The Experts below are selected from a list of 209601 Experts worldwide ranked by ideXlab platform
O. Ruuskanen - One of the best experts on this subject based on the ideXlab platform.
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Nasopharyngeal bacterial colonization during the first wheezing episode is associated with Longer Duration of hospitalization and higher risk of relapse in young children
European Journal of Clinical Microbiology & Infectious Diseases, 2011Co-Authors: T. Jartti, S. Kuneinen, P. Lehtinen, V. Peltola, T. Vuorinen, M. Leinonen, O. RuuskanenAbstract:The purpose of this study was to examine the association between bacterial colonization/infection and respiratory outcomes in children younger than 3 years old who were hospitalized for their first wheezing episode. This was an observational study. The primary outcome was hospitalization time and the secondary outcomes included relapses within 2 months and time to recurrent wheezing (i.e. three physician confirmed wheezing episodes) within 12 months. Bacterial antibody assays for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae and Chlamydia pneumoniae were studied as well as nasopharyngeal bacterial culture for the three former and urine pneumococcal antigen. Nasopharyngeal bacterial culture was positive in 31/52 (60%) children, serologic evidence of bacterial infection was found in 17/96 (18%) children, urine pneumococcal antigen was positive in 24/101 (24%), and any bacterial detection method was positive in 53/106 (50%) children. The children with positive nasopharyngeal bacterial culture had Longer Duration of hospitalization (hazard ratio 2.4) and more often relapsed within two months than those with negative culture (odds ratio 7.3). In this study, half of the first time wheezing children had bacterial colonization or symptomatic or asymptomatic bacterial infection. The bacterial colonization (i.e. positive nasopharyngeal bacterial culture) was associated with Longer Duration of hospitalization and higher risk of recurrent wheezing.
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Nasopharyngeal bacterial colonization during the first wheezing episode is associated with Longer Duration of hospitalization and higher risk of relapse in young children
European Journal of Clinical Microbiology and Infectious Diseases, 2010Co-Authors: T. Jartti, S. Kuneinen, P. Lehtinen, V. Peltola, T. Vuorinen, M. Leinonen, O. RuuskanenAbstract:The purpose of this study was to examine the association between bacterial colonization/infection and respiratory outcomes in children younger than 3 years old who were hospitalized for their first wheezing episode. This was an observational study. The primary outcome was hospitalization time and the secondary outcomes included relapses within 2 months and time to recurrent wheezing (i.e. three physician confirmed wheezing episodes) within 12 months. Bacterial antibody assays for and were studied as well as nasopharyngeal bacterial culture for the three former and urine pneumococcal antigen. Nasopharyngeal bacterial culture was positive in 31/52 (60%) children, serologic evidence of bacterial infection was found in 17/96 (18%) children, urine pneumococcal antigen was positive in 24/101 (24%), and any bacterial detection method was positive in 53/106 (50%) children. The children with positive nasopharyngeal bacterial culture had Longer Duration of hospitalization (hazard ratio 2.4) and more often relapsed within two months than those with negative culture (odds ratio 7.3). In this study, half of the first time wheezing children had bacterial colonization or symptomatic or asymptomatic bacterial infection. The bacterial colonization (i.e. positive nasopharyngeal bacterial culture) was associated with Longer Duration of hospitalization and higher risk of recurrent wheezing.
Jenny Ryden - One of the best experts on this subject based on the ideXlab platform.
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a Longer Duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion a cohort study
Transfusion, 2019Co-Authors: Jenny Ryden, Mark Clements, Eva Hellstromlindberg, Petter Hoglund, Gustaf EdgrenAbstract:BACKGROUND: RBC concentrates are commonly stored for up to 42 days but there has been conflicting evidence on the effect of storage Duration and clinical outcomes. Most clinical studies have focused on possible associations between Duration of storage time and risk for adverse outcomes, including mortality. Recent clinical trials did not find any such associations, but fewer studies have addressed whether storage time affects component efficacy. The main aim of this study was to determine the effect of RBC storage time on hemoglobin increment in transfused patients. STUDY DESIGN AND METHODS: Transfusion data on a cohort of patients with myelodysplastic syndromes were linked to hemoglobin measurements taken between 2 days before and 28 days after a transfusion episode. We applied a mixed-effect linear regression model, accounting for patient characteristics and time from transfusion to next hemoglobin measurement, to study the effect of RBC storage on the hemoglobin increment. RESULTS: The study population consisted of 225 patients who received 6437 RBC units. Compared to units stored less than 5 days, transfusion of blood units stored 5 to 9, 10 to 19, 20 to 29, or 30 or more days resulted in hemoglobin increases that were 0.83 (95% confidence interval [CI], 0.24-1.41), 0.92 (95% CI, 0.34-1.51), 1.33 (95% CI, 0.65-2.02) and 1.51 (95% CI, 0.58-2.43) g/L lower, respectively, per RBC unit. Results were consistent in sensitivity analyses. CONCLUSIONS: Longer RBC storage was associated with a smaller increase in hemoglobin concentration after transfusion. Although statistically significant, the effect was modest, and its clinical relevance in subgroups of patients should be investigated in prospective clinical trials.
