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Liying Cui - One of the best experts on this subject based on the ideXlab platform.
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Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory.
Frontiers in neurology, 2019Co-Authors: Yuze Cao, Ming Yao, Li-xin Zhou, Bin Peng, Yicheng Zhu, Mengyu Zhang, Liying CuiAbstract:Objective: Lipohyalinosis or atherosclerosis might be responsible for single subcortical infarctions (SSIs); however, ways of differentiating between the two clinically remain uncertain. We aimed to investigate whether consecutive slides on axial view or transversal diameter is more effective to differentiate mechanisms by comparing their relationships with white matter hyperintensities (WMHs). Methods: All the participants from the Standard Medical Management in Secondary Prevention of Ischemic stroke in China (SMART) cohort who had SSIs in the lenticulostriate artery territory were included and categorized according to consecutive slides on axial view (≥4 consecutive slices or not) and transversal diameter (≥15 mm or not). The associations between the severity of WMHs and the different categories were analyzed. Results: Among the 3,821 patients of the SMART study, 281 had diffusion-weighted image-proven SSIs in the lenticulostriate artery territory. When classified by consecutive slides on axial view, SSIs on ≥4 slices were significantly associated with the severity of the WMHs, both in deep WMH (DWMH) (odds ratio [OR], 0.32; 95% confidence interval [CI], 0.11–0.97; p = 0.04) and periventricular hyperintensity (PVH) (OR, 0.37; 95% CI, 0.17–0.78; p = 0.01). No such association was found on the basis of the transversal diameter (p > 0.1). Conclusion: Consecutive slides on axial view (≥4 consecutive slices) might be more effective than transversal diameter to identify the atherosclerotic mechanisms of SSIs in the lenticulostriate artery territory. Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: {"type":"clinical-trial","attrs":{"text":"NCT00664846","term_id":"NCT00664846"}}NCT00664846
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Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory
Frontiers Media S.A., 2019Co-Authors: Yuze Cao, Ming Yao, Li-xin Zhou, Bin Peng, Yicheng Zhu, Liying Cui, Mengyu ZhangAbstract:Objective: Lipohyalinosis or atherosclerosis might be responsible for single subcortical infarctions (SSIs); however, ways of differentiating between the two clinically remain uncertain. We aimed to investigate whether consecutive slides on axial view or transversal diameter is more effective to differentiate mechanisms by comparing their relationships with white matter hyperintensities (WMHs).Methods: All the participants from the Standard Medical Management in Secondary Prevention of Ischemic stroke in China (SMART) cohort who had SSIs in the lenticulostriate artery territory were included and categorized according to consecutive slides on axial view (≥4 consecutive slices or not) and transversal diameter (≥15 mm or not). The associations between the severity of WMHs and the different categories were analyzed.Results: Among the 3,821 patients of the SMART study, 281 had diffusion-weighted image-proven SSIs in the lenticulostriate artery territory. When classified by consecutive slides on axial view, SSIs on ≥4 slices were significantly associated with the severity of the WMHs, both in deep WMH (DWMH) (odds ratio [OR], 0.32; 95% confidence interval [CI], 0.11–0.97; p = 0.04) and periventricular hyperintensity (PVH) (OR, 0.37; 95% CI, 0.17–0.78; p = 0.01). No such association was found on the basis of the transversal diameter (p > 0.1).Conclusion: Consecutive slides on axial view (≥4 consecutive slices) might be more effective than transversal diameter to identify the atherosclerotic mechanisms of SSIs in the lenticulostriate artery territory.Clinical Trial Registration:http://www.clinicaltrials.gov. Unique identifier: NCT0066484
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Abstract WP183: Renal function is Associated With Severity of White Matter Hyperintensity in Patients With Acute Ischemic Stroke/TIA
Stroke, 2016Co-Authors: Lixia Zong, Ming Yao, Li-xin Zhou, Jing Yuan, Bin Peng, Yicheng Zhu, Liying CuiAbstract:Introduction: Renal function impairment is characterized by glomerular endothelial dysfunction and Lipohyalinosis, both of which are typical features of cerebral small vessel diseases(CSVD). We thus presume that renal function might be associated with silent CSVD-related MRI changes including white matter hyperintensity (WMH), lacune and microbleeds, which was supported by previous findings observed from the individuals without stroke. However, the relationship between renal function and WMH in patients with acute ischemic stroke or transcient ischemic stroke (AIS/TIA) remains unclear. Thus we aim to explore the potential risk factors of WMH in patients with AIS/TIA, especially the association between renal function and WMH located in both periventricular and deep area. Methods: A total of 1632 patients having an MRI examination were enrolled from SMART cohort for this analysis.The severity of WMH in both periventricular(PVH) and deep subcortical area(SDWMH) was evaluated using Fazekas scale. Estimated gl...
