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Steven Singh - One of the best experts on this subject based on the ideXlab platform.
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spontaneous conversion and maintenance of sinus rhythm by amiodarone in patients with heart failure and atrial fibrillation observations from the veterans affairs congestive heart failure survival trial of antiarrhythmic therapy chf stat the departme
Circulation, 1998Co-Authors: Prakash Deedwania, Bramah N Singh, Kenneth A Ellenbogen, Susan G Fisher, Ross D Fletcher, Steven SinghAbstract:BACKGROUND: In a multicenter, double-blind, placebo-controlled study, the long-term effects of amiodarone on morbidity and Mortality in patients with congestive heart failure (CHF) and atrial fibrillation (AF) were evaluated during a 4-year period. METHODS AND RESULTS: Of 667 patients with CHF, 103 (15%) had AF at baseline. Of these, 51 were randomized to amiodarone and 52 to placebo. The group with sinus rhythm and the group in AF were comparable except for a higher proportion of AF in patients with nonischemic versus ischemic cardiomyopathy (41% versus 27%, P<0.005). The mean ventricular response (VR) during AF over 24 hours was reduced by amiodarone at 2 weeks (20%, P=0.001), at 6 months (18%, P=0.001), and at 12 months (16%, P=0.006). Maximal VR was reduced 22% (P=0.001) at 2 weeks, 19% (P=0.001) at 6 months, and 14% (P=0.001) at 12 months. Sixteen of 51 patients on amiodarone and 4 of 52 on placebo converted to sinus rhythm during the study (chi2=9.23, P=0.002). During follow-up, 11 of 268 patients in sinus rhythm on amiodarone at baseline and 22 of the 263 in sinus rhythm on placebo developed AF; the difference was significant (chi2=12.88, P=0.005). Analysis of total Mortality during follow-up showed a significantly Lower Mortality Rate (P=0. 04) in patients in AF at baseline who subsequently converted to sinus rhythm on amiodarone than in those who did not convert to sinus rhythm on the drug. CONCLUSIONS: In patients with CHF, amiodarone has a significant potential to spontaneously convert patients in AF to sinus rhythm, with patients who convert having a Lower Mortality Rate than those who do not. The drug prevented the development of new-onset AF and significantly reduced the VR in those with persistent AF.
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spontaneous conversion and maintenance of sinus rhythm by amiodarone in patients with heart failure and atrial fibrillation observations from the veterans affairs congestive heart failure survival trial of antiarrhythmic therapy chf stat
Circulation, 1998Co-Authors: Prakash Deedwania, Bramah N Singh, Kenneth A Ellenbogen, Susan G Fisher, Ross D Fletcher, Steven SinghAbstract:Background —In a multicenter, double-blind, placebo-controlled study, the long-term effects of amiodarone on morbidity and Mortality in patients with congestive heart failure (CHF) and atrial fibrillation (AF) were evaluated during a 4-year period. Methods and Results —Of 667 patients with CHF, 103 (15%) had AF at baseline. Of these, 51 were randomized to amiodarone and 52 to placebo. The group with sinus rhythm and the group in AF were comparable except for a higher proportion of AF in patients with nonischemic versus ischemic cardiomyopathy (41% versus 27%, P P =0.001), at 6 months (18%, P =0.001), and at 12 months (16%, P =0.006). Maximal VR was reduced 22% ( P =0.001) at 2 weeks, 19% ( P =0.001) at 6 months, and 14% ( P =0.001) at 12 months. Sixteen of 51 patients on amiodarone and 4 of 52 on placebo converted to sinus rhythm during the study (χ 2 =9.23, P =0.002). During follow-up, 11 of 268 patients in sinus rhythm on amiodarone at baseline and 22 of the 263 in sinus rhythm on placebo developed AF; the difference was significant (χ 2 =12.88, P =0.005). Analysis of total Mortality during follow-up showed a significantly Lower Mortality Rate ( P =0.04) in patients in AF at baseline who subsequently converted to sinus rhythm on amiodarone than in those who did not convert to sinus rhythm on the drug. Conclusions —In patients with CHF, amiodarone has a significant potential to spontaneously convert patients in AF to sinus rhythm, with patients who convert having a Lower Mortality Rate than those who do not. The drug prevented the development of new-onset AF and significantly reduced the VR in those with persistent AF.
P Buekens - One of the best experts on this subject based on the ideXlab platform.
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Why do small twins have a Lower Mortality Rate than small singletons?
American journal of obstetrics and gynecology, 1993Co-Authors: P Buekens, A WilcoxAbstract:We propose an interpretation of the paradoxically better survival Rate among low-birth-weight twins compared with low-birth-weight singletons. We used data from Belgian birth and death certificates for 1983 and 1984. The data include 229,964 singletons, 2175 first twins, and 2153 second twins. Weight-specific perinatal Mortality Rates of twins and singletons were compared; the birth-weight distributions were adjusted to a single mean and SD. After adjustment, Mortality Rates at every weight were higher for twins than for singletons. The appearance of better survival among small twins compared with small singletons disappears after adjustment to relative birth-weight. There is a large risk resulting from twinning that falls on all twins, regardless of their weight.
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Why do small twins have a Lower Mortality Rate than small singletons
American Journal of Obstetrics and Gynecology, 1993Co-Authors: P Buekens, Allen J. WilcoxAbstract:OBJECTIVE: We propose an interpretation of the paradoxically better survival Rate among low-birth-weight twins compared with low-birth-weight singletons. STUDY DESIGN: We used data from Belgian birth and death certificates for 1983 and 1984. The data include 229,964 singletons, 2175 first twins, and 2153 second twins. Weight-specific perinatal Mortality Rates of twins and singletons were compared; the birth-weight distributions were adjusted to a single mean and SD. RESULTS: After adjustment, Mortality Rates at every weight were higher for twins than for singletons. CONCLUSIONS: The appearance of better survival among small twins compared with small Singletons disappears after adjustment to relative birth-weight. There is a large risk resulting from twinning that falls on all twins, regardless of their weight.
Prakash Deedwania - One of the best experts on this subject based on the ideXlab platform.
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spontaneous conversion and maintenance of sinus rhythm by amiodarone in patients with heart failure and atrial fibrillation observations from the veterans affairs congestive heart failure survival trial of antiarrhythmic therapy chf stat the departme
Circulation, 1998Co-Authors: Prakash Deedwania, Bramah N Singh, Kenneth A Ellenbogen, Susan G Fisher, Ross D Fletcher, Steven SinghAbstract:BACKGROUND: In a multicenter, double-blind, placebo-controlled study, the long-term effects of amiodarone on morbidity and Mortality in patients with congestive heart failure (CHF) and atrial fibrillation (AF) were evaluated during a 4-year period. METHODS AND RESULTS: Of 667 patients with CHF, 103 (15%) had AF at baseline. Of these, 51 were randomized to amiodarone and 52 to placebo. The group with sinus rhythm and the group in AF were comparable except for a higher proportion of AF in patients with nonischemic versus ischemic cardiomyopathy (41% versus 27%, P<0.005). The mean ventricular response (VR) during AF over 24 hours was reduced by amiodarone at 2 weeks (20%, P=0.001), at 6 months (18%, P=0.001), and at 12 months (16%, P=0.006). Maximal VR was reduced 22% (P=0.001) at 2 weeks, 19% (P=0.001) at 6 months, and 14% (P=0.001) at 12 months. Sixteen of 51 patients on amiodarone and 4 of 52 on placebo converted to sinus rhythm during the study (chi2=9.23, P=0.002). During follow-up, 11 of 268 patients in sinus rhythm on amiodarone at baseline and 22 of the 263 in sinus rhythm on placebo developed AF; the difference was significant (chi2=12.88, P=0.005). Analysis of total Mortality during follow-up showed a significantly Lower Mortality Rate (P=0. 04) in patients in AF at baseline who subsequently converted to sinus rhythm on amiodarone than in those who did not convert to sinus rhythm on the drug. CONCLUSIONS: In patients with CHF, amiodarone has a significant potential to spontaneously convert patients in AF to sinus rhythm, with patients who convert having a Lower Mortality Rate than those who do not. The drug prevented the development of new-onset AF and significantly reduced the VR in those with persistent AF.
