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Robert Escher - One of the best experts on this subject based on the ideXlab platform.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Background Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. Case presentation We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. Discussion and conclusions KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

Stefan Lauener - One of the best experts on this subject based on the ideXlab platform.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Background Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. Case presentation We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. Discussion and conclusions KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

Anne Bütikofer - One of the best experts on this subject based on the ideXlab platform.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Background Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. Case presentation We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. Discussion and conclusions KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

Sandra Eigenheer - One of the best experts on this subject based on the ideXlab platform.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

  • Thrombophlebitis hiding under a KILT – case report on 40 years long-term follow-up of neonatal renal vein Thrombosis
    BMC Pediatrics, 2019
    Co-Authors: Stefan Lauener, Anne Bütikofer, Sandra Eigenheer, Robert Escher
    Abstract:

    Background Neonatal renal vein Thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous Thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with Leg Thrombosis summarizes the pathological situation. Case presentation We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous Thrombosis first of the left, then the right Leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that Thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein Thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years. Discussion and conclusions KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein Thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or Thrombosis of the young, male and with no other identifiable risk factors for deep vein Thrombosis.

Pablo Demelo-rodríguez - One of the best experts on this subject based on the ideXlab platform.

  • Bilateral Deep Vein Thrombosis, Vena Cava Agenesis, and Renal Abnormalities: KILT Syndrome—A Case Report and Literature Review
    Journal of Cardiovascular Translational Research, 2019
    Co-Authors: Sergio Moragón-ledesma, Francisco Galeano-valle, Enrique Calleja-cartón, Jorge Del-toro-cervera, Pablo Demelo-rodríguez
    Abstract:

    KILT (kidney and IVC abnormalities with Leg Thrombosis) syndrome is a very rare condition that associates inferior vena cava abnormalities, renal defects, and venous Thrombosis. These vascular disorders appear in 0.6–2% of patients with cardiovascular events and condition a venous stasis that contributes to the formation of thrombus in the lower limbs. Only a few cases of KILT syndrome have been published in the literature and the genesis, epidemiology, and natural history of the disease are yet unknown. We present a case of a 39-year-old man with no medical background who developed Thrombosis of the inferior vena cava in its infrarrenal portion to both common iliac veins, all associated with agenesis of the rest of the vascular structure and an atrophic right kidney. The patient was treated with full anticoagulation, without the development of renal failure, postthrombotic syndrome, nor other complications. Thrombophilia study was normal, including mutations of prothrombin gene, factor V Leiden, and antiphospholipid antibodies. We hypothesize the benefit of an early diagnosis to improve the management of this condition. KILT syndrome must be taken into account in cases of proximal venous Thrombosis, especially in young patients without risk factors for the development of Thrombosis.