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Joséa. Castro - One of the best experts on this subject based on the ideXlab platform.
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Nicotinamide late protective effects against carbon tetrachloride-induced Liver Necrosis.
Experimental and molecular pathology, 1994Co-Authors: E.c. De Ferreyra, A.s. Bernacchi, G.d. Castro, M.f. San Martı́n, Joséa. CastroAbstract:Abstract Nicotinamide (NIC) is known to increase the synthesis of pyridine nucleotides and also to inhibit the hydrolysis of them to ADP-ribose, which in turn is involved in Ca 2+ release from mitochondria via the ADP ribosylation of crucial mitochondrial proteins. In this work, we test the potential ability of NIC to be a late protective agent against CCl 4 -induced Liver Necrosis. We observed that 1 g/kg po NIC, 30 min before or 6 or 10 hr after CCl 4 (1 ml/kg), given ip as a 20% (v/v) solution in olive oil, was able to significantly prevent the necrogenic effect of the hepatotoxin at 24 hr as evidenced by determination of isocitric dehydrogenase activity in plasma or by histological observation. NIC administration 6 hr after CCl 4 prevented fatty Liver induced by hepatotoxin at 24 hr. NIC did not modify CCl 4 -induced lipid peroxidation process at 1 hr after CCl 4 and decreased the covalent binding of 14 CCl 4 to lipids. NIC decreased the levels of 14 CCl 4 reaching the Liver when given 30 min before hepatotoxin but not when given 6 hr after it. NIC lowered body temperature of rats at 1, 3, and 6 hr and augmented it at 24 hr after CCl 4 . NIC concentrations in Liver as determined by GC/MS/SIM analysis were 21 μg/g Liver 1 hr after administration and 53 μg/g at 3 hr. Late preventive effects of NIC against CCl 4 induced Liver Necrosis when given at 6 or 10 hr after CCl 4 are compatible with the hypothesis that NIC restores mitochondrial ability for Ca 2+ uptake. This hypothesis remains to be proved and is being further challenged in our laboratory.
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N-acetyl cysteine is an early but also a late preventive agent against carbon tetrachloride-induced Liver Necrosis.
Toxicology letters, 1994Co-Authors: E.g. Valles, C.r. De Castro, Joséa. CastroAbstract:N-Acetyl cysteine (NAC) treatment 30 min before or 6 or 10 h after carbon tetrachloride (CCl4) administration significantly prevented the Liver Necrosis produced by the hepatotoxin at 24 h. NAC pretreatment was able to partially decrease the covalent binding of CCl4 reactive metabolites at 1 and 3 h of poisoning and, to a small extent, the concentration of CCl4 reaching the Liver at 3 h. NAC also diminished partially the CCl4-promoted increases in lipid peroxidation at 3 h, but had an enhancing effect of its own of small intensity. Results suggest that early and late protective effects of NAC might be attributable to its prior conversion to cysteine and glutathione.
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Prevention of CCl4-induced Liver Necrosis by the calcium chelator arsenazo III.
Experimental and Molecular Pathology, 1993Co-Authors: E.c. De Ferreyra, O.m. De Fenos, A.s. Bernacchi, M. C. Villarruel, Joséa. CastroAbstract:Arsenazo III (AIII) (100 mg/kg ip in saline) administration to Sprague-Dawley male rats 30 min before or 6 or 10 hr after CCl4 [1 ml/kg ip as a 20% (v/v) solution in olive oil] significantly prevented Liver Necrosis but not fatty Liver caused by the hepatotoxin at 24 hr as demonstrated either by histology or by determination of isocitric acid dehydrogenase in plasma. AIII did not modify the CCl4 concentrations reaching the Liver, the intensity of the covalent binding of CCl4-reactive metabolites to hepatic microsomal lipids, or the CCl4-promoted lipid peroxidation process at either 1 or 3 hr of poisoning. AIII administration enhanced glutathione (GSH) levels in Liver and significantly prevented the CCl4-induced minor decreases in GSH content and the CCl4-induced increases in calcium content at 24 hr of intoxication. AIII treatment further enhanced the CCl4-induced decreases in body temperature of the poisoned rats. Results suggest that AIII's preventive effects might be related to its very well-known calcium-chelating properties, but that additional factors related to AIII's ability to increase GSH content in Liver or to decrease body temperature of CCl4-intoxicated animals may also play a role.
