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John A Eisman - One of the best experts on this subject based on the ideXlab platform.
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a meta analysis of the association of Fracture risk and body mass index in women
Journal of Bone and Mineral Research, 2014Co-Authors: Helena Johansson, John A Kanis, Anders Oden, E V Mccloskey, Roland Chapurlat, Claus Christiansen, S R Cummings, Adolfo Diezperez, John A EismanAbstract:Several recent studies suggest that obesity may be a risk factor for Fracture. The aim of this study was to investigate the association between body mass index (BMI) and future Fracture risk at different skeletal sites. In prospective cohorts from more than 25 countries, baseline data on BMI were available in 398,610 women with an average age of 63 (range, 20-105) years and follow up of 2.2 million person-years during which 30,280 osteoporotic Fractures (6457 hip Fractures) occurred. Femoral neck BMD was measured in 108,267 of these women. Obesity (BMI ≥ 30 kg/m(2) ) was present in 22%. A majority of osteoporotic Fractures (81%) and hip Fractures (87%) arose in non-obese women. Compared to a BMI of 25 kg/m(2) , the hazard ratio (HR) for osteoporotic Fracture at a BMI of 35 kg/m(2) was 0.87 (95% confidence interval [CI], 0.85-0.90). When adjusted for bone mineral density (BMD), however, the same comparison showed that the HR for osteoporotic Fracture was increased (HR, 1.16; 95% CI, 1.09-1.23). Low BMI is a risk factor for hip and all osteoporotic Fracture, but is a protective factor for lower Leg Fracture, whereas high BMI is a risk factor for upper arm (humerus and elbow) Fracture. When adjusted for BMD, low BMI remained a risk factor for hip Fracture but was protective for osteoporotic Fracture, tibia and fibula Fracture, distal forearm Fracture, and upper arm Fracture. When adjusted for BMD, high BMI remained a risk factor for upper arm Fracture but was also a risk factor for all osteoporotic Fractures. The association between BMI and Fracture risk is complex, differs across skeletal sites, and is modified by the interaction between BMI and BMD. At a population level, high BMI remains a protective factor for most sites of fragility Fracture. The contribution of increasing population rates of obesity to apparent decreases in Fracture rates should be explored. © 2014 American Society for Bone and Mineral Research.
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a meta analysis of the association of Fracture risk and body mass index in women
Journal of Bone and Mineral Research, 2014Co-Authors: Helena Johansson, John A Kanis, Anders Oden, E V Mccloskey, Roland Chapurlat, Claus Christiansen, S R Cummings, Adolfo Diezperez, John A EismanAbstract:Several recent studies suggest that obesity may be a risk factor for Fracture. The aim of this study was to investigate the association between body mass index (BMI) and future Fracture risk at different skeletal sites. In prospective cohorts from more than 25 countries, baseline data on BMI were available in 398,610 women with an average age of 63 (range, 20-105) years and follow up of 2.2 million person-years during which 30,280 osteoporotic Fractures (6457 hip Fractures) occurred. Femoral neck BMD was measured in 108,267 of these women. Obesity (BMI ≥ 30 kg/m(2) ) was present in 22%. A majority of osteoporotic Fractures (81%) and hip Fractures (87%) arose in non-obese women. Compared to a BMI of 25 kg/m(2) , the hazard ratio (HR) for osteoporotic Fracture at a BMI of 35 kg/m(2) was 0.87 (95% confidence interval [CI], 0.85-0.90). When adjusted for bone mineral density (BMD), however, the same comparison showed that the HR for osteoporotic Fracture was increased (HR, 1.16; 95% CI, 1.09-1.23). Low BMI is a risk factor for hip and all osteoporotic Fracture, but is a protective factor for lower Leg Fracture, whereas high BMI is a risk factor for upper arm (humerus and elbow) Fracture. When adjusted for BMD, low BMI remained a risk factor for hip Fracture but was protective for osteoporotic Fracture, tibia and fibula Fracture, distal forearm Fracture, and upper arm Fracture. When adjusted for BMD, high BMI remained a risk factor for upper arm Fracture but was also a risk factor for all osteoporotic Fractures. The association between BMI and Fracture risk is complex, differs across skeletal sites, and is modified by the interaction between BMI and BMD. At a population level, high BMI remains a protective factor for most sites of fragility Fracture. The contribution of increasing population rates of obesity to apparent decreases in Fracture rates should be explored.
