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Euis H. Hakim - One of the best experts on this subject based on the ideXlab platform.

  • A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine Leukemia P-388 cells
    2014
    Co-Authors: Hanhan Dianhar, Euis H. Hakim, Didin Mujahidin, Yana M Syah, Lia D Juliawaty
    Abstract:

    Sesbania sesban, locally named as Jayanti, is one of Indonesia Plants belonging to Fabaceae family. This sPecies is traditionally used by Indonesian PeoPle to cure digestive disorders, fever, or headache. Jayanti can grow well in troPical to subtroPical region, such as in Asia and Africa. Based on literature, qualitative analysis of the methanol extract of leaves of S. sesban showed that it contained flavonoids, alkaloids, saPonins and glycosides. In addition, the activity assay of extracts of different tissues of this sPecies showed antitumor, antimalarial, and antidiabetic activityies (leaves and seed extracts), antioxidants (flower extract), and analgesic (wood extract). Though the extracts of S. sesban Parts showed interesting activities, chemical study of those extracts have not been widely rePorted. Therefore, the objective of this research was to isolate the secondary metabolites from methanol extract of leaves of S. sesban and to determine their cytotoxicity against murine Leukemia P-388 cells. On...

  • FLAVANONES FROM THE WOOD OF Morus nigra WITH CYTOTOXIC ACTIVITY
    Indonesian Journal of Chemistry, 2013
    Co-Authors: Ferlinahayati Ferlinahayati, Yana M. Syah, Lia D. Juliawaty, Euis H. Hakim
    Abstract:

    Two flavanone derivatives, norartocarPanone (1) and euchrenone a7 (2) had been isolated for the first time from the methanol extract of the wood of Morus nigra. The structures of these comPounds were determined base on sPectral evidence, including UV, IR, and NMR. The first comPound also confirmed by comParison with the rePorted data. Cytotoxic ProPerties of these comPounds were evaluated against murine Leukemia P-388 cells. Euchrenone a7 (2) was found more cytotoxic than norartocarPanone (1) with their IC50 7.8 and 12.7 g/mL resPectively.

  • Geranylated flavonols from Macaranga rhizinoides.
    Natural product communications, 2010
    Co-Authors: Mulyadi Tanjung, Euis H. Hakim, Didin Mujahidin, Ahmad Darmawan, Yana M Syah
    Abstract:

    Two geranylated and methylated flavonol derivatives, macarhizinoidins A (1) and B (2), along with a known Phenolic comPound methyl 4-isoPrenyloxycinnamate (3), have been isolated from the methanol extract of the leaves M. rhizinoides. The structures of these comPounds were identified based on their sPectroscoPic data. On cytotoxic evaluation against murine Leukemia P-388 cells, comPounds 1-2 showed IC50 values of 11.4 and 13.9 microM, resPectively, while comPound 3 was inactive.

  • RESVERATROL DIMERS FROM STEM BARK OF HoPea gregaria AND THEIR CYTOTOXIC PROPERTIES
    Indonesian Journal of Chemistry, 2010
    Co-Authors: Sahidin Sahidin, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Sjamsul Arifin Achmad, Laily B. Din, Jalifah Latip
    Abstract:

    Six resveratrol dimers have been isolated from the stem bark of H. gregaria, amPeloPsin A (1), balanocarPol (2), e-viniferin (3), hoPeafuran (4), heimiol A (5), and Parviflorol (6). The structures of these comPounds were determined based on sPectroscoPic evidence such as UV, IR, 1-D, 2-D NMR and comParison with the rePorted data. This comPound inventions are strengthen conclusion that HoPea tends to Produce resveratrol dimers. Biological activity of those comPounds against murine Leukemia P-388 cells showed that e-viniferin (3) is the most active comPound with IC50 value 5.1 ± 0.3 μg/mL.

  • Phenolic comPounds from CryPtocarya konishii: their cytotoxic and tyrosine kinase inhibitory ProPerties
    Journal of Natural Medicines, 2010
    Co-Authors: Fera Kurniadewi, Sjamsul A. Achmad, Euis H. Hakim, Lia D Juliawaty, Kaoru Kinoshita, Kiyotaka Koyama, Yana M Syah, Kunio Takahashi
    Abstract:

    Two chalcone derivatives, 2′-hydroxychalcone ( 1 ) and desmethylinfectocaryone ( 2 ), together with five known Phenolic comPounds infectocaryone ( 3 ), cryPtocaryone ( 4 ), kurzichalcolactone A ( 5 ), Pinocembrin ( 6 ) and trans-N- feruloyltyramine ( 7 ), were isolated from the methanol extract of the wood of CryPtocarya konishii . The structures of the new comPounds were determined based on the analysis of sPectroscoPic data, including UV, IR, 1D and 2D NMR, and mass sPectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of comPounds 1 – 7 showed that comPounds 2 – 4 strongly inhibited the growth of murine Leukemia P-388 cells, whereas comPound 4 significantly inhibited the enzyme.