Jun Niwa - One of the best experts on this subject based on the ideXlab platform.
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dotlike hemosiderin spots on t2 weighted magnetic resonance imaging as a predictor of stroke recurrence a prospective study
Journal of Neurosurgery, 2004Co-Authors: Toshio Imaizumi, Yoshifumi Horita, Yuji Hashimoto, Jun NiwaAbstract:Object. Microangiopathy associated with hypertension is a notable cause of cerebral small vessel disease (SVD), including deep intracerebral hemorrhage (ICH) and lacunar infarct. Dotlike low-intensity spots (dotlike hemosiderin spots: dotHSs) on T2*-weighted magnetic resonance (MR) images have been histologically diagnosed as old cerebral microbleeds associated with Lipohyalinosis, amyloid angiopathy, or other microangiopathies and located in deep or subcortical regions. The aim of this study was to determine whether dotHSs indicate the severity of microangiopathy, and if so, whether large numbers of deep dotHSs are associated with SVD recurrence. Methods. The authors prospectively analyzed the number of dotHSs in 337 patients—191 men and 146 women with a mean age of 66 ± 10.4 years (range 37–94 years)—with SVD (199 ICHs and 138 lacunar infarcts) who had been consecutively admitted to Hakodate Municipal Hospital. The follow-up period was 3.5 to 42 months (22.5 ± 13.1 months). Patients were divided into tw...
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dot like hemosiderin spots on gradient echo t2 weighted magnetic resonance imaging are associated with past history of small vessel disease in patients with intracerebral hemorrhage
Journal of Neuroimaging, 2004Co-Authors: Toshio Imaizumi, Yoshifumi Horita, Masahiko Chiba, Yuji Hashimoto, Toshimi Honma, Jun NiwaAbstract:BACKGROUND AND PURPOSE Lipohyalinosis is considered an important cause of cerebral small vessel disease (SVD), including hypertensive intracerebral hematoma (ICH) and lacunar infarction. Dot-like low-intensity spots (dot-like hemosiderin spots [dotHSs]) on gradient-echo T2*-weighted (T2*-w) magnetic resonance imaging (MRI) have been histologically diagnosed as old microbleeds associated with microangiopathies (Lipohyalinosis, amyloid angiopathy) and located in territories of perforating arteries (deep dotHSs) and subcortical regions (subcortical dotHSs). If dotHSs indicate the severity of Lipohyalinosis, larger numbers of deep dotHSs may be associated with past history of SVD. METHODS The number of dotHSs was investigated in 213 patients with deep ICH (106 men, 107 women, 37 to 94 years old, mean age = 65.8 +/- 11.2 years). Patients were divided into 2 subgroups according to past history of SVD. Odds ratio (OR) for the history was estimated from logistic regression analyses of the number of deep or subcortical dotHSs, as well as other factors. RESULTS Of 213 patients, 36 had a past history of SVD (symptomatic deep ICH in 18, symptomatic lacunar infarction in 17, and both in 1). An increased rate of history of SVD was found for patients with subcortical dotHSs. The OR per 1 subcortical dotHS was 1.09 (95% confidence internal (CI), 1.03-1.17; P =.005), and per deep dotHS, the OR was 1.07 (95% CI, 1.00-1.13; P =.039). CONCLUSIONS The findings suggest that deep and subcortical dotHSs on T2*-w MRI may indicate the severity of microangiopathy and may predict recurrence of SVD in patients with deep ICH.
