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W R Gilliland - One of the best experts on this subject based on the ideXlab platform.

  • Ovarian cancer presenting as Leukocytoclastic Vasculitis.
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M E Stashower, T A Rennie, G W Turiansky, W R Gilliland
    Abstract:

    We describe a 53-year-old woman with a 4-month history of palpable purpuric papules on the upper and lower extremities. Biopsy of the skin lesions revealed Leukocytoclastic Vasculitis. Although she denied any systemic symptoms, urinalysis demonstrated hematuria and proteinuria. Although the patient's skin lesions responded to prednisone, her urinalysis did not improve. A 10-cm complex mass involving the left ovary and adnexa was incidentally discovered on renal ultrasound. Serum CA-125, an ovarian cancer marker, was elevated. Laparotomy revealed ovarian carcinoma confined to the left ovary. After the cancer was resected, the patient's urinalysis slowly improved. Leukocytoclastic Vasculitis (LCV) is infrequently associated with underlying malignancy and only rarely with solid tumors. We postulate that the patient's Vasculitis represented a paraneoplastic phenomenon that allowed a diagnosis of asymptomatic ovarian carcinoma. To our knowledge, this is the first report of LCV occurring as the presenting sign of ovarian cancer.

  • Ovarian cancer presenting as Leukocytoclastic Vasculitis
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M E Stashower, T A Rennie, G W Turiansky, W R Gilliland
    Abstract:

    Abstract We describe a 53-year-old woman with a 4-month history of palpable purpuric papules on the upper and lower extremities. Biopsy of the skin lesions revealed Leukocytoclastic Vasculitis. Although she denied any systemic symptoms, urinalysis demonstrated hematuria and proteinuria. Although the patient's skin lesions responded to prednisone, her urinalysis did not improve. A 10-cm complex mass involving the left ovary and adnexa was incidentally discovered on renal ultrasound. Serum CA-125, an ovarian cancer marker, was elevated. Laparotomy revealed ovarian carcinoma confined to the left ovary. After the cancer was resected, the patient's urinalysis slowly improved. Leukocytoclastic Vasculitis (LCV) is infrequently associated with underlying malignancy and only rarely with solid tumors. We postulate that the patient's Vasculitis represented a paraneoplastic phenomenon that allowed a diagnosis of asymptomatic ovarian carcinoma. To our knowledge, this is the first report of LCV occurring as the presenting sign of ovarian cancer. (J Am Acad Dermatol 1999;40:287-9.)

Patricia Moriel - One of the best experts on this subject based on the ideXlab platform.

  • Leukocytoclastic Vasculitis complicating cisplatin + radiation treatment for laryngeal cancer: a case report
    BMC cancer, 2017
    Co-Authors: Júlia Coelho França Quintanilha, Marília Berlofa Visacri, Lais Sampaio Amaral, Carmen Silvia Passos Lima, Maria Letícia Cintra, Patricia Moriel
    Abstract:

    Background Leukocytoclastic Vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, Leukocytoclastic Vasculitis related to cisplatin has not yet been described in the scientific literature.

  • Leukocytoclastic Vasculitis complicating cisplatin + radiation treatment for laryngeal cancer: a case report
    BMC, 2017
    Co-Authors: Júlia Coelho França Quintanilha, Marília Berlofa Visacri, Lais Sampaio Amaral, Carmen Silvia Passos Lima, Maria Letícia Cintra, Patricia Moriel
    Abstract:

    Abstract Background Leukocytoclastic Vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, Leukocytoclastic Vasculitis related to cisplatin has not yet been described in the scientific literature. Case presentation We report a rare case of Leukocytoclastic Vasculitis after the first cycle of high-dose cisplatin chemotherapy in a patient with larynx carcinoma. A 48-year-old Caucasian man with larynx carcinoma received a high-dose of cisplatin monochemotherapy (100 mg/m2 every 21 days), along with 70 Gy of radiotherapy divided into 35 sessions, as a therapeutic schedule. Twelve days after the first chemotherapy administration and after 8 sessions of radiotherapy (total of 16 Gy), the patient presented with acute onset of palpable purpura in the lower limbs. The patient was hospitalized for 10 days, and during this period, he underwent several examinations to rule out infectious, autoimmune, and neoplastic disorders. A skin biopsy showed Leukocytoclastic Vasculitis with a positive pattern for IgM and C3, as detected through direct immunofluorescence. Twenty-five days after cisplatin administration, the chemotherapy regimen was changed to carboplatin AUC 5, and the episodes of purpura ceased, reinforcing the hypothesis of an adverse reaction to cisplatin. Conclusions Cisplatin can induce Leukocytoclastic Vasculitis and clinicians should be aware of this potential effect for better case management and diagnosis

J H Stone - One of the best experts on this subject based on the ideXlab platform.

  • Annular Leukocytoclastic Vasculitis associated with monoclonal gammopathy of unknown significance.
    Journal of the American Academy of Dermatology, 2000
    Co-Authors: H C Nousari, A Kimyai-asadi, J H Stone
    Abstract:

    Leukocytoclastic Vasculitis is a condition characterized by necrotizing neutrophilic inflammation of small dermal blood vessels usually resulting in palpable purpuric lesions. Leukocytoclastic Vasculitis may be secondary to a variety of medications and underlying disease processes, including infections, connective tissue disorders, and malignancies. We describe a patient with a monoclonal gammopathy of unknown significance in whom Leukocytoclastic Vasculitis developed, manifested by a few prominent annular plaques on the lower extremity. The rare association between monoclonal gammopathy of unknown significance and Leukocytoclastic Vasculitis as well as the unusual annular presentation of the disease in this patient is discussed, and the relevant literature is reviewed.

