The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Elke Lütjen-drecoll - One of the best experts on this subject based on the ideXlab platform.
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Choroidal ganglion cells in prenatal, young, and middle-aged human donor eyes.
Current eye research, 2005Co-Authors: Christian Albrecht May, Elke Lütjen-drecollAbstract:Purpose: In the current study, the appearance and development of choroidal ganglion cells (CGCs) was investigated in eyes of 18 human donors between the 13th week of gestation (wog) and 42 years of age. Methods: The number and diameter of CGCs was evaluated in scleral and choroidal whole mounts stained for NADPH diaphorase. To demonstrate the synaptic input of the CGCs, sections were stained with antibodies against synaptophysin, vesicular acetylcholin transporter, tyrosin hydroxylase, and vesicular monoaminergic transporter 2. Results: Clusters of small CGCs were first seen in the 18th wog next to the nasal and temporal Long Ciliary Nerves. Immunohistochemistry in the 25th wog revealed 3298 and 5429 nitric oxide synthase/NADPH diaphorase positive CGCs, surrounded by numerous cholinergic and aminergic boutons. The number of CGCs decreased to 1000–2500 after birth. During postnatal development, the CGCs spread into small groups, distributed all over the choroid. The size of CGCs increased markedly up to ad...
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Characterization of nitrergic neurons in the porcine and human Ciliary Nerves.
Investigative ophthalmology & visual science, 2002Co-Authors: C. Albrecht May, Anne V. Fuchs, Michael Scheib, Elke Lütjen-drecollAbstract:PURPOSE. To further characterize a subpopulation of choroidal ganglion cells associated with the Ciliary Nerves. METHODS. Isolated Long Ciliary Nerves of porcine and human eyes containing Ciliary nerve–associated ganglion cells (CNGCs) were embedded in Epon for ultrastructural investigation, or wholemounts were stained with antibodies against nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP), vesicular acetylcholine transporter, neuropeptide Y (NPY), tyrosine hydroxylase (TH), calcitonin gene-related peptide (CGRP), substance P (SP), and synaptophysin. In addition, wholemount preparations of the choroid and of the anterior segment were stained for reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-D). Serial sections through choroid and anterior segment were stained with the prior antibodies listed. RESULTS. In the porcine choroid only CNGCs were present. They stained for brain (b)NOS and VIP and were surrounded by SP and VIP-immunoreactive (IR) nerve terminals. The axonal processes of the CNGCs followed the Ciliary Nerves to the anterior eye segment, where they formed a nerve fiber plexus that terminated in the trabecular meshwork. None of the axons passed into the sparse NOS-IR nerve fiber plexus surrounding the choroidal vasculature. The CNGCs in the human choroid morphologically resembled those seen in the pig. CONCLUSIONS. The CNGC proportion of choroidal ganglion cells is presumably involved in the intrinsic (peripheral) innervation of the aqueous outflow tissues and of the choroid. (Invest Ophthalmol Vis Sci. 2002;43:581–586)
C. Albrecht May - One of the best experts on this subject based on the ideXlab platform.
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Characterization of nitrergic neurons in the porcine and human Ciliary Nerves.
Investigative ophthalmology & visual science, 2002Co-Authors: C. Albrecht May, Anne V. Fuchs, Michael Scheib, Elke Lütjen-drecollAbstract:PURPOSE. To further characterize a subpopulation of choroidal ganglion cells associated with the Ciliary Nerves. METHODS. Isolated Long Ciliary Nerves of porcine and human eyes containing Ciliary nerve–associated ganglion cells (CNGCs) were embedded in Epon for ultrastructural investigation, or wholemounts were stained with antibodies against nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP), vesicular acetylcholine transporter, neuropeptide Y (NPY), tyrosine hydroxylase (TH), calcitonin gene-related peptide (CGRP), substance P (SP), and synaptophysin. In addition, wholemount preparations of the choroid and of the anterior segment were stained for reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-D). Serial sections through choroid and anterior segment were stained with the prior antibodies listed. RESULTS. In the porcine choroid only CNGCs were present. They stained for brain (b)NOS and VIP and were surrounded by SP and VIP-immunoreactive (IR) nerve terminals. The axonal processes of the CNGCs followed the Ciliary Nerves to the anterior eye segment, where they formed a nerve fiber plexus that terminated in the trabecular meshwork. None of the axons passed into the sparse NOS-IR nerve fiber plexus surrounding the choroidal vasculature. The CNGCs in the human choroid morphologically resembled those seen in the pig. CONCLUSIONS. The CNGC proportion of choroidal ganglion cells is presumably involved in the intrinsic (peripheral) innervation of the aqueous outflow tissues and of the choroid. (Invest Ophthalmol Vis Sci. 2002;43:581–586)
Anne V. Fuchs - One of the best experts on this subject based on the ideXlab platform.