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Cerebral Blood Flow before and after Treatment with Amlodipine in Elderly Patients with Lacunar Infarction
Clinical drug investigation, 2004Co-Authors: Toshio Imaizumi, Masahiko Chiba, Toshimi Honma, Junpei Yoshikawa, Jun NiwaAbstract:ment of hypertension reduces the risk of ischaemic Patients were eligible for inclusion if they were stroke.[4-10] Moreover, a BP reduction in subacute admitted to Hakodate Municipal Hospital with and chronic stroke may also prevent Lipohyalinosis symptomatic lacunar infarction from October 2000 and other vascular lesions associated with stroke. to September 2001. Infarctions were 90mm Hg or a systolic BP of >150mm Hg 3 weeks the lower limit of CBF autoregulation downwards in after the onset of lacunar infarction. Patients with spontaneously hypertensive rats.[16] Amlodipine lacunar infarction associated with embolism (exdoes not significantly affect relative indices of CBF cluding atrial fibrillation or ulcerations of the cerviin elderly hypertensive patients after BP lowering[17] cal internal carotid arteries) or lacunar infarction and it reduces the rate of carotid artery atherosclerorelated to the stenosis of a main trunk of a cerebral sis.[18] BP lowering with amlodipine has been shown artery, as determined by magnetic resonance angioto reduce stroke occurrence.[9] Such findings suggest graphy and/or digital subtraction angiography, were that amlodipine may be a suitable antihypertensive excluded. medication for elderly patients with acute stroke. Written informed consent was obtained from In our experience, reduction of systolic/diastolic either the patient or their closest relative. The study BP to normal (
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Multiple intracerebral microhemorrhages associated with primary aldosteronism: a case report
No shinkei geka. Neurological surgery, 2003Co-Authors: Kei Miyata, Toshio Imaizumi, Yoshifumi Horita, Yuji Hashimoto, Katsutoshi Tanno, Akitomo Koide, Jun NiwaAbstract:We have observed dot-like low intensity spots (a dot-like hemosiderin spot: dotHS) on T2*-weighted (T2*-w) MRI, subsequently diagnosed histologically as previous microbleeds associated with Lipohyalinosis, amyloid angiopathy and cerebral small vessel disease (SVD) including an intracerebral hematoma (ICH) and a lacunar infarction. According to the literature, primary aldosteronism (PA), characterized by hypertension, is related to SVD. A 49-year-old female with a long history of untreated hypertension secondary to PA was admitted to our hospital for medical examinations on July 18th, 2000. She had the stepwise development of dementia, dysarthria and gait disturbance (right hemiparesis). CT and MRI demonstrated multiple lacunar infarctions. She was readmitted to our hospital on Jan 23rd, 2002. A neurological examination revealed right hemiparesis, dysarthria and consciousness disturbance. CT on admission demonstrated ICH in the left midbrain. Six days after the hemorrhage, T2*-w MRI showed thirty-two dotHSs in the basal ganglias and the cortical-subcortical regions. The incidence of ICH in patients with hypertension secondary to PA is reported to be higher than in patients with essential hypertension. Multiple dotHS may be associated with ICH, lacunar infarction, and severe microangiopathy related to hypertension secondary to PA.
Toshio Imaizumi - One of the best experts on this subject based on the ideXlab platform.
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dotlike hemosiderin spots on t2 weighted magnetic resonance imaging as a predictor of stroke recurrence a prospective study
Journal of Neurosurgery, 2004Co-Authors: Toshio Imaizumi, Yoshifumi Horita, Yuji Hashimoto, Jun NiwaAbstract:Object. Microangiopathy associated with hypertension is a notable cause of cerebral small vessel disease (SVD), including deep intracerebral hemorrhage (ICH) and lacunar infarct. Dotlike low-intensity spots (dotlike hemosiderin spots: dotHSs) on T2*-weighted magnetic resonance (MR) images have been histologically diagnosed as old cerebral microbleeds associated with Lipohyalinosis, amyloid angiopathy, or other microangiopathies and located in deep or subcortical regions. The aim of this study was to determine whether dotHSs indicate the severity of microangiopathy, and if so, whether large numbers of deep dotHSs are associated with SVD recurrence. Methods. The authors prospectively analyzed the number of dotHSs in 337 patients—191 men and 146 women with a mean age of 66 ± 10.4 years (range 37–94 years)—with SVD (199 ICHs and 138 lacunar infarcts) who had been consecutively admitted to Hakodate Municipal Hospital. The follow-up period was 3.5 to 42 months (22.5 ± 13.1 months). Patients were divided into tw...