Roumen Nakov - One of the best experts on this subject based on the ideXlab platform.
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use of the low molecular weight heparin reviparin to prevent deep vein thrombosis after Leg injury requiring immobilization
The New England Journal of Medicine, 2002Co-Authors: Michael R. Lassen, Lars C Borris, Roumen NakovAbstract:Background Deep-vein thrombosis is a well-recognized complication after trauma to the Legs and subsequent immobilization, but there are no generally accepted approaches to preventing this complication. Methods We performed a prospective, double-blind, placebo-controlled trial to evaluate the efficacy and safety of subcutaneous reviparin (1750 anti-Xa units given once daily) in 440 patients who required immobilization in a plaster cast or brace for at least five weeks after a Leg Fracture or rupture of the Achilles tendon. The study drug was given throughout the period of immobilization. Venography of the injured Leg was performed within one week after removal of the plaster cast or brace, or earlier if there were symptoms suggesting deep-vein thrombosis. Results Data on efficacy and end points were available for 371 patients. Deep-vein thrombosis was diagnosed in 17 of the 183 patients randomly assigned to receive reviparin (9 percent) and in 35 of the 188 patients randomly assigned to receive placebo (19...
Helena Johansson - One of the best experts on this subject based on the ideXlab platform.
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a meta analysis of the association of Fracture risk and body mass index in women
Journal of Bone and Mineral Research, 2014Co-Authors: Helena Johansson, John A Kanis, Anders Oden, E V Mccloskey, Roland Chapurlat, Claus Christiansen, S R Cummings, Adolfo Diezperez, John A EismanAbstract:Several recent studies suggest that obesity may be a risk factor for Fracture. The aim of this study was to investigate the association between body mass index (BMI) and future Fracture risk at different skeletal sites. In prospective cohorts from more than 25 countries, baseline data on BMI were available in 398,610 women with an average age of 63 (range, 20-105) years and follow up of 2.2 million person-years during which 30,280 osteoporotic Fractures (6457 hip Fractures) occurred. Femoral neck BMD was measured in 108,267 of these women. Obesity (BMI ≥ 30 kg/m(2) ) was present in 22%. A majority of osteoporotic Fractures (81%) and hip Fractures (87%) arose in non-obese women. Compared to a BMI of 25 kg/m(2) , the hazard ratio (HR) for osteoporotic Fracture at a BMI of 35 kg/m(2) was 0.87 (95% confidence interval [CI], 0.85-0.90). When adjusted for bone mineral density (BMD), however, the same comparison showed that the HR for osteoporotic Fracture was increased (HR, 1.16; 95% CI, 1.09-1.23). Low BMI is a risk factor for hip and all osteoporotic Fracture, but is a protective factor for lower Leg Fracture, whereas high BMI is a risk factor for upper arm (humerus and elbow) Fracture. When adjusted for BMD, low BMI remained a risk factor for hip Fracture but was protective for osteoporotic Fracture, tibia and fibula Fracture, distal forearm Fracture, and upper arm Fracture. When adjusted for BMD, high BMI remained a risk factor for upper arm Fracture but was also a risk factor for all osteoporotic Fractures. The association between BMI and Fracture risk is complex, differs across skeletal sites, and is modified by the interaction between BMI and BMD. At a population level, high BMI remains a protective factor for most sites of fragility Fracture. The contribution of increasing population rates of obesity to apparent decreases in Fracture rates should be explored. © 2014 American Society for Bone and Mineral Research.
