treat their hypotension while in their study Position {median (interquartile range [range]) 6 (0–12 [0–36]) mg vs. 12 (6–18 [0–36]) mg, respectively; p = 0.04} but ephedrine requirements were similar overall {12 (6–12 [0–36]) mg vs. 12 (6–18 [0–36]) mg}, respectively. The full left Lateral Position reduces the incidence of early hypotension compared with the tilted supine Position with tilt, and makes it easier to treat.
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hypotension following combined spinal epidural anaesthesia for caesarean section left Lateral Position vs tilted supine Position
Anaesthesia, 2003Co-Authors: C Mendonca, J Griffiths, B Ateleanu, R E CollisAbstract:Eighty-seven pregnant mothers undergoing elective Caesarean section were randomly allocated either to the full left Lateral Position (n = 45) or to the supine Position with 12 degrees left Lateral tilt (n = 42) after a combined spinal-epidural (CSE) in the sitting Position and an initial 2 min in the full right Lateral Position. Fewer mothers were hypotensive while in the study Position [29 (64%) in Lateral group vs. 38 (90%) in the tilted supine group; p = 0.03]. Mothers in the Lateral group tended to become hypotensive after turning them back to the tilted supine Position immediately before surgery; hence the number of mothers who were hypotensive from the insertion of the CSE until delivery were similar [36 (80%) vs. 38 (90%)]. Mothers in the Lateral group needed a lower dose of ephedrine to treat their hypotension while in their study Position (median (interquartile range [range]) 6 (0-12 [0-36]) mg vs. 12 (6-18 [0-36]) mg, respectively; p = 0.04) but ephedrine requirements were similar overall (12 (6-12 [0-36]) mg vs. 12 (6-18 [0-36]) mg), respectively. The full left Lateral Position reduces the incidence of early hypotension compared with the tilted supine Position with tilt, and makes it easier to treat.
