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Chang-phone Fung - One of the best experts on this subject based on the ideXlab platform.

  • proton pump inhibitor use significantly increases the risk of cryptogenic Liver Abscess a population based study
    Alimentary Pharmacology & Therapeutics, 2015
    Co-Authors: Yuanjen Wang, Cy Liu, Tsengshing Chen, Yungshuan Lin, Chang-phone Fung
    Abstract:

    SummaryBackground Proton pump inhibitors (PPIs) increase gastric pH and impair defence mechanisms against ingested pathogens, which may result in the overgrowth of virulent Klebsiella pneumoniae in the intestine and subsequent Liver Abscess. Aim We investigated the possible association between PPIs use and cryptogenic Liver Abscess in Taiwan. Methods We conducted a population-based case–control study using data from the National Health Insurance Research Database. A total of 958 adult cases of Liver Abscess and 3832 age- and sex-matched control patients were enrolled during 2000–2010. Conditional logistic regression was used to estimate the adjusted odds ratios (ORs) in patients using PPIs before cryptogenic Liver Abscess. Results The adjusted OR associating current use of PPIs (prescription within the past 30 days) with cryptogenic Liver Abscess was 4.7 [95% confidence interval (CI), 2.9–7.8], and recent use of PPIs (prescription within the past 31–90 days) with cryptogenic Liver Abscess was 2.9 (95% CI, 1.4–6.1). A dose–response relationship was apparent for cumulative dose of PPIs within 90 days. Adjusted OR was highest among the patients receiving PPIs more than 60 cumulative defined daily dose (OR = 6.5, 95% CI, 2.8–14.9). Conclusion Proton pump inhibitor therapy within the past 90 days was associated with an increased risk of cryptogenic Liver Abscess.

  • klebsiella pneumoniae in gastrointestinal tract and pyogenic Liver Abscess
    Emerging Infectious Diseases, 2012
    Co-Authors: Chang-phone Fung, Yi-tsung Lin, Te-li Chen, Chih-peng Tseng, Jungchung Lin, Kuoming Yeh, Fengyee Chang, Hanchuan Chuang, Kristopher L Siu
    Abstract:

    To determine the role of gastrointestinal carriage in Klebsiella pneumoniae Liver Abscess, we studied 43 patients. Bacterial isolates from Liver and fecal samples from 10 patients with this condition and 7 healthy carriers showed identical serotypes and genotypes with the same virulence. This finding indicated that gastrointestinal carriage is a predisposing factor for Liver Abscess.

  • Pyogenic Liver Abscess as the Initial Manifestation of Underlying Hepatocellular Carcinoma
    The American Journal of Medicine, 2011
    Co-Authors: Yi-tsung Lin, Chia-jen Liu, Tzeng-ji Chen, Te-li Chen, Yi-chen Yeh, Chih-peng Tseng, Fu-der Wang, Cheng-hwai Tzeng, Chang-phone Fung
    Abstract:

    Abstract Background Pyogenic Liver Abscess and hepatocellular carcinoma are common in Taiwan. We investigated the frequency of, risk factors for, and prognosis of pyogenic Liver Abscess as the initial manifestation of underlying hepatocellular carcinoma over a 12-year period in Taiwan. Methods We extracted 32,454 patients with pyogenic Liver Abscess from a nationwide health registry in Taiwan during the period 1997-2008. The frequency of and risk factors for pyogenic Liver Abscess as the initial manifestation of underlying hepatocellular carcinoma were determined. The prognosis of these patients was compared with patients with hepatocellular carcinoma but without Liver Abscess. Results A total of 698 (2.15%) patients presented with Liver Abscess as the initial manifestation of underlying hepatocellular carcinoma during the 12-year period. Liver cirrhosis, hepatitis B virus infection, hepatitis C virus infection, and age ≥65 years were independent risk factors for Liver Abscess as the initial manifestation of underlying hepatocellular carcinoma. Furthermore, these patients had a lower 2-year survival rate than patients with hepatocellular carcinoma but without Liver Abscess (30% vs 37%; P =.004). Conclusions The prognosis of patients who presented with pyogenic Liver Abscess as the initial manifestation of underlying hepatocellular carcinoma was poor. Physicians should not ignore the possibility of underlying hepatocellular carcinoma in patients with risk factors for the disease in regions with a high prevalence of both pyogenic Liver Abscess and hepatocellular carcinoma.