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dot like hemosiderin spots on gradient echo t2 weighted magnetic resonance imaging are associated with past history of small vessel disease in patients with intracerebral hemorrhage
Journal of Neuroimaging, 2004Co-Authors: Toshio Imaizumi, Yoshifumi Horita, Masahiko Chiba, Yuji Hashimoto, Toshimi Honma, Jun NiwaAbstract:BACKGROUND AND PURPOSE Lipohyalinosis is considered an important cause of cerebral small vessel disease (SVD), including hypertensive intracerebral hematoma (ICH) and lacunar infarction. Dot-like low-intensity spots (dot-like hemosiderin spots [dotHSs]) on gradient-echo T2*-weighted (T2*-w) magnetic resonance imaging (MRI) have been histologically diagnosed as old microbleeds associated with microangiopathies (Lipohyalinosis, amyloid angiopathy) and located in territories of perforating arteries (deep dotHSs) and subcortical regions (subcortical dotHSs). If dotHSs indicate the severity of Lipohyalinosis, larger numbers of deep dotHSs may be associated with past history of SVD. METHODS The number of dotHSs was investigated in 213 patients with deep ICH (106 men, 107 women, 37 to 94 years old, mean age = 65.8 +/- 11.2 years). Patients were divided into 2 subgroups according to past history of SVD. Odds ratio (OR) for the history was estimated from logistic regression analyses of the number of deep or subcortical dotHSs, as well as other factors. RESULTS Of 213 patients, 36 had a past history of SVD (symptomatic deep ICH in 18, symptomatic lacunar infarction in 17, and both in 1). An increased rate of history of SVD was found for patients with subcortical dotHSs. The OR per 1 subcortical dotHS was 1.09 (95% confidence internal (CI), 1.03-1.17; P =.005), and per deep dotHS, the OR was 1.07 (95% CI, 1.00-1.13; P =.039). CONCLUSIONS The findings suggest that deep and subcortical dotHSs on T2*-w MRI may indicate the severity of microangiopathy and may predict recurrence of SVD in patients with deep ICH.
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Cerebral Blood Flow before and after Treatment with Amlodipine in Elderly Patients with Lacunar Infarction
Clinical drug investigation, 2004Co-Authors: Toshio Imaizumi, Masahiko Chiba, Toshimi Honma, Junpei Yoshikawa, Jun NiwaAbstract:ment of hypertension reduces the risk of ischaemic Patients were eligible for inclusion if they were stroke.[4-10] Moreover, a BP reduction in subacute admitted to Hakodate Municipal Hospital with and chronic stroke may also prevent Lipohyalinosis symptomatic lacunar infarction from October 2000 and other vascular lesions associated with stroke. to September 2001. Infarctions were 90mm Hg or a systolic BP of >150mm Hg 3 weeks the lower limit of CBF autoregulation downwards in after the onset of lacunar infarction. Patients with spontaneously hypertensive rats.[16] Amlodipine lacunar infarction associated with embolism (exdoes not significantly affect relative indices of CBF cluding atrial fibrillation or ulcerations of the cerviin elderly hypertensive patients after BP lowering[17] cal internal carotid arteries) or lacunar infarction and it reduces the rate of carotid artery atherosclerorelated to the stenosis of a main trunk of a cerebral sis.[18] BP lowering with amlodipine has been shown artery, as determined by magnetic resonance angioto reduce stroke occurrence.[9] Such findings suggest graphy and/or digital subtraction angiography, were that amlodipine may be a suitable antihypertensive excluded. medication for elderly patients with acute stroke. Written informed consent was obtained from In our experience, reduction of systolic/diastolic either the patient or their closest relative. The study BP to normal (
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Multiple intracerebral microhemorrhages associated with primary aldosteronism: a case report
No shinkei geka. Neurological surgery, 2003Co-Authors: Kei Miyata, Toshio Imaizumi, Yoshifumi Horita, Yuji Hashimoto, Katsutoshi Tanno, Akitomo Koide, Jun NiwaAbstract:We have observed dot-like low intensity spots (a dot-like hemosiderin spot: dotHS) on T2*-weighted (T2*-w) MRI, subsequently diagnosed histologically as previous microbleeds associated with Lipohyalinosis, amyloid angiopathy and cerebral small vessel disease (SVD) including an intracerebral hematoma (ICH) and a lacunar infarction. According to the literature, primary aldosteronism (PA), characterized by hypertension, is related to SVD. A 49-year-old female with a long history of untreated hypertension secondary to PA was admitted to our hospital for medical examinations on July 18th, 2000. She had the stepwise development of dementia, dysarthria and gait disturbance (right hemiparesis). CT and MRI demonstrated multiple lacunar infarctions. She was readmitted to our hospital on Jan 23rd, 2002. A neurological examination revealed right hemiparesis, dysarthria and consciousness disturbance. CT on admission demonstrated ICH in the left midbrain. Six days after the hemorrhage, T2*-w MRI showed thirty-two dotHSs in the basal ganglias and the cortical-subcortical regions. The incidence of ICH in patients with hypertension secondary to PA is reported to be higher than in patients with essential hypertension. Multiple dotHS may be associated with ICH, lacunar infarction, and severe microangiopathy related to hypertension secondary to PA.
