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Paolo Palange - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiological adaptations to walking and cycling in primary pulmonary hypertension.
European journal of applied physiology, 2007Co-Authors: Gabriele Valli, Paolo Onorati, Pietro Serra, Carmine Dario Vizza, Roberto Badagliacca, R. Ciuffa, Roberto Poscia, Filippo Brandimarte, Francesco Fedele, Paolo PalangeAbstract:Exercise tolerance inversely correlates with the severity of the disease in patients with idiopathic pulmonary arterial hypertension (IPAH). Cycling and walking protocols are commonly utilized in the evaluation of exercise intolerance in IPAH, but little information exists on possible differences in ventilatory and Gas Exchange adaptations to these exercise modalities. In a group of patients with moderate to severe IPAH (n = 13), we studied the ventilatory, cardiovascular and Gas Exchange adaptations to maximal incremental walking (W) and maximal incremental cycling (C). During W, compared to C, the ventilatory equivalents for CO2 output (V′E/V′CO2) were significantly higher either expressed as the rate of increment (56 ± 5 vs. 45 ± 3; P < 0.0001) or as the absolute values at anaerobic threshold (AT) and at peak exercise. At AT, the increase in V′E/V′CO2 during W was associated with a significant lower value of end-tidal carbon dioxide. At peak W, compared to peak C, dyspnea sensation was higher and arterial oxygen saturation (SpO2) was lower (87 ± 2 vs. 91 ± 2, P < 0.001). In patients with IPAH the physiologic information obtained with W are different from those obtained with C. Tolerance to W exercise is limited by high ventilatory response and dyspnea sensation. W should be used to assess the degree of Lung Gas Exchange inefficiency and arterial O2 desaturation during exercise.
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Paolo Onorati, Rosa Antonucci, Gabriele Valli, Emanuela Berton, Francesca Marco, Pietro Serra, Paolo PalangeAbstract:Walking tests, such as the "shuttle" incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV_1): 1.2 (0.1) l; arterial O_2 tension ( P aO_2): 72 (2) mmHg; arterial CO_2 tension ( P aCO_2): 41 (1) mmHg]. Oxygen uptake ( V̇ O_2), CO_2 output ( V̇ CO_2), minute ventilation ( V̇ _E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, V̇ O_2, V̇ CO_2, V̇ _E, and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with V̇ O_2PEAK ( R =0.86, p
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Pietro Serra, Paolo Onorati, Rosa Antonucci, Gabriele Valli, Paolo Palange, Eric Berton, Francesca MarcoAbstract:Walking tests, such as the ``shuttle'' incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV1): 1.2 (0.1) 1; arterial O-2 tension (PaO2): 72 (2) mmHg; arterial CO2 tension (PaCO2): 41 (1) mmHg]. Oxygen uptake ((V) over dot O-2), CO2 output ((V) over dot CO2), minute ventilation (V-E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, (V) over dot O-2, (V) over dot CO2, (V) over dot (E), and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with (V) over dot O-2PEAK (R = 0.86, p < 0.001), (V) over dot CO2PEAK (R = 0.87, p < 0.001) and (V) over dot (EPEAK) (R = 0.74, p
Paolo Onorati - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiological adaptations to walking and cycling in primary pulmonary hypertension.
European journal of applied physiology, 2007Co-Authors: Gabriele Valli, Paolo Onorati, Pietro Serra, Carmine Dario Vizza, Roberto Badagliacca, R. Ciuffa, Roberto Poscia, Filippo Brandimarte, Francesco Fedele, Paolo PalangeAbstract:Exercise tolerance inversely correlates with the severity of the disease in patients with idiopathic pulmonary arterial hypertension (IPAH). Cycling and walking protocols are commonly utilized in the evaluation of exercise intolerance in IPAH, but little information exists on possible differences in ventilatory and Gas Exchange adaptations to these exercise modalities. In a group of patients with moderate to severe IPAH (n = 13), we studied the ventilatory, cardiovascular and Gas Exchange adaptations to maximal incremental walking (W) and maximal incremental cycling (C). During W, compared to C, the ventilatory equivalents for CO2 output (V′E/V′CO2) were significantly higher either expressed as the rate of increment (56 ± 5 vs. 45 ± 3; P < 0.0001) or as the absolute values at anaerobic threshold (AT) and at peak exercise. At AT, the increase in V′E/V′CO2 during W was associated with a significant lower value of end-tidal carbon dioxide. At peak W, compared to peak C, dyspnea sensation was higher and arterial oxygen saturation (SpO2) was lower (87 ± 2 vs. 91 ± 2, P < 0.001). In patients with IPAH the physiologic information obtained with W are different from those obtained with C. Tolerance to W exercise is limited by high ventilatory response and dyspnea sensation. W should be used to assess the degree of Lung Gas Exchange inefficiency and arterial O2 desaturation during exercise.
