The Experts below are selected from a list of 1110 Experts worldwide ranked by ideXlab platform

Chunxiang Jin - One of the best experts on this subject based on the ideXlab platform.

  • multimodal ultrasound model based on the Left Gastric Vein in b viral cirrhosis noninvasive prediction of esophageal varices
    Clinical and translational gastroenterology, 2020
    Co-Authors: Ying Jin, Yuanqiang Lin, Yaoyao Zhou, Hui Wang, Chunxiang Jin
    Abstract:

    OBJECTIVES To establish and verify a simple noninvasive model based on the Left Gastric Vein (LGV) to predict the grade of esophageal varices (EV) and high-risk EV (HEV), to facilitate clinical follow-up and timely treatment. METHODS We enrolled 320 patients with B-viral cirrhosis. All patients underwent endoscopy, laboratory tests, liver and spleen stiffness (SS), and ultrasonography. HEV were analyzed using the χ test/t test and logistic regression in the univariate and multivariate analyses, respectively. EV grades were analyzed using the variance/rank-sum test and logistic regression. A prediction model was derived from the multivariate predictors. RESULTS In the training set, multivariate analysis showed that the independent factors of different EV grades were SS, LGV diameter, and platelet count (PLT). We developed the LGV diameter-SS to PLT ratio index (LSPI) and LGV diameter/PLT models without SS. The area under the receiver operating characteristic curve of the LSPI for diagnosis of small EV, medium EV, large EV, and HEV was 0.897, 0.899, 0.853, and 0.954, respectively, and that of the LGV/PLT was 0.882, 0.890, 0.837, and 0.942, respectively. For the diagnosis of HEV, the negative predictive value was 94.07% when LSPI 23.0. The negative predictive value was 95.92% when LGV/PLT 7.40. The predicted values showed similar accuracy in the validation set. DISCUSSION Under appropriate conditions, the LSPI was an accurate method to detect the grade of EV and HEV. Alternatively, the LGV/PLT may also be useful in diagnosing the varices when condition limited.

  • Multimodal Ultrasound Model Based on the Left Gastric Vein in B-Viral Cirrhosis: Noninvasive Prediction of Esophageal Varices
    Clinical and translational gastroenterology, 2020
    Co-Authors: Ying Jin, Yuanqiang Lin, Yaoyao Zhou, Hui Wang, Chunxiang Jin
    Abstract:

    To establish and verify a simple noninvasive model based on the Left Gastric Vein (LGV) to predict the grade of esophageal varices (EV) and high-risk EV (HEV), to facilitate clinical follow-up and timely treatment. We enrolled 320 patients with B-viral cirrhosis. All patients underwent endoscopy, laboratory tests, liver and spleen stiffness (SS), and ultrasonography. HEV were analyzed using the χ test/t test and logistic regression in the univariate and multivariate analyses, respectively. EV grades were analyzed using the variance/rank-sum test and logistic regression. A prediction model was derived from the multivariate predictors. In the training set, multivariate analysis showed that the independent factors of different EV grades were SS, LGV diameter, and platelet count (PLT). We developed the LGV diameter-SS to PLT ratio index (LSPI) and LGV diameter/PLT models without SS. The area under the receiver operating characteristic curve of the LSPI for diagnosis of small EV, medium EV, large EV, and HEV was 0.897, 0.899, 0.853, and 0.954, respectively, and that of the LGV/PLT was 0.882, 0.890, 0.837, and 0.942, respectively. For the diagnosis of HEV, the negative predictive value was 94.07% when LSPI < 19.8 and the positive predictive value was 91.49% when LSPI > 23.0. The negative predictive value was 95.92% when LGV/PLT < 5.15, and the positive predictive value was 86.27% when LGV/PLT > 7.40. The predicted values showed similar accuracy in the validation set. Under appropriate conditions, the LSPI was an accurate method to detect the grade of EV and HEV. Alternatively, the LGV/PLT may also be useful in diagnosing the varices when condition limited.

Naoya Kato - One of the best experts on this subject based on the ideXlab platform.