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a Longer Duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion a cohort study
Transfusion, 2019Co-Authors: Jenny Ryden, Mark Clements, Eva Hellstromlindberg, Petter Hoglund, Gustaf EdgrenAbstract:BACKGROUND RBC concentrates are commonly stored for up to 42 days but there has been conflicting evidence on the effect of storage Duration and clinical outcomes. Most clinical studies have focused on possible associations between Duration of storage time and risk for adverse outcomes, including mortality. Recent clinical trials did not find any such associations, but fewer studies have addressed whether storage time affects component efficacy. The main aim of this study was to determine the effect of RBC storage time on hemoglobin increment in transfused patients. STUDY DESIGN AND METHODS Transfusion data on a cohort of patients with myelodysplastic syndromes were linked to hemoglobin measurements taken between 2 days before and 28 days after a transfusion episode. We applied a mixed-effect linear regression model, accounting for patient characteristics and time from transfusion to next hemoglobin measurement, to study the effect of RBC storage on the hemoglobin increment. RESULTS The study population consisted of 225 patients who received 6437 RBC units. Compared to units stored less than 5 days, transfusion of blood units stored 5 to 9, 10 to 19, 20 to 29, or 30 or more days resulted in hemoglobin increases that were 0.83 (95% confidence interval [CI], 0.24-1.41), 0.92 (95% CI, 0.34-1.51), 1.33 (95% CI, 0.65-2.02) and 1.51 (95% CI, 0.58-2.43) g/L lower, respectively, per RBC unit. Results were consistent in sensitivity analyses. CONCLUSIONS Longer RBC storage was associated with a smaller increase in hemoglobin concentration after transfusion. Although statistically significant, the effect was modest, and its clinical relevance in subgroups of patients should be investigated in prospective clinical trials.
T. Jartti - One of the best experts on this subject based on the ideXlab platform.
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Nasopharyngeal bacterial colonization during the first wheezing episode is associated with Longer Duration of hospitalization and higher risk of relapse in young children
European Journal of Clinical Microbiology & Infectious Diseases, 2011Co-Authors: T. Jartti, S. Kuneinen, P. Lehtinen, V. Peltola, T. Vuorinen, M. Leinonen, O. RuuskanenAbstract:The purpose of this study was to examine the association between bacterial colonization/infection and respiratory outcomes in children younger than 3 years old who were hospitalized for their first wheezing episode. This was an observational study. The primary outcome was hospitalization time and the secondary outcomes included relapses within 2 months and time to recurrent wheezing (i.e. three physician confirmed wheezing episodes) within 12 months. Bacterial antibody assays for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae and Chlamydia pneumoniae were studied as well as nasopharyngeal bacterial culture for the three former and urine pneumococcal antigen. Nasopharyngeal bacterial culture was positive in 31/52 (60%) children, serologic evidence of bacterial infection was found in 17/96 (18%) children, urine pneumococcal antigen was positive in 24/101 (24%), and any bacterial detection method was positive in 53/106 (50%) children. The children with positive nasopharyngeal bacterial culture had Longer Duration of hospitalization (hazard ratio 2.4) and more often relapsed within two months than those with negative culture (odds ratio 7.3). In this study, half of the first time wheezing children had bacterial colonization or symptomatic or asymptomatic bacterial infection. The bacterial colonization (i.e. positive nasopharyngeal bacterial culture) was associated with Longer Duration of hospitalization and higher risk of recurrent wheezing.
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Nasopharyngeal bacterial colonization during the first wheezing episode is associated with Longer Duration of hospitalization and higher risk of relapse in young children
European Journal of Clinical Microbiology and Infectious Diseases, 2010Co-Authors: T. Jartti, S. Kuneinen, P. Lehtinen, V. Peltola, T. Vuorinen, M. Leinonen, O. RuuskanenAbstract:The purpose of this study was to examine the association between bacterial colonization/infection and respiratory outcomes in children younger than 3 years old who were hospitalized for their first wheezing episode. This was an observational study. The primary outcome was hospitalization time and the secondary outcomes included relapses within 2 months and time to recurrent wheezing (i.e. three physician confirmed wheezing episodes) within 12 months. Bacterial antibody assays for and were studied as well as nasopharyngeal bacterial culture for the three former and urine pneumococcal antigen. Nasopharyngeal bacterial culture was positive in 31/52 (60%) children, serologic evidence of bacterial infection was found in 17/96 (18%) children, urine pneumococcal antigen was positive in 24/101 (24%), and any bacterial detection method was positive in 53/106 (50%) children. The children with positive nasopharyngeal bacterial culture had Longer Duration of hospitalization (hazard ratio 2.4) and more often relapsed within two months than those with negative culture (odds ratio 7.3). In this study, half of the first time wheezing children had bacterial colonization or symptomatic or asymptomatic bacterial infection. The bacterial colonization (i.e. positive nasopharyngeal bacterial culture) was associated with Longer Duration of hospitalization and higher risk of recurrent wheezing.