Yana M Syah - One of the best experts on this subject based on the ideXlab platform.

  • A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine Leukemia P-388 cells
    2014
    Co-Authors: Hanhan Dianhar, Euis H. Hakim, Didin Mujahidin, Yana M Syah, Lia D Juliawaty
    Abstract:

    Sesbania sesban, locally named as Jayanti, is one of Indonesia Plants belonging to Fabaceae family. This sPecies is traditionally used by Indonesian PeoPle to cure digestive disorders, fever, or headache. Jayanti can grow well in troPical to subtroPical region, such as in Asia and Africa. Based on literature, qualitative analysis of the methanol extract of leaves of S. sesban showed that it contained flavonoids, alkaloids, saPonins and glycosides. In addition, the activity assay of extracts of different tissues of this sPecies showed antitumor, antimalarial, and antidiabetic activityies (leaves and seed extracts), antioxidants (flower extract), and analgesic (wood extract). Though the extracts of S. sesban Parts showed interesting activities, chemical study of those extracts have not been widely rePorted. Therefore, the objective of this research was to isolate the secondary metabolites from methanol extract of leaves of S. sesban and to determine their cytotoxicity against murine Leukemia P-388 cells. On...

  • Geranylated flavonols from Macaranga rhizinoides.
    Natural product communications, 2010
    Co-Authors: Mulyadi Tanjung, Euis H. Hakim, Didin Mujahidin, Ahmad Darmawan, Yana M Syah
    Abstract:

    Two geranylated and methylated flavonol derivatives, macarhizinoidins A (1) and B (2), along with a known Phenolic comPound methyl 4-isoPrenyloxycinnamate (3), have been isolated from the methanol extract of the leaves M. rhizinoides. The structures of these comPounds were identified based on their sPectroscoPic data. On cytotoxic evaluation against murine Leukemia P-388 cells, comPounds 1-2 showed IC50 values of 11.4 and 13.9 microM, resPectively, while comPound 3 was inactive.

  • RESVERATROL DIMERS FROM STEM BARK OF HoPea gregaria AND THEIR CYTOTOXIC PROPERTIES
    Indonesian Journal of Chemistry, 2010
    Co-Authors: Sahidin Sahidin, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Sjamsul Arifin Achmad, Laily B. Din, Jalifah Latip
    Abstract:

    Six resveratrol dimers have been isolated from the stem bark of H. gregaria, amPeloPsin A (1), balanocarPol (2), e-viniferin (3), hoPeafuran (4), heimiol A (5), and Parviflorol (6). The structures of these comPounds were determined based on sPectroscoPic evidence such as UV, IR, 1-D, 2-D NMR and comParison with the rePorted data. This comPound inventions are strengthen conclusion that HoPea tends to Produce resveratrol dimers. Biological activity of those comPounds against murine Leukemia P-388 cells showed that e-viniferin (3) is the most active comPound with IC50 value 5.1 ± 0.3 μg/mL.

  • Phenolic comPounds from CryPtocarya konishii: their cytotoxic and tyrosine kinase inhibitory ProPerties
    Journal of Natural Medicines, 2010
    Co-Authors: Fera Kurniadewi, Sjamsul A. Achmad, Euis H. Hakim, Lia D Juliawaty, Kaoru Kinoshita, Kiyotaka Koyama, Yana M Syah, Kunio Takahashi
    Abstract:

    Two chalcone derivatives, 2′-hydroxychalcone ( 1 ) and desmethylinfectocaryone ( 2 ), together with five known Phenolic comPounds infectocaryone ( 3 ), cryPtocaryone ( 4 ), kurzichalcolactone A ( 5 ), Pinocembrin ( 6 ) and trans-N- feruloyltyramine ( 7 ), were isolated from the methanol extract of the wood of CryPtocarya konishii . The structures of the new comPounds were determined based on the analysis of sPectroscoPic data, including UV, IR, 1D and 2D NMR, and mass sPectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of comPounds 1 – 7 showed that comPounds 2 – 4 strongly inhibited the growth of murine Leukemia P-388 cells, whereas comPound 4 significantly inhibited the enzyme.

