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Jason J. Nichols - One of the best experts on this subject based on the ideXlab platform.
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Prevention of UV-Induced DAmAge to the Anterior Segment Using ClAss I UV-Absorbing Hydrogel ContAct Lenses
2015Co-Authors: Kathleen S. Reuter, Loraine T. Sinnott, Jason J. NicholsAbstract:blocking contAct lenses prevent UV-induced pAthologic chAnges in A rAbbit model. METHODS. Twelve rAbbits were Assigned to 1 of 3 treAtment groups (n 4), As follows: senofilcon A (clAss I UV blocking) contAct lenses; LotrAfilcon A contAct lenses (no reported UV blocking); no contAct lens. The contrAlAterAl eye wAs pAtched without A contAct lens. AnimAls received UV-B (1.667 J/cm2) exposure dAily for 5 dAys. Postmortem tissue wAs exAmined As follows: in the corneA, the expression of mAtrix-metAlloprotein-Ases (MMPs) wAs evAluAted by zymogrAphy, And Apoptosis wAs evAluAted by TUNEL And cAspAse-3 ELISA; AscorbAte in the Aqueous humor wAs evAluAted by nucleAr mAgnetic resonAnce spectroscopy; crystAlline lens Apoptosis wAs evAluAted by TUNEL And cAspAse-3 ELISA. RESULTS. Exposed corneAs showed A significAnt increAse i
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A method of imAging lipids on silicone hydrogel contAct lenses.
Optometry and vision science : official publication of the American Academy of Optometry, 2012Co-Authors: Andrew D Pucker, Jason J. NicholsAbstract:PURPOSE To determine whether Nile Red And Oil Red O stAins Are Able to detect teAr film lipids deposited on silicone hydrogel contAct lenses. METHODS Eight unworn LotrAfilcon A lenses were individuAlly soAked in successively decreAsing Amounts of cholesterol oleAte solution (5.6 to 0.00 mg/ml) for 1 dAy in triplicAte for eAch stAining procedure (etAfilcon A lenses were Also soAked As A control). The sets of lenses were then stAined with Nile Red or Oil Red O. The lenses were then individuAlly visuAlized with A Nikon Eclipse 80i florescent microscope At 100× mAgnificAtion, And two representAtive photos were tAken of eAch lens. Both stAining procedures were repeAted with humAn worn LotrAfilcon A lenses. RESULTS The Nile Red stAin detected vAriAble yet decreAsing Amounts of lipids when lenses were incubAted in lipid concentrAtions ≥0.09 mg/ml. Oil Red O detected decreAsing Amounts of lipids when lenses were soAked in lipid concentrAtions ≥0.35 mg/ml. The Nile Red stAin produced considerAbly more bAckground stAining thAn Oil Red O, And ApproximAtely hAlf of the negAtive control lenses stAined with Nile Red while there wAs minimAl stAining of lenses stAined with Oil Red O. EtAfilcon A lenses yielded decreAsing Amounts of lipid when soAked in successively lower concentrAtions of lipid when stAined with Nile Red. HumAn-worn LotrAfilcon A lenses yielded similAr lipid chArActeristics when compAred with in vitro lenses, with vAriAble Amounts of lipid detection when compAring individuAl subjects. CONCLUSIONS Nile Red And Oil Red O Are both Able to detect lipids on soft lenses in both in vitro And ex vivo conditions. Oil Red O AppeArs to be A better stAin for silicone hydrogel lenses As it offers A higher signAl to noise rAtio.
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In Vitro Lipid Deposition on Hydrogel And Silicone Hydrogel ContAct Lenses
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Andrew D Pucker, Mirunalni Thangavelu, Jason J. NicholsAbstract:To understAnd vArious soft contAct lens mAteriAls' Ability to Adsorb common teAr lipids. Ten unworn polymers of nine types were individuAlly soAked in 1.0 mL of 1.75 μg/mL cholesterol oleAte or 1.0 mL of 0.5 μg/mL phosphAtidylcholine solutions for 1 or 14 dAys. The Adsorbed lipids were extrActed with chloroform-methAnol, which underwent AssAy quAntificAtion for cholesterol oleAte And inorgAnic phosphAte. More phosphAtidylcholine wAs extrActed After 14 dAys thAn After 1 dAy in only LotrAfilcon B, bAlAfilcon A, And enfilcon A (All P < 0.005). After 1 dAy of incubAtion in phosphAtidylcholine, 0.54 to 4.17 μg/lens phosphAtidylcholine wAs recovered from the polymers, And After 14 dAys of incubAtion in phosphAtidylcholine, 0.58 to 5.77 μg/lens phosphAtidylcholine wAs recovered from the polymers. EtAfilcon A hAd significAntly more cholesterol oleAte At 1 dAy thAn At 14 dAys, And LotrAfilcon A, LotrAfilcon B, And bAlAfilcon A hAd significAntly more cholesterol oleAte At 14 dAys thAn At 1 dAy (P < 0.005). After 1 dAy of incubAtion in cholesterol oleAte, 0.14 to 4.80 μg/lens cholesterol oleAte wAs recovered from the polymers. After 14 dAys of incubAtion in cholesterol oleAte, 1.40 to 6.84 μg/lens cholesterol oleAte wAs recovered from the polymers. Hydrogel And most silicone hydrogels AppeAr to Adsorb lipids relAtively quickly (i.e., within the first dAy). Although there is some vAriAbility in the Amounts recovered Across mAteriAls, it is uncertAin whether these differences hAve Any clinicAl significAnce.
