The Experts below are selected from a list of 1017 Experts worldwide ranked by ideXlab platform

Iolo Doull - One of the best experts on this subject based on the ideXlab platform.

  • The evaluation of a novel conductometric device for the diagnosis of cystic fibrosis.
    Annals of Clinical Biochemistry, 2006
    Co-Authors: Helen C Losty, Heather Wheatley, Iolo Doull
    Abstract:

    Background We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct®) which measures Sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). Methods The device was evaluated in comparison to the measurement of Sweat chloride with the established quantitative pilocarpine iontophoresis test (QPIT) and extended in a number of patients to conductivity measurements in Liquid Sweat collected with the Macroduct® system. Sweat testing was conducted simultaneously on patients referred for diagnostic Sweat testing, on patients known to have CF and on adult volunteers. The intra-individual variability, the failure rate and diagnostic accuracy were determined. Results A total of 110 tests were performed on 100 individuals, 36 of whom had classical CF and six of whom had non-classical CF. The Nanoduct system produced a false negative result in one quarter of the patients with classical CF. Moreover, conductivity was negatively biased compared with chloride in this group. Repeat testing of the false negatives using a new batch of sensors and/or measuring conductivity in Liquid Sweat collected with the Macroduct device gave accurate diagnostic discrimination indicating that the original sensors were faulty. Photographic examination confirmed that a batch of sensors were defective. Conclusions Our experience suggests that the prototype microflow cell conductometric device cannot be used for the diagnosis of CF due to the high false negative rate. As a consequence of this study, the manufacturers have implemented a pre-testing system to quality control the sensors prior to issue.

  • The evaluation of a novel conductometric device for the diagnosis of cystic fibrosis.
    Annals of clinical biochemistry, 2006
    Co-Authors: Helen C Losty, Heather Wheatley, Iolo Doull
    Abstract:

    We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct) which measures Sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). The device was evaluated in comparison to the measurement of Sweat chloride with the established quantitative pilocarpine iontophoresis test (QPIT) and extended in a number of patients to conductivity measurements in Liquid Sweat collected with the Macroduct system. Sweat testing was conducted simultaneously on patients referred for diagnostic Sweat testing, on patients known to have CF and on adult volunteers. The intra-individual variability, the failure rate and diagnostic accuracy were determined. A total of 110 tests were performed on 100 individuals, 36 of whom had classical CF and six of whom had non-classical CF. The Nanoduct system produced a false negative result in one quarter of the patients with classical CF. Moreover, conductivity was negatively biased compared with chloride in this group. Repeat testing of the false negatives using a new batch of sensors and/or measuring conductivity in Liquid Sweat collected with the Macroduct device gave accurate diagnostic discrimination indicating that the original sensors were faulty. Photographic examination confirmed that a batch of sensors were defective. Our experience suggests that the prototype microflow cell conductometric device cannot be used for the diagnosis of CF due to the high false negative rate. As a consequence of this study, the manufacturers have implemented a pre-testing system to quality control the sensors prior to issue.

Helen C Losty - One of the best experts on this subject based on the ideXlab platform.

  • The evaluation of a novel conductometric device for the diagnosis of cystic fibrosis.
    Annals of Clinical Biochemistry, 2006
    Co-Authors: Helen C Losty, Heather Wheatley, Iolo Doull
    Abstract:

    Background We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct®) which measures Sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). Methods The device was evaluated in comparison to the measurement of Sweat chloride with the established quantitative pilocarpine iontophoresis test (QPIT) and extended in a number of patients to conductivity measurements in Liquid Sweat collected with the Macroduct® system. Sweat testing was conducted simultaneously on patients referred for diagnostic Sweat testing, on patients known to have CF and on adult volunteers. The intra-individual variability, the failure rate and diagnostic accuracy were determined. Results A total of 110 tests were performed on 100 individuals, 36 of whom had classical CF and six of whom had non-classical CF. The Nanoduct system produced a false negative result in one quarter of the patients with classical CF. Moreover, conductivity was negatively biased compared with chloride in this group. Repeat testing of the false negatives using a new batch of sensors and/or measuring conductivity in Liquid Sweat collected with the Macroduct device gave accurate diagnostic discrimination indicating that the original sensors were faulty. Photographic examination confirmed that a batch of sensors were defective. Conclusions Our experience suggests that the prototype microflow cell conductometric device cannot be used for the diagnosis of CF due to the high false negative rate. As a consequence of this study, the manufacturers have implemented a pre-testing system to quality control the sensors prior to issue.

  • The evaluation of a novel conductometric device for the diagnosis of cystic fibrosis.
    Annals of clinical biochemistry, 2006
    Co-Authors: Helen C Losty, Heather Wheatley, Iolo Doull
    Abstract:

    We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct) which measures Sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). The device was evaluated in comparison to the measurement of Sweat chloride with the established quantitative pilocarpine iontophoresis test (QPIT) and extended in a number of patients to conductivity measurements in Liquid Sweat collected with the Macroduct system. Sweat testing was conducted simultaneously on patients referred for diagnostic Sweat testing, on patients known to have CF and on adult volunteers. The intra-individual variability, the failure rate and diagnostic accuracy were determined. A total of 110 tests were performed on 100 individuals, 36 of whom had classical CF and six of whom had non-classical CF. The Nanoduct system produced a false negative result in one quarter of the patients with classical CF. Moreover, conductivity was negatively biased compared with chloride in this group. Repeat testing of the false negatives using a new batch of sensors and/or measuring conductivity in Liquid Sweat collected with the Macroduct device gave accurate diagnostic discrimination indicating that the original sensors were faulty. Photographic examination confirmed that a batch of sensors were defective. Our experience suggests that the prototype microflow cell conductometric device cannot be used for the diagnosis of CF due to the high false negative rate. As a consequence of this study, the manufacturers have implemented a pre-testing system to quality control the sensors prior to issue.