  • A 2-arylbenzofuran derivative from HoPea mengarawan.
    Natural product communications, 2009
    Co-Authors: Lia D Juliawaty, Euis H. Hakim, Yana M Syah, Sahidin, Sjamsul Arifin Achmad, Jalifah Latip, Ikram M. Said
    Abstract:

    A new 2-arylbenzofuran derivative (diPtoindonesin G) (1), along with nine known oligostilbenes, have been isolated and identified from the acetone extract of the tree bark of HoPea mengarawan. The structures of these comPounds were determined based on sPectroscoPic data, including 2D NMR and HREIMS sPectra. On cytotoxic evaluation of the isolated comPounds against murin Leukemia P-388 cells, comPound 1 was the strongest in inhibiting the growth of the cells.

Lia D Juliawaty - One of the best experts on this subject based on the ideXlab platform.

  • A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine Leukemia P-388 cells
    2014
    Co-Authors: Hanhan Dianhar, Euis H. Hakim, Didin Mujahidin, Yana M Syah, Lia D Juliawaty
    Abstract:

    Sesbania sesban, locally named as Jayanti, is one of Indonesia Plants belonging to Fabaceae family. This sPecies is traditionally used by Indonesian PeoPle to cure digestive disorders, fever, or headache. Jayanti can grow well in troPical to subtroPical region, such as in Asia and Africa. Based on literature, qualitative analysis of the methanol extract of leaves of S. sesban showed that it contained flavonoids, alkaloids, saPonins and glycosides. In addition, the activity assay of extracts of different tissues of this sPecies showed antitumor, antimalarial, and antidiabetic activityies (leaves and seed extracts), antioxidants (flower extract), and analgesic (wood extract). Though the extracts of S. sesban Parts showed interesting activities, chemical study of those extracts have not been widely rePorted. Therefore, the objective of this research was to isolate the secondary metabolites from methanol extract of leaves of S. sesban and to determine their cytotoxicity against murine Leukemia P-388 cells. On...

  • RESVERATROL DIMERS FROM STEM BARK OF HoPea gregaria AND THEIR CYTOTOXIC PROPERTIES
    Indonesian Journal of Chemistry, 2010
    Co-Authors: Sahidin Sahidin, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Sjamsul Arifin Achmad, Laily B. Din, Jalifah Latip
    Abstract:

    Six resveratrol dimers have been isolated from the stem bark of H. gregaria, amPeloPsin A (1), balanocarPol (2), e-viniferin (3), hoPeafuran (4), heimiol A (5), and Parviflorol (6). The structures of these comPounds were determined based on sPectroscoPic evidence such as UV, IR, 1-D, 2-D NMR and comParison with the rePorted data. This comPound inventions are strengthen conclusion that HoPea tends to Produce resveratrol dimers. Biological activity of those comPounds against murine Leukemia P-388 cells showed that e-viniferin (3) is the most active comPound with IC50 value 5.1 ± 0.3 μg/mL.

  • Phenolic comPounds from CryPtocarya konishii: their cytotoxic and tyrosine kinase inhibitory ProPerties
    Journal of Natural Medicines, 2010
    Co-Authors: Fera Kurniadewi, Sjamsul A. Achmad, Euis H. Hakim, Lia D Juliawaty, Kaoru Kinoshita, Kiyotaka Koyama, Yana M Syah, Kunio Takahashi
    Abstract:

    Two chalcone derivatives, 2′-hydroxychalcone ( 1 ) and desmethylinfectocaryone ( 2 ), together with five known Phenolic comPounds infectocaryone ( 3 ), cryPtocaryone ( 4 ), kurzichalcolactone A ( 5 ), Pinocembrin ( 6 ) and trans-N- feruloyltyramine ( 7 ), were isolated from the methanol extract of the wood of CryPtocarya konishii . The structures of the new comPounds were determined based on the analysis of sPectroscoPic data, including UV, IR, 1D and 2D NMR, and mass sPectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of comPounds 1 – 7 showed that comPounds 2 – 4 strongly inhibited the growth of murine Leukemia P-388 cells, whereas comPound 4 significantly inhibited the enzyme.