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In vitro lipid deposition on hydrogel And silicone hydrogel contAct lenses.
Investigative ophthalmology & visual science, 2010Co-Authors: Andrew D Pucker, Mirunalni Thangavelu, Jason J. NicholsAbstract:PURPOSE To understAnd vArious soft contAct lens mAteriAls' Ability to Adsorb common teAr lipids. METHODS Ten unworn polymers of nine types were individuAlly soAked in 1.0 mL of 1.75 μg/mL cholesterol oleAte or 1.0 mL of 0.5 μg/mL phosphAtidylcholine solutions for 1 or 14 dAys. The Adsorbed lipids were extrActed with chloroform-methAnol, which underwent AssAy quAntificAtion for cholesterol oleAte And inorgAnic phosphAte. RESULTS More phosphAtidylcholine wAs extrActed After 14 dAys thAn After 1 dAy in only LotrAfilcon B, bAlAfilcon A, And enfilcon A (All P < 0.005). After 1 dAy of incubAtion in phosphAtidylcholine, 0.54 to 4.17 μg/lens phosphAtidylcholine wAs recovered from the polymers, And After 14 dAys of incubAtion in phosphAtidylcholine, 0.58 to 5.77 μg/lens phosphAtidylcholine wAs recovered from the polymers. EtAfilcon A hAd significAntly more cholesterol oleAte At 1 dAy thAn At 14 dAys, And LotrAfilcon A, LotrAfilcon B, And bAlAfilcon A hAd significAntly more cholesterol oleAte At 14 dAys thAn At 1 dAy (P < 0.005). After 1 dAy of incubAtion in cholesterol oleAte, 0.14 to 4.80 μg/lens cholesterol oleAte wAs recovered from the polymers. After 14 dAys of incubAtion in cholesterol oleAte, 1.40 to 6.84 μg/lens cholesterol oleAte wAs recovered from the polymers. CONCLUSIONS Hydrogel And most silicone hydrogels AppeAr to Adsorb lipids relAtively quickly (i.e., within the first dAy). Although there is some vAriAbility in the Amounts recovered Across mAteriAls, it is uncertAin whether these differences hAve Any clinicAl significAnce.
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Prevention of UV-induced dAmAge to the Anterior segment using clAss I UV-Absorbing hydrogel contAct lenses.
Investigative ophthalmology & visual science, 2009Co-Authors: Heather L. Chandler, Kathleen Reuter, Loraine T. Sinnott, Jason J. NicholsAbstract:PURPOSE: To determine whether clAss I ultrAviolet (UV) light-blocking contAct lenses prevent UV-induced pAthologic chAnges in A rAbbit model. METHODS: Twelve rAbbits were Assigned to 1 of 3 treAtment groups (n = 4), As follows: senofilcon A (clAss I UV blocking) contAct lenses; LotrAfilcon A contAct lenses (no reported UV blocking); no contAct lens. The contrAlAterAl eye wAs pAtched without A contAct lens. AnimAls received UV-B (1.667 J/cm(2)) exposure dAily for 5 dAys. Postmortem tissue wAs exAmined As follows: in the corneA, the expression of mAtrix-metAlloproteinAses (MMPs) wAs evAluAted by zymogrAphy, And Apoptosis wAs evAluAted by TUNEL And cAspAse-3 ELISA; AscorbAte in the Aqueous humor wAs evAluAted by nucleAr mAgnetic resonAnce spectroscopy; crystAlline lens Apoptosis wAs evAluAted by TUNEL And cAspAse-3 ELISA. RESULTS: Exposed corneAs showed A significAnt increAse in MMP-2 And -9, TUNEL-positive cells, And cAspAse-3 Activity in the LotrAfilcon A group compAred with the senofilcon A group (All P = 0.03). A significAnt decreAse in Aqueous humor AscorbAte wAs observed in the exposed LotrAfilcon A lens-weAring group compAred with the exposed senofilcon A lens-weAring group (P = 0.03). Exposed crystAlline lenses hAd significAntly increAsed cAspAse-3 Activity in the LotrAfilcon A group compAred with the senofilcon A group (P = 0.03). IncreAsed numbers of TUNEL-positive cells were noted in both the LotrAfilcon A And the non-contAct lens groups. CONCLUSIONS: The Authors show thAt senofilcon A clAss I UV-blocking contAct lenses Are cApAble of protecting the corneA, Aqueous humor, And crystAlline lens of rAbbits from UV-induced pAthologic chAnges.
Robin L. Chalmers - One of the best experts on this subject based on the ideXlab platform.
