The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform

D K Smith - One of the best experts on this subject based on the ideXlab platform.

  • lipid and lipoprotein levels in adults receiving Liposyn II
    Nutrition, 1991
    Co-Authors: G E Nichoalds, R L Weinsier, W J Millikan, D K Smith
    Abstract:

    Lipid and lipoprotein levels were measured in 45 adult patients receiving parenteral nutrition for 10-14 days who were administered 20-50% of their daily total calorie requirement as Liposyn II. The study was an unblinded noncomparative multicenter investigation. Measurements were made on days 1, 3, 7, 10, and 14. Patients gained an average of 1.2 +/- 0.5 kg body wt during the study. No patient had to be removed from the study due to clinically significant adverse effects. Some changes in hematology, blood chemistry, and liver function parameters occurred, but these changes were consistent with alterations typically observed in patients receiving total parenteral nutrition. Total protein levels increased by an average of 0.30 +/- 0.13 g/dl (p less than 0.03). Plasma levels of phospholipid, triglycerides, total free fatty acids, very-low-density lipoprotein (VLDL) cholesterol and high-density-lipoprotein (HDL) cholesterol were normal or below normal at all times and did not change during the study. Significant increases occurred in total cholesterol (p less than 0.03) and low-density-lipoprotein (LDL) cholesterol (p less than 0.02) that were consistent with the mobilization of tissue cholesterol during intravenous lipid infusions. These increases do not infer any increased risk of coronary heart disease. The ratio of HDL to LDL cholesterol was 0.24-0.28 at all times.

G E Nichoalds - One of the best experts on this subject based on the ideXlab platform.

  • lipid and lipoprotein levels in adults receiving Liposyn II
    Nutrition, 1991
    Co-Authors: G E Nichoalds, R L Weinsier, W J Millikan, D K Smith
    Abstract:

    Lipid and lipoprotein levels were measured in 45 adult patients receiving parenteral nutrition for 10-14 days who were administered 20-50% of their daily total calorie requirement as Liposyn II. The study was an unblinded noncomparative multicenter investigation. Measurements were made on days 1, 3, 7, 10, and 14. Patients gained an average of 1.2 +/- 0.5 kg body wt during the study. No patient had to be removed from the study due to clinically significant adverse effects. Some changes in hematology, blood chemistry, and liver function parameters occurred, but these changes were consistent with alterations typically observed in patients receiving total parenteral nutrition. Total protein levels increased by an average of 0.30 +/- 0.13 g/dl (p less than 0.03). Plasma levels of phospholipid, triglycerides, total free fatty acids, very-low-density lipoprotein (VLDL) cholesterol and high-density-lipoprotein (HDL) cholesterol were normal or below normal at all times and did not change during the study. Significant increases occurred in total cholesterol (p less than 0.03) and low-density-lipoprotein (LDL) cholesterol (p less than 0.02) that were consistent with the mobilization of tissue cholesterol during intravenous lipid infusions. These increases do not infer any increased risk of coronary heart disease. The ratio of HDL to LDL cholesterol was 0.24-0.28 at all times.

R L Weinsier - One of the best experts on this subject based on the ideXlab platform.

  • lipid and lipoprotein levels in adults receiving Liposyn II
    Nutrition, 1991
    Co-Authors: G E Nichoalds, R L Weinsier, W J Millikan, D K Smith
    Abstract:

    Lipid and lipoprotein levels were measured in 45 adult patients receiving parenteral nutrition for 10-14 days who were administered 20-50% of their daily total calorie requirement as Liposyn II. The study was an unblinded noncomparative multicenter investigation. Measurements were made on days 1, 3, 7, 10, and 14. Patients gained an average of 1.2 +/- 0.5 kg body wt during the study. No patient had to be removed from the study due to clinically significant adverse effects. Some changes in hematology, blood chemistry, and liver function parameters occurred, but these changes were consistent with alterations typically observed in patients receiving total parenteral nutrition. Total protein levels increased by an average of 0.30 +/- 0.13 g/dl (p less than 0.03). Plasma levels of phospholipid, triglycerides, total free fatty acids, very-low-density lipoprotein (VLDL) cholesterol and high-density-lipoprotein (HDL) cholesterol were normal or below normal at all times and did not change during the study. Significant increases occurred in total cholesterol (p less than 0.03) and low-density-lipoprotein (LDL) cholesterol (p less than 0.02) that were consistent with the mobilization of tissue cholesterol during intravenous lipid infusions. These increases do not infer any increased risk of coronary heart disease. The ratio of HDL to LDL cholesterol was 0.24-0.28 at all times.

W J Millikan - One of the best experts on this subject based on the ideXlab platform.

  • lipid and lipoprotein levels in adults receiving Liposyn II
    Nutrition, 1991
    Co-Authors: G E Nichoalds, R L Weinsier, W J Millikan, D K Smith
    Abstract:

    Lipid and lipoprotein levels were measured in 45 adult patients receiving parenteral nutrition for 10-14 days who were administered 20-50% of their daily total calorie requirement as Liposyn II. The study was an unblinded noncomparative multicenter investigation. Measurements were made on days 1, 3, 7, 10, and 14. Patients gained an average of 1.2 +/- 0.5 kg body wt during the study. No patient had to be removed from the study due to clinically significant adverse effects. Some changes in hematology, blood chemistry, and liver function parameters occurred, but these changes were consistent with alterations typically observed in patients receiving total parenteral nutrition. Total protein levels increased by an average of 0.30 +/- 0.13 g/dl (p less than 0.03). Plasma levels of phospholipid, triglycerides, total free fatty acids, very-low-density lipoprotein (VLDL) cholesterol and high-density-lipoprotein (HDL) cholesterol were normal or below normal at all times and did not change during the study. Significant increases occurred in total cholesterol (p less than 0.03) and low-density-lipoprotein (LDL) cholesterol (p less than 0.02) that were consistent with the mobilization of tissue cholesterol during intravenous lipid infusions. These increases do not infer any increased risk of coronary heart disease. The ratio of HDL to LDL cholesterol was 0.24-0.28 at all times.

Michael Barton - One of the best experts on this subject based on the ideXlab platform.

  • effects of a 48 h fat infusion on insulin secretion and glucose utilization
    Diabetes, 1995
    Co-Authors: Guenther Boden, Xinhua Chen, Joel Rosner, Michael Barton
    Abstract:

    To determine the effects of prolonged elevation of plasma free fatty acids (FFAs) on insulin secretion, we infused Liposyn II (4.3 μmol · kg −1 · min −1 ) plus heparin (0.4 U · kg −1 · min −1 ) intravenously into six healthy volunteers for 48 h. Another six volunteers received saline infusions and served as control subjects. In all 12 subjects (11 men and 1 woman), plasma glucose was clamped at ∼8.6 mmol/l. Liposyn/heparin infusion resulted in a 9.4-fold increase in plasma FFA concentration (from 132 to 1,237 μmol/l), a 46% increase in insulin secretion rates (from 241 to 352 pmol/min, P −1 · min −1 , P 1 ) potentiated glucose-stimulated insulin secretion for 48 h and 2 ) initially caused peripheral insulin resistance that disappeared during the 2nd day, probably as a result of elevated circulating insulin levels. We conclude that in healthy volunteers under hyperglycemic conditions, fat infusion produced insulin resistance that was compensated for after ∼24 h by persistent hypersecretion of insulin.