The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform
K. Aho - One of the best experts on this subject based on the ideXlab platform.
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Measuring rheumatoid factor in nonrheumatoid subjects: immunoturbidimetric assay, Latex slide Test, and enzyme-linked immunosorbent assay compared.
Clinical Chemistry, 1991Co-Authors: K. Ailus, L. Melamies, Tiinamaija Tuomi, T. Palosuo, K. AhoAbstract:Previous studies of patients with rheumatoid arthritis (RA) have shown a good correlation between results from immunoturbidimetric assays of rheumatoid factor (RF) and Latex Fixation Tests. To extend the research to non-RA subjects, we Tested sera from 1000 pregnant women, half each in the first and third trimesters. By turbidimetry, 24 non-RA sera were regarded as positive for RF (greater than or equal to 20 int. units/mL) and 18 sera as borderline (15-19 int. units/mL). By the Latex Fixation Test, 28 non-RA sera gave a clear reaction (positive) and 17 sera a weak reaction (borderline). The association between the Tests was statistically highly significant (P less than 0.001). All sera with positive and borderline reactions were Tested by enzyme-linked immunosorbent assay for RF isotypes, together with a random subsample of about one-sixth of the original serum samples. Positive RF results by immunoturbidimetry were predominantly due to the presence of IgM-RF. In contrast to some earlier findings, we saw no difference in the prevalence of positive RF reactions between sera from the first and third trimesters.
J. Edgren - One of the best experts on this subject based on the ideXlab platform.
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lupus like syndrome associated with pulmonary reaction to nitrofurantoin report of three cases
Acta Medica Scandinavica, 2009Co-Authors: Olof Selroos, J. EdgrenAbstract:: A systemic lupus erythematosus-like syndrome developed simultaneously with pulmonary reactions of the chronic type in three female patients after treatment with nitrofurantoin for 12, 27 and 38 months, respectively. The syndrome was characterized by elevated ESR, polyclonal hypergammaglobulinaemia, the presence of IgG antinuclear antibodies and a positive Latex-Fixation Test. Two patients had severe arthralgia and one of them peripheral lymphadenopathy. Pleural effusion and a chronic active hepatitis were present in the third patient, in whom interstitial cystitis also developed. All signs and symptoms of the lupus-like syndrome disappeared, without corticosteroid or other medication, when nitrofurantoin was omitted. The diminution of pulmonary infiltrates and the reversal of interstitial cystitis also appeared to be directly related to cessation of nitrofurantoin therapy. Our findings indicate that long-term medication with nitrofurantoin may cause, in addition to pulmonary changes, a simultaneous lupus-like syndrome our data also raise the possibility that interstitial cystitis may occur as an adverse reaction to nitrofurantoin therapy.
K. Ailus - One of the best experts on this subject based on the ideXlab platform.
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Measuring rheumatoid factor in nonrheumatoid subjects: immunoturbidimetric assay, Latex slide Test, and enzyme-linked immunosorbent assay compared.
Clinical Chemistry, 1991Co-Authors: K. Ailus, L. Melamies, Tiinamaija Tuomi, T. Palosuo, K. AhoAbstract:Previous studies of patients with rheumatoid arthritis (RA) have shown a good correlation between results from immunoturbidimetric assays of rheumatoid factor (RF) and Latex Fixation Tests. To extend the research to non-RA subjects, we Tested sera from 1000 pregnant women, half each in the first and third trimesters. By turbidimetry, 24 non-RA sera were regarded as positive for RF (greater than or equal to 20 int. units/mL) and 18 sera as borderline (15-19 int. units/mL). By the Latex Fixation Test, 28 non-RA sera gave a clear reaction (positive) and 17 sera a weak reaction (borderline). The association between the Tests was statistically highly significant (P less than 0.001). All sera with positive and borderline reactions were Tested by enzyme-linked immunosorbent assay for RF isotypes, together with a random subsample of about one-sixth of the original serum samples. Positive RF results by immunoturbidimetry were predominantly due to the presence of IgM-RF. In contrast to some earlier findings, we saw no difference in the prevalence of positive RF reactions between sera from the first and third trimesters.
L. Melamies - One of the best experts on this subject based on the ideXlab platform.
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Measuring rheumatoid factor in nonrheumatoid subjects: immunoturbidimetric assay, Latex slide Test, and enzyme-linked immunosorbent assay compared.
Clinical Chemistry, 1991Co-Authors: K. Ailus, L. Melamies, Tiinamaija Tuomi, T. Palosuo, K. AhoAbstract:Previous studies of patients with rheumatoid arthritis (RA) have shown a good correlation between results from immunoturbidimetric assays of rheumatoid factor (RF) and Latex Fixation Tests. To extend the research to non-RA subjects, we Tested sera from 1000 pregnant women, half each in the first and third trimesters. By turbidimetry, 24 non-RA sera were regarded as positive for RF (greater than or equal to 20 int. units/mL) and 18 sera as borderline (15-19 int. units/mL). By the Latex Fixation Test, 28 non-RA sera gave a clear reaction (positive) and 17 sera a weak reaction (borderline). The association between the Tests was statistically highly significant (P less than 0.001). All sera with positive and borderline reactions were Tested by enzyme-linked immunosorbent assay for RF isotypes, together with a random subsample of about one-sixth of the original serum samples. Positive RF results by immunoturbidimetry were predominantly due to the presence of IgM-RF. In contrast to some earlier findings, we saw no difference in the prevalence of positive RF reactions between sera from the first and third trimesters.
Tiinamaija Tuomi - One of the best experts on this subject based on the ideXlab platform.
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Measuring rheumatoid factor in nonrheumatoid subjects: immunoturbidimetric assay, Latex slide Test, and enzyme-linked immunosorbent assay compared.
Clinical Chemistry, 1991Co-Authors: K. Ailus, L. Melamies, Tiinamaija Tuomi, T. Palosuo, K. AhoAbstract:Previous studies of patients with rheumatoid arthritis (RA) have shown a good correlation between results from immunoturbidimetric assays of rheumatoid factor (RF) and Latex Fixation Tests. To extend the research to non-RA subjects, we Tested sera from 1000 pregnant women, half each in the first and third trimesters. By turbidimetry, 24 non-RA sera were regarded as positive for RF (greater than or equal to 20 int. units/mL) and 18 sera as borderline (15-19 int. units/mL). By the Latex Fixation Test, 28 non-RA sera gave a clear reaction (positive) and 17 sera a weak reaction (borderline). The association between the Tests was statistically highly significant (P less than 0.001). All sera with positive and borderline reactions were Tested by enzyme-linked immunosorbent assay for RF isotypes, together with a random subsample of about one-sixth of the original serum samples. Positive RF results by immunoturbidimetry were predominantly due to the presence of IgM-RF. In contrast to some earlier findings, we saw no difference in the prevalence of positive RF reactions between sera from the first and third trimesters.