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Antioxidative stress therapy with dithiothreitol tetraacetate I. Protection against carbon tetrachloride induced Liver Necrosis
Archives of toxicology, 1993Co-Authors: M. M. De Mecca, G.d. Castro, Joséa. CastroAbstract:Dithiothreitol (DTT) is kown to prevent or even reverse several deleterious effects of radiation or of chemical agents operating via free radical and oxidative stress. However, its use has been hampered by its chemical instability and toxic properties. In this work, we synthesized and characterized dithiothreitol tetraacetate (DTT-Ac) which is less toxic and chemically stable, and we provided GLC/MS evidence that it is able to rapidly generate fully deacetylated DTT in Liver after its administration to rats. Treatment with DTT-Ac simultaneously with CCl4 or 3 h after the hepatotoxin was able to significantly prevent the CCl4-induced Liver Necrosis at 24 h after poisoning. DTT-Ac administration was able to significantly reduce the intensity of the covalent binding of CCl4 reactive metabolites to microsomal lipids (CB), but it did not prevent the CCl4-induced initiation of a lipid peroxidation (LP) process as evidenced by diene hyperconjugation of microsomal lipids.
Michel Ducreux - One of the best experts on this subject based on the ideXlab platform.
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Predisposing Factors of Liver Necrosis after Transcatheter Arterial Chemoembolization in Liver Metastases from Neuroendocrine Tumor
CardioVascular and Interventional Radiology, 2015Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:PURPOSE: To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases. METHODS: A total of 164 patients receiving 374 TACE were reviewed retrospectively to analyze predictive factors of Liver Necrosis. We analyzed patient age and sex; metastasis number and location; percentage of Liver involvement; baseline Liver function test; and pretreatment imaging abnormalities such as bile duct dilatation (BDD), portal vein narrowing (PVN), and portal vein thrombosis (PVT). We analyzed TACE technique such as Lipiodol or drug-eluting beads (DEB) as the drug's vector; dose of chemotherapy; diameter of DEB; and number, frequency, and selectivity of TACE. RESULTS: Liver Necrosis developed after 23 (6.1 %) of 374 TACE. In multivariate analysis, DEB > 300 μm in size induced more Liver Necrosis compared to Lipiodol (odds ratio [OR] 35.20; p < 0.0001) or with DEB < 300 μm in size (OR 19.95; p < 0.010). Pretreatment BDD (OR 119.64; p < 0.0001) and PVT (OR 9.83; p = 0.030) were predictive of Liver Necrosis. BDD or PVT responsible for Liver Necrosis were present before TACE in 59 % (13 of 22) and were induced by a previous TACE in 41 % (9 of 22) of cases. CONCLUSION: DEB > 300 μm in size, BDD, and PVT are responsible for increased rate of Liver Necrosis after TACE. Careful analysis of BDD or PVT on pretreatment images as well as images taken between two courses can help avoid TACE complications.
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Predisposing factors of Liver Necrosis after transcatheter arterial chemoembolization in Liver metastases from neuroendocrine tumor.
Cardiovascular and interventional radiology, 2014Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:Purpose To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases.
Julien Joskin - One of the best experts on this subject based on the ideXlab platform.
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Predisposing Factors of Liver Necrosis after Transcatheter Arterial Chemoembolization in Liver Metastases from Neuroendocrine Tumor
CardioVascular and Interventional Radiology, 2015Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:PURPOSE: To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases. METHODS: A total of 164 patients receiving 374 TACE were reviewed retrospectively to analyze predictive factors of Liver Necrosis. We analyzed patient age and sex; metastasis number and location; percentage of Liver involvement; baseline Liver function test; and pretreatment imaging abnormalities such as bile duct dilatation (BDD), portal vein narrowing (PVN), and portal vein thrombosis (PVT). We analyzed TACE technique such as Lipiodol or drug-eluting beads (DEB) as the drug's vector; dose of chemotherapy; diameter of DEB; and number, frequency, and selectivity of TACE. RESULTS: Liver Necrosis developed after 23 (6.1 %) of 374 TACE. In multivariate analysis, DEB > 300 μm in size induced more Liver Necrosis compared to Lipiodol (odds ratio [OR] 35.20; p < 0.0001) or with DEB < 300 μm in size (OR 19.95; p < 0.010). Pretreatment BDD (OR 119.64; p < 0.0001) and PVT (OR 9.83; p = 0.030) were predictive of Liver Necrosis. BDD or PVT responsible for Liver Necrosis were present before TACE in 59 % (13 of 22) and were induced by a previous TACE in 41 % (9 of 22) of cases. CONCLUSION: DEB > 300 μm in size, BDD, and PVT are responsible for increased rate of Liver Necrosis after TACE. Careful analysis of BDD or PVT on pretreatment images as well as images taken between two courses can help avoid TACE complications.
