The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform

Michael D Dixon - One of the best experts on this subject based on the ideXlab platform.

  • post pleistocene range expansion of the recently imperiled eastern little brown bat myotis lucifugus lucifugus from a single southern refugium
    Ecology and Evolution, 2011
    Co-Authors: Michael D Dixon
    Abstract:

    Myotis lucifugus, once among the most widespread and common bats in North America, has been forecast to be extirpated east of the Rockies in as few as 16 years by the spread of white-nose syndrome. Recent Genetic research has demonstrated that this species is paraphyletic and part of a broader species complex; however, only one Lineage (Myotis lucifugus lucifugus [M. l. lucifugus]) is present in eastern North America. I used molecular tools and niche modeling to validate this and investigate the role that historical biogeography has played in the phyloGenetic and population Genetic structure of this species to determine if the eastern subspecies represents an evolutionarily distinct population. To establish the Genetic structure within M. l. lucifugus, I densely sampled maternity colonies in Minnesota and sequenced 182 individuals for a portion of cytochrome b. PhyloGenetic reconstruction and a haplotype network were used to infer the relationships among mitochondrial haplotypes. Population growth statistics were calculated to determine if there was evidence of significant expansion, and an environmental niche model (ENM) was constructed based on conditions during the last glacial maximum (LGM) to illustrate potential glacial refugia. All individuals derived from a single mitochondrial Lineage. Genetic evidence points to population growth starting approximately 18 kya. ENM results show that there was likely a single large southern refugium extending across the southeastern United States and possibly several isolated refugia in western North America. Myotis lucifugus lucifugus likely maintained both a large range and a large population during the peaks of the glacial cycles, and its population appears to have expanded following the retreat of the Laurentide ice sheet. This imperiled Lineage likely diverged in isolation from other members of the M. lucifugus/western long-eared Myotis during the Pleistocene.

Alan Mcnally - One of the best experts on this subject based on the ideXlab platform.

  • phylogeographic separation and formation of sexually discrete Lineages in a global population of yersinia pseudotuberculosis
    Microbial genomics, 2017
    Co-Authors: Tristan Seecharran, Laura Kalinmanttari, Katja A Koskela, Simo Nikkari, Benjamin J A Dickins, Jukka Corander, Mikael Skurnik, Alan Mcnally
    Abstract:

    Yersinia pseudotuberculosis is a Gram-negative intestinal pathogen of humans and has been responsible for several nationwide gastrointestinal outbreaks. Large-scale population genomic studies have been performed on the other human pathogenic species of the genus Yersinia, Yersinia pestis and Yersinia enterocolitica allowing a high-resolution understanding of the ecology, evolution and dissemination of these pathogens. However, to date no purpose-designed large-scale global population genomic analysis of Y. pseudotuberculosis has been performed. Here we present analyses of the genomes of 134 strains of Y. pseudotuberculosis isolated from around the world, from multiple ecosystems since the 1960s. Our data display a phylogeographic split within the population, with an Asian ancestry and subsequent dispersal of successful clonal Lineages into Europe and the rest of the world. These Lineages can be differentiated by CRISPR cluster arrays, and we show that the Lineages are limited with respect to inter-Lineage Genetic exchange. This restriction of Genetic exchange maintains the discrete Lineage structure in the population despite co-existence of Lineages for thousands of years in multiple countries. Our data highlights how CRISPR can be informative of the evolutionary trajectory of bacterial Lineages, and merits further study across bacteria.

  • phylogeographic separation and formation of sexually discrete Lineages in a global population of yersinia pseudotuberculosis
    bioRxiv, 2017
    Co-Authors: Tristan Seecharran, Katja A Koskela, Benjamin J A Dickins, Jukka Corander, Mikael Skurnik, Laura Karinmantarri, Simmo Nikari, Alan Mcnally
    Abstract:

    Yersinia pseudotuberculosis is a Gram negative intestinal pathogen of humans and has been responsible for several nation-wide gastro-intestinal outbreaks. Large-scale population genomic studies have been performed on the other human pathogenic Yersinia, Y. pestis and Y. enterocolitica allowing a high-resolution understanding of the ecology, evolution and dissemination of these pathogens. However, to date no large-scale global population genomic analysis of Y. pseudotuberculosis has been performed. Here we present analyses of the genomes of 134 strains of Y. pseudotuberculosis isolated from around the world, from multiple ecosystems since 1960s. Our data display a phylogeographic split within the population, with an Asian ancestry and subsequent dispersal of successful clonal Lineages into Europe and the rest of the world. These Lineages can be differentiated by CRISPR cluster arrays, and we show that the Lineages are limited with respect to inter-Lineage Genetic exchange. This restriction of Genetic exchange maintains the discrete Lineage structure in the population despite co-existence of Lineages for thousands of years in multiple countries. Our data highlights how CRISPR can be informative of the evolutionary trajectory of bacterial Lineages, and merits further study across bacteria.

Vanessa V Sarathy - One of the best experts on this subject based on the ideXlab platform.

Tristan Seecharran - One of the best experts on this subject based on the ideXlab platform.

  • phylogeographic separation and formation of sexually discrete Lineages in a global population of yersinia pseudotuberculosis
    Microbial genomics, 2017
    Co-Authors: Tristan Seecharran, Laura Kalinmanttari, Katja A Koskela, Simo Nikkari, Benjamin J A Dickins, Jukka Corander, Mikael Skurnik, Alan Mcnally
    Abstract:

    Yersinia pseudotuberculosis is a Gram-negative intestinal pathogen of humans and has been responsible for several nationwide gastrointestinal outbreaks. Large-scale population genomic studies have been performed on the other human pathogenic species of the genus Yersinia, Yersinia pestis and Yersinia enterocolitica allowing a high-resolution understanding of the ecology, evolution and dissemination of these pathogens. However, to date no purpose-designed large-scale global population genomic analysis of Y. pseudotuberculosis has been performed. Here we present analyses of the genomes of 134 strains of Y. pseudotuberculosis isolated from around the world, from multiple ecosystems since the 1960s. Our data display a phylogeographic split within the population, with an Asian ancestry and subsequent dispersal of successful clonal Lineages into Europe and the rest of the world. These Lineages can be differentiated by CRISPR cluster arrays, and we show that the Lineages are limited with respect to inter-Lineage Genetic exchange. This restriction of Genetic exchange maintains the discrete Lineage structure in the population despite co-existence of Lineages for thousands of years in multiple countries. Our data highlights how CRISPR can be informative of the evolutionary trajectory of bacterial Lineages, and merits further study across bacteria.

  • phylogeographic separation and formation of sexually discrete Lineages in a global population of yersinia pseudotuberculosis
    bioRxiv, 2017
    Co-Authors: Tristan Seecharran, Katja A Koskela, Benjamin J A Dickins, Jukka Corander, Mikael Skurnik, Laura Karinmantarri, Simmo Nikari, Alan Mcnally
    Abstract:

    Yersinia pseudotuberculosis is a Gram negative intestinal pathogen of humans and has been responsible for several nation-wide gastro-intestinal outbreaks. Large-scale population genomic studies have been performed on the other human pathogenic Yersinia, Y. pestis and Y. enterocolitica allowing a high-resolution understanding of the ecology, evolution and dissemination of these pathogens. However, to date no large-scale global population genomic analysis of Y. pseudotuberculosis has been performed. Here we present analyses of the genomes of 134 strains of Y. pseudotuberculosis isolated from around the world, from multiple ecosystems since 1960s. Our data display a phylogeographic split within the population, with an Asian ancestry and subsequent dispersal of successful clonal Lineages into Europe and the rest of the world. These Lineages can be differentiated by CRISPR cluster arrays, and we show that the Lineages are limited with respect to inter-Lineage Genetic exchange. This restriction of Genetic exchange maintains the discrete Lineage structure in the population despite co-existence of Lineages for thousands of years in multiple countries. Our data highlights how CRISPR can be informative of the evolutionary trajectory of bacterial Lineages, and merits further study across bacteria.

Natalie D Collins - One of the best experts on this subject based on the ideXlab platform.