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Bartolome R Celli - One of the best experts on this subject based on the ideXlab platform.
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity-to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV(1), 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV(1), and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV(1) and predicted mortality independently of the BODE Index. We conclude that IC/TLC is an independent risk factor for mortality in subjects with chronic obstructive pulmonary disease. We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease.
Mohamad Mohty - One of the best experts on this subject based on the ideXlab platform.
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impact of pre transplant diffusion Lung Capacity for nitric oxide dlno and of dlno pre transplant diffusion Lung Capacity for carbon monoxide dlno dlco ratio on pulmonary outcomes in adults receiving allogeneic stem cell transplantation for hematological diseases
Bone Marrow Transplantation, 2016Co-Authors: Le A Bourgeois, Florent Malard, Patrice Chevallier, Thierry Guillaume, Jacques Delaunay, Pierre Peterlin, Patricia Lemarchand, Patrick Germaud, G Urbistandoy, Mohamad MohtyAbstract:Impact of pre-transplant diffusion Lung Capacity for nitric oxide (DLNO) and of DLNO/pre-transplant diffusion Lung Capacity for carbon monoxide (DLNO/DLCO) ratio on pulmonary outcomes in adults receiving allogeneic stem cell transplantation for hematological diseases
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impact of pre transplant diffusion Lung Capacity for nitric oxide dlno and of dlno pre transplant diffusion Lung Capacity for carbon monoxide dlno dlco ratio on pulmonary outcomes in adults receiving allogeneic stem cell transplantation for haematolo
Blood, 2015Co-Authors: Amandine Le Bourgeois, Florent Malard, Patrice Chevallier, Thierry Guillaume, Jacques Delaunay, Pierre Peterlin, Patricia Lemarchand, Patrick Germaud, Mohamad MohtyAbstract:Background: Pre-transplant pulmonary function testing (PFT) is required in all patients eligible for allogeneic stem cell transplantation (allo-SCT). Diffusion Lung Capacity for carbon monoxide (DLCO) is the main parameter taken into account but the overall impact of this factor is debated. Diffusion Lung Capacity for nitric oxide (DLNO) may be of higher interest to predict pulmonary complications, because radiotherapy and chemotherapy used to treat patients with haematological diseases affect mostly the alveolar-capillary membrane, which destruction is more appreciate by DLNO than DLCO measure. Also, DLNO/DLCO ratio represents a new index of gas exchange and an alternative way of investigating the alveolar membrane and the blood reacting with the gas. Methods: We considered all patients who received an allo-SCT for hematological malignancies between March 2012 and January 2014 in our department and for whom a pre-transplant PFT, including DLCO and DLNO measures, was validated. Factors influencing pre-transplant DLCO, DLNO and DLNO/DLCO ratio were analyzed as well as impact of those 3 diffusion Lung parameters on general outcomes and pulmonary complications (severe pulmonary complications (SPC) defined as any pulmonary complication responsible for hospitalization, pulmonary related mortality (PRM), acute respiratory distress syndrome (ARDS). Results: We included 103 patients (male: n=68, median age at transplant: 58 years) in this study. Majority of them had a myeloid disease (n=67), and were in complete (n=56) or partial (n=23) remission at transplant. Type of donor was: matched related donor (N=35), haploidentical related donor (n=5), matched unrelated donor (n=43), mismatched unrelated donor (n=9) and umbilical cord blood (n=10). First stem cell source used was peripheral blood stem cell (n=83). Eight five percent of patient received a reduced intensity regimen. With a median follow up of 21.5 months (range: 3.8-34.7), 2 year cumulative incidence of overall survival, Disease free survival, relapse incidence, non-relapse mortality, SPC, ARDS and PRM were respectively 65.4% ( 55.2-73.6), 52.5% (42.7-62.2), 31.8% (22.3-41.7), 15.8% (9.4-23.5), 25.4% (17-34), 7.8% (4-14), and 4.9% (1.8-10.4). Normal DLCO and DLNO percentages of predicted normal value (>80%) were documented in 48 and 44 patients, respectively but median percentages for the all cohort were under the normal at transplant: DLCO: 78.9%, DLNO: 78.1%. Median DLNO/DLCO ratio was 5.3 (range: 2.7-8.6). Regarding factors influencing pre-transplant PFT results, DLCO was significantly decreased in patients with respiratory history (72.3% versus 81.5%, p=0.001), in patients having received therapeutic with cardiac or pulmonary toxicities (74.2% versus 80.6%, p=0.02) and in patients over 58 years (81.0% versus 75.4%, p=0.05). Similarly, DLNO was significantly decreased in patients with respiratory history (74.3% versus 80.9%, p=0.03) and in patients9 smokers or with history of smoking (75.3% versus 81.8%, p=0.03). Finally, patients9 age was the only parameter with a significant impact on DLNO/DLCO (5.5 in patients >58 years versus 5.2 in patients ≤58years, p=0.04). In univariate analysis, a DLNO value Conclusion: DLNO and DLNO/DLCO ratio may be more appropriate to predict pulmonary complications than DLCO alone after allo-SCT. These results have to be confirmed prospectively. Disclosures Mohty:Janssen: Honoraria; Celgene: Honoraria. Moreau:Takeda: Other: Adboard; Amgen: Other: Adboard; Novartis: Other: Adboard; Celgene: Honoraria, Other: Adboard; Janssen: Other: Adboard.
Ciro Casanova - One of the best experts on this subject based on the ideXlab platform.
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity-to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV(1), 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV(1), and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV(1) and predicted mortality independently of the BODE Index. We conclude that IC/TLC is an independent risk factor for mortality in subjects with chronic obstructive pulmonary disease. We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease.
Juan P De Torres - One of the best experts on this subject based on the ideXlab platform.
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity-to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV(1), 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV(1), and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV(1) and predicted mortality independently of the BODE Index. We conclude that IC/TLC is an independent risk factor for mortality in subjects with chronic obstructive pulmonary disease. We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease.
Victor Pintoplata - One of the best experts on this subject based on the ideXlab platform.
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity–to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV1, 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV1, and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV1 and predicted mortality...
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inspiratory to total Lung Capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Ciro Casanova, Juan P De Torres, Victor Pintoplata, A Aguirrejaime, Claudia Cote, Jose M Marin, Bartolome R CelliAbstract:Static Lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of Lung hyperinflation as measured by the inspiratory Capacity-to-total Lung Capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV(1), 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV(1), and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV(1) and predicted mortality independently of the BODE Index. We conclude that IC/TLC is an independent risk factor for mortality in subjects with chronic obstructive pulmonary disease. We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease.
