The Experts below are selected from a list of 124224 Experts worldwide ranked by ideXlab platform
Bryan Williams - One of the best experts on this subject based on the ideXlab platform.
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blood Leucocyte telomere dna content predicts vascular telomere dna content in humans with and without vascular disease
European Heart Journal, 2008Co-Authors: Richard W W Wilson, Karl E Herbert, Yogita Mistry, Suzanne E Stevens, Hash R Patel, R Hastings, M M Thompson, Bryan WilliamsAbstract:Aims Previous studies have suggested that reduced telomere length in circulating Leucocytes in humans is associated with premature vascular disease and by implication, accelerated vascular ageing. Importantly, a link between telomere length in circulating Leucocytes and the blood vessel wall has never been established. We, thus, investigated the relationship between vascular wall and circulating Leucocyte telomere length in humans with and without overt vascular disease. Methods and results Aortic biopsies and paired blood Leucocytes were obtained from 20 patients with asymptomatic abdominal aortic aneurysms (AAAs), undergoing elective open repair, and 12 morphologically normal aortas from a group of cadaveric organ donors of similar mean age. Telomere content was compared by quantitative PCR and expressed as telomere:genomic DNA ratio. The telomere:genomic DNA content was significantly reduced in wall biopsies of AAA vs. normal aorta, and this difference remained after adjusting for age and gender. There were strong correlations between Leucocyte and vascular telomere content when the AAA and control groups were analysed either separately or grouped irrespective of the presence of vascular disease ( r = 0.62, P < 0.001). Conclusion The findings demonstrate that Leucocyte DNA content is predictive of vascular telomere content and is an accurate surrogate for human vascular age.
Richard W W Wilson - One of the best experts on this subject based on the ideXlab platform.
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blood Leucocyte telomere dna content predicts vascular telomere dna content in humans with and without vascular disease
European Heart Journal, 2008Co-Authors: Richard W W Wilson, Karl E Herbert, Yogita Mistry, Suzanne E Stevens, Hash R Patel, R Hastings, M M Thompson, Bryan WilliamsAbstract:Aims Previous studies have suggested that reduced telomere length in circulating Leucocytes in humans is associated with premature vascular disease and by implication, accelerated vascular ageing. Importantly, a link between telomere length in circulating Leucocytes and the blood vessel wall has never been established. We, thus, investigated the relationship between vascular wall and circulating Leucocyte telomere length in humans with and without overt vascular disease. Methods and results Aortic biopsies and paired blood Leucocytes were obtained from 20 patients with asymptomatic abdominal aortic aneurysms (AAAs), undergoing elective open repair, and 12 morphologically normal aortas from a group of cadaveric organ donors of similar mean age. Telomere content was compared by quantitative PCR and expressed as telomere:genomic DNA ratio. The telomere:genomic DNA content was significantly reduced in wall biopsies of AAA vs. normal aorta, and this difference remained after adjusting for age and gender. There were strong correlations between Leucocyte and vascular telomere content when the AAA and control groups were analysed either separately or grouped irrespective of the presence of vascular disease ( r = 0.62, P < 0.001). Conclusion The findings demonstrate that Leucocyte DNA content is predictive of vascular telomere content and is an accurate surrogate for human vascular age.
Frederik P. Lindberg - One of the best experts on this subject based on the ideXlab platform.
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Leucocyte Adhesion Molecules in Host Defence against Infection
Annals of medicine, 1996Co-Authors: Eric J. Brown, Frederik P. LindbergAbstract:The destructive potential of Leucocytes needs to be fully held in check in the circulation, while being released at the site of tissue destruction and infection. Leucocyte adhesion molecules are the key to this regulation, the recognition by the Leucocytes of areas of tissue damage, and to transendothelial migration of Leucocytes into these areas. The three classes of Leucocyte adhesion molecules - the integrins, selectins and immunoglobulin superfamily members - are reviewed with their ligands and presented in the context of Leucocyte migration, activation and host defence.
Hash R Patel - One of the best experts on this subject based on the ideXlab platform.
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blood Leucocyte telomere dna content predicts vascular telomere dna content in humans with and without vascular disease
European Heart Journal, 2008Co-Authors: Richard W W Wilson, Karl E Herbert, Yogita Mistry, Suzanne E Stevens, Hash R Patel, R Hastings, M M Thompson, Bryan WilliamsAbstract:Aims Previous studies have suggested that reduced telomere length in circulating Leucocytes in humans is associated with premature vascular disease and by implication, accelerated vascular ageing. Importantly, a link between telomere length in circulating Leucocytes and the blood vessel wall has never been established. We, thus, investigated the relationship between vascular wall and circulating Leucocyte telomere length in humans with and without overt vascular disease. Methods and results Aortic biopsies and paired blood Leucocytes were obtained from 20 patients with asymptomatic abdominal aortic aneurysms (AAAs), undergoing elective open repair, and 12 morphologically normal aortas from a group of cadaveric organ donors of similar mean age. Telomere content was compared by quantitative PCR and expressed as telomere:genomic DNA ratio. The telomere:genomic DNA content was significantly reduced in wall biopsies of AAA vs. normal aorta, and this difference remained after adjusting for age and gender. There were strong correlations between Leucocyte and vascular telomere content when the AAA and control groups were analysed either separately or grouped irrespective of the presence of vascular disease ( r = 0.62, P < 0.001). Conclusion The findings demonstrate that Leucocyte DNA content is predictive of vascular telomere content and is an accurate surrogate for human vascular age.
Karl E Herbert - One of the best experts on this subject based on the ideXlab platform.
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blood Leucocyte telomere dna content predicts vascular telomere dna content in humans with and without vascular disease
European Heart Journal, 2008Co-Authors: Richard W W Wilson, Karl E Herbert, Yogita Mistry, Suzanne E Stevens, Hash R Patel, R Hastings, M M Thompson, Bryan WilliamsAbstract:Aims Previous studies have suggested that reduced telomere length in circulating Leucocytes in humans is associated with premature vascular disease and by implication, accelerated vascular ageing. Importantly, a link between telomere length in circulating Leucocytes and the blood vessel wall has never been established. We, thus, investigated the relationship between vascular wall and circulating Leucocyte telomere length in humans with and without overt vascular disease. Methods and results Aortic biopsies and paired blood Leucocytes were obtained from 20 patients with asymptomatic abdominal aortic aneurysms (AAAs), undergoing elective open repair, and 12 morphologically normal aortas from a group of cadaveric organ donors of similar mean age. Telomere content was compared by quantitative PCR and expressed as telomere:genomic DNA ratio. The telomere:genomic DNA content was significantly reduced in wall biopsies of AAA vs. normal aorta, and this difference remained after adjusting for age and gender. There were strong correlations between Leucocyte and vascular telomere content when the AAA and control groups were analysed either separately or grouped irrespective of the presence of vascular disease ( r = 0.62, P < 0.001). Conclusion The findings demonstrate that Leucocyte DNA content is predictive of vascular telomere content and is an accurate surrogate for human vascular age.