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improving contAct lens relAted dryness symptoms with silicone hydrogel lenses
Optometry and Vision Science, 2008Co-Authors: Robin L. Chalmers, Bill Long, Sally Dillehay, Carolyn G BegleyAbstract:Purpose. To determine dryness symptoms AttributAble to hydrogel contAct lens (HCL) weAr by compAring symptoms from Age-mAtched HCL weArers And non-weArers in A cross-sectionAl study, And to compAre thAt difference to the chAnge in proportion of subjects reporting frequent dryness Among HCL weArers After refitting with LotrAfilcon A or B silicone hydrogels (SHCLs). Methods. PrevAlence of frequent dryness symptoms wAs compAred between HCL And non-weArers from A cross-sectionAl, historicAl dAtAset of Dry Eye/ContAct Lens Dry Eye QuestionnAires using An Age-mAtched subset of 259 HCL And 246 non-weArers. Prospective chAnge in prevAlence of frequent dryness from non-rAndomized studies (n 1036), in which dAily weAr (DW) HCL weArers were refit with LotrAfilcon A or B SHCLs, wAs then compAred to the cross-sectionAl difference between HCL weArers And non-weArers. Results. In the Dry Eye/ContAct Lens Dry Eye QuestionnAires dAtAset, 47% fewer non-weArers reported frequent dryness thAn HCL weArers (p 0.0001). In the LotrAfilcon A DW refitting triAls, frequent dryness wAs reported by 67 And 62% fewer subjects for during the dAy (DD) And end of the dAy (EOD) dryness (p 0.0001, both) After refitting. In continuous weAr LotrAfilcon A triAls, there were 63 And 41% reductions in the proportion reporting frequent DD And EOD dryness (p 0.014 And p 0.02). Refitting to DW LotrAfilcon B yielded A 48 And 46% reduction in the number of subjects reporting frequent DD And EOD dryness (p 0.0001, both). Conclusions. After refitting DW HCL weArers with either LotrAfilcon A or B SHCLs, the proportion of symptomAtic weArers wAs ApproximAtely hAlf; An Amount similAr to the difference in proportion between HCL And non-weArers. This rAises the possibility thAt refitting HCL weArers with SHCLs eliminAtes the component of dryness thAt is induced by HCL weAr. Further reseArch with more robust experimentAl design is recommended to test this hypothesis. (Optom Vis Sci 2008;85:778–784)
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long term clinicAl results 3 yeArs of up to 30 night continuous weAr of LotrAfilcon A silicone hydrogel And dAily weAr of low dk t hydrogel lenses
Eye & Contact Lens-science and Clinical Practice, 2007Co-Authors: Peter Bergenske, Bill Long, Peter C. Donshik, Sally Dillehay, Joseph T. Barr, Glenda Secor, John Yoakum, Robin L. ChalmersAbstract:PURPOSE: To summArize results of A 3-yeAr clinicAl triAl Assessing subjective And objective experience with LotrAfilcon A silicone hydrogel (SH) lenses for up to 30 nights of continuous weAr or low-Dk/t dAily-weAr (LDW) hydrogel lenses. METHODS: Nineteen sites dispensed SH lenses to 317 subjects (286 current weArers And 31 new weArers) And 2-week replAcement LDW lenses to 81 new weArers in A 3-yeAr study. RESULTS: For the SH cohort, limbAl redness, conjunctivAl redness, And corneAl neovAsculArizAtion improved Among 23%, 21%, And 13% of eyes, respectively (P<0.001), with no signs increAsing significAntly. For the LDW cohort, limbAl redness, pApillAry conjunctivitis, And corneAl stAining increAsed Among 11%, 21%, And 13% of eyes, respectively (P<0.02), with no signs improving significAntly. The chAnge in AverAge sphericAl equivAlent power wAs -0.03 diopters for the Age-mAtched SH cohort And -0.40 diopters for the LDW cohort (P=0.007). During the 3 yeArs, the SH group reported significAntly less frequent dryness during And At the end of the dAy, redness, photophobiA, lens AwAreness, And blurred vision. SignificAntly more LDW lens weArers reported frequent during-the-dAy And end-of-dAy dryness And blurred vision. CONCLUSIONS: During the 3 yeArs, LotrAfilcon A lens weArers who wore their lenses continuously for up to 30 nights showed stAble, long-term improvements in mAny signs of corneAl heAlth And symptoms Along with less myopic progression versus dAily weArers of low-Dk/t hydrogel lenses. MAny biomicroscopy signs And symptoms worsened Among neophytes weAring dAily-weAr low-Dk/t hydrogel lenses. The use of LotrAfilcon A lenses mAy minimize mAny oculAr chAnges from soft contAct lens weAr.
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InflAmmAtory And mechAnicAl complicAtions AssociAted with 3 yeArs of up to 30 nights of continuous weAr of LotrAfilcon A silicone hydrogel lenses.
Eye & contact lens, 2007Co-Authors: Peter C. Donshik, Bill Long, Sally Dillehay, Joseph T. Barr, Peter Bergenske, Glenda Secor, John Yoakum, Robin L. ChalmersAbstract:PURPOSE To report the oculAr complicAtions occurring during A 3-yeAr clinicAl triAl of subjects weAring LotrAfilcon A silicone hydrogel lenses for up to 30 nights of continuous weAr. METHODS Nineteen sites enrolled 317 subjects (286 current weArers And 31 new weArers), who were dispensed LotrAfilcon A lenses with 3 yeArs of follow-up. RESULTS By the 1-month visit, continuous weAr of up to 30 nights wAs recommended for 87% of subjects. The 27 lens-relAted Adverse events included 15 (2.4%) eyes in yeAr 1, seven (1.3%) eyes in yeAr 2, And five (0.8%) eyes in yeAr 3. Lens-relAted inflAmmAtory events involved 12 (1.9%) eyes in yeAr 1 And five (0.8%) eyes eAch in yeArs 2 And 3. One third of the inflAmmAtory events occurred in the first 3 months. MechAnicAl events included two superior epitheliAl ArcuAte lesions And one cAse of bilAterAl contAct lens pApillAry conjunctivitis in yeArs 1 And 2. No subjects experienced microbiAl kerAtitis during the 3-yeAr triAl. Two subjects with events discontinued from the triAl. CONCLUSIONS These results show thAt the rAte of contAct lens Adverse events occurring with LotrAfilcon A is low in this cohort, with the highest likelihood occurring during the first 3 months of the study. There wAs A decreAse in the rAte of events during the lAter yeArs of the study. Although cliniciAns should understAnd the likelihood of Adverse inflAmmAtory And mechAnicAl events And their possible recurrence, the rAte of these events mAy be lower in prActice thAn previously reported.
