The Experts below are selected from a list of 1476 Experts worldwide ranked by ideXlab platform
Per Hansson - One of the best experts on this subject based on the ideXlab platform.
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physicochemical properties of a mixed alkylglucoside surfactant water system phase behavior salt effects and microstructure surrounding a closed loop Liquid Liquid Miscibility Gap
Langmuir, 2002Co-Authors: Christy Whiddon, Olle Soderman, Per HanssonAbstract:Mixtures of n-decyl β-d-gluco-pyranoside (C10G1) and n-nonyl β-d-gluco-pyranoside (C9G1) in water were studied to determine the location of a closed-loop Liquid/Liquid Miscibility Gap. A phase diagram including the point at which the closed loop first appeared was determined, as well as the effect of salts on the location of the consolute boundaries of the loop. The microstructure surrounding the Miscibility Gap was investigated using time-resolved fluorescence quenching, cryo-transmission electron spectroscopy, and self-diffusion NMR. There appear to be bicontinuous structures of interconnected rods on both sides of the Miscibility Gap, with evidence for more extensive networks in the concentrated micellar and higher temperature regions surrounding the closed-loop Miscibility Gap.
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Physicochemical properties of a mixed alkylglucoside surfactant/water system: Phase behavior, salt effects, and microstructure surrounding a closed-loop Liquid/Liquid Miscibility Gap
Langmuir, 2002Co-Authors: Christy Whiddon, Olle Soderman, Per HanssonAbstract:Mixtures of n-decyl β-d-gluco-pyranoside (C10G1) and n-nonyl β-d-gluco-pyranoside (C9G1) in water were studied to determine the location of a closed-loop Liquid/Liquid Miscibility Gap. A phase diagram including the point at which the closed loop first appeared was determined, as well as the effect of salts on the location of the consolute boundaries of the loop. The microstructure surrounding the Miscibility Gap was investigated using time-resolved fluorescence quenching, cryo-transmission electron spectroscopy, and self-diffusion NMR. There appear to be bicontinuous structures of interconnected rods on both sides of the Miscibility Gap, with evidence for more extensive networks in the concentrated micellar and higher temperature regions surrounding the closed-loop Miscibility Gap.
Gérard Coquerel - One of the best experts on this subject based on the ideXlab platform.
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impact of sodium chloride on the expansion of a Liquid Liquid Miscibility Gap in an api water system case study of brivaracetam
International Journal of Pharmaceutics, 2016Co-Authors: Nicolas Couvrat, Eric Schenkel, Julien Mahieux, Baptiste Fours, Yohann Cartigny, Luc Quéré, Luc Aerts, Gérard CoquerelAbstract:Brivaracetam, or (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butanamide, is an active pharmaceutical ingredient designed for the treatment of epilepsy. During the development of the IV administration mode, a Liquid-Liquid Miscibility Gap has been observed with pure water, isotonic and hypertonic solutions (vehicle at 0.9% w/w and 5%w/w NaCl respectively). The study reveals that the NaCl concentration has a direct impact on the extent of the demixing domain; from a sub-micronic demixing in pure water towards a macroscopic Miscibility Gap in hypertonic aqueous solutions. The thorough exploration of these heterogeneous equilibria led to define experimental parameters for safe IV injections without risk of Liquid - Liquid Miscibility Gap at 37°C.
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Impact of sodium chloride on the expansion of a Liquid-Liquid Miscibility Gap in an API/water system. Case study of Brivaracetam.
International journal of pharmaceutics, 2016Co-Authors: Nicolas Couvrat, Eric Schenkel, Julien Mahieux, Baptiste Fours, Yohann Cartigny, Luc Quéré, Luc Aerts, Gérard CoquerelAbstract:Brivaracetam, or (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butanamide, is an active pharmaceutical ingredient designed for the treatment of epilepsy. During the development of the IV administration mode, a Liquid-Liquid Miscibility Gap has been observed with pure water, isotonic and hypertonic solutions (vehicle at 0.9% w/w and 5%w/w NaCl respectively). The study reveals that the NaCl concentration has a direct impact on the extent of the demixing domain; from a sub-micronic demixing in pure water towards a macroscopic Miscibility Gap in hypertonic aqueous solutions. The thorough exploration of these heterogeneous equilibria led to define experimental parameters for safe IV injections without risk of Liquid - Liquid Miscibility Gap at 37°C.
Christy Whiddon - One of the best experts on this subject based on the ideXlab platform.
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physicochemical properties of a mixed alkylglucoside surfactant water system phase behavior salt effects and microstructure surrounding a closed loop Liquid Liquid Miscibility Gap
Langmuir, 2002Co-Authors: Christy Whiddon, Olle Soderman, Per HanssonAbstract:Mixtures of n-decyl β-d-gluco-pyranoside (C10G1) and n-nonyl β-d-gluco-pyranoside (C9G1) in water were studied to determine the location of a closed-loop Liquid/Liquid Miscibility Gap. A phase diagram including the point at which the closed loop first appeared was determined, as well as the effect of salts on the location of the consolute boundaries of the loop. The microstructure surrounding the Miscibility Gap was investigated using time-resolved fluorescence quenching, cryo-transmission electron spectroscopy, and self-diffusion NMR. There appear to be bicontinuous structures of interconnected rods on both sides of the Miscibility Gap, with evidence for more extensive networks in the concentrated micellar and higher temperature regions surrounding the closed-loop Miscibility Gap.
