The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform
Manuel Marí-beffa - One of the best experts on this subject based on the ideXlab platform.
-
Ray and inter-ray blastemas interact to control bifurcations of Danio rerio fin rays
The International Journal of Developmental Biology, 2001Co-Authors: Carmen Murciano, Josefa Ruiz, Damian Maseda, Tahia D. Fernandez, Ivan Duran, José Becerra, Manuel Marí-beffaAbstract:Teleost fin rays bifurcations are characteristic of each fin ray of the fishes. These structures are formed of two parenthesis-like dermal bones (hemi-rays) and surrounded by a Loose Connective Tissue and a multistratified planar epidermis. Each ray is joined to their neighbour rays by the interray. The interray is composed of a Loose Connective Tissue surrounded by the epidermis (Becerra et al., 1983). In previous works we have shown the necessity of Tissues neighbour to the ray blastema for a proper bifurcation (Mari-Beffa et al., 1996, 1999). In this communication we present evidences in favour of the hypothesis that the interray blastema is specifically necessary for a proper differentiation of the bifurcation processes in each ray during regeneration in Danio rerio (Hamilton-Buchanan) (Cyprinidae, Teleostei).
Patricia A Nuttall - One of the best experts on this subject based on the ideXlab platform.
-
dissemination replication and trans stadial persistence of dugbe virus nairovirus bunyaviridae in the tick vector amblyomma variegatum
American Journal of Tropical Medicine and Hygiene, 1991Co-Authors: Timothy F Booth, Gordon M Steele, Anthony C Marriott, Patricia A NuttallAbstract:The dissemination and replication of Dugbe (DUG) virus and its Tissue tropisms in the tick vector Amblyomma variegatum were examined by immunohistochemical analysis using specific antibody, in situ hybridization with a viral-complementary riboprobe, and infectivity assays of dissected Tissues. Dugbe virus was localized in both unfed and feeding adults inoculated as nymphs or orally infected by capillary feeding, and in nymphs infected by capillary feeding. In non-feeding ticks, the main sites of DUG virus replication were the epidermis, hemocytes associated with Loose Connective Tissue, and a small number of phagocytic digestive cells in the gut lumen. Virus infectivity in the hemolymph was associated entirely with hemocytes. Dugbe viral antigen or infectivity was not detected in the salivary glands until after the start of feeding. Viral titers in the salivary glands of feeding ticks were about ten-fold higher than in gut, ovary, or Loose Connective Tissue. The level of infection decreased during molting and increased during feeding. Viral particles and pathologic effects were not detected in infected ticks. The primary site of trans-stadial persistence of DUG virus is the hemocytes. Tick hemocytes and other motile cells may be important in the transmission of persistent virus infection from one cell or organ to another by diapedesis.
Karen L. Herbst - One of the best experts on this subject based on the ideXlab platform.
-
Dercum’s disease: estimating the prevalence of a rare painful Loose Connective Tissue disease
Future Rare Diseases, 2021Co-Authors: Natalie Corina Munguia, B. Robert Mozayeni, Thomas F Wright, Karen L. HerbstAbstract:Background: In the USA, the Orphan Drug Act of 1983 defines a rare disease as affecting under 200,000 individuals. Dercum’s disease (DD) is a Loose Connective (adipose) Tissue disease characterized by painful lipomas. While considered a rare disease, the prevalence of DD has not been systematically assessed previously. The objective of this paper is to estimate the prevalence of DD to determine if it is rare or not. Results: Estimates of prevalence of DD using PubMed, the UK Biobank, the US Agency for Health Research and Quality Healthcare Cost and Utilization, physician practices, social media forums and internet searches found the prevalence of DD to be less than 200,000 individuals in the US. These prevalence likely overestimate the disease; however, underestimation may also occur because DD is not well known and may be misdiagnosed. Conclusion: DD meets requirements of the Orphan Drug Act to be classified as a rare disease. Further research should focus on representative population samples in the USA to better estimate the prevalence of DD. Estimating the prevalence is an important first step to increase recognition, research efforts and patient care for people living with DD.
