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Ira B. Lamster - One of the best experts on this subject based on the ideXlab platform.

  • A prospective study of oral lesions and their predictive value for progression of HIV disease
    Oral diseases, 2008
    Co-Authors: Begg, Dennis Mitchell-lewis, Joan A. Phelan, Ira B. Lamster, Ks Panageas, John T. Grbic
    Abstract:

    OBJECTIVE: This report evaluates and compares individual oral lesions and combinations of lesions in predicting progression-free survival in a seroprevalent cohort of men and women with HIV infection. DESIGN: This was a prospective study of HIV-infected patients, initially AIDS-free, followed for approximately 30 months. SETTING: Patients were volunteers examined at an academic medical center and at an inner-city hospital in New York. Participants identified themselves as homosexual men or as injection drug users (IDU). OUTCOME MEASURES: The primary outcome being assessed is time from a baseline oral examination until the development of an AIDS-defining condition or death from any cause within 12 months of the last study visit. Correlation is measured by relative risk (RR). RESULTS: While oral lesions were not predictive of progression among subjects with CD4 > or = 200, they were highly predictive of progression among those with CD4 < 200. For subjects with CD4 < 200, the only individual lesion that was significantly associated with progression-free survival was oral candidiasis (RR = 4.12, P = 0.009). Positivity for one or more lesions in a set demonstrated greater prognostic value among those with CD4 < 200, with RR's of 6.03 (P = 0.018) for the set consisting of oral candidiasis, hairy leukoplakia, and necrotizing ulcerative gingivitis (NUG), and 8.77 (P = 0.036) for the set consisting of the above lesions plus Linear Gingival Erythema (LGE). Analysis by cohort suggested that the improvement in correlation was stronger in homosexual men than in IDU, but this question could not be resolved conclusively with these data. CONCLUSIONS: Lesion sets might be better prognosticators of progression-free survival than individual lesions among HIV-infected subjects with CD4 < 200. Prognostic value of the core lesion set (oral candidiasis and hairy leukoplakia) was enhanced by the addition of other lesions (NUG and LGE) not usually included in HIV staging systems. These results suggest that staging systems for HIV might be improved by the inclusion of other, survival-related oral lesions.

  • New Concepts Regarding the Pathogenesis of Periodontal Disease in HIV Infection
    Annals of periodontology, 1998
    Co-Authors: Ira B. Lamster, John T. Grbic, Dennis Mitchell-lewis, Melissa D. Begg, And Aaron Mitchell
    Abstract:

    Abstract Periodontal manifestations of human immunodeficiency virus (HPV) infection were first described in 1987. Initially, the lesions receiving attention were HW-associated gingivitis (now known as Linear Gingival Erythema [LGE]) and HTV-associated periodontitis (now known as necrotizing ulcerative periodontitis [NUP]). The true prevalence of LGE was difficult to determine due to variable diagnostic criteria. Recently, LGE has been associated with intraoral Candida infection. The prevalence of NUP is low (≤ 5%), and this lesion is associated with pronounced immunosuppression. Current focus on the periodontal manifestations of HIV infection centers on rapid progression of chronic adult periodontitis in HIV+ patients. Attempts to identify the pathogenesis of the increased progression of periodontitis have not proven successful. For example, analysis of subGingival plaque for the presence of bacterial pathogens has failed to detect differences between HIV+ and HIV− patients. Recently our laboratory has id...

  • The Relationship of Candidiasis to Linear Gingival Erythema in HIV‐Infected Homosexual Men and Parenteral Drug Users
    Journal of periodontology, 1995
    Co-Authors: John T. Grbic, Dennis Mitchell-lewis, James B. Fine, Joan A. Phelan, Ronni Sue Bucklan, Joseph J. Zambon, Ira B. Lamster
    Abstract:

    Periodontal status was evaluated in two cohorts participating in a study of the natural history of human immunodeficiency virus (HIV) infection. One cohort consisted of 77 seropositive and 44 seronegative homosexual men, and the other cohort was comprised of 44 seropositive and 39 seronegative parenteral drug users (PDU). No differences were observed between seropositive and seronegative individuals within a cohort in terms of clinical periodontal” parameters (percent of sites with ≥4 mm probing depth, percent of sites exhibiting bleeding on probing, mean oral hygiene index). The PDU displayed more existing periodontal disease than the homosexual men. Periodontal disease in the seropositive individuals in both cohorts was not strictly related to the number of CD4+ lymphocytes. Linear Gingival Erythema (LGE), defined as an Erythematous band of at least 2 mm extending between adjacent papilla, was observed in all 4 groups. Seropositive homosexual men displayed more LGE than seronegative homosexual men (16.6...