  • high prevalence of phagocytic resistant capsular serotypes of klebsiella pneumoniae in Liver Abscess
    Microbes and Infection, 2004
    Co-Authors: Jungchung Lin, Chang-phone Fung, Fengyee Chang, Hsiaopei Cheng, Jaangjiun Wang, Liyueh Huang, L K Siu
    Abstract:

    To better understand the role of capsular polysaccharide (CPS) K1 or K2 in Klebsiella pneumoniae Liver Abscess as well as the development of metastasis to eye, neutrophil phagocytosis of 70 CPS isolates including K1 (n = 23)/K2 (n = 10), non-K1/K2 (n = 37) was evaluated by flow cytometry, fluorescence imaging, and electron microscopy. K1/K2 isolates were significantly more resistant to phagocytosis (P < 0.0001) than non-K1/K2 isolates and displayed increased resistance to intracellular killing. Although mucoid phenotype (M-type) K1/K2 isolates were significantly more resistant to phagocytosis (P = 0.0029) than M-type non-K1/K2, no significant difference in the phagocytosis rate was observed between K1/K2 isolates with M-type and non-M-type (P = 0.0924). Mucoidy is an associated factor that was predominant in K1/K2 isolates, but which itself is not an independent influence on phagocytic resistance. The K1/K2 CPS proved significantly more resistant to phagocytosis than non-K1/K2 CPS in Liver Abscess isolates (P < 0.0001) and non-Abscess isolates (P = 0.0001), suggesting that K1/K2 isolates were generally more virulent in both Liver Abscess and in non-Liver Abscess conditions. These findings indicate that resistance of CPS K1 or K2 K. pneumoniae to phagocytosis and intracellular killing presumably contributes to their high prevalence in Liver Abscess and uniquely in endophthalmitis.

Sang Won Park - One of the best experts on this subject based on the ideXlab platform.

  • risk factor analysis of invasive Liver Abscess caused by the k1 serotype klebsiella pneumoniae
    European Journal of Clinical Microbiology & Infectious Diseases, 2009
    Co-Authors: Jinkyung Kim, Doo Ryeon Chung, Seong Heon Wie, J H Yoo, Sang Won Park
    Abstract:

    The increasing prevalence of Klebsiella pneumoniae Liver Abscess in Asian countries is attributable to virulent strains of the K1 serotype. We investigated the risk factors for the K1 serotype K. pneumoniae Liver Abscess. A case-control study was performed using the database of a nationwide study of Liver Abscess in Korea. Multivariate logistic regression analysis was performed for 78 cases of the K1 serotype K. pneumoniae Liver Abscess and 81 controls with non-Klebsiella. Diabetes mellitus was the significant risk factor (OR 2.13; 95% CI 1.026 ~ 4.428; P = 0.042) for the K1 serotype K. pneumoniae Liver Abscess. Biliary disorders had a strong negative association (OR 0.18; 95% CI 0.078 ~ 0.410; P < 0.001). This study suggests that diabetes mellitus is a more significant risk factor for the K1 serotype K. pneumoniae Liver Abscess than for the non-Klebsiella Liver Abscess.

Wenhsin Huang - One of the best experts on this subject based on the ideXlab platform.

  • pyogenic Liver Abscess associated with large colonic tubulovillous adenoma
    World Journal of Gastroenterology, 2006
    Co-Authors: Cho-yu Chan, Chih Bin Chen, Chengyuan Peng, Wenhsin Huang
    Abstract:

    (7-9) . We hereby report two cases of pyogenic Liver Abscess both of which were found to have colonic tubulovillous adenoma two to three weeks later after the diagnosis of Liver Abscess. The association of pyogenic Liver Abscess and colonic tubulovillous adenoma and the implications of these two cases are discussed. Abstract Pyogenic Liver Abscesses usually occur in association with a variety of diseases. Rarely, Liver Abscess has been reported as the presenting manifestation of colonic tubu- lovillous adenoma. We report two cases of pyogenic Liver Abscess without hepatobiliary disease or other obvious etiologies except that one had a history of diabetes mellitus (DM). The pathogen in the patient with DM was Klebsiella pneumonia (KP). In both of the patients, ileus developed about two to three weeks after the diagnosis of Liver Abscess. Colonoscopy revealed large polypoid tumors with pathological findings of tubulovillous adenoma in both cases. Two lessons were learned from these two cases: (1) an underlying cause should be aggressively investigated in patients with cryptogenic Liver Abscess; (2) DM could be one of the etiologies but not necessarily the only cause of KP Liver Abscess.

  • pyogenic Liver Abscess associated with large colonic tubulovillous adenoma
    World Journal of Gastroenterology, 2006
    Co-Authors: Hsueh Chou Lai, Chih Bin Chen, Chengyuan Peng, Cho-yu Chan, Wenhsin Huang
    Abstract:

    Pyogenic Liver Abscesses usually occur in association with a variety of diseases. Rarely, Liver Abscess has been reported as the presenting manifestation of colonic tubulovillous adenoma. We report two cases of pyogenic Liver Abscess without hepatobiliary disease or other obvious etiologies except that one had a history of diabetes mellitus (DM). The pathogen in the patient with DM was Klebsiella pneumonia (KP). In both of the patients, ileus developed about two to three weeks after the diagnosis of Liver Abscess. Colonoscopy revealed large polypoid tumors with pathological findings of tubulovillous adenoma in both cases. Two lessons were learned from these two cases: (1) an underlying cause should be aggressively investigated in patients with cryptogenic Liver Abscess; (2) DM could be one of the etiologies but not necessarily the only cause of KP Liver Abscess.