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a meta analysis of the association of Fracture risk and body mass index in women
Journal of Bone and Mineral Research, 2014Co-Authors: Helena Johansson, John A Kanis, Anders Oden, E V Mccloskey, Roland Chapurlat, Claus Christiansen, S R Cummings, Adolfo Diezperez, John A EismanAbstract:Several recent studies suggest that obesity may be a risk factor for Fracture. The aim of this study was to investigate the association between body mass index (BMI) and future Fracture risk at different skeletal sites. In prospective cohorts from more than 25 countries, baseline data on BMI were available in 398,610 women with an average age of 63 (range, 20-105) years and follow up of 2.2 million person-years during which 30,280 osteoporotic Fractures (6457 hip Fractures) occurred. Femoral neck BMD was measured in 108,267 of these women. Obesity (BMI ≥ 30 kg/m(2) ) was present in 22%. A majority of osteoporotic Fractures (81%) and hip Fractures (87%) arose in non-obese women. Compared to a BMI of 25 kg/m(2) , the hazard ratio (HR) for osteoporotic Fracture at a BMI of 35 kg/m(2) was 0.87 (95% confidence interval [CI], 0.85-0.90). When adjusted for bone mineral density (BMD), however, the same comparison showed that the HR for osteoporotic Fracture was increased (HR, 1.16; 95% CI, 1.09-1.23). Low BMI is a risk factor for hip and all osteoporotic Fracture, but is a protective factor for lower Leg Fracture, whereas high BMI is a risk factor for upper arm (humerus and elbow) Fracture. When adjusted for BMD, low BMI remained a risk factor for hip Fracture but was protective for osteoporotic Fracture, tibia and fibula Fracture, distal forearm Fracture, and upper arm Fracture. When adjusted for BMD, high BMI remained a risk factor for upper arm Fracture but was also a risk factor for all osteoporotic Fractures. The association between BMI and Fracture risk is complex, differs across skeletal sites, and is modified by the interaction between BMI and BMD. At a population level, high BMI remains a protective factor for most sites of fragility Fracture. The contribution of increasing population rates of obesity to apparent decreases in Fracture rates should be explored.
Milton T M Little - One of the best experts on this subject based on the ideXlab platform.
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low molecular weight heparin did not differ from placebo in preventing clinically important deep venous thrombosis after surgical repair of Leg Fracture
Journal of Bone and Joint Surgery American Volume, 2016Co-Authors: Milton T M LittleAbstract:Selby R, Geerts WH, Kreder HJ, Crowther MA, Kaus L, Sealey F; D-KAF (Dalteparin in Knee-to-Ankle Fracture) Investigators. A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower Leg Fractures. J Orthop Trauma. 2015 May;29(5):224-30. ### Question: In patients having surgery for Fractures distal to the knee, does low-molecular-weight heparin prevent clinically important venous thromboembolism (CIVTE)? ### Design: Randomized (allocation concealed), blinded (patients, clinicians, and outcome assessors), controlled trial with 3 months of follow-up. ### Setting: 13 hospitals in Canada. ### Patients: 265 patients (mean age, 48 years, 52% men) undergoing Leg Fracture fixation were enrolled. Exclusion criteria were presentation >72 hours after injury, ongoing requirement for anticoagulation, other major trauma, active uncontrolled bleeding, contraindications to the use of contrast medium, previous deep venous thrombosis (DVT) or pulmonary embolism (PE), active cancer, lower extremity vascular injury requiring intervention, bleeding disorder or major bleeding in the past 4 weeks, or hypercoagulable state. 258 …
Michael R. Lassen - One of the best experts on this subject based on the ideXlab platform.
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use of the low molecular weight heparin reviparin to prevent deep vein thrombosis after Leg injury requiring immobilization
The New England Journal of Medicine, 2002Co-Authors: Michael R. Lassen, Lars C Borris, Roumen NakovAbstract:Background Deep-vein thrombosis is a well-recognized complication after trauma to the Legs and subsequent immobilization, but there are no generally accepted approaches to preventing this complication. Methods We performed a prospective, double-blind, placebo-controlled trial to evaluate the efficacy and safety of subcutaneous reviparin (1750 anti-Xa units given once daily) in 440 patients who required immobilization in a plaster cast or brace for at least five weeks after a Leg Fracture or rupture of the Achilles tendon. The study drug was given throughout the period of immobilization. Venography of the injured Leg was performed within one week after removal of the plaster cast or brace, or earlier if there were symptoms suggesting deep-vein thrombosis. Results Data on efficacy and end points were available for 371 patients. Deep-vein thrombosis was diagnosed in 17 of the 183 patients randomly assigned to receive reviparin (9 percent) and in 35 of the 188 patients randomly assigned to receive placebo (19...