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Predisposing factors of Liver Necrosis after transcatheter arterial chemoembolization in Liver metastases from neuroendocrine tumor.
Cardiovascular and interventional radiology, 2014Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:Purpose To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases.
David Malka - One of the best experts on this subject based on the ideXlab platform.
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Predisposing Factors of Liver Necrosis after Transcatheter Arterial Chemoembolization in Liver Metastases from Neuroendocrine Tumor
CardioVascular and Interventional Radiology, 2015Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:PURPOSE: To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases. METHODS: A total of 164 patients receiving 374 TACE were reviewed retrospectively to analyze predictive factors of Liver Necrosis. We analyzed patient age and sex; metastasis number and location; percentage of Liver involvement; baseline Liver function test; and pretreatment imaging abnormalities such as bile duct dilatation (BDD), portal vein narrowing (PVN), and portal vein thrombosis (PVT). We analyzed TACE technique such as Lipiodol or drug-eluting beads (DEB) as the drug's vector; dose of chemotherapy; diameter of DEB; and number, frequency, and selectivity of TACE. RESULTS: Liver Necrosis developed after 23 (6.1 %) of 374 TACE. In multivariate analysis, DEB > 300 μm in size induced more Liver Necrosis compared to Lipiodol (odds ratio [OR] 35.20; p < 0.0001) or with DEB < 300 μm in size (OR 19.95; p < 0.010). Pretreatment BDD (OR 119.64; p < 0.0001) and PVT (OR 9.83; p = 0.030) were predictive of Liver Necrosis. BDD or PVT responsible for Liver Necrosis were present before TACE in 59 % (13 of 22) and were induced by a previous TACE in 41 % (9 of 22) of cases. CONCLUSION: DEB > 300 μm in size, BDD, and PVT are responsible for increased rate of Liver Necrosis after TACE. Careful analysis of BDD or PVT on pretreatment images as well as images taken between two courses can help avoid TACE complications.
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Predisposing factors of Liver Necrosis after transcatheter arterial chemoembolization in Liver metastases from neuroendocrine tumor.
Cardiovascular and interventional radiology, 2014Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:Purpose To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases.
Thierry De Baere - One of the best experts on this subject based on the ideXlab platform.
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Predisposing Factors of Liver Necrosis after Transcatheter Arterial Chemoembolization in Liver Metastases from Neuroendocrine Tumor
CardioVascular and Interventional Radiology, 2015Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:PURPOSE: To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases. METHODS: A total of 164 patients receiving 374 TACE were reviewed retrospectively to analyze predictive factors of Liver Necrosis. We analyzed patient age and sex; metastasis number and location; percentage of Liver involvement; baseline Liver function test; and pretreatment imaging abnormalities such as bile duct dilatation (BDD), portal vein narrowing (PVN), and portal vein thrombosis (PVT). We analyzed TACE technique such as Lipiodol or drug-eluting beads (DEB) as the drug's vector; dose of chemotherapy; diameter of DEB; and number, frequency, and selectivity of TACE. RESULTS: Liver Necrosis developed after 23 (6.1 %) of 374 TACE. In multivariate analysis, DEB > 300 μm in size induced more Liver Necrosis compared to Lipiodol (odds ratio [OR] 35.20; p < 0.0001) or with DEB < 300 μm in size (OR 19.95; p < 0.010). Pretreatment BDD (OR 119.64; p < 0.0001) and PVT (OR 9.83; p = 0.030) were predictive of Liver Necrosis. BDD or PVT responsible for Liver Necrosis were present before TACE in 59 % (13 of 22) and were induced by a previous TACE in 41 % (9 of 22) of cases. CONCLUSION: DEB > 300 μm in size, BDD, and PVT are responsible for increased rate of Liver Necrosis after TACE. Careful analysis of BDD or PVT on pretreatment images as well as images taken between two courses can help avoid TACE complications.
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Predisposing factors of Liver Necrosis after transcatheter arterial chemoembolization in Liver metastases from neuroendocrine tumor.
Cardiovascular and interventional radiology, 2014Co-Authors: Julien Joskin, Thierry De Baere, Anne Aupérin, Lambros Tselikas, Boris Guiu, Geoffroy Farouil, Valérie Boige, David Malka, Sophie Leboulleux, Michel DucreuxAbstract:Purpose To investigate predictive factors for Liver Necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine Liver metastases.