Amos D. Korczyn - One of the best experts on this subject based on the ideXlab platform.
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The underdiagnosis of the vascular contribution to dementia.
Journal of the Neurological Sciences, 2005Co-Authors: Amos D. KorczynAbstract:The existence of vascular dementia (VaD) was first identified by Marie, who described the etat lacunaire, and by Binswanger, who identified white matter lesions in the brain subcortical areas. Alois Alzheimer, when defining the disease now bearing his name, did so in a patient with a presenile onset. The majority of demented elderly people were then believed to have cerebral arteriosclerosis underlying their cognitive decline. The role of cortical vascular lesions, while clear to clinicians, was highlighted only later, by the pathological studies of Tomlinson et al. and the clinical demonstrations of Hachinski et al. who have defined multi-infarct dementia. Lately, the emphasis shifted to pathogenic mechanisms for vascular brain disease with the identification of a multitude of processes, such as Lipohyalinosis, cardiac dysfunction and genetic causes, to name only a few. Epidemiologic studies have demonstrated the high frequency of vascular lesions in brains of demented individuals, as well as the fact that vascular factors can contribute to Alzheimer's disease (AD). Moreover, many factors, which were identified as contributing to cerebrovascular disease in general and VaD in particular, are frequently suspected as predisposing to AD as well. All these considerations converge to the realization that vascular components are extremely important in the pathogenesis of old-age dementia and that prevention and perhaps treatment of dementia are within reach. These surprising findings highlight the importance of mixed vascular-degenerative dementia as a disorder that has to be properly defined.
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The complex nosological concept of vascular dementia
Journal of the Neurological Sciences, 2002Co-Authors: Amos D. KorczynAbstract:The existence of vascular dementia (VaD) was first identified by Marie, who described the etat lacunaire, and by Binswanger, who identified white matter lesions in demented individuals. The role of cortical lesions, while clear to clinicians, was highlighted only later by the pathological studies of Tomlinson and the clinical demonstrations of Hachinski et al., who have defined multi-infarct dementia. Lately, the emphasis shifted to pathogenic mechanisms with the identification of a multitude of processes, such as Lipohyalinosis, cardiac dysfunction and genetic causes, to name only a few. Epidemiologic studies have demonstrated the high frequency of VaD, as well as the fact that vascular factors can contribute to Alzheimer's disease (AD). All these considerations converge to the realization that VaD is an extremely important clinical entity and that its prevention and treatment are within reach. In fact, there is more data on how to prevent strokes (and presumably VaD) than on how to prevent AD. Moreover, many factors which were identified as contributing to cerebrovascular disease in general and VaD in particular are frequently suspected as predisposing to AD as well. These unexpected findings highlight the importance of mixed vascular-degenerative dementia as a disorder which has to be properly defined and has important implications on prevention and treatment.
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Mixed dementia--the most common cause of dementia.
Annals of the New York Academy of Sciences, 2002Co-Authors: Amos D. KorczynAbstract:The existence of vascular dementia (VaD) was first identified by Marie, who described the etat lacunaire, and by Binswanger, who identified white matter lesions. The role of cortical lesions, while clear to clinicians, was highlighted only later by the pathological studies of Tomlinson and the clinical demonstrations of Hachinski et al., who have defined multi-infarct dementia. Lately, the emphasis shifted to pathogenic mechanisms with the identification of a multitude of processes, including Lipohyalinosis, cardiac dysfunction, and genetic causes, to name only a few. Epidemiologic studies have demonstrated the high frequency of VaD, as well as the fact that vascular factors can contribute to Alzheimer's disease (AD). All these considerations converge to the realization that VaD is an extremely important clinical entity and that its prevention and treatment are within reach. In fact, there are more data on how to prevent strokes (and presumably VaD) than AD. Moreover, many factors that were identified as contributing to cerebrovascular disease in general and VaD in particular are frequently suspected as predisposing to AD as well. This surprising finding highlights the importance of mixed vascular-degenerative dementia as a disorder that has to be properly defined and has important implications on prevention and treatment.
Bin Peng - One of the best experts on this subject based on the ideXlab platform.
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Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory.