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Physicochemical properties of a mixed alkylglucoside surfactant/water system: Phase behavior, salt effects, and microstructure surrounding a closed-loop Liquid/Liquid Miscibility Gap
Langmuir, 2002Co-Authors: Christy Whiddon, Olle Soderman, Per HanssonAbstract:Mixtures of n-decyl β-d-gluco-pyranoside (C10G1) and n-nonyl β-d-gluco-pyranoside (C9G1) in water were studied to determine the location of a closed-loop Liquid/Liquid Miscibility Gap. A phase diagram including the point at which the closed loop first appeared was determined, as well as the effect of salts on the location of the consolute boundaries of the loop. The microstructure surrounding the Miscibility Gap was investigated using time-resolved fluorescence quenching, cryo-transmission electron spectroscopy, and self-diffusion NMR. There appear to be bicontinuous structures of interconnected rods on both sides of the Miscibility Gap, with evidence for more extensive networks in the concentrated micellar and higher temperature regions surrounding the closed-loop Miscibility Gap.
Robert Prieler - One of the best experts on this subject based on the ideXlab platform.
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direct observation of the Liquid Miscibility Gap in the zirconia silica system
Journal of The European Ceramic Society, 2015Co-Authors: Rainer Telle, Fabian Greffrath, Robert PrielerAbstract:Abstract In the technically important ZrO 2 –SiO 2 phase system we studied Liquid phase formation and solidification by means of the containerless aero acoustic levitation preventing contamination by contact to crucible material. The behaviour of the melt was recorded by a high-speed camera allowing for direct observation of convection, formation and solidification of emulsified reams. For the first time since 1956, we re-treated the Liquidus Miscibility Gap between 59.5 mol-% and 78 mol-% SiO 2 at 2250 °C with the critical point at 2430 °C and 70 mol% SiO 2 . Quenching preserved primary microstructures of the monotectic equilibrium with ZrO 2 -dendrites in a matrix of silica glass and secondary ZrO 2 but also frozen-in Benard-Marangoni cell patterns of metastably undercooled of emulsified droplets. These microstructures remind to the partitioning and coagulation behaviour of alkali-borosilicate glasses.
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Direct observation of the Liquid Miscibility Gap in the zirconia–silica system
Journal of the European Ceramic Society, 2015Co-Authors: Rainer Telle, Fabian Greffrath, Robert PrielerAbstract:Abstract In the technically important ZrO 2 –SiO 2 phase system we studied Liquid phase formation and solidification by means of the containerless aero acoustic levitation preventing contamination by contact to crucible material. The behaviour of the melt was recorded by a high-speed camera allowing for direct observation of convection, formation and solidification of emulsified reams. For the first time since 1956, we re-treated the Liquidus Miscibility Gap between 59.5 mol-% and 78 mol-% SiO 2 at 2250 °C with the critical point at 2430 °C and 70 mol% SiO 2 . Quenching preserved primary microstructures of the monotectic equilibrium with ZrO 2 -dendrites in a matrix of silica glass and secondary ZrO 2 but also frozen-in Benard-Marangoni cell patterns of metastably undercooled of emulsified droplets. These microstructures remind to the partitioning and coagulation behaviour of alkali-borosilicate glasses.
Nicolas Couvrat - One of the best experts on this subject based on the ideXlab platform.
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impact of sodium chloride on the expansion of a Liquid Liquid Miscibility Gap in an api water system case study of brivaracetam
International Journal of Pharmaceutics, 2016Co-Authors: Nicolas Couvrat, Eric Schenkel, Julien Mahieux, Baptiste Fours, Yohann Cartigny, Luc Quéré, Luc Aerts, Gérard CoquerelAbstract:Brivaracetam, or (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butanamide, is an active pharmaceutical ingredient designed for the treatment of epilepsy. During the development of the IV administration mode, a Liquid-Liquid Miscibility Gap has been observed with pure water, isotonic and hypertonic solutions (vehicle at 0.9% w/w and 5%w/w NaCl respectively). The study reveals that the NaCl concentration has a direct impact on the extent of the demixing domain; from a sub-micronic demixing in pure water towards a macroscopic Miscibility Gap in hypertonic aqueous solutions. The thorough exploration of these heterogeneous equilibria led to define experimental parameters for safe IV injections without risk of Liquid - Liquid Miscibility Gap at 37°C.
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Impact of sodium chloride on the expansion of a Liquid-Liquid Miscibility Gap in an API/water system. Case study of Brivaracetam.
International journal of pharmaceutics, 2016Co-Authors: Nicolas Couvrat, Eric Schenkel, Julien Mahieux, Baptiste Fours, Yohann Cartigny, Luc Quéré, Luc Aerts, Gérard CoquerelAbstract:Brivaracetam, or (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butanamide, is an active pharmaceutical ingredient designed for the treatment of epilepsy. During the development of the IV administration mode, a Liquid-Liquid Miscibility Gap has been observed with pure water, isotonic and hypertonic solutions (vehicle at 0.9% w/w and 5%w/w NaCl respectively). The study reveals that the NaCl concentration has a direct impact on the extent of the demixing domain; from a sub-micronic demixing in pure water towards a macroscopic Miscibility Gap in hypertonic aqueous solutions. The thorough exploration of these heterogeneous equilibria led to define experimental parameters for safe IV injections without risk of Liquid - Liquid Miscibility Gap at 37°C.