  • the relationship of candidiasis to Linear Gingival Erythema in hiv infected homosexual men and parenteral drug users
    Journal of Periodontology, 1995
    Co-Authors: John T. Grbic, James B. Fine, Joan A. Phelan, Ronni Sue Bucklan, Joseph J. Zambon, Dennis Mitchelllewis, Ira B. Lamster
    Abstract:

    Periodontal status was evaluated in two cohorts participating in a study of the natural history of human immunodeficiency virus (HIV) infection. One cohort consisted of 77 seropositive and 44 seronegative homosexual men, and the other cohort was comprised of 44 seropositive and 39 seronegative parenteral drug users (PDU). No differences were observed between seropositive and seronegative individuals within a cohort in terms of clinical periodontal” parameters (percent of sites with ≥4 mm probing depth, percent of sites exhibiting bleeding on probing, mean oral hygiene index). The PDU displayed more existing periodontal disease than the homosexual men. Periodontal disease in the seropositive individuals in both cohorts was not strictly related to the number of CD4+ lymphocytes. Linear Gingival Erythema (LGE), defined as an Erythematous band of at least 2 mm extending between adjacent papilla, was observed in all 4 groups. Seropositive homosexual men displayed more LGE than seronegative homosexual men (16.6...

John T. Grbic - One of the best experts on this subject based on the ideXlab platform.

  • A prospective study of oral lesions and their predictive value for progression of HIV disease
    Oral diseases, 2008
    Co-Authors: Begg, Dennis Mitchell-lewis, Joan A. Phelan, Ira B. Lamster, Ks Panageas, John T. Grbic
    Abstract:

    OBJECTIVE: This report evaluates and compares individual oral lesions and combinations of lesions in predicting progression-free survival in a seroprevalent cohort of men and women with HIV infection. DESIGN: This was a prospective study of HIV-infected patients, initially AIDS-free, followed for approximately 30 months. SETTING: Patients were volunteers examined at an academic medical center and at an inner-city hospital in New York. Participants identified themselves as homosexual men or as injection drug users (IDU). OUTCOME MEASURES: The primary outcome being assessed is time from a baseline oral examination until the development of an AIDS-defining condition or death from any cause within 12 months of the last study visit. Correlation is measured by relative risk (RR). RESULTS: While oral lesions were not predictive of progression among subjects with CD4 > or = 200, they were highly predictive of progression among those with CD4 < 200. For subjects with CD4 < 200, the only individual lesion that was significantly associated with progression-free survival was oral candidiasis (RR = 4.12, P = 0.009). Positivity for one or more lesions in a set demonstrated greater prognostic value among those with CD4 < 200, with RR's of 6.03 (P = 0.018) for the set consisting of oral candidiasis, hairy leukoplakia, and necrotizing ulcerative gingivitis (NUG), and 8.77 (P = 0.036) for the set consisting of the above lesions plus Linear Gingival Erythema (LGE). Analysis by cohort suggested that the improvement in correlation was stronger in homosexual men than in IDU, but this question could not be resolved conclusively with these data. CONCLUSIONS: Lesion sets might be better prognosticators of progression-free survival than individual lesions among HIV-infected subjects with CD4 < 200. Prognostic value of the core lesion set (oral candidiasis and hairy leukoplakia) was enhanced by the addition of other lesions (NUG and LGE) not usually included in HIV staging systems. These results suggest that staging systems for HIV might be improved by the inclusion of other, survival-related oral lesions.

