The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Huan Yao Lei - One of the best experts on this subject based on the ideXlab platform.
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A role for chronic parvovirus B19 infection in Liver Dysfunction in renal transplant recipients
Transplantation, 2002Co-Authors: Po-chang Lee, Chung-jye Hung, Yih Jyh Lin, Jen Ren Wang, Ming-shiou Jan, Huan Yao LeiAbstract:Clinically, Liver Dysfunction in renal transplant recipients is related to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. The contribution of parvovirus B19 (B19) to Liver disease in renal transplant recipients has not been studied. Here we present the association of Liver Dysfunction with or without the coinfection of B19, HBV, and HCV after renal transplantation. We used enzyme-linked immunosorbent assay to identify B19, HBV, and HCV infections in serum samples taken from 144 renal transplant recipients before transplantation and at 12 and 24 months after transplantation. After each patient had fasted for 12 hr, blood was taken for measurement of aspartate aminotransferase and alanine aminotransferase monthly for at least 6 months. Liver Dysfunction developed at the significantly higher incidence of 47% in the anti-HCV(+) patients compared with 6% in the noninfected group (P<0.0001). HBV infection had no impact on the incidence of Liver Dysfunction in renal transplant recipients. A higher incidence of Liver Dysfunction was found in 42% of B19 IgG(+)IgM(-) group patients compared with 13% of the B19 IgG(+)IgM(+) group (P=0.0051) and 9.5% of the B19 IgG(-)IgM(-) group (P=0.0003). A B19 polymerase chain reaction (PCR) assay revealed significantly higher Liver Dysfunction in 29% of B19 PCR(+) group patients compared with 13.6% of B19 PCR(-) patients (P=0.0419). Patients who were anti-HCV(+) and B19 PCR(+) had a significantly higher incidence of Liver Dysfunction than B19 PCR(-) patients (P=0.002). Chronic B19 infection and HCV infection, both separately and in combination, increase the incidence of Liver Dysfunction in renal transplant recipients. HBV infection does not seem to be independently or synergistically associated with Liver Dysfunction.
Takashi Minakawa - One of the best experts on this subject based on the ideXlab platform.
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Liver Dysfunction in Spontaneous Intracerebral Hemorrhage
Neurosurgery, 1994Co-Authors: Yukihiko Fujii, Shigekazu Takeuchi, Ryuichi Tanaka, Tetsuo Koike, Osamu Sasaki, Takashi MinakawaAbstract:The purpose of this study was to investigate the relationship between mild degrees of Liver Dysfunction and spontaneous intracerebral hemorrhage (ICH) from the hemostatic standpoint. A detailed study of hemostatic systems was made in 462 patients with ICH. To compare ICH with the other cerebrovascular diseases, data from 120 patients with subarachnoid hemorrhage and 114 others with cerebral infarction were reviewed. At admission, the medical histories of the patients, including information about previous alcohol consumption, was taken, and blood samples were collected to perform the following studies: platelet count, fibrinogen level, prothrombin time, activated partial thromboplastin time, antithrombin III, plasminogen and alpha 2-antiplasmin activity, platelet aggregability, and Liver function tests. The incidence of Liver Dysfunction and alcohol consumption in patients with ICH was significantly (P < 0.05) higher than in patients with subarachnoid hemorrhage and in those with cerebral infarction. Hematoma volume, mortality rate, and past alcohol consumption in patients with ICH significantly increased with worsening severity of Liver Dysfunction. Although almost all hemostatic parameters became worse with increasing severity of Liver Dysfunction, they changed within the normal limits. Platelet aggregability and alpha 2-antiplasmin activity in patients with Liver Dysfunction were remarkably deteriorated beyond normal limits. In conclusion, Liver Dysfunction associated with alcohol consumption appears to be an important factor in the deterioration of the clinical status of patients with ICH and may be one of the causative factors in the development of ICH. Although mildly impaired hemostatic systems may be partially responsible for these adverse effects of Liver Dysfunction on ICH, it seems probable that nonhemostatic mechanisms are attributed to the effects.