Christopher Collett Butler - One of the best experts on this subject based on the ideXlab platform.
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overview of systematic reviews assessing the evidence for shorter versus Longer Duration antibiotic treatment for bacterial infections in secondary care
PLOS ONE, 2018Co-Authors: Igho Onakpoya, Sarah A Walker, Pui San Tan, Elizabeth A Spencer, Oghenekome A Gbinigie, Johanna Cook, Martin J Llewelyn, Christopher Collett ButlerAbstract:Our objective was to assess the clinical effectiveness of shorter versus Longer Duration antibiotics for treatment of bacterial infections in adults and children in secondary care settings, using the evidence from published systematic reviews. We conducted electronic searches in MEDLINE, Embase, Cochrane, and Cinahl. Our primary outcome was clinical resolution. The quality of included reviews was assessed using the AMSTAR criteria, and the quality of the evidence was rated using the GRADE criteria. We included 6 systematic reviews (n = 3,162). Four reviews were rated high quality, and two of moderate quality. In adults, there was no difference between shorter versus Longer Duration in clinical resolution rates for peritonitis (RR 1.03, 95% CI 0.98 to 1.09, I2 = 0%), ventilator-associated pneumonia (RR 0.93; 95% CI 0.81 to 1.08, I2 = 24%), or acute pyelonephritis and septic UTI (clinical failure: RR 1.00, 95% CI 0.46 to 2.18). The quality of the evidence was very low to moderate. In children, there was no difference in clinical resolution rates for pneumonia (RR 0.98, 95% CI 0.91 to 1.04, I2 = 48%), pyelonephritis (RR 0.95, 95% CI 0.88 to 1.04) and confirmed bacterial meningitis (RR 1.02, 95% CI 0.93 to 1.11, I2 = 0%). The quality of the evidence was low to moderate. In conclusion, there is currently a limited body of evidence to clearly assess the clinical benefits of shorter versus Longer Duration antibiotics in secondary care. High quality trials assessing strategies to shorten antibiotic treatment Duration for bacterial infections in secondary care settings should now be a priority.
Martin J Llewelyn - One of the best experts on this subject based on the ideXlab platform.
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overview of systematic reviews assessing the evidence for shorter versus Longer Duration antibiotic treatment for bacterial infections in secondary care
PLOS ONE, 2018Co-Authors: Igho Onakpoya, Sarah A Walker, Pui San Tan, Elizabeth A Spencer, Oghenekome A Gbinigie, Johanna Cook, Martin J Llewelyn, Christopher Collett ButlerAbstract:Our objective was to assess the clinical effectiveness of shorter versus Longer Duration antibiotics for treatment of bacterial infections in adults and children in secondary care settings, using the evidence from published systematic reviews. We conducted electronic searches in MEDLINE, Embase, Cochrane, and Cinahl. Our primary outcome was clinical resolution. The quality of included reviews was assessed using the AMSTAR criteria, and the quality of the evidence was rated using the GRADE criteria. We included 6 systematic reviews (n = 3,162). Four reviews were rated high quality, and two of moderate quality. In adults, there was no difference between shorter versus Longer Duration in clinical resolution rates for peritonitis (RR 1.03, 95% CI 0.98 to 1.09, I2 = 0%), ventilator-associated pneumonia (RR 0.93; 95% CI 0.81 to 1.08, I2 = 24%), or acute pyelonephritis and septic UTI (clinical failure: RR 1.00, 95% CI 0.46 to 2.18). The quality of the evidence was very low to moderate. In children, there was no difference in clinical resolution rates for pneumonia (RR 0.98, 95% CI 0.91 to 1.04, I2 = 48%), pyelonephritis (RR 0.95, 95% CI 0.88 to 1.04) and confirmed bacterial meningitis (RR 1.02, 95% CI 0.93 to 1.11, I2 = 0%). The quality of the evidence was low to moderate. In conclusion, there is currently a limited body of evidence to clearly assess the clinical benefits of shorter versus Longer Duration antibiotics in secondary care. High quality trials assessing strategies to shorten antibiotic treatment Duration for bacterial infections in secondary care settings should now be a priority.