  • New Concepts Regarding the Pathogenesis of Periodontal Disease in HIV Infection
    Annals of periodontology, 1998
    Co-Authors: Ira B. Lamster, John T. Grbic, Dennis Mitchell-lewis, Melissa D. Begg, And Aaron Mitchell
    Abstract:

    Abstract Periodontal manifestations of human immunodeficiency virus (HPV) infection were first described in 1987. Initially, the lesions receiving attention were HW-associated gingivitis (now known as Linear Gingival Erythema [LGE]) and HTV-associated periodontitis (now known as necrotizing ulcerative periodontitis [NUP]). The true prevalence of LGE was difficult to determine due to variable diagnostic criteria. Recently, LGE has been associated with intraoral Candida infection. The prevalence of NUP is low (≤ 5%), and this lesion is associated with pronounced immunosuppression. Current focus on the periodontal manifestations of HIV infection centers on rapid progression of chronic adult periodontitis in HIV+ patients. Attempts to identify the pathogenesis of the increased progression of periodontitis have not proven successful. For example, analysis of subGingival plaque for the presence of bacterial pathogens has failed to detect differences between HIV+ and HIV− patients. Recently our laboratory has id...

  • The Relationship of Candidiasis to Linear Gingival Erythema in HIV‐Infected Homosexual Men and Parenteral Drug Users
    Journal of periodontology, 1995
    Co-Authors: John T. Grbic, Dennis Mitchell-lewis, James B. Fine, Joan A. Phelan, Ronni Sue Bucklan, Joseph J. Zambon, Ira B. Lamster
    Abstract:

    Periodontal status was evaluated in two cohorts participating in a study of the natural history of human immunodeficiency virus (HIV) infection. One cohort consisted of 77 seropositive and 44 seronegative homosexual men, and the other cohort was comprised of 44 seropositive and 39 seronegative parenteral drug users (PDU). No differences were observed between seropositive and seronegative individuals within a cohort in terms of clinical periodontal” parameters (percent of sites with ≥4 mm probing depth, percent of sites exhibiting bleeding on probing, mean oral hygiene index). The PDU displayed more existing periodontal disease than the homosexual men. Periodontal disease in the seropositive individuals in both cohorts was not strictly related to the number of CD4+ lymphocytes. Linear Gingival Erythema (LGE), defined as an Erythematous band of at least 2 mm extending between adjacent papilla, was observed in all 4 groups. Seropositive homosexual men displayed more LGE than seronegative homosexual men (16.6...

  • the relationship of candidiasis to Linear Gingival Erythema in hiv infected homosexual men and parenteral drug users
    Journal of Periodontology, 1995
    Co-Authors: John T. Grbic, James B. Fine, Joan A. Phelan, Ronni Sue Bucklan, Joseph J. Zambon, Dennis Mitchelllewis, Ira B. Lamster
    Abstract:

    Periodontal status was evaluated in two cohorts participating in a study of the natural history of human immunodeficiency virus (HIV) infection. One cohort consisted of 77 seropositive and 44 seronegative homosexual men, and the other cohort was comprised of 44 seropositive and 39 seronegative parenteral drug users (PDU). No differences were observed between seropositive and seronegative individuals within a cohort in terms of clinical periodontal” parameters (percent of sites with ≥4 mm probing depth, percent of sites exhibiting bleeding on probing, mean oral hygiene index). The PDU displayed more existing periodontal disease than the homosexual men. Periodontal disease in the seropositive individuals in both cohorts was not strictly related to the number of CD4+ lymphocytes. Linear Gingival Erythema (LGE), defined as an Erythematous band of at least 2 mm extending between adjacent papilla, was observed in all 4 groups. Seropositive homosexual men displayed more LGE than seronegative homosexual men (16.6...

Anggreta Galuh Auriadini - One of the best experts on this subject based on the ideXlab platform.

  • PREVALENSI Linear Gingival Erythema PADA PENGGUNA NARKOBA SUNTIK YANG TERINFEKSI HIV/AIDS DI YAYASAN ORBIT SURABAYA
    2016
    Co-Authors: Anggreta Galuh Auriadini
    Abstract:

    Background. Human Immunodeficiency Virus (HIV) is a virus that causes Acquired Immune Deficiency Syndrome (AIDS). The number HIV cases in Indonesia tend to increase. Injecting Drug Users are one of the high risk group for transmiting HIV infection. HIV-infected patient has a weak immune system so it is vulnerable to opportunistic infection and might give clinical manifestation in oral cavity. Linear Gingival Erythema (LGE) is a Gingival manifestation on HIV-infected patient and can be as a biomarker of HIV infection. Purpose. The purpose of this study was to find out the prevalence of LGE in Injecting Drug Users infected with HIV/AIDS at Yayasan Orbit Surabaya. Methods. Descriptive observasional study with cross-sectional and total sampling method. Subject consisted of 55 Injecting Drug Users who are infected with HIV/AIDS at Yayasan Orbit Surabaya from September to November 2015. Oral examination conducted by dentist to observe LGE. Results. Prevalence of LGE in Injecting Drug Users infected with HIV/AIDS is 3 cases from 55 patient (5,5%). Conclusion. LGE is less common lesion in Injecting Drug Users infected with HIV/AIDS.