-
Interstitial Fluid in Lipedema and Control Skin
Women's health reports (New Rochelle N.Y.), 2020Co-Authors: Marisol Allen, Michael S. Schwartz, Karen L. HerbstAbstract:Background: Fluid in lymphedema Tissue appears histologically as spaces around vessels and between dermal skin fibers. Lipedema is a painful disease of excess Loose Connective Tissue (fat) in limbs...
-
Dercum’s Disease: Estimating the prevalence of a rare painful Loose Connective Tissue disease
2020Co-Authors: Natalie Corina Munguia, B. Robert Mozayeni, Thomas Wright, Karen L. HerbstAbstract:Abstract Background In the United States (US), the Orphan Drug Act of 1983 defines a rare disease as affecting less than 200,000 individuals. In Europe, a rare disease or disorder is defined as affecting 5 individuals in 10,000 which the European commission reports to be approximately 246,000 individuals. Dercum’s disease, also known as Adiposis Dolorosa, is a rare Loose Connective (fat) Tissue disease that is characterized by painful lipomas (fatty masses). Orphanet, the National Organization for Rare Disease (NORD) and the United States National Institutes of Health (NIH) have classified Dercum’s disease as a rare disorder. The prevalence of Dercum’s disease is not well studied or understood. The objective of this paper is to estimate the prevalence of Dercum’s disease, whether it is in fact a rare disease, and increase awareness for this painful disease. Results An in-depth literature review was conducted in PubMed, the UK Biobank, the U.S. Agency for Health Research and Quality Healthcare Cost and Utilization, by incidence of disease in medical practice, in social media forums and by internet search in order to understand, estimate and determine the prevalence of Dercum’s disease. The prevalence of Dercum’s disease was found to range from 150 to 150,000 in the US population. Conclusion The data collected in this paper meet the requirements of the Orphan Drug Act which requires 200,000 individuals or less to be affected by a disorder for it to be classified as rare. These conclusions may apply to Europe as supporting data was utilized from both Sweden and the UK. Further research must be conducted to better understand subclassifications of this rare disorder.
Carmen Murciano - One of the best experts on this subject based on the ideXlab platform.
-
Ray and inter-ray blastemas interact to control bifurcations of Danio rerio fin rays
The International Journal of Developmental Biology, 2001Co-Authors: Carmen Murciano, Josefa Ruiz, Damian Maseda, Tahia D. Fernandez, Ivan Duran, José Becerra, Manuel Marí-beffaAbstract:Teleost fin rays bifurcations are characteristic of each fin ray of the fishes. These structures are formed of two parenthesis-like dermal bones (hemi-rays) and surrounded by a Loose Connective Tissue and a multistratified planar epidermis. Each ray is joined to their neighbour rays by the interray. The interray is composed of a Loose Connective Tissue surrounded by the epidermis (Becerra et al., 1983). In previous works we have shown the necessity of Tissues neighbour to the ray blastema for a proper bifurcation (Mari-Beffa et al., 1996, 1999). In this communication we present evidences in favour of the hypothesis that the interray blastema is specifically necessary for a proper differentiation of the bifurcation processes in each ray during regeneration in Danio rerio (Hamilton-Buchanan) (Cyprinidae, Teleostei).
Ricardo Azziz - One of the best experts on this subject based on the ideXlab platform.
-
Endocrinology of the Ovary
Endocrinology, 1Co-Authors: Denis A. Magoffin, A. Kumar, Bulent O. Yildiz, Ricardo AzzizAbstract:The ovary is a complex endocrine organ with both a cortex and a medulla. The medulla contains primarily Loose Connective Tissue, blood vessels, and nerves, but few follicles. The ovarian cortex is composed of primordial and developing follicles, corpora lutea, and corpora albicantia distributed in Loose Connective Tissue known as the interfollicular stroma (Fig. 1).