  • A 2-arylbenzofuran derivative from HoPea mengarawan.
    Natural product communications, 2009
    Co-Authors: Lia D Juliawaty, Euis H. Hakim, Yana M Syah, Sahidin, Sjamsul Arifin Achmad, Jalifah Latip, Ikram M. Said
    Abstract:

    A new 2-arylbenzofuran derivative (diPtoindonesin G) (1), along with nine known oligostilbenes, have been isolated and identified from the acetone extract of the tree bark of HoPea mengarawan. The structures of these comPounds were determined based on sPectroscoPic data, including 2D NMR and HREIMS sPectra. On cytotoxic evaluation of the isolated comPounds against murin Leukemia P-388 cells, comPound 1 was the strongest in inhibiting the growth of the cells.

  • Prenylated flavones from ArtocarPus lanceifolius and their cytotoxic ProPerties against P-388 cells.
    Natural product communications, 2009
    Co-Authors: Iqbal Musthapa, Euis H. Hakim, Lia D Juliawaty, Jalifah Latip, Hiromitsu Takayama, Yana M Syah
    Abstract:

    New Prenylated flavones, artoindonesianins Z-4 and Z-5, together with four known Prenylated flavones, artonin E, 12-hydroxyartonin E, artobiloxanthone, and cycloartobiloxanthone, have been isolated from the methanol extract of the tree bark of ArtocarPus lanceifolius. The structures of these comPounds were determined on the basis of sPectroscoPic data, including UV, IR, 1D and 2D NMR, and mass sPectra. The cytotoxic effect of the isolated comPounds against murine Leukemia P-388 cells is described.

Jalifah Latip - One of the best experts on this subject based on the ideXlab platform.

  • RESVERATROL DIMERS FROM STEM BARK OF HoPea gregaria AND THEIR CYTOTOXIC PROPERTIES
    Indonesian Journal of Chemistry, 2010
    Co-Authors: Sahidin Sahidin, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Sjamsul Arifin Achmad, Laily B. Din, Jalifah Latip
    Abstract:

    Six resveratrol dimers have been isolated from the stem bark of H. gregaria, amPeloPsin A (1), balanocarPol (2), e-viniferin (3), hoPeafuran (4), heimiol A (5), and Parviflorol (6). The structures of these comPounds were determined based on sPectroscoPic evidence such as UV, IR, 1-D, 2-D NMR and comParison with the rePorted data. This comPound inventions are strengthen conclusion that HoPea tends to Produce resveratrol dimers. Biological activity of those comPounds against murine Leukemia P-388 cells showed that e-viniferin (3) is the most active comPound with IC50 value 5.1 ± 0.3 μg/mL.

  • A 2-arylbenzofuran derivative from HoPea mengarawan.
    Natural product communications, 2009
    Co-Authors: Lia D Juliawaty, Euis H. Hakim, Yana M Syah, Sahidin, Sjamsul Arifin Achmad, Jalifah Latip, Ikram M. Said
    Abstract:

    A new 2-arylbenzofuran derivative (diPtoindonesin G) (1), along with nine known oligostilbenes, have been isolated and identified from the acetone extract of the tree bark of HoPea mengarawan. The structures of these comPounds were determined based on sPectroscoPic data, including 2D NMR and HREIMS sPectra. On cytotoxic evaluation of the isolated comPounds against murin Leukemia P-388 cells, comPound 1 was the strongest in inhibiting the growth of the cells.

  • Prenylated flavones from ArtocarPus lanceifolius and their cytotoxic ProPerties against P-388 cells.
    Natural product communications, 2009
    Co-Authors: Iqbal Musthapa, Euis H. Hakim, Lia D Juliawaty, Jalifah Latip, Hiromitsu Takayama, Yana M Syah
    Abstract:

    New Prenylated flavones, artoindonesianins Z-4 and Z-5, together with four known Prenylated flavones, artonin E, 12-hydroxyartonin E, artobiloxanthone, and cycloartobiloxanthone, have been isolated from the methanol extract of the tree bark of ArtocarPus lanceifolius. The structures of these comPounds were determined on the basis of sPectroscoPic data, including UV, IR, 1D and 2D NMR, and mass sPectra. The cytotoxic effect of the isolated comPounds against murine Leukemia P-388 cells is described.

  • An oxePinoflavone from ArtocarPus elasticus with cytotoxic activity against P-388 cells
    Archives of Pharmacal Research, 2009
    Co-Authors: Iqbal Musthapa, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Jalifah Latip, Emilio L. Ghisalberti
    Abstract:

    A new oxePinoflavone, artoindonesianin E1 ( 1 ), was isolated from the wood of ArtocarPus elasticus , along with four known Prenylated flavones: artocarPin ( 2 ), cycloartocarPin ( 3 ), cudraflavones A ( 4 ) and C ( 5 ). The structure of the new comPound was identified by sPectroscoPic methods. UPon cytotoxic evaluation against murine Leukemia P-388 cells, the new comPound showed IC_50 5.0 μg/mL.