  • Annular Leukocytoclastic Vasculitis associated with monoclonal gammopathy of unknown significance.
    Journal of the American Academy of Dermatology, 2000
    Co-Authors: H C Nousari, A Kimyai-asadi, J H Stone
    Abstract:

    Leukocytoclastic Vasculitis is a condition characterized by necrotizing neutrophilic inflammation of small dermal blood vessels usually resulting in palpable purpuric lesions. Leukocytoclastic Vasculitis may be secondary to a variety of medications and underlying disease processes, including infections, connective tissue disorders, and malignancies. We describe a patient with a monoclonal gammopathy of unknown significance in whom Leukocytoclastic Vasculitis developed, manifested by a few prominent annular plaques on the lower extremity. The rare association between monoclonal gammopathy of unknown significance and Leukocytoclastic Vasculitis as well as the unusual annular presentation of the disease in this patient is discussed, and the relevant literature is reviewed. (J Am Acad Dermatol 2000;43:955-7.)

M E Stashower - One of the best experts on this subject based on the ideXlab platform.

  • Ovarian cancer presenting as Leukocytoclastic Vasculitis.
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M E Stashower, T A Rennie, G W Turiansky, W R Gilliland
    Abstract:

    We describe a 53-year-old woman with a 4-month history of palpable purpuric papules on the upper and lower extremities. Biopsy of the skin lesions revealed Leukocytoclastic Vasculitis. Although she denied any systemic symptoms, urinalysis demonstrated hematuria and proteinuria. Although the patient's skin lesions responded to prednisone, her urinalysis did not improve. A 10-cm complex mass involving the left ovary and adnexa was incidentally discovered on renal ultrasound. Serum CA-125, an ovarian cancer marker, was elevated. Laparotomy revealed ovarian carcinoma confined to the left ovary. After the cancer was resected, the patient's urinalysis slowly improved. Leukocytoclastic Vasculitis (LCV) is infrequently associated with underlying malignancy and only rarely with solid tumors. We postulate that the patient's Vasculitis represented a paraneoplastic phenomenon that allowed a diagnosis of asymptomatic ovarian carcinoma. To our knowledge, this is the first report of LCV occurring as the presenting sign of ovarian cancer.

  • Ovarian cancer presenting as Leukocytoclastic Vasculitis
    Journal of the American Academy of Dermatology, 1999
    Co-Authors: M E Stashower, T A Rennie, G W Turiansky, W R Gilliland
    Abstract:

    Abstract We describe a 53-year-old woman with a 4-month history of palpable purpuric papules on the upper and lower extremities. Biopsy of the skin lesions revealed Leukocytoclastic Vasculitis. Although she denied any systemic symptoms, urinalysis demonstrated hematuria and proteinuria. Although the patient's skin lesions responded to prednisone, her urinalysis did not improve. A 10-cm complex mass involving the left ovary and adnexa was incidentally discovered on renal ultrasound. Serum CA-125, an ovarian cancer marker, was elevated. Laparotomy revealed ovarian carcinoma confined to the left ovary. After the cancer was resected, the patient's urinalysis slowly improved. Leukocytoclastic Vasculitis (LCV) is infrequently associated with underlying malignancy and only rarely with solid tumors. We postulate that the patient's Vasculitis represented a paraneoplastic phenomenon that allowed a diagnosis of asymptomatic ovarian carcinoma. To our knowledge, this is the first report of LCV occurring as the presenting sign of ovarian cancer. (J Am Acad Dermatol 1999;40:287-9.)

Mohamed Effat - One of the best experts on this subject based on the ideXlab platform.

  • Warfarin induced Leukocytoclastic Vasculitis: an extraordinary side effect
    Journal of Thrombosis and Thrombolysis, 2019
    Co-Authors: Dina Elantably, Ahmed Mourad, Ahmed Elantably, Mohamed Effat
    Abstract:

    Warfarin is one of the most commonly used anticoagulants in the management of thromboembolic events. Herein we report a rare case of warfarin induced Leukocytoclastic Vasculitis in a patient with history of rheumatic heart disease and a mechanical mitral valve prosthesis who presented with heart failure and palpable purpura. Upon clinical suspicion of cutaneous small vessel Vasculitis, a comprehensive laboratory panel was performed. Warfarin induced Vasculitis was suspected when withdrawal of warfarin, due to rising INR, led to improvement of the skin lesions. The diagnosis was finally confirmed when re-instatement of warfarin reproduced the skin lesions and a skin biopsy showed evidence for Leukocytoclastic Vasculitis with eosinophilic infiltration. A third of cases of Leukocytoclastic Vasculitis are due to drug hypersensitivity which being a diagnosis of exclusion with varying manifestations, requires a high index of clinical suspicion. Since drug induced Leukocytoclastic Vasculitis may affect multiple organ systems and even cause mortality, clinicians must be aware of this rare adverse event, promptly discontinue the drug, and commence anti-inflammatory or immunosuppressive treatment when necessary.