  • Left Gastric Vein-based noninvasive test for esophageal varices: a same-day comparison of portal hemodynamic assessment with endoscopic appearance
    Clinical and Translational Gastroenterology, 2018
    Co-Authors: Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Naoya Kato
    Abstract:

    Objective To examine the effect of hemodynamic assessment of the Left Gastric Vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients. Methods This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11.8 years; Child-Pugh score 5–14). One hundred fifty-four patients had EV (67.2%; small, 53; medium, 71; large, 30). All patients underwent a blood test and Doppler ultrasound followed by upper gastrointestinal endoscopy on the same day. The diagnostic ability for EV was compared between LGV-related findings and the platelet count/spleen diameter ratio (Plt/Spl). Results The detectability of the LGV was higher in patients with EV (129/144, 89.6%) than in those without (35/75, 46.7%; p  

  • Left Gastric Vein-based noninvasive test for esophageal varices: a same-day comparison of portal hemodynamic assessment with endoscopic appearance
    Clinical and translational gastroenterology, 2018
    Co-Authors: Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Naoya Kato
    Abstract:

    To examine the effect of hemodynamic assessment of the Left Gastric Vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients. This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11.8 years; Child-Pugh score 5–14). One hundred fifty-four patients had EV (67.2%; small, 53; medium, 71; large, 30). All patients underwent a blood test and Doppler ultrasound followed by upper gastrointestinal endoscopy on the same day. The diagnostic ability for EV was compared between LGV-related findings and the platelet count/spleen diameter ratio (Plt/Spl). The detectability of the LGV was higher in patients with EV (129/144, 89.6%) than in those without (35/75, 46.7%; p 

  • Left Gastric Vein based noninvasive test for esophageal varices a same day comparison of portal hemodynamic assessment with endoscopic appearance
    Clinical and translational gastroenterology, 2018
    Co-Authors: Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Naoya Kato
    Abstract:

    To examine the effect of hemodynamic assessment of the Left Gastric Vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients. This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11.8 years; Child-Pugh score 5–14). One hundred fifty-four patients had EV (67.2%; small, 53; medium, 71; large, 30). All patients underwent a blood test and Doppler ultrasound followed by upper gastrointestinal endoscopy on the same day. The diagnostic ability for EV was compared between LGV-related findings and the platelet count/spleen diameter ratio (Plt/Spl). The detectability of the LGV was higher in patients with EV (129/144, 89.6%) than in those without (35/75, 46.7%; p < 0.0001), and was higher in those with large EV (30/30, 100%) than in those without (134/199, 67.3%; p = 0.0002). The positive detection of the LGV showed 100% sensitivity and negative predictive value (NPV) to identify large EV in the whole cohort and compensated group (n = 127). The best cutoff value in the LGV diameter was 5.35 mm to identify large EV, showing 0.753 area under the receiver operating characteristic curve (AUROC) with 90% sensitivity and 96.5% NPV. The Plt/Spl showed 62.1% sensitivity and 87.1% NPV, and the best cutoff value was 442.9 to identify large EV with 0.658 AUROC, which was comparable to LGV-based assessment (p = 0.162). This same-day comparison study demonstrated the value of LGV-based noninvasive test to identify large EV with high sensitivity and NPV in cirrhosis patients at a lower cost.

Hitoshi Maruyama - One of the best experts on this subject based on the ideXlab platform.

  • Left Gastric Vein-based noninvasive test for esophageal varices: a same-day comparison of portal hemodynamic assessment with endoscopic appearance
    Clinical and translational gastroenterology, 2018
    Co-Authors: Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Naoya Kato
    Abstract:

    To examine the effect of hemodynamic assessment of the Left Gastric Vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients. This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11.8 years; Child-Pugh score 5–14). One hundred fifty-four patients had EV (67.2%; small, 53; medium, 71; large, 30). All patients underwent a blood test and Doppler ultrasound followed by upper gastrointestinal endoscopy on the same day. The diagnostic ability for EV was compared between LGV-related findings and the platelet count/spleen diameter ratio (Plt/Spl). The detectability of the LGV was higher in patients with EV (129/144, 89.6%) than in those without (35/75, 46.7%; p 

  • Left Gastric Vein-based noninvasive test for esophageal varices: a same-day comparison of portal hemodynamic assessment with endoscopic appearance
    Clinical and Translational Gastroenterology, 2018
    Co-Authors: Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Naoya Kato
    Abstract:

    Objective To examine the effect of hemodynamic assessment of the Left Gastric Vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients. Methods This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11.8 years; Child-Pugh score 5–14). One hundred fifty-four patients had EV (67.2%; small, 53; medium, 71; large, 30). All patients underwent a blood test and Doppler ultrasound followed by upper gastrointestinal endoscopy on the same day. The diagnostic ability for EV was compared between LGV-related findings and the platelet count/spleen diameter ratio (Plt/Spl). Results The detectability of the LGV was higher in patients with EV (129/144, 89.6%) than in those without (35/75, 46.7%; p  

  • Left Gastric Vein based noninvasive test for esophageal varices a same day comparison of portal hemodynamic assessment with endoscopic appearance
    Clinical and translational gastroenterology, 2018
    Co-Authors: Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Naoya Kato
    Abstract:

    To examine the effect of hemodynamic assessment of the Left Gastric Vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients. This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11.8 years; Child-Pugh score 5–14). One hundred fifty-four patients had EV (67.2%; small, 53; medium, 71; large, 30). All patients underwent a blood test and Doppler ultrasound followed by upper gastrointestinal endoscopy on the same day. The diagnostic ability for EV was compared between LGV-related findings and the platelet count/spleen diameter ratio (Plt/Spl). The detectability of the LGV was higher in patients with EV (129/144, 89.6%) than in those without (35/75, 46.7%; p < 0.0001), and was higher in those with large EV (30/30, 100%) than in those without (134/199, 67.3%; p = 0.0002). The positive detection of the LGV showed 100% sensitivity and negative predictive value (NPV) to identify large EV in the whole cohort and compensated group (n = 127). The best cutoff value in the LGV diameter was 5.35 mm to identify large EV, showing 0.753 area under the receiver operating characteristic curve (AUROC) with 90% sensitivity and 96.5% NPV. The Plt/Spl showed 62.1% sensitivity and 87.1% NPV, and the best cutoff value was 442.9 to identify large EV with 0.658 AUROC, which was comparable to LGV-based assessment (p = 0.162). This same-day comparison study demonstrated the value of LGV-based noninvasive test to identify large EV with high sensitivity and NPV in cirrhosis patients at a lower cost.

  • Hemodynamic response of the Left Gastric Vein to glucagon in patients with portal hypertension and esophageal varices.
    Ultrasound in medicine & biology, 2003
    Co-Authors: Shoichi Matsutani, Hideaki Mizumoto, Takeshi Fukuzawa, Goro Sato, Hitoshi Maruyama, Hiromitsu Saisho
    Abstract:

    Abstract Flow direction and flow velocity of the Left Gastric Vein (LGV) and the portal Vein (PV) were examined by a Doppler sonographic machine in 33 patients with esophageal varices, before and after venous injection of glucagon (1 mg). In two patients with hepatopetal blood flow in the LGV, the flow direction changed to hepatofugal after injection of glucagon. In 31 patients with hepatofugal blood flow in the LGV, a significant increase of flow velocity was observed in the LGV in 18 patients (58.1%) and the changes (26.4 ± 24.6%) were significantly larger than those in the PV (7.9 ± 16.0%). The changes in flow velocity decreased in the LGV as the diameter of the LGV and the size of varices increased. In conclusion, glucagon increased collateral blood flow in the LGV in portal hypertension. However, the grade of the response decreased as the grade of portal hypertension increased. (E-mail: matsu@med.m.chiba-u.ac.jp)

  • Hemodynamics in the Left Gastric Vein after endoscopic ligation of esophageal varices combined with sclerotherapy.
    Journal of gastroenterology and hepatology, 2001
    Co-Authors: Hideaki Mizumoto, Shoichi Matsutani, Hiroshi Ishii, Takeshi Fukuzawa, Goro Sato, Hitoshi Maruyama, Hiromitsu Saisho
    Abstract:

    Background and Methods: We examined the changes in portal hemodynamics after endoscopic variceal ligation (EVL) combined with endoscopic injection sclerotherapy (EIS) in relation to post-treatment relapse. The present study included 93 patients who underwent EVL–EIS combination therapy. Portal hemodynamics were examined by Doppler ultrasonography and percutaneous transhepatic portography (PTP). Results: Therapy with EVL–EIS resulted in the complete disappearance of varices in 89 of 93 patients. Cumulative relapse-free rates (Kaplan–Meier method) were 75.8 and 50.2%, respectively, 1 and 3–5 years after treatment. At the end of treatment, the flow in the Left Gastric Vein was examined by Doppler ultrasonography. In 50 of 63 patients, the flow remained hepatofugal. In 23 of these patients, PTP was performed at the end of treatment; selective Left Gastric venography did not reveal any palisade zone vessels or varices. However, fine blood vessels were seen around the lower esophagus in nine patients, only the paraesophageal Vein was found in 10 patients and these two findings were present in four patients, indicating that collateral blood flow remained in the lower esophagus in 13 of 23 patients. These findings suggest that frequent relapse of varices results from insufficient blockage of blood flow from the Left Gastric Vein to the lower esophagus. However, in patients with a patent paraesophageal Vein, long-term effects obtained by EVL–EIS combination therapy were satisfactory. Conclusions: The pattern of the development of collateral Left Gastric Veins represents important hemodynamic changes that predict the long-term prognosis of patients after treatment.

Ying Jin - One of the best experts on this subject based on the ideXlab platform.

  • multimodal ultrasound model based on the Left Gastric Vein in b viral cirrhosis noninvasive prediction of esophageal varices
    Clinical and translational gastroenterology, 2020
    Co-Authors: Ying Jin, Yuanqiang Lin, Yaoyao Zhou, Hui Wang, Chunxiang Jin
    Abstract:

    OBJECTIVES To establish and verify a simple noninvasive model based on the Left Gastric Vein (LGV) to predict the grade of esophageal varices (EV) and high-risk EV (HEV), to facilitate clinical follow-up and timely treatment. METHODS We enrolled 320 patients with B-viral cirrhosis. All patients underwent endoscopy, laboratory tests, liver and spleen stiffness (SS), and ultrasonography. HEV were analyzed using the χ test/t test and logistic regression in the univariate and multivariate analyses, respectively. EV grades were analyzed using the variance/rank-sum test and logistic regression. A prediction model was derived from the multivariate predictors. RESULTS In the training set, multivariate analysis showed that the independent factors of different EV grades were SS, LGV diameter, and platelet count (PLT). We developed the LGV diameter-SS to PLT ratio index (LSPI) and LGV diameter/PLT models without SS. The area under the receiver operating characteristic curve of the LSPI for diagnosis of small EV, medium EV, large EV, and HEV was 0.897, 0.899, 0.853, and 0.954, respectively, and that of the LGV/PLT was 0.882, 0.890, 0.837, and 0.942, respectively. For the diagnosis of HEV, the negative predictive value was 94.07% when LSPI 23.0. The negative predictive value was 95.92% when LGV/PLT 7.40. The predicted values showed similar accuracy in the validation set. DISCUSSION Under appropriate conditions, the LSPI was an accurate method to detect the grade of EV and HEV. Alternatively, the LGV/PLT may also be useful in diagnosing the varices when condition limited.

  • Multimodal Ultrasound Model Based on the Left Gastric Vein in B-Viral Cirrhosis: Noninvasive Prediction of Esophageal Varices
    Clinical and translational gastroenterology, 2020
    Co-Authors: Ying Jin, Yuanqiang Lin, Yaoyao Zhou, Hui Wang, Chunxiang Jin
    Abstract:

    To establish and verify a simple noninvasive model based on the Left Gastric Vein (LGV) to predict the grade of esophageal varices (EV) and high-risk EV (HEV), to facilitate clinical follow-up and timely treatment. We enrolled 320 patients with B-viral cirrhosis. All patients underwent endoscopy, laboratory tests, liver and spleen stiffness (SS), and ultrasonography. HEV were analyzed using the χ test/t test and logistic regression in the univariate and multivariate analyses, respectively. EV grades were analyzed using the variance/rank-sum test and logistic regression. A prediction model was derived from the multivariate predictors. In the training set, multivariate analysis showed that the independent factors of different EV grades were SS, LGV diameter, and platelet count (PLT). We developed the LGV diameter-SS to PLT ratio index (LSPI) and LGV diameter/PLT models without SS. The area under the receiver operating characteristic curve of the LSPI for diagnosis of small EV, medium EV, large EV, and HEV was 0.897, 0.899, 0.853, and 0.954, respectively, and that of the LGV/PLT was 0.882, 0.890, 0.837, and 0.942, respectively. For the diagnosis of HEV, the negative predictive value was 94.07% when LSPI < 19.8 and the positive predictive value was 91.49% when LSPI > 23.0. The negative predictive value was 95.92% when LGV/PLT < 5.15, and the positive predictive value was 86.27% when LGV/PLT > 7.40. The predicted values showed similar accuracy in the validation set. Under appropriate conditions, the LSPI was an accurate method to detect the grade of EV and HEV. Alternatively, the LGV/PLT may also be useful in diagnosing the varices when condition limited.