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Long-term clinicAl results: 3 yeArs of up to 30-night continuous weAr of LotrAfilcon A silicone hydrogel And dAily weAr of low-Dk/t hydrogel lenses.
Eye & contact lens, 2007Co-Authors: Peter Bergenske, Bill Long, Peter C. Donshik, Sally Dillehay, Joseph T. Barr, Glenda Secor, John Yoakum, Robin L. ChalmersAbstract:PURPOSE: To summArize results of A 3-yeAr clinicAl triAl Assessing subjective And objective experience with LotrAfilcon A silicone hydrogel (SH) lenses for up to 30 nights of continuous weAr or low-Dk/t dAily-weAr (LDW) hydrogel lenses. METHODS: Nineteen sites dispensed SH lenses to 317 subjects (286 current weArers And 31 new weArers) And 2-week replAcement LDW lenses to 81 new weArers in A 3-yeAr study. RESULTS: For the SH cohort, limbAl redness, conjunctivAl redness, And corneAl neovAsculArizAtion improved Among 23%, 21%, And 13% of eyes, respectively (P
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ImpAct of previous extended And dAily weAr schedules on signs And symptoms with high Dk LotrAfilcon A lenses.
Optometry and vision science : official publication of the American Academy of Optometry, 2005Co-Authors: Robin L. Chalmers, Bill Long, Peter C. Donshik, Sally Dillehay, Joseph T. Barr, Peter Bergenske, Glenda Secor, John YoakumAbstract:Purpose. This study meAsured the impAct of previous contAct lens weAring schedule on the resolution of signs And contAct lens-relAted symptoms Among weArers of LotrAfilcon A lenses. Methods. One hundred forty AdApted low Dk dAily weAr (DW) And 140 AdApted low Dk extended weAr (EW) subjects were enrolled And exAmined for 1 yeAr (overAll study length is 3 yeArs). All subjects wore LotrAfilcon A lenses on A weAring schedule of up to 30 nights continuous weAr with monthly replAcement of lenses. ExAminAtions were conducted At 1 week, 1,6, And 12 months. Results. The former EW weArers presented At bAseline with significAntly higher conjunctivAl stAining And epitheliAl microcysts (p < 0.05) And lower oculAr surfAce symptoms of end of dAy dryness thAn the former DW weArers. There were no significAnt differences in other oculAr signs At bAseline for the former DW And EW weArers. After use of LotrAfilcon A, clinicAl signs of limbAl, conjunctivAl redness, And neovAsculArizAtion were significAntly better by the 1 -week visit for both groups of weArers. RegArdless of former weAring schedule, symptoms of dryness (during And At the end of the dAy) And photophobiA were significAntly better After 1 week of LotrAfilcon A use. The frequency And severity of symptoms of dryness during the dAy improved significAntly Among former low Dk DW And EW weArers within 1 week As did severity of dryness during the dAy for the former DW weArers, in pArt As A result of their higher prevAlence At bAseline in the DW group. Subjects reported redness improved significAntly by the 1-month visit. Conclusions. Continuous weAr of high Dk silicone hydrogel lenses resulted in An improvement in oculAr redness And neovAsculArizAtion And dryness symptoms Among subjects in this triAl, regArdless of their previous low Dk lens-weAring schedule. All improvements in signs And symptoms were sustAined through 12 months.
Bill Long - One of the best experts on this subject based on the ideXlab platform.
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ExpAnding your use of silicone hydrogel contAct lenses: using LotrAfilcon A for dAily weAr.
Eye & contact lens, 2009Co-Authors: Bill Long, Helmer Schweizer, Hans Bleshoy, Fabrizio ZeriAbstract:Objective:The purpose of this study wAs to profile contAct lens (CL) experience Among pAtients in eyecAre prActitioner (ECP) offices And the response to dAily weAr (DW) of LotrAfilcon A silicone hydrogel CLs.Methods:PAtients At ECP offices were surveyed for their vision correction modAlity And exper
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improving contAct lens relAted dryness symptoms with silicone hydrogel lenses
Optometry and Vision Science, 2008Co-Authors: Robin L. Chalmers, Bill Long, Sally Dillehay, Carolyn G BegleyAbstract:Purpose. To determine dryness symptoms AttributAble to hydrogel contAct lens (HCL) weAr by compAring symptoms from Age-mAtched HCL weArers And non-weArers in A cross-sectionAl study, And to compAre thAt difference to the chAnge in proportion of subjects reporting frequent dryness Among HCL weArers After refitting with LotrAfilcon A or B silicone hydrogels (SHCLs). Methods. PrevAlence of frequent dryness symptoms wAs compAred between HCL And non-weArers from A cross-sectionAl, historicAl dAtAset of Dry Eye/ContAct Lens Dry Eye QuestionnAires using An Age-mAtched subset of 259 HCL And 246 non-weArers. Prospective chAnge in prevAlence of frequent dryness from non-rAndomized studies (n 1036), in which dAily weAr (DW) HCL weArers were refit with LotrAfilcon A or B SHCLs, wAs then compAred to the cross-sectionAl difference between HCL weArers And non-weArers. Results. In the Dry Eye/ContAct Lens Dry Eye QuestionnAires dAtAset, 47% fewer non-weArers reported frequent dryness thAn HCL weArers (p 0.0001). In the LotrAfilcon A DW refitting triAls, frequent dryness wAs reported by 67 And 62% fewer subjects for during the dAy (DD) And end of the dAy (EOD) dryness (p 0.0001, both) After refitting. In continuous weAr LotrAfilcon A triAls, there were 63 And 41% reductions in the proportion reporting frequent DD And EOD dryness (p 0.014 And p 0.02). Refitting to DW LotrAfilcon B yielded A 48 And 46% reduction in the number of subjects reporting frequent DD And EOD dryness (p 0.0001, both). Conclusions. After refitting DW HCL weArers with either LotrAfilcon A or B SHCLs, the proportion of symptomAtic weArers wAs ApproximAtely hAlf; An Amount similAr to the difference in proportion between HCL And non-weArers. This rAises the possibility thAt refitting HCL weArers with SHCLs eliminAtes the component of dryness thAt is induced by HCL weAr. Further reseArch with more robust experimentAl design is recommended to test this hypothesis. (Optom Vis Sci 2008;85:778–784)
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predictive fActors for corneAl infiltrAtes with continuous weAr of silicone hydrogel contAct lenses
Archives of Ophthalmology, 2007Co-Authors: Loretta B Szczotkaflynn, Bill Long, Sara M. Debanne, Sally Dillehay, Joseph T. Barr, Peter Bergenske, Vinay K Cheruvu, Peter Donshik, Glenda SecorAbstract:Objective To estimAte the cumulAtive probAbility And risk fActors for developing corneAl infiltrAtes After up to 3 yeArs of continuous weAr (CW) with LotrAfilcon A lenses. Methods PAtients were fitted with LotrAfilcon A lenses And followed up for 3 yeArs. The mAin outcome vAriAble wAs the first occurrence of Any infiltrAtive event in either eye. Cox proportionAl hAzArds regression wAs used to model the probAbility of developing infiltrAtes As A function of demogrAphic And biomicroscopy findings. Results A totAl of 317 pAtients pArticipAted in this study. The KAplAn-Meier unAdjusted cumulAtive incidence of A corneAl infiltrAte After CW wAs 5.7% (95% confidence intervAl [CI], 3.0%-8.4%) At the end of 1 yeAr, 8.5% (95% CI, 5.2%-11.9%) At the end of 2 yeArs, And 10.3% (95% CI, 6.6%-13.9%) At the end of 3 yeArs. CorneAl stAining And limbAl redness present in the Affected eye on A previous visit were significAntly AssociAted with the development of An infiltrAtive event (hAzArd rAtios, 7.23 And 3.18; P P = .02, respectively). Conclusions CorneAl stAining And limbAl redness mAy predict the subsequent development of An infiltrAtive event Among CW contAct lens pAtients. The probAbility of remAining free of Any corneAl infiltrAtes At the end of 3 yeArs of CW of contAct lenses wAs 89.7% (95% CI, 86.1%-93.4%).
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long term clinicAl results 3 yeArs of up to 30 night continuous weAr of LotrAfilcon A silicone hydrogel And dAily weAr of low dk t hydrogel lenses
Eye & Contact Lens-science and Clinical Practice, 2007Co-Authors: Peter Bergenske, Bill Long, Peter C. Donshik, Sally Dillehay, Joseph T. Barr, Glenda Secor, John Yoakum, Robin L. ChalmersAbstract:PURPOSE: To summArize results of A 3-yeAr clinicAl triAl Assessing subjective And objective experience with LotrAfilcon A silicone hydrogel (SH) lenses for up to 30 nights of continuous weAr or low-Dk/t dAily-weAr (LDW) hydrogel lenses. METHODS: Nineteen sites dispensed SH lenses to 317 subjects (286 current weArers And 31 new weArers) And 2-week replAcement LDW lenses to 81 new weArers in A 3-yeAr study. RESULTS: For the SH cohort, limbAl redness, conjunctivAl redness, And corneAl neovAsculArizAtion improved Among 23%, 21%, And 13% of eyes, respectively (P<0.001), with no signs increAsing significAntly. For the LDW cohort, limbAl redness, pApillAry conjunctivitis, And corneAl stAining increAsed Among 11%, 21%, And 13% of eyes, respectively (P<0.02), with no signs improving significAntly. The chAnge in AverAge sphericAl equivAlent power wAs -0.03 diopters for the Age-mAtched SH cohort And -0.40 diopters for the LDW cohort (P=0.007). During the 3 yeArs, the SH group reported significAntly less frequent dryness during And At the end of the dAy, redness, photophobiA, lens AwAreness, And blurred vision. SignificAntly more LDW lens weArers reported frequent during-the-dAy And end-of-dAy dryness And blurred vision. CONCLUSIONS: During the 3 yeArs, LotrAfilcon A lens weArers who wore their lenses continuously for up to 30 nights showed stAble, long-term improvements in mAny signs of corneAl heAlth And symptoms Along with less myopic progression versus dAily weArers of low-Dk/t hydrogel lenses. MAny biomicroscopy signs And symptoms worsened Among neophytes weAring dAily-weAr low-Dk/t hydrogel lenses. The use of LotrAfilcon A lenses mAy minimize mAny oculAr chAnges from soft contAct lens weAr.
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InflAmmAtory And mechAnicAl complicAtions AssociAted with 3 yeArs of up to 30 nights of continuous weAr of LotrAfilcon A silicone hydrogel lenses.
Eye & contact lens, 2007Co-Authors: Peter C. Donshik, Bill Long, Sally Dillehay, Joseph T. Barr, Peter Bergenske, Glenda Secor, John Yoakum, Robin L. ChalmersAbstract:PURPOSE To report the oculAr complicAtions occurring during A 3-yeAr clinicAl triAl of subjects weAring LotrAfilcon A silicone hydrogel lenses for up to 30 nights of continuous weAr. METHODS Nineteen sites enrolled 317 subjects (286 current weArers And 31 new weArers), who were dispensed LotrAfilcon A lenses with 3 yeArs of follow-up. RESULTS By the 1-month visit, continuous weAr of up to 30 nights wAs recommended for 87% of subjects. The 27 lens-relAted Adverse events included 15 (2.4%) eyes in yeAr 1, seven (1.3%) eyes in yeAr 2, And five (0.8%) eyes in yeAr 3. Lens-relAted inflAmmAtory events involved 12 (1.9%) eyes in yeAr 1 And five (0.8%) eyes eAch in yeArs 2 And 3. One third of the inflAmmAtory events occurred in the first 3 months. MechAnicAl events included two superior epitheliAl ArcuAte lesions And one cAse of bilAterAl contAct lens pApillAry conjunctivitis in yeArs 1 And 2. No subjects experienced microbiAl kerAtitis during the 3-yeAr triAl. Two subjects with events discontinued from the triAl. CONCLUSIONS These results show thAt the rAte of contAct lens Adverse events occurring with LotrAfilcon A is low in this cohort, with the highest likelihood occurring during the first 3 months of the study. There wAs A decreAse in the rAte of events during the lAter yeArs of the study. Although cliniciAns should understAnd the likelihood of Adverse inflAmmAtory And mechAnicAl events And their possible recurrence, the rAte of these events mAy be lower in prActice thAn previously reported.
Lyndon Jones - One of the best experts on this subject based on the ideXlab platform.
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EfficAcy of ContAct Lens CAre Solutions in Removing Cholesterol Deposits From Silicone Hydrogel ContAct Lenses
Eye & contact lens, 2019Co-Authors: Hendrik Walther, Lakshman N Subbaraman, Lyndon JonesAbstract:Purpose:To determine the efficAcy of multipurpose solutions (MPSs) on the removAl of cholesterol deposits from silicone hydrogel (SH) contAct lens mAteriAls using An in vitro model.MAteriAls And Methods:Five SH lens mAteriAls: senofilcon A, comfilcon A, bAlAfilcon A, LotrAfilcon A, And LotrAfilcon B
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In vitro AnAlysis of the physicAl properties of contAct lens blister pAck solutions.
Optometry and Vision Science, 2011Co-Authors: Kara L. Menzies, Lyndon JonesAbstract:Purpose Since the initiAl development of silicone hydrogels, mAny modificAtions to the bulk And surfAce properties of the lenses hAve been undertAken to improve the wettAbility And comfort of the lenses. Recently, mAnufActurers hAve incorporAted vArious "wetting Agents" or surfAce-Active Agents into the blister pAckAging solutions (BPSs) of the lenses to improve initiAl comfort of the lens on eye. The purpose of this study wAs to meAsure And compAre the pH, surfAce tension (ST), viscosity, And osmolAlity of BPSs for A vAriety of silicone hydrogel And polyHEMA-bAsed hydrogel lenses. In Addition, two sAline solutions were tested for compArison purposes. Methods The pH, osmolAlity, ST, And viscosity were meAsured for the BPSs for LotrAfilcon B And LotrAfilcon A And LotrAfilcon B with A "modified BPS" (m-LotrAfilcon A, m-LotrAfilcon B) (CIBA Vision, Duluth, GA); bAlAfilcon A (BAusch & Lomb, Rochester, NY); gAlyfilcon A, senofilcon A, And nArAfilcon A (Johnson & Johnson, JAcksonville, FL); And comfilcon A And enfilcon A (CooperVision, PleAsAnton, CA) And BPSs from two conventionAl polyHEMA-bAsed mAteriAls-etAfilcon A (Johnson & Johnson) And omAfilcon A (CooperVision). The two sAline solutions tested were Unisol (Alcon, Fort Worth, TX) And SoftweAr SAline (CIBA Vision). Results The pH results for the two sAline solutions And All BPSs remAined in the pH rAnge of teArs (6.6-7.8). The ST of the modified BPS wAs significAntly lower (p 0.05) between BPSs mAde by the sAme mAnufActurer but were significAntly different compAred with BPSs mAde by different mAnufActurers (p Conclusions The incorporAtion of wetting Agents And surfActAnts into BPSs does Alter the physicAl properties of the BPSs, which mAy hAve clinicAl implicAtions regArding initiAl in-eye comfort.
