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Santo Davide Ferrara - One of the best experts on this subject based on the ideXlab platform.
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A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.
Forensic science international, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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A case of β-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
Forensic Science International, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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Case report A case of b-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:b-Carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amineneurotransmitters,orbydirectinteractionwithspecificreceptors; theyarefoundinnumerousplants,includingPeganumharmala,Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing b-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography‐mass spectrometry in the seed extract and the patient’s urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings. # 2008 Elsevier Ireland Ltd. All rights reserved.
Giampietro Frison - One of the best experts on this subject based on the ideXlab platform.
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A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.
Forensic science international, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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A case of β-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
Forensic Science International, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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Case report A case of b-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:b-Carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amineneurotransmitters,orbydirectinteractionwithspecificreceptors; theyarefoundinnumerousplants,includingPeganumharmala,Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing b-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography‐mass spectrometry in the seed extract and the patient’s urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings. # 2008 Elsevier Ireland Ltd. All rights reserved.
Masanobu Kano - One of the best experts on this subject based on the ideXlab platform.
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Roles of phospholipase Cβ4 in synapse elimination and plasticity in developing and mature cerebellum
Molecular Neurobiology, 2001Co-Authors: Kouichi Hashimoto, Masahiko Watanabe, Mariko Miyata, Masanobu KanoAbstract:The β isoforms of phospholipase C (PLCβs) are thought to mediate signals from metabotropic glutamate receptor subtype 1 (mGluR1) that is crucial for the modulation of synaptic transmission and plasticity. Among four PLCβ isoforms, PLCβ4 is one of the two major isoforms expressed in cerebellar Purkinje cells. The authors have studied the roles of PLCβ4 by analyzing PLCβ4 knock-out mice, which are viable, but exhibit Locomotor Ataxia. Their cerebellar histology, parallel fiber synapse formation, and basic electrophysiology appear normal. However, developmental elimination of multiple climbing fiber innervation is clearly impaired in the rostral portion of the cerebellar vermis, where PLCβ4 mRNA is predominantly expressed in the wild-type mice. In the adult, long-term depression is deficient at parallel fiber to Purkinje cell synapses in the rostral cerebellum of the PLCβ4 knockout mice. The impairment of climbing fiber synapse elimination and the loss of long-term depression are similar to those seen in mice defective in mGluR1, Gαq, or protein kinase C. Thus, the authors’ results strongly suggest that PLCβ4 is part of a signaling pathway, including the mGluR1, Gαq and protein kinase C, which is crucial for both climbing fiber synapse elimination in the developing cerebellum and long-term depression induction in the mature cerebellum.
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Roles of phospholipase Cbeta4 in synapse elimination and plasticity in developing and mature cerebellum.
Molecular neurobiology, 2001Co-Authors: Kouichi Hashimoto, Masahiko Watanabe, Mariko Miyata, Masanobu KanoAbstract:The beta isoforms of phospholipase C (PLCbetas) are thought to mediate signals from metabotropic glutamate receptor subtype 1 (mGluR1) that is crucial for the modulation of synaptic transmission and plasticity. Among four PLCbeta isoforms, PLCbeta4 is one of the two major isoforms expressed in cerebellar Purkinje cells. The authors have studied the roles of PLCbeta4 by analyzing PLCbeta4 knockout mice, which are viable, but exhibit Locomotor Ataxia. Their cerebellar histology, parallel fiber synapse formation, and basic electrophysiology appear normal. However, developmental elimination of multiple climbing fiber innervation is clearly impaired in the rostral portion of the cerebellar vermis, where PLCbeta4 mRNA is predominantly expressed in the wild-type mice. In the adult, long-term depression is deficient at parallel fiber to Purkinje cell synapses in the rostral cerebellum of the PLCbeta4 knockout mice. The impairment of climbing fiber synapse elimination and the loss of long-term depression are similar to those seen in mice defective in mGluR1, Galphaq, or protein kinase C. Thus, the authors' results strongly suggest that PLCbeta4 is part of a signaling pathway, including the mGluR1, Galphaq and protein kinase C, which is crucial for both climbing fiber synapse elimination in the developing cerebellum and long-term depression induction in the mature cerebellum.
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Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum
Proceedings of the National Academy of Sciences of the United States of America, 1998Co-Authors: Masanobu Kano, Kouichi Hashimoto, Masahiko Watanabe, Hideo Kurihara, Stefan Offermanns, Huiping Jiang, Kisun Jun, Hee-sup Shin, Yoshiro InoueAbstract:Elimination of excess climbing fiber (CF)–Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Gαq, and the γ isoform of protein kinase C. To identify phospholipase C (PLC) isoforms involved in this process, we generated mice deficient in PLCβ4, one of two major isoforms expressed in Purkinje cells. PLCβ4 mutant mice are viable but exhibit Locomotor Ataxia. Their cerebellar histology, parallel fiber synapse formation, and basic electrophysiology appear normal. However, developmental elimination of multiple CF innervation clearly is impaired in the rostral portion of the cerebellar vermis, in which PLCβ4 mRNA is predominantly expressed. By contrast, CF synapse elimination is normal in the caudal cerebellum, in which low levels of PLCβ4 mRNA but reciprocally high levels of PLCβ3 mRNA are found. These results indicate that PLCβ4 transduces signals that are required for CF synapse elimination in the rostral cerebellum.
Donata Favretto - One of the best experts on this subject based on the ideXlab platform.
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A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.
Forensic science international, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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A case of β-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
Forensic Science International, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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Case report A case of b-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:b-Carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amineneurotransmitters,orbydirectinteractionwithspecificreceptors; theyarefoundinnumerousplants,includingPeganumharmala,Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing b-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography‐mass spectrometry in the seed extract and the patient’s urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings. # 2008 Elsevier Ireland Ltd. All rights reserved.
Giorgio Fazzin - One of the best experts on this subject based on the ideXlab platform.
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A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.
Forensic science international, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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A case of β-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
Forensic Science International, 2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:Beta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings.
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Case report A case of b-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract
2008Co-Authors: Giampietro Frison, Donata Favretto, Giorgio Fazzin, Flavio Zancanaro, Santo Davide FerraraAbstract:b-Carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amineneurotransmitters,orbydirectinteractionwithspecificreceptors; theyarefoundinnumerousplants,includingPeganumharmala,Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing b-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, Locomotor Ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography‐mass spectrometry in the seed extract and the patient’s urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings. # 2008 Elsevier Ireland Ltd. All rights reserved.