Heather Wheatley - One of the best experts on this subject based on the ideXlab platform.

  • The evaluation of a novel conductometric device for the diagnosis of cystic fibrosis.
    Annals of Clinical Biochemistry, 2006
    Co-Authors: Helen C Losty, Heather Wheatley, Iolo Doull
    Abstract:

    Background We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct®) which measures Sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). Methods The device was evaluated in comparison to the measurement of Sweat chloride with the established quantitative pilocarpine iontophoresis test (QPIT) and extended in a number of patients to conductivity measurements in Liquid Sweat collected with the Macroduct® system. Sweat testing was conducted simultaneously on patients referred for diagnostic Sweat testing, on patients known to have CF and on adult volunteers. The intra-individual variability, the failure rate and diagnostic accuracy were determined. Results A total of 110 tests were performed on 100 individuals, 36 of whom had classical CF and six of whom had non-classical CF. The Nanoduct system produced a false negative result in one quarter of the patients with classical CF. Moreover, conductivity was negatively biased compared with chloride in this group. Repeat testing of the false negatives using a new batch of sensors and/or measuring conductivity in Liquid Sweat collected with the Macroduct device gave accurate diagnostic discrimination indicating that the original sensors were faulty. Photographic examination confirmed that a batch of sensors were defective. Conclusions Our experience suggests that the prototype microflow cell conductometric device cannot be used for the diagnosis of CF due to the high false negative rate. As a consequence of this study, the manufacturers have implemented a pre-testing system to quality control the sensors prior to issue.

  • The evaluation of a novel conductometric device for the diagnosis of cystic fibrosis.
    Annals of clinical biochemistry, 2006
    Co-Authors: Helen C Losty, Heather Wheatley, Iolo Doull
    Abstract:

    We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct) which measures Sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). The device was evaluated in comparison to the measurement of Sweat chloride with the established quantitative pilocarpine iontophoresis test (QPIT) and extended in a number of patients to conductivity measurements in Liquid Sweat collected with the Macroduct system. Sweat testing was conducted simultaneously on patients referred for diagnostic Sweat testing, on patients known to have CF and on adult volunteers. The intra-individual variability, the failure rate and diagnostic accuracy were determined. A total of 110 tests were performed on 100 individuals, 36 of whom had classical CF and six of whom had non-classical CF. The Nanoduct system produced a false negative result in one quarter of the patients with classical CF. Moreover, conductivity was negatively biased compared with chloride in this group. Repeat testing of the false negatives using a new batch of sensors and/or measuring conductivity in Liquid Sweat collected with the Macroduct device gave accurate diagnostic discrimination indicating that the original sensors were faulty. Photographic examination confirmed that a batch of sensors were defective. Our experience suggests that the prototype microflow cell conductometric device cannot be used for the diagnosis of CF due to the high false negative rate. As a consequence of this study, the manufacturers have implemented a pre-testing system to quality control the sensors prior to issue.

Li Yi - One of the best experts on this subject based on the ideXlab platform.

  • Effect of clothing material on thermal responses of the human body
    Modelling and Simulation in Materials Science and Engineering, 2005
    Co-Authors: Li Fengzhi, Li Yi
    Abstract:

    The influence of clothing material on thermal responses of the human body are investigated by using an integrated model of a clothed thermoregulatory human body. A modified 25-nodes model considering the Sweat accumulation on the skin surface is applied to simulate the human physiological regulatory responses. The heat and moisture coupled transfer mechanisms, including water vapour diffusion, the moisture evaporation/condensation, the moisture sorbtion/desorption by fibres, Liquid Sweat transfer under capillary pressure, and latent heat absorption/release due to phase change, are considered in the clothing model. On comparing prediction results with the experimental data in the literature, the proposed model seems able to predict dynamic heat and moisture transfer between the human body and the clothing system. The human body's thermal responses and clothing temperature and moisture variations are compared for different clothing materials during transient periods. We concluded that the hygroscopicity of clothing materials influences the human thermoregulation process significantly during environmental transients

Li Fengzhi - One of the best experts on this subject based on the ideXlab platform.

  • Effect of clothing material on thermal responses of the human body
    Modelling and Simulation in Materials Science and Engineering, 2005
    Co-Authors: Li Fengzhi, Li Yi
    Abstract:

    The influence of clothing material on thermal responses of the human body are investigated by using an integrated model of a clothed thermoregulatory human body. A modified 25-nodes model considering the Sweat accumulation on the skin surface is applied to simulate the human physiological regulatory responses. The heat and moisture coupled transfer mechanisms, including water vapour diffusion, the moisture evaporation/condensation, the moisture sorbtion/desorption by fibres, Liquid Sweat transfer under capillary pressure, and latent heat absorption/release due to phase change, are considered in the clothing model. On comparing prediction results with the experimental data in the literature, the proposed model seems able to predict dynamic heat and moisture transfer between the human body and the clothing system. The human body's thermal responses and clothing temperature and moisture variations are compared for different clothing materials during transient periods. We concluded that the hygroscopicity of clothing materials influences the human thermoregulation process significantly during environmental transients