The Experts below are selected from a list of 34980 Experts worldwide ranked by ideXlab platform
Yasser Iturriamedina - One of the best experts on this subject based on the ideXlab platform.
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a molecular gradient along the Longitudinal Axis of the human hippocampus informs large scale behavioral systems
Nature Communications, 2020Co-Authors: Jacob W Vogel, Renaud La Joie, Michel J Grothe, Alexandr Diazpapkovich, Andrew Doyle, Etienne Vachonpresseau, Claude Lepage, Reinder Vos De Wael, Rhalena A Thomas, Yasser IturriamedinaAbstract:The functional organization of the hippocampus is distributed as a gradient along its Longitudinal Axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the Longitudinal Axis of the adult human hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. Futhermore, this model generalizes to an external set of tissue samples from prenatal human hippocampi. We examine variation in this specific gene expression pattern across the whole brain, finding a distinct anterioventral-posteriodorsal gradient. We find frontal and anterior temporal regions involved in social and motivational behaviors, and more functionally connected to the anterior hippocampus, to be clearly differentiated from posterior parieto-occipital regions involved in visuospatial cognition and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single molecular gradient.
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a molecular gradient along the Longitudinal Axis of the human hippocampus informs large scale behavioral systems
bioRxiv, 2019Co-Authors: Jacob W Vogel, Renaud La Joie, Michel J Grothe, Alexandr Diazpapkovich, Andrew Doyle, Etienne Vachonpresseau, Claude Lepage, Reinder Vos De Wael, Yasser Iturriamedina, Boris C BernhardtAbstract:Abstract The functional organization of the hippocampus is distributed as a gradient along its Longitudinal Axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the Longitudinal Axis of the hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. When variation in this specific gene expression pattern was observed across the whole brain, a distinct anterioventral-posteriodorsal gradient was observed. Frontal, anterior temporal and brainstem regions involved in social and motivational behaviors, selectively vulnerable to frontotemporal dementia and more functionally connected to the anterior hippocampus could be clearly differentiated from posterior parieto-occipital and cerebellar regions involved in spatial cognition, selectively vulnerable to Alzheimers disease, and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single distinct molecular gradient. (148/150)
Edvard I Moser - One of the best experts on this subject based on the ideXlab platform.
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functional organization of the hippocampal Longitudinal Axis
Nature Reviews Neuroscience, 2014Co-Authors: Bryan A Strange, Menno P Witter, Ed S Lein, Edvard I MoserAbstract:The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) hippocampus mediates anxiety-related behaviours. However, this 'dichotomy view' may need revision. Gene expression studies demonstrate multiple functional domains along the hippocampal long Axis, which often exhibit sharply demarcated borders. By contrast, anatomical studies and electrophysiological recordings in rodents suggest that the long Axis is organized along a gradient. Together, these observations suggest a model in which functional long-Axis gradients are superimposed on discrete functional domains. This model provides a potential framework to explain and test the multiple functions ascribed to the hippocampus.
Jacob W Vogel - One of the best experts on this subject based on the ideXlab platform.
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a molecular gradient along the Longitudinal Axis of the human hippocampus informs large scale behavioral systems
Nature Communications, 2020Co-Authors: Jacob W Vogel, Renaud La Joie, Michel J Grothe, Alexandr Diazpapkovich, Andrew Doyle, Etienne Vachonpresseau, Claude Lepage, Reinder Vos De Wael, Rhalena A Thomas, Yasser IturriamedinaAbstract:The functional organization of the hippocampus is distributed as a gradient along its Longitudinal Axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the Longitudinal Axis of the adult human hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. Futhermore, this model generalizes to an external set of tissue samples from prenatal human hippocampi. We examine variation in this specific gene expression pattern across the whole brain, finding a distinct anterioventral-posteriodorsal gradient. We find frontal and anterior temporal regions involved in social and motivational behaviors, and more functionally connected to the anterior hippocampus, to be clearly differentiated from posterior parieto-occipital regions involved in visuospatial cognition and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single molecular gradient.
