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Naveen L Pereira - One of the best experts on this subject based on the ideXlab platform.
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response by wong et al to letter regarding article importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2018Co-Authors: Ka L Wong, Byron H Smith, Walter K Kremers, Naveen L PereiraAbstract:We thank Clerkin et al for their interest in our study addressing the importance of routine monitoring for de novo donor–specific antibodies (dnDSA) not only in predicting cellular and Antibody-mediated rejection (AMR) but also for the first time demonstrating its association with allograft vasculopathy detected by intravascular ultrasound.1 Our data were analyzed using a Cox regression survival analysis model accounting for the timing of dnDSA events when predicting subsequent incidence of AMR. In 2 previous studies cited by Clerkin, patients at time of transplant were classified according to posttransplant outcomes such as dnDSA or AMR. Statistical theory does not …
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importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2017Co-Authors: Ka L Wong, Timucin Taner, Byron H Smith, Sudhir S Kushwaha, Brooks S Edwards, Manish J Gandhi, Walter K Kremers, Richard C Daly, Naveen L PereiraAbstract:The significance of de novo donor-specific antibodies (dnDSAs) after heart transplantation (HTx) on alloimmune injury, including acute cellular rejection (ACR), Antibody-mediated rejection (AMR), and cardiac allograft vasculopathy, remains unclear. In this study, we examined the importance of routine solid-phase arrays in detecting dnDSA during long-term follow-up of recipients of HTx. The study protocol was approved by the Mayo Clinic Institutional Review Board, and patients gave informed consent. Between January 2009 and December 2013, 86 of 101 consecutive adult recipients of HTx underwent routine serial antihuman Leukocyte antigen (HLA) Antibody monitoring before and 1 week, 4 months, 1 year, and annually after HTx using a panel of single-antigen beads (LABScreen, One Lambda, Inc.) read on a Luminex (Luminex Corp.) platform. Mean fluorescence intensity levels ≥2000 were considered positive. According to the International Society for Heart and Lung Transplantation classification, 1546 endomyocardial biopsies scored with severe ACR defined as grade 2R or 3R. Serial 3-dimensional intravascular ultrasound examinations were performed as previously published.1 Cumulative incidences were estimated using the Kaplan-Meier method. Cox-proportional hazard models were used for analysis of time-to-event data. Variables with a P value <0.10 by univariable …
Ka L Wong - One of the best experts on this subject based on the ideXlab platform.
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response by wong et al to letter regarding article importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2018Co-Authors: Ka L Wong, Byron H Smith, Walter K Kremers, Naveen L PereiraAbstract:We thank Clerkin et al for their interest in our study addressing the importance of routine monitoring for de novo donor–specific antibodies (dnDSA) not only in predicting cellular and Antibody-mediated rejection (AMR) but also for the first time demonstrating its association with allograft vasculopathy detected by intravascular ultrasound.1 Our data were analyzed using a Cox regression survival analysis model accounting for the timing of dnDSA events when predicting subsequent incidence of AMR. In 2 previous studies cited by Clerkin, patients at time of transplant were classified according to posttransplant outcomes such as dnDSA or AMR. Statistical theory does not …
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importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2017Co-Authors: Ka L Wong, Timucin Taner, Byron H Smith, Sudhir S Kushwaha, Brooks S Edwards, Manish J Gandhi, Walter K Kremers, Richard C Daly, Naveen L PereiraAbstract:The significance of de novo donor-specific antibodies (dnDSAs) after heart transplantation (HTx) on alloimmune injury, including acute cellular rejection (ACR), Antibody-mediated rejection (AMR), and cardiac allograft vasculopathy, remains unclear. In this study, we examined the importance of routine solid-phase arrays in detecting dnDSA during long-term follow-up of recipients of HTx. The study protocol was approved by the Mayo Clinic Institutional Review Board, and patients gave informed consent. Between January 2009 and December 2013, 86 of 101 consecutive adult recipients of HTx underwent routine serial antihuman Leukocyte antigen (HLA) Antibody monitoring before and 1 week, 4 months, 1 year, and annually after HTx using a panel of single-antigen beads (LABScreen, One Lambda, Inc.) read on a Luminex (Luminex Corp.) platform. Mean fluorescence intensity levels ≥2000 were considered positive. According to the International Society for Heart and Lung Transplantation classification, 1546 endomyocardial biopsies scored with severe ACR defined as grade 2R or 3R. Serial 3-dimensional intravascular ultrasound examinations were performed as previously published.1 Cumulative incidences were estimated using the Kaplan-Meier method. Cox-proportional hazard models were used for analysis of time-to-event data. Variables with a P value <0.10 by univariable …
Donna Mancini - One of the best experts on this subject based on the ideXlab platform.
