The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform

Franz Ludwig Dumoulin - One of the best experts on this subject based on the ideXlab platform.

  • Detection of Klatskin’s Tumor in Extrahepatic Bile Duct Strictures Using Delayed 18F-FDG PET/CT: Preliminary Results for 22 Patient Studies
    2014
    Co-Authors: M J Reinhardt, Ursula Jaeger, Md Holger Strunk, Md Thomas Gerhardt, Md Rol, Md Jan Bucerius, Md Tilman Sauerbruch, Md Hans-juergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    Detection of cholangiocarcinoma in extrahepatic bile duct stric-tures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using 18F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. Methods: Twenty-two PET/CT studies were per-formed on 20 patients (10 women, 10 men; mean age SD, 63 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 22 min after injection of 369 48 MBq of 18F-FDG. Blood glucose was 100 20 mg/dL. PET images were reconstructed itera-tively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quan-titative evaluation of PET images by means of standardized uptake values (SUVs). Results: Final diagnosis was histologi-cally proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 3 mo. All patients with cholangio-carcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 3.3 (range, 3.9–15.8), compared with 2.9 0.3 (range, 2.5–3.3) in patients with benign causes of strictures (P 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. Conclusion: 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures

  • detection of klatskin s tumor in extrahepatic bile duct strictures using delayed 18f fdg pet ct preliminary results for 22 patient studies
    The Journal of Nuclear Medicine, 2005
    Co-Authors: M J Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, T Sauerbruch, Hansjuergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    UNLABELLED Detection of cholangiocarcinoma in extrahepatic bile duct strictures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using (18)F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. METHODS Twenty-two PET/CT studies were performed on 20 patients (10 women, 10 men; mean age +/- SD, 63 +/- 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 +/- 22 min after injection of 369 +/- 48 MBq of 18F-FDG. Blood glucose was 100 +/- 20 mg/dL. PET images were reconstructed iteratively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quantitative evaluation of PET images by means of standardized uptake values (SUVs). RESULTS Final diagnosis was histologically proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 +/- 3 mo. All patients with cholangiocarcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 +/- 3.3 (range, 3.9-15.8), compared with 2.9 +/- 0.3 (range, 2.5-3.3) in patients with benign causes of strictures (P = 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. CONCLUSION 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures.

M J Reinhardt - One of the best experts on this subject based on the ideXlab platform.

  • Detection of Klatskin’s Tumor in Extrahepatic Bile Duct Strictures Using Delayed 18F-FDG PET/CT: Preliminary Results for 22 Patient Studies
    2014
    Co-Authors: M J Reinhardt, Ursula Jaeger, Md Holger Strunk, Md Thomas Gerhardt, Md Rol, Md Jan Bucerius, Md Tilman Sauerbruch, Md Hans-juergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    Detection of cholangiocarcinoma in extrahepatic bile duct stric-tures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using 18F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. Methods: Twenty-two PET/CT studies were per-formed on 20 patients (10 women, 10 men; mean age SD, 63 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 22 min after injection of 369 48 MBq of 18F-FDG. Blood glucose was 100 20 mg/dL. PET images were reconstructed itera-tively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quan-titative evaluation of PET images by means of standardized uptake values (SUVs). Results: Final diagnosis was histologi-cally proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 3 mo. All patients with cholangio-carcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 3.3 (range, 3.9–15.8), compared with 2.9 0.3 (range, 2.5–3.3) in patients with benign causes of strictures (P 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. Conclusion: 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures

  • detection of klatskin s tumor in extrahepatic bile duct strictures using delayed 18f fdg pet ct preliminary results for 22 patient studies
    The Journal of Nuclear Medicine, 2005
    Co-Authors: M J Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, T Sauerbruch, Hansjuergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    UNLABELLED Detection of cholangiocarcinoma in extrahepatic bile duct strictures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using (18)F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. METHODS Twenty-two PET/CT studies were performed on 20 patients (10 women, 10 men; mean age +/- SD, 63 +/- 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 +/- 22 min after injection of 369 +/- 48 MBq of 18F-FDG. Blood glucose was 100 +/- 20 mg/dL. PET images were reconstructed iteratively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quantitative evaluation of PET images by means of standardized uptake values (SUVs). RESULTS Final diagnosis was histologically proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 +/- 3 mo. All patients with cholangiocarcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 +/- 3.3 (range, 3.9-15.8), compared with 2.9 +/- 0.3 (range, 2.5-3.3) in patients with benign causes of strictures (P = 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. CONCLUSION 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures.

Ursula Jaeger - One of the best experts on this subject based on the ideXlab platform.