Po-chang Lee - One of the best experts on this subject based on the ideXlab platform.
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A role for chronic parvovirus B19 infection in Liver Dysfunction in renal transplant recipients
Transplantation, 2002Co-Authors: Po-chang Lee, Chung-jye Hung, Yih Jyh Lin, Jen Ren Wang, Ming-shiou Jan, Huan Yao LeiAbstract:Clinically, Liver Dysfunction in renal transplant recipients is related to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. The contribution of parvovirus B19 (B19) to Liver disease in renal transplant recipients has not been studied. Here we present the association of Liver Dysfunction with or without the coinfection of B19, HBV, and HCV after renal transplantation. We used enzyme-linked immunosorbent assay to identify B19, HBV, and HCV infections in serum samples taken from 144 renal transplant recipients before transplantation and at 12 and 24 months after transplantation. After each patient had fasted for 12 hr, blood was taken for measurement of aspartate aminotransferase and alanine aminotransferase monthly for at least 6 months. Liver Dysfunction developed at the significantly higher incidence of 47% in the anti-HCV(+) patients compared with 6% in the noninfected group (P<0.0001). HBV infection had no impact on the incidence of Liver Dysfunction in renal transplant recipients. A higher incidence of Liver Dysfunction was found in 42% of B19 IgG(+)IgM(-) group patients compared with 13% of the B19 IgG(+)IgM(+) group (P=0.0051) and 9.5% of the B19 IgG(-)IgM(-) group (P=0.0003). A B19 polymerase chain reaction (PCR) assay revealed significantly higher Liver Dysfunction in 29% of B19 PCR(+) group patients compared with 13.6% of B19 PCR(-) patients (P=0.0419). Patients who were anti-HCV(+) and B19 PCR(+) had a significantly higher incidence of Liver Dysfunction than B19 PCR(-) patients (P=0.002). Chronic B19 infection and HCV infection, both separately and in combination, increase the incidence of Liver Dysfunction in renal transplant recipients. HBV infection does not seem to be independently or synergistically associated with Liver Dysfunction.
Yukihiko Fujii - One of the best experts on this subject based on the ideXlab platform.
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Liver Dysfunction in Spontaneous Intracerebral Hemorrhage
Neurosurgery, 1994Co-Authors: Yukihiko Fujii, Shigekazu Takeuchi, Ryuichi Tanaka, Tetsuo Koike, Osamu Sasaki, Takashi MinakawaAbstract:The purpose of this study was to investigate the relationship between mild degrees of Liver Dysfunction and spontaneous intracerebral hemorrhage (ICH) from the hemostatic standpoint. A detailed study of hemostatic systems was made in 462 patients with ICH. To compare ICH with the other cerebrovascular diseases, data from 120 patients with subarachnoid hemorrhage and 114 others with cerebral infarction were reviewed. At admission, the medical histories of the patients, including information about previous alcohol consumption, was taken, and blood samples were collected to perform the following studies: platelet count, fibrinogen level, prothrombin time, activated partial thromboplastin time, antithrombin III, plasminogen and alpha 2-antiplasmin activity, platelet aggregability, and Liver function tests. The incidence of Liver Dysfunction and alcohol consumption in patients with ICH was significantly (P < 0.05) higher than in patients with subarachnoid hemorrhage and in those with cerebral infarction. Hematoma volume, mortality rate, and past alcohol consumption in patients with ICH significantly increased with worsening severity of Liver Dysfunction. Although almost all hemostatic parameters became worse with increasing severity of Liver Dysfunction, they changed within the normal limits. Platelet aggregability and alpha 2-antiplasmin activity in patients with Liver Dysfunction were remarkably deteriorated beyond normal limits. In conclusion, Liver Dysfunction associated with alcohol consumption appears to be an important factor in the deterioration of the clinical status of patients with ICH and may be one of the causative factors in the development of ICH. Although mildly impaired hemostatic systems may be partially responsible for these adverse effects of Liver Dysfunction on ICH, it seems probable that nonhemostatic mechanisms are attributed to the effects.
Patrick Starlinger - One of the best experts on this subject based on the ideXlab platform.
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The value of indocyanine green clearance assessment to predict postoperative Liver Dysfunction in patients undergoing Liver resection.
Scientific reports, 2019Co-Authors: Christoph Schwarz, Immanuel Plass, Fabian Fitschek, Antonia Punzengruber, Martina Mittlböck, Stephanie Kampf, Ulrika Asenbaum, Patrick Starlinger, Stefan Stremitzer, Martin BodingbauerAbstract:Postoperative Liver Dysfunction remains a major concern following hepatic resection. In order to identify patients who are at risk of developing Liver Dysfunction, indocyanine green (ICG) clearance has been proposed to predict postoperative Liver function. All patients who underwent Liver resection at the Medical University Vienna, Austria between 2006 and 2015 with preoperative ICG clearance testing (PDR, R15) were analyzed in this study. Postoperative Liver Dysfunction was analyzed as defined by the International Study Group of Liver Surgery. Overall, 698 patients (male: 394 (56.4%); female: 304 (43.6%)) with a mean age of 61.3 years (SD: 12.9) were included in this study, including 313 minor Liver resections (44.8%) and 385 major Liver resections (55.2%). One hundred and seven patients developed postoperative Liver Dysfunction after Liver resection (15.3%). Factors associated with Liver Dysfunction were: male sex (p = 0.043), major Liver resection (p 5.6%. To the best of our knowledge, this is the largest study analyzing the predictive value of preoperative ICG clearance assessment in patients undergoing Liver resection. ICG clearance is useful to identify patients at risk of postoperative Liver Dysfunction.
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Plasma thrombospondin 1 as a predictor of postoperative Liver Dysfunction.
The British journal of surgery, 2015Co-Authors: Patrick Starlinger, S. Haegele, David Wanek, Silvia Zikeli, Dominic Schauer, Lejla Alidzanovic, Edith Fleischmann, Birgit Gruenberger, T. Gruenberger, Christine BrostjanAbstract:Liver regeneration following Liver resection involves a complex interplay of growth factors and their antagonists. Thrombospondin 1 has recently been identified as a critical inhibitor of Liver regeneration by the activation of transforming growth factor β1 in mice, and preliminary data seem to confirm its relevance in humans. This study aimed to confirm these observations in an independent validation cohort. Perioperative circulating levels of thrombospondin 1 were measured in patients undergoing Liver resection between January 2012 and September 2013. Postoperative Liver Dysfunction was defined according to the International Study Group of Liver Surgery and classification of morbidity was based on the criteria by Dindo et al. In 85 patients (44 major and 41 minor Liver resections), plasma levels of thrombospondin 1 increased 1 day after Liver resection (mean 51·6 ng/ml before surgery and 68·3 ng/ml on postoperative day 1; P = 0·001). Circulating thrombospondin 1 concentration on the first postoperative day specifically predicted Liver Dysfunction (area under the receiver operating characteristic (ROC) curve 0·818, P = 0·003) and was confirmed as a significant predictor in multivariable analysis (Exp(B) 1·020, 95 per cent c.i. 1·005 to 1·035; P = 0·009). Patients with a high thrombospondin 1 concentration (over 80 ng/ml) on postoperative day 1 more frequently had postoperative Liver Dysfunction than those with a lower level (28 versus 2 per cent) and severe morbidity (44 versus 15 per cent), and their length of hospital stay was more than doubled (19·7 versus 9·9 days). Thrombospondin 1 may prove a helpful clinical marker to predict postoperative Liver Dysfunction as early as postoperative day 1. © 2015 BJS Society Ltd Published by John Wiley & Sons Ltd.