Frontiers in neurology, 2019Co-Authors: Yuze Cao, Ming Yao, Li-xin Zhou, Bin Peng, Yicheng Zhu, Mengyu Zhang, Liying CuiAbstract:Objective: Lipohyalinosis or atherosclerosis might be responsible for single subcortical infarctions (SSIs); however, ways of differentiating between the two clinically remain uncertain. We aimed to investigate whether consecutive slides on axial view or transversal diameter is more effective to differentiate mechanisms by comparing their relationships with white matter hyperintensities (WMHs). Methods: All the participants from the Standard Medical Management in Secondary Prevention of Ischemic stroke in China (SMART) cohort who had SSIs in the lenticulostriate artery territory were included and categorized according to consecutive slides on axial view (≥4 consecutive slices or not) and transversal diameter (≥15 mm or not). The associations between the severity of WMHs and the different categories were analyzed. Results: Among the 3,821 patients of the SMART study, 281 had diffusion-weighted image-proven SSIs in the lenticulostriate artery territory. When classified by consecutive slides on axial view, SSIs on ≥4 slices were significantly associated with the severity of the WMHs, both in deep WMH (DWMH) (odds ratio [OR], 0.32; 95% confidence interval [CI], 0.11–0.97; p = 0.04) and periventricular hyperintensity (PVH) (OR, 0.37; 95% CI, 0.17–0.78; p = 0.01). No such association was found on the basis of the transversal diameter (p > 0.1). Conclusion: Consecutive slides on axial view (≥4 consecutive slices) might be more effective than transversal diameter to identify the atherosclerotic mechanisms of SSIs in the lenticulostriate artery territory. Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: {"type":"clinical-trial","attrs":{"text":"NCT00664846","term_id":"NCT00664846"}}NCT00664846
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Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory
Frontiers Media S.A., 2019Co-Authors: Yuze Cao, Ming Yao, Li-xin Zhou, Bin Peng, Yicheng Zhu, Liying Cui, Mengyu ZhangAbstract:Objective: Lipohyalinosis or atherosclerosis might be responsible for single subcortical infarctions (SSIs); however, ways of differentiating between the two clinically remain uncertain. We aimed to investigate whether consecutive slides on axial view or transversal diameter is more effective to differentiate mechanisms by comparing their relationships with white matter hyperintensities (WMHs).Methods: All the participants from the Standard Medical Management in Secondary Prevention of Ischemic stroke in China (SMART) cohort who had SSIs in the lenticulostriate artery territory were included and categorized according to consecutive slides on axial view (≥4 consecutive slices or not) and transversal diameter (≥15 mm or not). The associations between the severity of WMHs and the different categories were analyzed.Results: Among the 3,821 patients of the SMART study, 281 had diffusion-weighted image-proven SSIs in the lenticulostriate artery territory. When classified by consecutive slides on axial view, SSIs on ≥4 slices were significantly associated with the severity of the WMHs, both in deep WMH (DWMH) (odds ratio [OR], 0.32; 95% confidence interval [CI], 0.11–0.97; p = 0.04) and periventricular hyperintensity (PVH) (OR, 0.37; 95% CI, 0.17–0.78; p = 0.01). No such association was found on the basis of the transversal diameter (p > 0.1).Conclusion: Consecutive slides on axial view (≥4 consecutive slices) might be more effective than transversal diameter to identify the atherosclerotic mechanisms of SSIs in the lenticulostriate artery territory.Clinical Trial Registration:http://www.clinicaltrials.gov. Unique identifier: NCT0066484
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Abstract WP183: Renal function is Associated With Severity of White Matter Hyperintensity in Patients With Acute Ischemic Stroke/TIA
Stroke, 2016Co-Authors: Lixia Zong, Ming Yao, Li-xin Zhou, Jing Yuan, Bin Peng, Yicheng Zhu, Liying CuiAbstract:Introduction: Renal function impairment is characterized by glomerular endothelial dysfunction and Lipohyalinosis, both of which are typical features of cerebral small vessel diseases(CSVD). We thus presume that renal function might be associated with silent CSVD-related MRI changes including white matter hyperintensity (WMH), lacune and microbleeds, which was supported by previous findings observed from the individuals without stroke. However, the relationship between renal function and WMH in patients with acute ischemic stroke or transcient ischemic stroke (AIS/TIA) remains unclear. Thus we aim to explore the potential risk factors of WMH in patients with AIS/TIA, especially the association between renal function and WMH located in both periventricular and deep area. Methods: A total of 1632 patients having an MRI examination were enrolled from SMART cohort for this analysis.The severity of WMH in both periventricular(PVH) and deep subcortical area(SDWMH) was evaluated using Fazekas scale. Estimated gl...