  • Detection of Klatskin’s Tumor in Extrahepatic Bile Duct Strictures Using Delayed 18F-FDG PET/CT: Preliminary Results for 22 Patient Studies
    2014
    Co-Authors: M J Reinhardt, Ursula Jaeger, Md Holger Strunk, Md Thomas Gerhardt, Md Rol, Md Jan Bucerius, Md Tilman Sauerbruch, Md Hans-juergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    Detection of cholangiocarcinoma in extrahepatic bile duct stric-tures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using 18F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. Methods: Twenty-two PET/CT studies were per-formed on 20 patients (10 women, 10 men; mean age SD, 63 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 22 min after injection of 369 48 MBq of 18F-FDG. Blood glucose was 100 20 mg/dL. PET images were reconstructed itera-tively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quan-titative evaluation of PET images by means of standardized uptake values (SUVs). Results: Final diagnosis was histologi-cally proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 3 mo. All patients with cholangio-carcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 3.3 (range, 3.9–15.8), compared with 2.9 0.3 (range, 2.5–3.3) in patients with benign causes of strictures (P 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. Conclusion: 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures

  • detection of klatskin s tumor in extrahepatic bile duct strictures using delayed 18f fdg pet ct preliminary results for 22 patient studies
    The Journal of Nuclear Medicine, 2005
    Co-Authors: M J Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, T Sauerbruch, Hansjuergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    UNLABELLED Detection of cholangiocarcinoma in extrahepatic bile duct strictures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using (18)F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. METHODS Twenty-two PET/CT studies were performed on 20 patients (10 women, 10 men; mean age +/- SD, 63 +/- 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 +/- 22 min after injection of 369 +/- 48 MBq of 18F-FDG. Blood glucose was 100 +/- 20 mg/dL. PET images were reconstructed iteratively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quantitative evaluation of PET images by means of standardized uptake values (SUVs). RESULTS Final diagnosis was histologically proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 +/- 3 mo. All patients with cholangiocarcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 +/- 3.3 (range, 3.9-15.8), compared with 2.9 +/- 0.3 (range, 2.5-3.3) in patients with benign causes of strictures (P = 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. CONCLUSION 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures.

Holger Strunk - One of the best experts on this subject based on the ideXlab platform.

  • detection of klatskin s tumor in extrahepatic bile duct strictures using delayed 18f fdg pet ct preliminary results for 22 patient studies
    The Journal of Nuclear Medicine, 2005
    Co-Authors: M J Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, T Sauerbruch, Hansjuergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    UNLABELLED Detection of cholangiocarcinoma in extrahepatic bile duct strictures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using (18)F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. METHODS Twenty-two PET/CT studies were performed on 20 patients (10 women, 10 men; mean age +/- SD, 63 +/- 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 +/- 22 min after injection of 369 +/- 48 MBq of 18F-FDG. Blood glucose was 100 +/- 20 mg/dL. PET images were reconstructed iteratively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quantitative evaluation of PET images by means of standardized uptake values (SUVs). RESULTS Final diagnosis was histologically proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 +/- 3 mo. All patients with cholangiocarcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 +/- 3.3 (range, 3.9-15.8), compared with 2.9 +/- 0.3 (range, 2.5-3.3) in patients with benign causes of strictures (P = 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. CONCLUSION 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures.

Thomas Gerhardt - One of the best experts on this subject based on the ideXlab platform.

  • detection of klatskin s tumor in extrahepatic bile duct strictures using delayed 18f fdg pet ct preliminary results for 22 patient studies
    The Journal of Nuclear Medicine, 2005
    Co-Authors: M J Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, T Sauerbruch, Hansjuergen Biersack, Franz Ludwig Dumoulin
    Abstract:

    UNLABELLED Detection of cholangiocarcinoma in extrahepatic bile duct strictures is a continuing challenge in clinical practice because brush cytology taken at endoscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using (18)F-FDG for noninvasive differentiation of extrahepatic bile duct strictures. METHODS Twenty-two PET/CT studies were performed on 20 patients (10 women, 10 men; mean age +/- SD, 63 +/- 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 +/- 22 min after injection of 369 +/- 48 MBq of 18F-FDG. Blood glucose was 100 +/- 20 mg/dL. PET images were reconstructed iteratively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the Liver Hilus for quantitative evaluation of PET images by means of standardized uptake values (SUVs). RESULTS Final diagnosis was histologically proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 +/- 3 mo. All patients with cholangiocarcinoma presented with focal increased uptake in the Liver Hilus with an SUV of 6.8 +/- 3.3 (range, 3.9-15.8), compared with 2.9 +/- 0.3 (range, 2.5-3.3) in patients with benign causes of strictures (P = 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the Liver Hilus. CONCLUSION 18F-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures.