The Experts below are selected from a list of 2853 Experts worldwide ranked by ideXlab platform
Kamal Dua - One of the best experts on this subject based on the ideXlab platform.
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Formulation and evaluation of proniosomes containing Lornoxicam
Drug Delivery and Translational Research, 2016Co-Authors: Jyotsana R. Madan, Nitesh P. Ghuge, Kamal DuaAbstract:Proniosomes are the new generation provesicular drug delivery system of non-ionic surfactant, lecithin and cholesterol which upon reconstitution get converted into niosomes. The objective of current study was to develop stable and sustain transdermal delivery system for Lornoxicam. Lornoxicam-loaded topically applied proniosomal gel was formulated, optimized, and evaluated with the aim to deliver drug transdermally. Lornoxicam-loaded proniosomal gels were prepared that contained Lutrol F68 and lecithin as surfactants, cholesterol as a stabilizer, and minimal amount of ethanol and trace water. The resultant Lornoxicam-loaded proniosomal gel were assessed for stability and the proniosomes-derived niosomes were characterized for morphology, size, zeta potential, and entrapment efficiency, which revealed that they were suitable for skin application. The coacervation phase separation technique was used in formulation of Lornoxicam proniosomal gel and the gel was further assessed for in vitro permeation of Lornoxicam through the freshly excised rat skin and the cumulative permeation amount of Lornoxicam from proniosome, all exhibited significant increase as compared to 1.0 % Lornoxicam-loaded pure gel. The optimized F5 batch had shown maximum entrapment efficiency up to 66.98 %. It has shown sustained drug release for more than 24 h. The skin permeability of proniosomal gel was found to be 59.73 %. The SEM and zeta potential studies showed formation of good and stable vesicles. Thus, proniosomes proved to have better potential for transdermal delivery of Lornoxicam over conventional gel formulations.
Mohamed Hashish - One of the best experts on this subject based on the ideXlab platform.
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Effects of Lornoxicam on the hemodynamic and catecholamine response to laryngoscopy and tracheal intubation
European Journal of Clinical Pharmacology, 2011Co-Authors: Mohamed Daabiss, Mohamed HashishAbstract:Background and objectives Laryngoscopy and tracheal intubation are associated with hemodynamic responses that might increase morbidity and mortality in some patients. Lornoxicam is a nonsteroidal anti-inflammatory drug, which, when added to fentanyl, successfully attenuated the pressor response of intubation. The aim of this study was to evaluate the effect of Lornoxicam on the hemodynamic response and serum catecholamine levels following laryngoscopy and tracheal intubation. Methods Fifty adult patients scheduled for general anaesthesia with endotracheal intubation were enrolled in this randomized, double-blind placebo-controlled study. They were divided into two equal groups to receive intravenously either Lornoxicam 16 mg or placebo 30 min before surgery. Mean arterial pressure and heart rate were recorded before and after induction of anaesthesia, and every minute after intubation for 10 min. Serum catecholamine levels were measured before induction and 1 min after intubation. Results After induction, there was a significant decrease in blood pressure in both groups. In the first 3 min after tracheal intubation, a significant increase in the hemodynamic parameters and in the serum norepinephrine level was observed in the control group. Conclusion Lornoxicam 16 mg attenuates the pressor response to laryngoscopy and intubation of the trachea.
Jyotsana R. Madan - One of the best experts on this subject based on the ideXlab platform.
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Formulation and evaluation of proniosomes containing Lornoxicam
Drug Delivery and Translational Research, 2016Co-Authors: Jyotsana R. Madan, Nitesh P. Ghuge, Kamal DuaAbstract:Proniosomes are the new generation provesicular drug delivery system of non-ionic surfactant, lecithin and cholesterol which upon reconstitution get converted into niosomes. The objective of current study was to develop stable and sustain transdermal delivery system for Lornoxicam. Lornoxicam-loaded topically applied proniosomal gel was formulated, optimized, and evaluated with the aim to deliver drug transdermally. Lornoxicam-loaded proniosomal gels were prepared that contained Lutrol F68 and lecithin as surfactants, cholesterol as a stabilizer, and minimal amount of ethanol and trace water. The resultant Lornoxicam-loaded proniosomal gel were assessed for stability and the proniosomes-derived niosomes were characterized for morphology, size, zeta potential, and entrapment efficiency, which revealed that they were suitable for skin application. The coacervation phase separation technique was used in formulation of Lornoxicam proniosomal gel and the gel was further assessed for in vitro permeation of Lornoxicam through the freshly excised rat skin and the cumulative permeation amount of Lornoxicam from proniosome, all exhibited significant increase as compared to 1.0 % Lornoxicam-loaded pure gel. The optimized F5 batch had shown maximum entrapment efficiency up to 66.98 %. It has shown sustained drug release for more than 24 h. The skin permeability of proniosomal gel was found to be 59.73 %. The SEM and zeta potential studies showed formation of good and stable vesicles. Thus, proniosomes proved to have better potential for transdermal delivery of Lornoxicam over conventional gel formulations.
A Moussa - One of the best experts on this subject based on the ideXlab platform.
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Lornoxicam attenuates the haemodynamic responses to laryngoscopy and tracheal intubation in the elderly
European Journal of Anaesthesiology, 2008Co-Authors: W Riad, A MoussaAbstract:BACKGROUND AND OBJECTIVES: Lornoxicam is a novel non-steroidal anti-inflammatory drug with marked analgesic property. It has been shown to have analgesic potency similar to morphine and meperidine. Laryngoscopy and tracheal intubation provoke major haemodynamic responses. Minimizing perioperative adverse events in elderly patients is of utmost importance. The aim of this study was to demonstrate the effect of preoperative administration of Lornoxicam on haemodynamic changes during laryngoscopy and tracheal intubation in the elderly. METHODS: Fifty patients aged between 65 and 75 yr were randomly recruited to this randomized, double-blind, placebo-controlled study. They were divided into two groups to receive either Lornoxicam 8 mg or placebo half an hour before surgery. Systolic and diastolic blood pressure, mean arterial pressure, and heart rate were recorded before and after administration of the intravenous anaesthetic, also at 1, 3, 5 and 10 min after tracheal intubation. RESULTS: In the control group, significant increases in the haemodynamic parameters were observed during the first 10 min following tracheal intubation (P < 0.05). CONCLUSION: Preoperative administration of Lornoxicam attenuates the haemodynamic response to laryngoscopy and tracheal intubation in the elderly.
Nitesh P. Ghuge - One of the best experts on this subject based on the ideXlab platform.
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Formulation and evaluation of proniosomes containing Lornoxicam
Drug Delivery and Translational Research, 2016Co-Authors: Jyotsana R. Madan, Nitesh P. Ghuge, Kamal DuaAbstract:Proniosomes are the new generation provesicular drug delivery system of non-ionic surfactant, lecithin and cholesterol which upon reconstitution get converted into niosomes. The objective of current study was to develop stable and sustain transdermal delivery system for Lornoxicam. Lornoxicam-loaded topically applied proniosomal gel was formulated, optimized, and evaluated with the aim to deliver drug transdermally. Lornoxicam-loaded proniosomal gels were prepared that contained Lutrol F68 and lecithin as surfactants, cholesterol as a stabilizer, and minimal amount of ethanol and trace water. The resultant Lornoxicam-loaded proniosomal gel were assessed for stability and the proniosomes-derived niosomes were characterized for morphology, size, zeta potential, and entrapment efficiency, which revealed that they were suitable for skin application. The coacervation phase separation technique was used in formulation of Lornoxicam proniosomal gel and the gel was further assessed for in vitro permeation of Lornoxicam through the freshly excised rat skin and the cumulative permeation amount of Lornoxicam from proniosome, all exhibited significant increase as compared to 1.0 % Lornoxicam-loaded pure gel. The optimized F5 batch had shown maximum entrapment efficiency up to 66.98 %. It has shown sustained drug release for more than 24 h. The skin permeability of proniosomal gel was found to be 59.73 %. The SEM and zeta potential studies showed formation of good and stable vesicles. Thus, proniosomes proved to have better potential for transdermal delivery of Lornoxicam over conventional gel formulations.