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Kinetics of Lysozyme Activity Recovered from ConventionAl And Silicone Hydrogel ContAct Lens MAteriAls
Journal of Biomaterials Science Polymer Edition, 2010Co-Authors: Lakshman N Subbaraman, Lyndon JonesAbstract:We determined the Activity of lysozyme recovered from vArious conventionAl And silicone hydrogel (SH) contAct lens mAteriAls As A function of time, using An in vitro model. PolymAcon, omAfilcon, etAfilcon, vifilcon, LotrAfilcon A, LotrAfilcon B, bAlAfilcon A, gAlyfilcon A And senofilcon A contAct lenses (n = 5) were incubAted in lysozyme solution for time periods rAnging from 1 h to 28 dAys. Following the specified incubAtion period, the lysozyme deposited on the lenses wAs extrActed And the sAmple extrActs were Assessed for lysozyme Activity And totAl lysozyme. We found no significAnt difference (NSD) between omAfilcon And polymAcon lens mAteriAls for the initiAl 3 dAys (P > 0.05); however, there wAs A significAnt difference between the two lenses from 5 to 28 dAys (P 0.05) between etAfilcon And vifilcon lens mAteriAls At All time-points And significAnt differences were seen between vArious SH lens mAteriAls At different time points. After 28 dAys, lysozyme deposited on etAfil...
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LocAlizAtion of Lysozyme Sorption to ConventionAl And Silicone Hydrogel ContAct Lenses Using ConfocAl Microscopy
Current eye research, 2009Co-Authors: Doerte Luensmann, Lakshman N Subbaraman, Heather Sheardown, Feng Zhang, Lyndon JonesAbstract:Purpose: To investigAte the distribution profile of hen egg lysozyme (HEL) through poly-2-hydroxyethyl methAcrylAte (pHEMA)-bAsed lens mAteriAls And silicone hydrogel (SH) lens mAteriAls using confocAl lAser scAnning microscopy (CLSM). Methods: Five silicone SH mAteriAls (bAlAfilcon A, LotrAfilcon A, LotrAfilcon B, gAlyfilcon A, senofilcon A) And four pHEMA-bAsed mAteriAls (AlphAfilcon A, etAfilcon A, omAfilcon A, vifilcon A) were incubAted in 1.9 mg/ml protein solution for 24 hours. The protein solution consisted of HEL, which wAs conjugAted with either fluorescein isothiocyAnAte (FITC) or lucifer yellow VS dilithium sAlt (LY). CLSM (Zeiss LSM 510 META) identified the locAtion of the fluorescently lAbeled protein by using 1 μ m depth scAns through the lens. In A second experiment, lenses were incubAted with 2% 125 I lAbeled HEL to determine the Amount of deposited protein on eAch lens. Both techniques were combined to describe the individuAl HEL profiles. Results: After the incubAtion in fluorescently lA...
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Kinetics of in Vitro LActoferrin Deposition on Silicone Hydrogel And FDA Group II And Group IV Hydrogel ContAct Lens MAteriAls
Journal of biomaterials science. Polymer edition, 2009Co-Authors: Lisa M. Chow, Lakshman N Subbaraman, Heather Sheardown, Lyndon JonesAbstract:The Aim of this study wAs to compAre the kinetics of lActoferrin deposition on silicone hydrogel (SH) And conventionAl FDA group II And group IV hydrogel contAct lens mAteriAls. Seven lens mAteriAls, two conventionAl (etAfilcon A, FDA group IV; omAfilcon A, FDA group II) And five SH (LotrAfilcon A, LotrAfilcon B, bAlAfilcon A, gAlyfilcon A And senofilcon A), were incubAted in 1 ml 125I-lAbeled lActoferrin solution for time periods rAnging from 1 h to 28 dAys. At the end of specified incubAtion periods rAdioActive counts were determined on the lenses using An AutomAtic GAmmA Counter. There wAs A grAduAl increAse in lActoferrin deposition on All the lenses Across All time points. At the end of 28 dAys the Amount of lActoferrin/lens in μg wAs 11.3 ± 1.9 for etAfilcon A, 6.8 ± 2.0 for omAfilcon A, 2.1 ± 0.9 for LotrAfilcon A, 3.1 ± 1.0 for LotrAfilcon B, 11.8 ± 2.9 for bAlAfilcon A, 5.4 ± 1.1 for gAlyfilcon A And 5.6 ± 0.6 for senofilcon A. After 28 dAys, etAfilcon A And bAlAfilcon A deposited lActoferrin to ...
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A method of imAging lipids on silicone hydrogel contAct lenses.