Shih-wei Lai - One of the best experts on this subject based on the ideXlab platform.

  • statin use correlates with reduced risk of pyogenic Liver Abscess a population based case control study
    Basic & Clinical Pharmacology & Toxicology, 2017
    Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei Lai
    Abstract:

    Little research is available on the relationship between statin use and pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of pyogenic Liver Abscess diagnosis, respectively. Relative risk of pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use <12 months (95% CI 0.43, 1.07), compared with participants with never use of statins. Our findings provide strong evidence that patients with current use of statins are associated with a 35% reduced odds of pyogenic Liver Abscess. The protective effect is stronger for longer duration of statin use.

  • correlation between proton pump inhibitors and risk of pyogenic Liver Abscess
    European Journal of Clinical Pharmacology, 2017
    Co-Authors: Hsienfeng Lin, Kuan-fu Liao, Cheng-li Lin, Chingmei Chang, Shih-wei Lai
    Abstract:

    Little is known about the relationship between proton pump inhibitors use and pyogenic Liver Abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and pyogenic Liver Abscess in Taiwan. This was a population-based case-control study using the database of the Taiwan National Health Insurance Program since 2000 to 2011. Subjects aged 20 to 84 who experienced their first episode of pyogenic Liver Abscess were enrolled as the case group (n = 1372). Randomly selected subjects aged 20 to 84 without pyogenic Liver Abscess were enrolled as the control group (n = 1372). Current use, early use, and late use of proton pump inhibitors was defined as subjects whose last one tablet for proton pump inhibitors was noted ≤30 days, between 31 to 90 days and ≥91 days before the date of admission for pyogenic Liver Abscess. Subjects who never received a prescription for proton pump inhibitors were defined as nonusers of proton pump inhibitors. A multivariable unconditional logistic regression model was used to measure the odds ratio and 95% confidence interval to evaluate the correlation between proton pump inhibitors use and pyogenic Liver Abscess. After adjusting for confounders, the adjusted odds ratio of pyogenic Liver Abscess was 7.59 for subjects with current use of proton pump inhibitors (95% confidence interval 5.05, 11.4), when compared with nonusers. Current use of proton pump inhibitors is associated with a greater risk of pyogenic Liver Abscess.

  • Appendectomy correlates with increased risk of pyogenic Liver Abscess: A population-based cohort study in Taiwan
    Medicine, 2016
    Co-Authors: Kuan-fu Liao, Cheng-li Lin, Shih-wei Lai, Sou-hsin Chien
    Abstract:

    Little is known on the association between appendectomy and pyogenic Liver Abscess. The objective of this study was to investigate the association between appendectomy and the risk of pyogenic Liver Abscess in Taiwan. This population-based retrospective cohort study was conducted using the hospitalization dataset of the Taiwan National Health Insurance Program. There were 212,530 subjects age 20 to 84 years with newly diagnosed appendectomy as the appendectomy group since 1998 to 2010, and 850,099 randomly selected subjects without appendectomy as the nonappendectomy group. Both appendectomy and nonappendectomy groups were matched with sex, age, comorbidities, and index year of diagnosing appendectomy. The incidence of pyogenic Liver Abscess at the end of 2011 was estimated in both groups. The multivariable Cox proportional hazards regression model was applied to investigate the hazard ratio (HR) and 95% confidence interval (CI) for risk of pyogenic Liver Abscess associated with appendectomy and other comorbidities including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus. The overall incidence of pyogenic Liver Abscess was 1.73-fold greater in the appendectomy group than that in the nonappendectomy group (3.85 vs 2.22 per 10,000 person-years, 95% CI 1.71, 1.76). The multivariable regression analysis disclosed that the adjusted HR of pyogenic Liver Abscess was 1.77 for the appendectomy group (95% CI 1.59, 1.97), when compared with the nonappendectomy group. Appendectomy is associated with increased hazard of pyogenic Liver Abscess. Further studies remain necessary to confirm our findings.

Kuan-fu Liao - One of the best experts on this subject based on the ideXlab platform.