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letter by clerkin et al regarding article importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2018Co-Authors: Kevin J Clerkin, Maryjane Farr, Donna ManciniAbstract:We read the article by Wong et al with interest and congratulate the authors for their addition to the literature regarding de novo donor specific antihuman Leukocyte antigen antibodies (dnDSA) following heart transplantation.1 DSA have been shown to be detrimental following heart transplantation, leading to increased cellular rejection, cardiac allograft vasculopathy, Antibody mediated rejection (AMR), and mortality.2–4 We recently reported our experience with a prospective cohort of …
Walter K Kremers - One of the best experts on this subject based on the ideXlab platform.
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response by wong et al to letter regarding article importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2018Co-Authors: Ka L Wong, Byron H Smith, Walter K Kremers, Naveen L PereiraAbstract:We thank Clerkin et al for their interest in our study addressing the importance of routine monitoring for de novo donor–specific antibodies (dnDSA) not only in predicting cellular and Antibody-mediated rejection (AMR) but also for the first time demonstrating its association with allograft vasculopathy detected by intravascular ultrasound.1 Our data were analyzed using a Cox regression survival analysis model accounting for the timing of dnDSA events when predicting subsequent incidence of AMR. In 2 previous studies cited by Clerkin, patients at time of transplant were classified according to posttransplant outcomes such as dnDSA or AMR. Statistical theory does not …
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importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2017Co-Authors: Ka L Wong, Timucin Taner, Byron H Smith, Sudhir S Kushwaha, Brooks S Edwards, Manish J Gandhi, Walter K Kremers, Richard C Daly, Naveen L PereiraAbstract:The significance of de novo donor-specific antibodies (dnDSAs) after heart transplantation (HTx) on alloimmune injury, including acute cellular rejection (ACR), Antibody-mediated rejection (AMR), and cardiac allograft vasculopathy, remains unclear. In this study, we examined the importance of routine solid-phase arrays in detecting dnDSA during long-term follow-up of recipients of HTx. The study protocol was approved by the Mayo Clinic Institutional Review Board, and patients gave informed consent. Between January 2009 and December 2013, 86 of 101 consecutive adult recipients of HTx underwent routine serial antihuman Leukocyte antigen (HLA) Antibody monitoring before and 1 week, 4 months, 1 year, and annually after HTx using a panel of single-antigen beads (LABScreen, One Lambda, Inc.) read on a Luminex (Luminex Corp.) platform. Mean fluorescence intensity levels ≥2000 were considered positive. According to the International Society for Heart and Lung Transplantation classification, 1546 endomyocardial biopsies scored with severe ACR defined as grade 2R or 3R. Serial 3-dimensional intravascular ultrasound examinations were performed as previously published.1 Cumulative incidences were estimated using the Kaplan-Meier method. Cox-proportional hazard models were used for analysis of time-to-event data. Variables with a P value <0.10 by univariable …
Byron H Smith - One of the best experts on this subject based on the ideXlab platform.
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response by wong et al to letter regarding article importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2018Co-Authors: Ka L Wong, Byron H Smith, Walter K Kremers, Naveen L PereiraAbstract:We thank Clerkin et al for their interest in our study addressing the importance of routine monitoring for de novo donor–specific antibodies (dnDSA) not only in predicting cellular and Antibody-mediated rejection (AMR) but also for the first time demonstrating its association with allograft vasculopathy detected by intravascular ultrasound.1 Our data were analyzed using a Cox regression survival analysis model accounting for the timing of dnDSA events when predicting subsequent incidence of AMR. In 2 previous studies cited by Clerkin, patients at time of transplant were classified according to posttransplant outcomes such as dnDSA or AMR. Statistical theory does not …
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importance of routine antihuman Leukocyte Antibody monitoring de novo donor specific antibodies are associated with rejection and allograft vasculopathy after heart transplantation
Circulation, 2017Co-Authors: Ka L Wong, Timucin Taner, Byron H Smith, Sudhir S Kushwaha, Brooks S Edwards, Manish J Gandhi, Walter K Kremers, Richard C Daly, Naveen L PereiraAbstract:The significance of de novo donor-specific antibodies (dnDSAs) after heart transplantation (HTx) on alloimmune injury, including acute cellular rejection (ACR), Antibody-mediated rejection (AMR), and cardiac allograft vasculopathy, remains unclear. In this study, we examined the importance of routine solid-phase arrays in detecting dnDSA during long-term follow-up of recipients of HTx. The study protocol was approved by the Mayo Clinic Institutional Review Board, and patients gave informed consent. Between January 2009 and December 2013, 86 of 101 consecutive adult recipients of HTx underwent routine serial antihuman Leukocyte antigen (HLA) Antibody monitoring before and 1 week, 4 months, 1 year, and annually after HTx using a panel of single-antigen beads (LABScreen, One Lambda, Inc.) read on a Luminex (Luminex Corp.) platform. Mean fluorescence intensity levels ≥2000 were considered positive. According to the International Society for Heart and Lung Transplantation classification, 1546 endomyocardial biopsies scored with severe ACR defined as grade 2R or 3R. Serial 3-dimensional intravascular ultrasound examinations were performed as previously published.1 Cumulative incidences were estimated using the Kaplan-Meier method. Cox-proportional hazard models were used for analysis of time-to-event data. Variables with a P value <0.10 by univariable …