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Paolo Onorati, Rosa Antonucci, Gabriele Valli, Emanuela Berton, Francesca Marco, Pietro Serra, Paolo PalangeAbstract:Walking tests, such as the "shuttle" incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV_1): 1.2 (0.1) l; arterial O_2 tension ( P aO_2): 72 (2) mmHg; arterial CO_2 tension ( P aCO_2): 41 (1) mmHg]. Oxygen uptake ( V̇ O_2), CO_2 output ( V̇ CO_2), minute ventilation ( V̇ _E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, V̇ O_2, V̇ CO_2, V̇ _E, and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with V̇ O_2PEAK ( R =0.86, p
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Pietro Serra, Paolo Onorati, Rosa Antonucci, Gabriele Valli, Paolo Palange, Eric Berton, Francesca MarcoAbstract:Walking tests, such as the ``shuttle'' incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV1): 1.2 (0.1) 1; arterial O-2 tension (PaO2): 72 (2) mmHg; arterial CO2 tension (PaCO2): 41 (1) mmHg]. Oxygen uptake ((V) over dot O-2), CO2 output ((V) over dot CO2), minute ventilation (V-E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, (V) over dot O-2, (V) over dot CO2, (V) over dot (E), and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with (V) over dot O-2PEAK (R = 0.86, p < 0.001), (V) over dot CO2PEAK (R = 0.87, p < 0.001) and (V) over dot (EPEAK) (R = 0.74, p
Pietro Serra - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiological adaptations to walking and cycling in primary pulmonary hypertension.
European journal of applied physiology, 2007Co-Authors: Gabriele Valli, Paolo Onorati, Pietro Serra, Carmine Dario Vizza, Roberto Badagliacca, R. Ciuffa, Roberto Poscia, Filippo Brandimarte, Francesco Fedele, Paolo PalangeAbstract:Exercise tolerance inversely correlates with the severity of the disease in patients with idiopathic pulmonary arterial hypertension (IPAH). Cycling and walking protocols are commonly utilized in the evaluation of exercise intolerance in IPAH, but little information exists on possible differences in ventilatory and Gas Exchange adaptations to these exercise modalities. In a group of patients with moderate to severe IPAH (n = 13), we studied the ventilatory, cardiovascular and Gas Exchange adaptations to maximal incremental walking (W) and maximal incremental cycling (C). During W, compared to C, the ventilatory equivalents for CO2 output (V′E/V′CO2) were significantly higher either expressed as the rate of increment (56 ± 5 vs. 45 ± 3; P < 0.0001) or as the absolute values at anaerobic threshold (AT) and at peak exercise. At AT, the increase in V′E/V′CO2 during W was associated with a significant lower value of end-tidal carbon dioxide. At peak W, compared to peak C, dyspnea sensation was higher and arterial oxygen saturation (SpO2) was lower (87 ± 2 vs. 91 ± 2, P < 0.001). In patients with IPAH the physiologic information obtained with W are different from those obtained with C. Tolerance to W exercise is limited by high ventilatory response and dyspnea sensation. W should be used to assess the degree of Lung Gas Exchange inefficiency and arterial O2 desaturation during exercise.
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Paolo Onorati, Rosa Antonucci, Gabriele Valli, Emanuela Berton, Francesca Marco, Pietro Serra, Paolo PalangeAbstract:Walking tests, such as the "shuttle" incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV_1): 1.2 (0.1) l; arterial O_2 tension ( P aO_2): 72 (2) mmHg; arterial CO_2 tension ( P aCO_2): 41 (1) mmHg]. Oxygen uptake ( V̇ O_2), CO_2 output ( V̇ CO_2), minute ventilation ( V̇ _E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, V̇ O_2, V̇ CO_2, V̇ _E, and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with V̇ O_2PEAK ( R =0.86, p
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Pietro Serra, Paolo Onorati, Rosa Antonucci, Gabriele Valli, Paolo Palange, Eric Berton, Francesca MarcoAbstract:Walking tests, such as the ``shuttle'' incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV1): 1.2 (0.1) 1; arterial O-2 tension (PaO2): 72 (2) mmHg; arterial CO2 tension (PaCO2): 41 (1) mmHg]. Oxygen uptake ((V) over dot O-2), CO2 output ((V) over dot CO2), minute ventilation (V-E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, (V) over dot O-2, (V) over dot CO2, (V) over dot (E), and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with (V) over dot O-2PEAK (R = 0.86, p < 0.001), (V) over dot CO2PEAK (R = 0.87, p < 0.001) and (V) over dot (EPEAK) (R = 0.74, p
Gabriele Valli - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiological adaptations to walking and cycling in primary pulmonary hypertension.
European journal of applied physiology, 2007Co-Authors: Gabriele Valli, Paolo Onorati, Pietro Serra, Carmine Dario Vizza, Roberto Badagliacca, R. Ciuffa, Roberto Poscia, Filippo Brandimarte, Francesco Fedele, Paolo PalangeAbstract:Exercise tolerance inversely correlates with the severity of the disease in patients with idiopathic pulmonary arterial hypertension (IPAH). Cycling and walking protocols are commonly utilized in the evaluation of exercise intolerance in IPAH, but little information exists on possible differences in ventilatory and Gas Exchange adaptations to these exercise modalities. In a group of patients with moderate to severe IPAH (n = 13), we studied the ventilatory, cardiovascular and Gas Exchange adaptations to maximal incremental walking (W) and maximal incremental cycling (C). During W, compared to C, the ventilatory equivalents for CO2 output (V′E/V′CO2) were significantly higher either expressed as the rate of increment (56 ± 5 vs. 45 ± 3; P < 0.0001) or as the absolute values at anaerobic threshold (AT) and at peak exercise. At AT, the increase in V′E/V′CO2 during W was associated with a significant lower value of end-tidal carbon dioxide. At peak W, compared to peak C, dyspnea sensation was higher and arterial oxygen saturation (SpO2) was lower (87 ± 2 vs. 91 ± 2, P < 0.001). In patients with IPAH the physiologic information obtained with W are different from those obtained with C. Tolerance to W exercise is limited by high ventilatory response and dyspnea sensation. W should be used to assess the degree of Lung Gas Exchange inefficiency and arterial O2 desaturation during exercise.
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Paolo Onorati, Rosa Antonucci, Gabriele Valli, Emanuela Berton, Francesca Marco, Pietro Serra, Paolo PalangeAbstract:Walking tests, such as the "shuttle" incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV_1): 1.2 (0.1) l; arterial O_2 tension ( P aO_2): 72 (2) mmHg; arterial CO_2 tension ( P aCO_2): 41 (1) mmHg]. Oxygen uptake ( V̇ O_2), CO_2 output ( V̇ CO_2), minute ventilation ( V̇ _E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, V̇ O_2, V̇ CO_2, V̇ _E, and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with V̇ O_2PEAK ( R =0.86, p
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Pietro Serra, Paolo Onorati, Rosa Antonucci, Gabriele Valli, Paolo Palange, Eric Berton, Francesca MarcoAbstract:Walking tests, such as the ``shuttle'' incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV1): 1.2 (0.1) 1; arterial O-2 tension (PaO2): 72 (2) mmHg; arterial CO2 tension (PaCO2): 41 (1) mmHg]. Oxygen uptake ((V) over dot O-2), CO2 output ((V) over dot CO2), minute ventilation (V-E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, (V) over dot O-2, (V) over dot CO2, (V) over dot (E), and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with (V) over dot O-2PEAK (R = 0.86, p < 0.001), (V) over dot CO2PEAK (R = 0.87, p < 0.001) and (V) over dot (EPEAK) (R = 0.74, p
Francesca Marco - One of the best experts on this subject based on the ideXlab platform.
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Paolo Onorati, Rosa Antonucci, Gabriele Valli, Emanuela Berton, Francesca Marco, Pietro Serra, Paolo PalangeAbstract:Walking tests, such as the "shuttle" incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV_1): 1.2 (0.1) l; arterial O_2 tension ( P aO_2): 72 (2) mmHg; arterial CO_2 tension ( P aCO_2): 41 (1) mmHg]. Oxygen uptake ( V̇ O_2), CO_2 output ( V̇ CO_2), minute ventilation ( V̇ _E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, V̇ O_2, V̇ CO_2, V̇ _E, and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with V̇ O_2PEAK ( R =0.86, p
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Non-invasive evaluation of Gas Exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients
European Journal of Applied Physiology, 2003Co-Authors: Pietro Serra, Paolo Onorati, Rosa Antonucci, Gabriele Valli, Paolo Palange, Eric Berton, Francesca MarcoAbstract:Walking tests, such as the ``shuttle'' incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because Lung Gas Exchange indexes are not measured, little is known about the physiological response elicited by different walking protocols. We compared exercise adaptation during the 6'WT and SWT in 13 male stable COPD patients [mean (SE) age: 70 (1) years; forced expiratory volume in 1 s (FEV1): 1.2 (0.1) 1; arterial O-2 tension (PaO2): 72 (2) mmHg; arterial CO2 tension (PaCO2): 41 (1) mmHg]. Oxygen uptake ((V) over dot O-2), CO2 output ((V) over dot CO2), minute ventilation (V-E), and heart rate (HR) were monitored by a portable telemetric system. During the SWT a linear response in Lung Gas Exchange indexes was observed while, during the 6'WT, the response was exponential. During the 6'WT, (V) over dot O-2, (V) over dot CO2, (V) over dot (E), and HR values at steady-state (SS) were significantly lower compared to SWT peak values. For SWT, distance covered correlated with (V) over dot O-2PEAK (R = 0.86, p < 0.001), (V) over dot CO2PEAK (R = 0.87, p < 0.001) and (V) over dot (EPEAK) (R = 0.74, p