  • statin use correlates with reduced risk of pyogenic Liver Abscess a population based case control study
    Basic & Clinical Pharmacology & Toxicology, 2017
    Co-Authors: Kuan-fu Liao, Cheng-li Lin, Kao-chi Cheng, Shih-wei Lai
    Abstract:

    Little research is available on the relationship between statin use and pyogenic Liver Abscess. The objective of the study was to determine whether prior use of statins is associated with pyogenic Liver Abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of pyogenic Liver Abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without pyogenic Liver Abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of pyogenic Liver Abscess diagnosis, respectively. Relative risk of pyogenic Liver Abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of pyogenic Liver Abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of pyogenic Liver Abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use <12 months (95% CI 0.43, 1.07), compared with participants with never use of statins. Our findings provide strong evidence that patients with current use of statins are associated with a 35% reduced odds of pyogenic Liver Abscess. The protective effect is stronger for longer duration of statin use.

  • correlation between proton pump inhibitors and risk of pyogenic Liver Abscess
    European Journal of Clinical Pharmacology, 2017
    Co-Authors: Hsienfeng Lin, Kuan-fu Liao, Cheng-li Lin, Chingmei Chang, Shih-wei Lai
    Abstract:

    Little is known about the relationship between proton pump inhibitors use and pyogenic Liver Abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and pyogenic Liver Abscess in Taiwan. This was a population-based case-control study using the database of the Taiwan National Health Insurance Program since 2000 to 2011. Subjects aged 20 to 84 who experienced their first episode of pyogenic Liver Abscess were enrolled as the case group (n = 1372). Randomly selected subjects aged 20 to 84 without pyogenic Liver Abscess were enrolled as the control group (n = 1372). Current use, early use, and late use of proton pump inhibitors was defined as subjects whose last one tablet for proton pump inhibitors was noted ≤30 days, between 31 to 90 days and ≥91 days before the date of admission for pyogenic Liver Abscess. Subjects who never received a prescription for proton pump inhibitors were defined as nonusers of proton pump inhibitors. A multivariable unconditional logistic regression model was used to measure the odds ratio and 95% confidence interval to evaluate the correlation between proton pump inhibitors use and pyogenic Liver Abscess. After adjusting for confounders, the adjusted odds ratio of pyogenic Liver Abscess was 7.59 for subjects with current use of proton pump inhibitors (95% confidence interval 5.05, 11.4), when compared with nonusers. Current use of proton pump inhibitors is associated with a greater risk of pyogenic Liver Abscess.

  • Appendectomy correlates with increased risk of pyogenic Liver Abscess: A population-based cohort study in Taiwan
    Medicine, 2016
    Co-Authors: Kuan-fu Liao, Cheng-li Lin, Shih-wei Lai, Sou-hsin Chien
    Abstract:

    Little is known on the association between appendectomy and pyogenic Liver Abscess. The objective of this study was to investigate the association between appendectomy and the risk of pyogenic Liver Abscess in Taiwan. This population-based retrospective cohort study was conducted using the hospitalization dataset of the Taiwan National Health Insurance Program. There were 212,530 subjects age 20 to 84 years with newly diagnosed appendectomy as the appendectomy group since 1998 to 2010, and 850,099 randomly selected subjects without appendectomy as the nonappendectomy group. Both appendectomy and nonappendectomy groups were matched with sex, age, comorbidities, and index year of diagnosing appendectomy. The incidence of pyogenic Liver Abscess at the end of 2011 was estimated in both groups. The multivariable Cox proportional hazards regression model was applied to investigate the hazard ratio (HR) and 95% confidence interval (CI) for risk of pyogenic Liver Abscess associated with appendectomy and other comorbidities including alcoholism, biliary stone, chronic kidney disease, chronic Liver diseases, and diabetes mellitus. The overall incidence of pyogenic Liver Abscess was 1.73-fold greater in the appendectomy group than that in the nonappendectomy group (3.85 vs 2.22 per 10,000 person-years, 95% CI 1.71, 1.76). The multivariable regression analysis disclosed that the adjusted HR of pyogenic Liver Abscess was 1.77 for the appendectomy group (95% CI 1.59, 1.97), when compared with the nonappendectomy group. Appendectomy is associated with increased hazard of pyogenic Liver Abscess. Further studies remain necessary to confirm our findings.

  • clinical outcome and prognostic factors of patients with pyogenic Liver Abscess requiring intensive care
    Critical Care Medicine, 2008
    Co-Authors: Wei Chen, Kuan-fu Liao, Chia Hung Chen, Kuo Liang Chiu, Hsueh Chou Lai, Wuhuei Hsu
    Abstract:

    Objective:Despite improvements in diagnosis and treatment, pyogenic Liver Abscess remains a life-threatening disease. This study evaluated clinical outcome and prognostic factors in patients with pyogenic Liver Abscess admitted to the intensive care unit.Design:Retrospective study.Setting:Medical an