  • prevalensi Linear Gingival Erythema pada pengguna narkoba suntik yang terinfeksi hiv aids di yayasan orbit surabaya
    2016
    Co-Authors: Anggreta Galuh Auriadini
    Abstract:

    Background. Human Immunodeficiency Virus (HIV) is a virus that causes Acquired Immune Deficiency Syndrome (AIDS). The number HIV cases in Indonesia tend to increase. Injecting Drug Users are one of the high risk group for transmiting HIV infection. HIV-infected patient has a weak immune system so it is vulnerable to opportunistic infection and might give clinical manifestation in oral cavity. Linear Gingival Erythema (LGE) is a Gingival manifestation on HIV-infected patient and can be as a biomarker of HIV infection. Purpose. The purpose of this study was to find out the prevalence of LGE in Injecting Drug Users infected with HIV/AIDS at Yayasan Orbit Surabaya. Methods. Descriptive observasional study with cross-sectional and total sampling method. Subject consisted of 55 Injecting Drug Users who are infected with HIV/AIDS at Yayasan Orbit Surabaya from September to November 2015. Oral examination conducted by dentist to observe LGE. Results. Prevalence of LGE in Injecting Drug Users infected with HIV/AIDS is 3 cases from 55 patient (5,5%). Conclusion. LGE is less common lesion in Injecting Drug Users infected with HIV/AIDS.

Maristela Barbosa Portela - One of the best experts on this subject based on the ideXlab platform.

  • candida spp in Linear Gingival Erythema lesions in hiv infected children reports of six cases
    Rio de Janeiro Dental Journal (Revista Científica do CRO-RJ), 2018
    Co-Authors: Maristela Barbosa Portela, Daniella Ferraz Cerqueira, Renato Vieira De Paiva, Adrielle Mangabeira Santos, Tamiris Ramos Vargas, Gloria Fernanda Barbosa De Araujo Castro
    Abstract:

    Introduction: Linear Gingival Erythema (LGE), formally referred to as HIV-gingivitis, is the most common form of HIV-associated periodontal disease in HIV-infected individuals These lesions have been recently evaluated as a possible form of Erythematous oral candidosis, mainly caused by Candida albicans. Other species such as C. tropicalis, C. stellatoidea, C. krusei, C. parapsilosis, C. glabrata and C. dubliniensis, have also been identified in some HIV-infected subjects. Objective: This case report reveals the presence of typical LGE lesions in six HIV-infected children, and also investigates the etiologic agent through microbiological exams and correlates this oral manifestation with the patients’ systemic conditions. Case report: Microbiological analyses showed growth for Candida spp in all patients; all of whom had severe immunosuppression. However, the regression of lesions was noted after antifungal medication. Conclusion: The presence of LGE in pediatric patients with AIDS may be a predictive marker in the progression of AIDS or it may be the first clinical manifestation of HIV infection in children. Hence it is important for dentists to be aware of such lesions.

  • candida spp in Linear Gingival Erythema lesions in hiv infeceted children reports of six cases
    International Journal of Science Dentistry, 2013
    Co-Authors: Maristela Barbosa Portela
    Abstract:

    Linear Gingival Erythema (LGE), formally referred as HIV-gingivitis, is the most common form of HIV-associated periodontal disease in HIV-infection. These lesions were recently evaluated as a possible form of Erythematous oral candidosis, mainly caused by Candida albicans. Other species are also being associated such as C. tropicalis, C. stellatoidea, C. krusei, C. parapsilosis, C. glabrata and C. dubliniensis, that was identified in some HIV-infected subjects. This case report demonstrates the presence of typical LGE lesions in six HIV-infected children, also investigates the etiologic agent by microbiological exams and correlates this oral manifestation with patients’ systemic conditions. Microbiological analyses showed positive growth for Candida spp in all patients, all of whom had severe imunessupression. After antifungal medication, the regression of lesions could be note. The presence of LGE in pediatric patients with AIDS may indicate its feature as a predictive marker in progression of HIV-infection in children.