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Characterization of nitrergic neurons in the porcine and human Ciliary Nerves.
Investigative ophthalmology & visual science, 2002Co-Authors: C. Albrecht May, Anne V. Fuchs, Michael Scheib, Elke Lütjen-drecollAbstract:PURPOSE. To further characterize a subpopulation of choroidal ganglion cells associated with the Ciliary Nerves. METHODS. Isolated Long Ciliary Nerves of porcine and human eyes containing Ciliary nerve–associated ganglion cells (CNGCs) were embedded in Epon for ultrastructural investigation, or wholemounts were stained with antibodies against nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP), vesicular acetylcholine transporter, neuropeptide Y (NPY), tyrosine hydroxylase (TH), calcitonin gene-related peptide (CGRP), substance P (SP), and synaptophysin. In addition, wholemount preparations of the choroid and of the anterior segment were stained for reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-D). Serial sections through choroid and anterior segment were stained with the prior antibodies listed. RESULTS. In the porcine choroid only CNGCs were present. They stained for brain (b)NOS and VIP and were surrounded by SP and VIP-immunoreactive (IR) nerve terminals. The axonal processes of the CNGCs followed the Ciliary Nerves to the anterior eye segment, where they formed a nerve fiber plexus that terminated in the trabecular meshwork. None of the axons passed into the sparse NOS-IR nerve fiber plexus surrounding the choroidal vasculature. The CNGCs in the human choroid morphologically resembled those seen in the pig. CONCLUSIONS. The CNGC proportion of choroidal ganglion cells is presumably involved in the intrinsic (peripheral) innervation of the aqueous outflow tissues and of the choroid. (Invest Ophthalmol Vis Sci. 2002;43:581–586)
Michael Scheib - One of the best experts on this subject based on the ideXlab platform.
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Characterization of nitrergic neurons in the porcine and human Ciliary Nerves.
Investigative ophthalmology & visual science, 2002Co-Authors: C. Albrecht May, Anne V. Fuchs, Michael Scheib, Elke Lütjen-drecollAbstract:PURPOSE. To further characterize a subpopulation of choroidal ganglion cells associated with the Ciliary Nerves. METHODS. Isolated Long Ciliary Nerves of porcine and human eyes containing Ciliary nerve–associated ganglion cells (CNGCs) were embedded in Epon for ultrastructural investigation, or wholemounts were stained with antibodies against nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP), vesicular acetylcholine transporter, neuropeptide Y (NPY), tyrosine hydroxylase (TH), calcitonin gene-related peptide (CGRP), substance P (SP), and synaptophysin. In addition, wholemount preparations of the choroid and of the anterior segment were stained for reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-D). Serial sections through choroid and anterior segment were stained with the prior antibodies listed. RESULTS. In the porcine choroid only CNGCs were present. They stained for brain (b)NOS and VIP and were surrounded by SP and VIP-immunoreactive (IR) nerve terminals. The axonal processes of the CNGCs followed the Ciliary Nerves to the anterior eye segment, where they formed a nerve fiber plexus that terminated in the trabecular meshwork. None of the axons passed into the sparse NOS-IR nerve fiber plexus surrounding the choroidal vasculature. The CNGCs in the human choroid morphologically resembled those seen in the pig. CONCLUSIONS. The CNGC proportion of choroidal ganglion cells is presumably involved in the intrinsic (peripheral) innervation of the aqueous outflow tissues and of the choroid. (Invest Ophthalmol Vis Sci. 2002;43:581–586)
David G. Charteris - One of the best experts on this subject based on the ideXlab platform.
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Neurotrophic corneal ulceration after retinal detachment surgery with retinectomy and endolaser: a case series.
JAMA ophthalmology, 2014Co-Authors: Philip J. Banerjee, Aman Chandra, Paul M. Sullivan, David G. CharterisAbstract:Importance Trigeminal nerve lesions at differing levels can result in complete or partial corneal anesthesia and ensuing epithelial breakdown. Disease progression can lead to corneal ulceration, melt, and perforation. To our knowledge, neurotrophic corneal ulceration has not previously been reported after retinal detachment surgery and argon endolaser. Observation Herein, we report a series of 5 cases of patients without diabetes who developed neuropathic corneal ulceration presumed secondary to Long Ciliary nerve compromise. This occurred within 5 to 10 weeks following vitrectomy surgery with endolaser and silicone oil tamponade for retinal detachment. Conclusions and Relevance Clinicians should be mindful of the Long Ciliary Nerves intraoperatively and, where possible, avoid heavy confluent treatment at these sites without compromising the need for adequate retinopexy. Where corneal anesthesia occurs, it is important to recognize this early and treat promptly to minimize the risk for ulceration and visual loss.
