The Experts below are selected from a list of 10518 Experts worldwide ranked by ideXlab platform
Peter R Bergethon - One of the best experts on this subject based on the ideXlab platform.
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reversible posterior Leukoencephalopathy syndrome after bevacizumab folfiri regimen for metastatic colon cancer
JAMA Neurology, 2006Co-Authors: Jeffrey A Allen, Ashish Adlakha, Peter R BergethonAbstract:Objective To describe a patient with reversible posterior Leukoencephalopathy syndrome following the administration of bevacizumab (Avastin), a monoclonal antibody against vascular endothelial growth factor. Design Case report/literature review. Setting University hospital. Patient A 52-year-old man receiving chemotherapy for stage IV rectal carcinoma. Results Clinical and radiographic evidence consistent with reversible posterior Leukoencephalopathy syndrome was found following the administration of irinotecan hydrochloride, leucovorin calcium, and fluorouracil (FOLFIRI) regimen chemotherapy and bevacizumab. Conclusions Reversible posterior Leukoencephalopathy syndrome following treatment with angiogenesis modulators can occur. In addition to raising clinical suspicion in appropriate patients, this report may yield clues to the pathophysiologic underpinnings of reversible posterior Leukoencephalopathy syndrome.
Stefan Weidauer - One of the best experts on this subject based on the ideXlab platform.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients
Clinical Neuroradiology-klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Background and Purpose: Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients
Clinical Neuroradiology-klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented. All three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded. MRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected. Toxic Leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic Leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients original article
Klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Background and Purpose:Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented.Patients and Methods:All three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded.Results:MRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected.Conclusion:Toxic Leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic Leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
Stella Blasel - One of the best experts on this subject based on the ideXlab platform.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients
Clinical Neuroradiology-klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Background and Purpose: Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients
Clinical Neuroradiology-klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented. All three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded. MRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected. Toxic Leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic Leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients original article
Klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Background and Purpose:Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented.Patients and Methods:All three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded.Results:MRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected.Conclusion:Toxic Leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic Leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
Y. Kuroda - One of the best experts on this subject based on the ideXlab platform.
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Carmofur-induced Leukoencephalopathy: MRI
Neuroradiology, 1995Co-Authors: S. Matsumoto, S. Nishizawa, M. Murakami, S. Noma, A. Sano, Y. KurodaAbstract:Carmofur, a derivative of 5-fluorouracil, has recently been noted to have an infrequent but serious association with Leukoencephalopathy. To our knowledge, there has been no report of early MRI findings in this Leukoencephalopathy. We describe a case in which diffuse high signal intensity of the entire cerebral white matter, including the corpus callosum, was seen on T2-weighted magnetic resonance images. Although similar findings can be seen in many other diseases, carmofur-induced Leukoencephalopathy should be suspected in a patient treated with carmofur. It is important to know the clinical and MRI characteristics of this condition, for early diagnosis and better prognosis.
Michael Adelmann - One of the best experts on this subject based on the ideXlab platform.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients
Clinical Neuroradiology-klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Background and Purpose: Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients
Clinical Neuroradiology-klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented. All three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded. MRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected. Toxic Leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic Leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
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toxic Leukoencephalopathy after heroin abuse without heroin vapor inhalation mr imaging and clinical features in three patients original article
Klinische Neuroradiologie, 2010Co-Authors: Stella Blasel, Elke Hattingen, Michael Adelmann, Michael Nichtweis, Friedhelm E Zanella, Stefan WeidauerAbstract:Background and Purpose:Toxic Leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic Leukoencephalopathy after heroin abuse other than vapor inhalation is presented.Patients and Methods:All three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded.Results:MRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected.Conclusion:Toxic Leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic Leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