  • Effect of serine-type protease of Candida spp. isolated from Linear Gingival Erythema of HIV-positive children: critical factors in the colonization.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pat, 2010
    Co-Authors: Maristela Barbosa Portela, Ivete Pomarico Ribeiro De Souza, Celina Monteiro Abreu, Martinna Bertolini, Carla Holandino, Celuta S. Alviano, André L.s. Santos, Rosangela Maria De Araújo Soares
    Abstract:

    J Oral Pathol Med (2010) 39: 753–760 Background:  There are several kinds of oral soft tissue lesions that are common manifestations observed in human immunodeficiency virus (HIV)-infected children; for example, Linear Gingival Erythema (LGE) that is a distinctive fiery red band along the margin of the gingivae. The etiology and pathogenesis of LGE are questionable, but a candidal origin has been suggested. Proteases are key virulence attributes produced by a variety of pathogenic fungi, including Candida. The objective of the present study is to identify the protease production in Candida species including, C. albicans (n = 5), C. dubliniensis (n = 1) and C. tropicalis (n = 1), isolated directly from typical LGE lesions observed in six HIV-positive children, and also to test the effect of a serine protease inhibitor on the interaction of Candida spp. and epithelial cells in vitro. Methods:  The ability of Candida strains to release proteases in the culture supernatant fluids was visualized by gelatin-SDS–PAGE. Gel strips containing 30-fold concentrated supernatant (1.5 × 108 yeasts) were incubated at 37°C for 48 h in 50 mM sodium phosphate buffer, pH 5.5. The concentrated supernatants were also incubated with fibronectin, laminin, immunoglobulin G, bovine serum albumin and human serum albumin. The effect of serine protease inhibitor on the interaction of Candida spp. and epithelial cells (MA 104) was measured after pre-treatment of fungi with the inhibitor (phenylmethylsulphonyl fluoride, PMSF). Results:  All the extracellular proteases were completely inhibited by PMSF, identifying these activities as serine-type proteases. Interestingly, a common 62-kDa serine protease was observed in all Candida strains. The culture supernatants, rich in serine protease activities, cleaved several soluble proteinaceous substrates. Additionally, we demonstrated that pre-treatment of C. albicans, C. dubliniensis and C. tropicalis with PMSF diminished the interaction with epithelial cells. Conclusions:  Collectively, our results show that Candida spp. isolated from LGE lesions produced and secreted serine proteases and these enzymes may be involved in the initial colonization events.

Niklaus P. Lang - One of the best experts on this subject based on the ideXlab platform.

  • Long-term results of supportive periodontal therapy (SPT) in HIV-seropositive and HIV-seronegative patients.
    Journal of clinical periodontology, 2002
    Co-Authors: Dominik Hofer, Christoph H. F. Hämmerle, Markus Grassi, Niklaus P. Lang
    Abstract:

    Aim: The aim of the present study was to investigate the long-term results of periodontal supportive therapy in HIV-seropositive and HIV-seronegative patients. Material and methods: Baseline examination of 18 HIV-seropositive patients (14 males and four females, median age of 29.7 years) revealed the following periodontal diagnoses: eight patients with Linear Gingival Erythema, four patients with necrotizing periodontitis, five patients with conventional gingivitis and one patient with chronic periodontitis. In the HIV-seronegative group, out of 16 patients (12 males and four females, median age 35.5 years), one patient presented with conventional gingivitis and 15 patients with chronic periodontitis. Periodontal therapy and maintenance care consisted of supra- and subGingival removal of plaque and calculus and instruction in oral hygiene. Based on the individual patient's needs, the mechanical therapy was repeated. Results: In the test group, the mean maintenance period was 22.7 ± 9.4 months (range 11.0–37.4) and in the control group, 48.9 ± 32.0 months (range 9.3–110.8). In the test group, the mean PlI (1.1 ± 0.8) remained at the same level (1.1 ± 0.5; p = 0.73, Wilcoxon sign rank test, p