  • oligostilbenoids from shorea gibbosa and their cytotoxic ProPerties against P 388 cells
    Journal of Natural Medicines, 2008
    Co-Authors: Haryoto Saroyobudiono, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Sjamsul Arifin Achmad, Jalifah Latip, Ikram M. Said
    Abstract:

    A new oligostilbenoid derivative, diPtoindonesin F (1), along with five known oligostilbenoids, (−)-amPeloPsin A (2), (−)-α-viniferin (3), amPeloPsin E (4), (−)-vaticanol B (5), and (−)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new comPound was determined based on the analysis of sPectroscoPic data, including UV, IR, NMR 1-D and 2-D, and mass sPectra. Cytotoxic ProPerties of the isolated oligostilbenoids were evaluated against murine Leukemia P-388 cells with the result that comPounds 2 and 4 showed the highest cytotoxicity.

Emilio L. Ghisalberti - One of the best experts on this subject based on the ideXlab platform.

  • An oxePinoflavone from ArtocarPus elasticus with cytotoxic activity against P-388 cells
    Archives of Pharmacal Research, 2009
    Co-Authors: Iqbal Musthapa, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Jalifah Latip, Emilio L. Ghisalberti
    Abstract:

    A new oxePinoflavone, artoindonesianin E1 ( 1 ), was isolated from the wood of ArtocarPus elasticus , along with four known Prenylated flavones: artocarPin ( 2 ), cycloartocarPin ( 3 ), cudraflavones A ( 4 ) and C ( 5 ). The structure of the new comPound was identified by sPectroscoPic methods. UPon cytotoxic evaluation against murine Leukemia P-388 cells, the new comPound showed IC_50 5.0 μg/mL.

  • Cytotoxic resveratrol oligomers from the tree bark of DiPterocarPus hasseltii.
    Fitoterapia, 2006
    Co-Authors: Muhtadi, Sjamsul A. Achmad, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Jalifah Latip, Emilio L. Ghisalberti
    Abstract:

    A new resveratrol tetramer, named diPtoindonesin E, was isolated from the acetone extract of the tree bark of DiPterocarPus hasseltii, together with five known resveratrol oligomers (-)-ePsilon-viniferin, laevifonol, (-)-alPha-viniferin, vaticanol B, (-)-hoPeaPhenol, and a coumarin, scoPoletin. The structures of these comPounds were determined from sPectroscoPic evidence. Cytotoxicity test of the isolated comPounds showed that hoPeaPhenol strongly inhibited murine Leukemia P-388 cells.

  • Cytotoxic ProPerties of oligostilbenoids from the tree barks of HoPea dryobalanoides.
    Zeitschrift fur Naturforschung. C Journal of biosciences, 2005
    Co-Authors: Sahidin, Euis H. Hakim, Lia D Juliawaty, Yana M Syah, Jalifah Latip, Emilio L. Ghisalberti, Ikram M. Said, Laily B. Din, Sjamsul Arifin Achmad
    Abstract:

    A new modified stilbene dimer, diPtoindonesin D (1), was isolated from the acetone extract of the tree bark of HoPea dryobalanoides, together with seven known comPounds, Parviflorol (2), (-)-balanocarPol (3), heimiol A (4), hoPeafuran (5), (+)-alPha-viniferin (6), vaticanol B (7) and (-)-hoPeaPhenol (8). Cytotoxic ProPerties of comPounds 1-8 were evaluated against murine Leukemia P-388 cells. ComPound 8 was found to be the most active with IC50 of 5.7 microM.

  • Artoindonesianins A and B, two new Prenylated flavones from the root of ArtocarPus chamPeden
    Journal of natural products, 1999
    Co-Authors: Euis H. Hakim, Sjamsul Arifin Achmad, Emilio L. Ghisalberti, Ati Fahriyati, Mulhimah Sidqiyah Kau, Lukman Makmur, Taro Nomura
    Abstract:

    Two new Prenylated flavones, named artoindonesianin A (1) and artoindonesianin B (2), were isolated from the root of ArtocarPus chamPeden, together with a known Prenylated flavone, artonin A. The structures of artoindonesianins A and B were determined on the basis of sPectral evidence (MS, 1H and 13C NMR) and by comParison with known related comPounds. ComPounds 1 and 2 exhibited cytotoxic activity against murine Leukemia (P-388) cells.