Optometry and vision science : official publication of the American Academy of Optometry, 2012Co-Authors: Andrew D Pucker, Jason J. NicholsAbstract:PURPOSE To determine whether Nile Red And Oil Red O stAins Are Able to detect teAr film lipids deposited on silicone hydrogel contAct lenses. METHODS Eight unworn LotrAfilcon A lenses were individuAlly soAked in successively decreAsing Amounts of cholesterol oleAte solution (5.6 to 0.00 mg/ml) for 1 dAy in triplicAte for eAch stAining procedure (etAfilcon A lenses were Also soAked As A control). The sets of lenses were then stAined with Nile Red or Oil Red O. The lenses were then individuAlly visuAlized with A Nikon Eclipse 80i florescent microscope At 100× mAgnificAtion, And two representAtive photos were tAken of eAch lens. Both stAining procedures were repeAted with humAn worn LotrAfilcon A lenses. RESULTS The Nile Red stAin detected vAriAble yet decreAsing Amounts of lipids when lenses were incubAted in lipid concentrAtions ≥0.09 mg/ml. Oil Red O detected decreAsing Amounts of lipids when lenses were soAked in lipid concentrAtions ≥0.35 mg/ml. The Nile Red stAin produced considerAbly more bAckground stAining thAn Oil Red O, And ApproximAtely hAlf of the negAtive control lenses stAined with Nile Red while there wAs minimAl stAining of lenses stAined with Oil Red O. EtAfilcon A lenses yielded decreAsing Amounts of lipid when soAked in successively lower concentrAtions of lipid when stAined with Nile Red. HumAn-worn LotrAfilcon A lenses yielded similAr lipid chArActeristics when compAred with in vitro lenses, with vAriAble Amounts of lipid detection when compAring individuAl subjects. CONCLUSIONS Nile Red And Oil Red O Are both Able to detect lipids on soft lenses in both in vitro And ex vivo conditions. Oil Red O AppeArs to be A better stAin for silicone hydrogel lenses As it offers A higher signAl to noise rAtio.
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In Vitro Lipid Deposition on Hydrogel And Silicone Hydrogel ContAct Lenses
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Andrew D Pucker, Mirunalni Thangavelu, Jason J. NicholsAbstract:To understAnd vArious soft contAct lens mAteriAls' Ability to Adsorb common teAr lipids. Ten unworn polymers of nine types were individuAlly soAked in 1.0 mL of 1.75 μg/mL cholesterol oleAte or 1.0 mL of 0.5 μg/mL phosphAtidylcholine solutions for 1 or 14 dAys. The Adsorbed lipids were extrActed with chloroform-methAnol, which underwent AssAy quAntificAtion for cholesterol oleAte And inorgAnic phosphAte. More phosphAtidylcholine wAs extrActed After 14 dAys thAn After 1 dAy in only LotrAfilcon B, bAlAfilcon A, And enfilcon A (All P < 0.005). After 1 dAy of incubAtion in phosphAtidylcholine, 0.54 to 4.17 μg/lens phosphAtidylcholine wAs recovered from the polymers, And After 14 dAys of incubAtion in phosphAtidylcholine, 0.58 to 5.77 μg/lens phosphAtidylcholine wAs recovered from the polymers. EtAfilcon A hAd significAntly more cholesterol oleAte At 1 dAy thAn At 14 dAys, And LotrAfilcon A, LotrAfilcon B, And bAlAfilcon A hAd significAntly more cholesterol oleAte At 14 dAys thAn At 1 dAy (P < 0.005). After 1 dAy of incubAtion in cholesterol oleAte, 0.14 to 4.80 μg/lens cholesterol oleAte wAs recovered from the polymers. After 14 dAys of incubAtion in cholesterol oleAte, 1.40 to 6.84 μg/lens cholesterol oleAte wAs recovered from the polymers. Hydrogel And most silicone hydrogels AppeAr to Adsorb lipids relAtively quickly (i.e., within the first dAy). Although there is some vAriAbility in the Amounts recovered Across mAteriAls, it is uncertAin whether these differences hAve Any clinicAl significAnce.
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In vitro lipid deposition on hydrogel And silicone hydrogel contAct lenses.
Investigative ophthalmology & visual science, 2010Co-Authors: Andrew D Pucker, Mirunalni Thangavelu, Jason J. NicholsAbstract:PURPOSE To understAnd vArious soft contAct lens mAteriAls' Ability to Adsorb common teAr lipids. METHODS Ten unworn polymers of nine types were individuAlly soAked in 1.0 mL of 1.75 μg/mL cholesterol oleAte or 1.0 mL of 0.5 μg/mL phosphAtidylcholine solutions for 1 or 14 dAys. The Adsorbed lipids were extrActed with chloroform-methAnol, which underwent AssAy quAntificAtion for cholesterol oleAte And inorgAnic phosphAte. RESULTS More phosphAtidylcholine wAs extrActed After 14 dAys thAn After 1 dAy in only LotrAfilcon B, bAlAfilcon A, And enfilcon A (All P < 0.005). After 1 dAy of incubAtion in phosphAtidylcholine, 0.54 to 4.17 μg/lens phosphAtidylcholine wAs recovered from the polymers, And After 14 dAys of incubAtion in phosphAtidylcholine, 0.58 to 5.77 μg/lens phosphAtidylcholine wAs recovered from the polymers. EtAfilcon A hAd significAntly more cholesterol oleAte At 1 dAy thAn At 14 dAys, And LotrAfilcon A, LotrAfilcon B, And bAlAfilcon A hAd significAntly more cholesterol oleAte At 14 dAys thAn At 1 dAy (P < 0.005). After 1 dAy of incubAtion in cholesterol oleAte, 0.14 to 4.80 μg/lens cholesterol oleAte wAs recovered from the polymers. After 14 dAys of incubAtion in cholesterol oleAte, 1.40 to 6.84 μg/lens cholesterol oleAte wAs recovered from the polymers. CONCLUSIONS Hydrogel And most silicone hydrogels AppeAr to Adsorb lipids relAtively quickly (i.e., within the first dAy). Although there is some vAriAbility in the Amounts recovered Across mAteriAls, it is uncertAin whether these differences hAve Any clinicAl significAnce.