Hui Wang - One of the best experts on this subject based on the ideXlab platform.

  • multimodal ultrasound model based on the Left Gastric Vein in b viral cirrhosis noninvasive prediction of esophageal varices
    Clinical and translational gastroenterology, 2020
    Co-Authors: Ying Jin, Yuanqiang Lin, Yaoyao Zhou, Hui Wang, Chunxiang Jin
    Abstract:

    OBJECTIVES To establish and verify a simple noninvasive model based on the Left Gastric Vein (LGV) to predict the grade of esophageal varices (EV) and high-risk EV (HEV), to facilitate clinical follow-up and timely treatment. METHODS We enrolled 320 patients with B-viral cirrhosis. All patients underwent endoscopy, laboratory tests, liver and spleen stiffness (SS), and ultrasonography. HEV were analyzed using the χ test/t test and logistic regression in the univariate and multivariate analyses, respectively. EV grades were analyzed using the variance/rank-sum test and logistic regression. A prediction model was derived from the multivariate predictors. RESULTS In the training set, multivariate analysis showed that the independent factors of different EV grades were SS, LGV diameter, and platelet count (PLT). We developed the LGV diameter-SS to PLT ratio index (LSPI) and LGV diameter/PLT models without SS. The area under the receiver operating characteristic curve of the LSPI for diagnosis of small EV, medium EV, large EV, and HEV was 0.897, 0.899, 0.853, and 0.954, respectively, and that of the LGV/PLT was 0.882, 0.890, 0.837, and 0.942, respectively. For the diagnosis of HEV, the negative predictive value was 94.07% when LSPI 23.0. The negative predictive value was 95.92% when LGV/PLT 7.40. The predicted values showed similar accuracy in the validation set. DISCUSSION Under appropriate conditions, the LSPI was an accurate method to detect the grade of EV and HEV. Alternatively, the LGV/PLT may also be useful in diagnosing the varices when condition limited.

  • Multimodal Ultrasound Model Based on the Left Gastric Vein in B-Viral Cirrhosis: Noninvasive Prediction of Esophageal Varices
    Clinical and translational gastroenterology, 2020
    Co-Authors: Ying Jin, Yuanqiang Lin, Yaoyao Zhou, Hui Wang, Chunxiang Jin
    Abstract:

    To establish and verify a simple noninvasive model based on the Left Gastric Vein (LGV) to predict the grade of esophageal varices (EV) and high-risk EV (HEV), to facilitate clinical follow-up and timely treatment. We enrolled 320 patients with B-viral cirrhosis. All patients underwent endoscopy, laboratory tests, liver and spleen stiffness (SS), and ultrasonography. HEV were analyzed using the χ test/t test and logistic regression in the univariate and multivariate analyses, respectively. EV grades were analyzed using the variance/rank-sum test and logistic regression. A prediction model was derived from the multivariate predictors. In the training set, multivariate analysis showed that the independent factors of different EV grades were SS, LGV diameter, and platelet count (PLT). We developed the LGV diameter-SS to PLT ratio index (LSPI) and LGV diameter/PLT models without SS. The area under the receiver operating characteristic curve of the LSPI for diagnosis of small EV, medium EV, large EV, and HEV was 0.897, 0.899, 0.853, and 0.954, respectively, and that of the LGV/PLT was 0.882, 0.890, 0.837, and 0.942, respectively. For the diagnosis of HEV, the negative predictive value was 94.07% when LSPI < 19.8 and the positive predictive value was 91.49% when LSPI > 23.0. The negative predictive value was 95.92% when LGV/PLT < 5.15, and the positive predictive value was 86.27% when LGV/PLT > 7.40. The predicted values showed similar accuracy in the validation set. Under appropriate conditions, the LSPI was an accurate method to detect the grade of EV and HEV. Alternatively, the LGV/PLT may also be useful in diagnosing the varices when condition limited.