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spontaneous conversion and maintenance of sinus rhythm by amiodarone in patients with heart failure and atrial fibrillation observations from the veterans affairs congestive heart failure survival trial of antiarrhythmic therapy chf stat
Circulation, 1998Co-Authors: Prakash Deedwania, Bramah N Singh, Kenneth A Ellenbogen, Susan G Fisher, Ross D Fletcher, Steven SinghAbstract:Background —In a multicenter, double-blind, placebo-controlled study, the long-term effects of amiodarone on morbidity and Mortality in patients with congestive heart failure (CHF) and atrial fibrillation (AF) were evaluated during a 4-year period. Methods and Results —Of 667 patients with CHF, 103 (15%) had AF at baseline. Of these, 51 were randomized to amiodarone and 52 to placebo. The group with sinus rhythm and the group in AF were comparable except for a higher proportion of AF in patients with nonischemic versus ischemic cardiomyopathy (41% versus 27%, P P =0.001), at 6 months (18%, P =0.001), and at 12 months (16%, P =0.006). Maximal VR was reduced 22% ( P =0.001) at 2 weeks, 19% ( P =0.001) at 6 months, and 14% ( P =0.001) at 12 months. Sixteen of 51 patients on amiodarone and 4 of 52 on placebo converted to sinus rhythm during the study (χ 2 =9.23, P =0.002). During follow-up, 11 of 268 patients in sinus rhythm on amiodarone at baseline and 22 of the 263 in sinus rhythm on placebo developed AF; the difference was significant (χ 2 =12.88, P =0.005). Analysis of total Mortality during follow-up showed a significantly Lower Mortality Rate ( P =0.04) in patients in AF at baseline who subsequently converted to sinus rhythm on amiodarone than in those who did not convert to sinus rhythm on the drug. Conclusions —In patients with CHF, amiodarone has a significant potential to spontaneously convert patients in AF to sinus rhythm, with patients who convert having a Lower Mortality Rate than those who do not. The drug prevented the development of new-onset AF and significantly reduced the VR in those with persistent AF.
A Wilcox - One of the best experts on this subject based on the ideXlab platform.
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Why do small twins have a Lower Mortality Rate than small singletons?
American journal of obstetrics and gynecology, 1993Co-Authors: P Buekens, A WilcoxAbstract:We propose an interpretation of the paradoxically better survival Rate among low-birth-weight twins compared with low-birth-weight singletons. We used data from Belgian birth and death certificates for 1983 and 1984. The data include 229,964 singletons, 2175 first twins, and 2153 second twins. Weight-specific perinatal Mortality Rates of twins and singletons were compared; the birth-weight distributions were adjusted to a single mean and SD. After adjustment, Mortality Rates at every weight were higher for twins than for singletons. The appearance of better survival among small twins compared with small singletons disappears after adjustment to relative birth-weight. There is a large risk resulting from twinning that falls on all twins, regardless of their weight.
Allen J. Wilcox - One of the best experts on this subject based on the ideXlab platform.
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Why do small twins have a Lower Mortality Rate than small singletons
American Journal of Obstetrics and Gynecology, 1993Co-Authors: P Buekens, Allen J. WilcoxAbstract:OBJECTIVE: We propose an interpretation of the paradoxically better survival Rate among low-birth-weight twins compared with low-birth-weight singletons. STUDY DESIGN: We used data from Belgian birth and death certificates for 1983 and 1984. The data include 229,964 singletons, 2175 first twins, and 2153 second twins. Weight-specific perinatal Mortality Rates of twins and singletons were compared; the birth-weight distributions were adjusted to a single mean and SD. RESULTS: After adjustment, Mortality Rates at every weight were higher for twins than for singletons. CONCLUSIONS: The appearance of better survival among small twins compared with small Singletons disappears after adjustment to relative birth-weight. There is a large risk resulting from twinning that falls on all twins, regardless of their weight.