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a molecular gradient along the Longitudinal Axis of the human hippocampus informs large scale behavioral systems
bioRxiv, 2019Co-Authors: Jacob W Vogel, Renaud La Joie, Michel J Grothe, Alexandr Diazpapkovich, Andrew Doyle, Etienne Vachonpresseau, Claude Lepage, Reinder Vos De Wael, Yasser Iturriamedina, Boris C BernhardtAbstract:Abstract The functional organization of the hippocampus is distributed as a gradient along its Longitudinal Axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the Longitudinal Axis of the hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. When variation in this specific gene expression pattern was observed across the whole brain, a distinct anterioventral-posteriodorsal gradient was observed. Frontal, anterior temporal and brainstem regions involved in social and motivational behaviors, selectively vulnerable to frontotemporal dementia and more functionally connected to the anterior hippocampus could be clearly differentiated from posterior parieto-occipital and cerebellar regions involved in spatial cognition, selectively vulnerable to Alzheimers disease, and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single distinct molecular gradient. (148/150)
Bryan A Strange - One of the best experts on this subject based on the ideXlab platform.
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functional organization of the hippocampal Longitudinal Axis
Nature Reviews Neuroscience, 2014Co-Authors: Bryan A Strange, Menno P Witter, Ed S Lein, Edvard I MoserAbstract:The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) hippocampus mediates anxiety-related behaviours. However, this 'dichotomy view' may need revision. Gene expression studies demonstrate multiple functional domains along the hippocampal long Axis, which often exhibit sharply demarcated borders. By contrast, anatomical studies and electrophysiological recordings in rodents suggest that the long Axis is organized along a gradient. Together, these observations suggest a model in which functional long-Axis gradients are superimposed on discrete functional domains. This model provides a potential framework to explain and test the multiple functions ascribed to the hippocampus.
Renaud La Joie - One of the best experts on this subject based on the ideXlab platform.
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a molecular gradient along the Longitudinal Axis of the human hippocampus informs large scale behavioral systems
Nature Communications, 2020Co-Authors: Jacob W Vogel, Renaud La Joie, Michel J Grothe, Alexandr Diazpapkovich, Andrew Doyle, Etienne Vachonpresseau, Claude Lepage, Reinder Vos De Wael, Rhalena A Thomas, Yasser IturriamedinaAbstract:The functional organization of the hippocampus is distributed as a gradient along its Longitudinal Axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the Longitudinal Axis of the adult human hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. Futhermore, this model generalizes to an external set of tissue samples from prenatal human hippocampi. We examine variation in this specific gene expression pattern across the whole brain, finding a distinct anterioventral-posteriodorsal gradient. We find frontal and anterior temporal regions involved in social and motivational behaviors, and more functionally connected to the anterior hippocampus, to be clearly differentiated from posterior parieto-occipital regions involved in visuospatial cognition and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single molecular gradient.
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a molecular gradient along the Longitudinal Axis of the human hippocampus informs large scale behavioral systems
bioRxiv, 2019Co-Authors: Jacob W Vogel, Renaud La Joie, Michel J Grothe, Alexandr Diazpapkovich, Andrew Doyle, Etienne Vachonpresseau, Claude Lepage, Reinder Vos De Wael, Yasser Iturriamedina, Boris C BernhardtAbstract:Abstract The functional organization of the hippocampus is distributed as a gradient along its Longitudinal Axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the Longitudinal Axis of the hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. When variation in this specific gene expression pattern was observed across the whole brain, a distinct anterioventral-posteriodorsal gradient was observed. Frontal, anterior temporal and brainstem regions involved in social and motivational behaviors, selectively vulnerable to frontotemporal dementia and more functionally connected to the anterior hippocampus could be clearly differentiated from posterior parieto-occipital and cerebellar regions involved in spatial cognition, selectively vulnerable to Alzheimers disease, and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single distinct molecular gradient. (148/150)
