Lung Insufficiency

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Bengt Nellgård - One of the best experts on this subject based on the ideXlab platform.

  • Prone position in mechanically ventilated patients with reduced intracranial compliance.
    Acta Anaesthesiologica Scandinavica, 2006
    Co-Authors: Anneli Thelandersson, Åsa Cider, Bengt Nellgård
    Abstract:

    BACKGROUND: Prone position has been used for several years to treat acute Lung Insufficiency, but in previous studies patients with unstable intracranial pressure (ICP) are mostly excluded. The aim of this study was to investigate if prone position is a safe and useful treatment in patients with reduced intracranial compliance. METHODS: A consecutive, prospective pilot study of 11 patients admitted to the neuro intensive care unit (NICU) due to traumatic brain injury or intracerebral haemorrhage. ICP, cerebral perfusion pressure (CPP), heart rate (HR), mean arterial blood pressure (MABP), arterial partial pressure of oxygen (PaO(2)), arterial partial pressure of carbon dioxide (PaCO(2)), arterial oxygen saturation (SaO(2)) and respiratory system compliance were measured before, three times during and two times after the patients were placed in the prone position. RESULTS: No significant changes were demonstrated in ICP, CPP or MABP. PaO(2) and SaO(2) were significantly increased in the prone position. HR was significantly increased in the prone position and after 10 min in the supine post-prone position and the respiratory system compliance was increased after 1 h in the supine post-prone position. CONCLUSION: Turning NICU patients from the supine to the prone position did not influence ICP, CPP or MABP, but significantly improved patient PaO(2), SaO(2) and respiratory system compliance.

  • Prone position in mechanically ventilated patients with reduced intracranial compliance.
    Acta Anaesthesiologica Scandinavica, 2006
    Co-Authors: Anneli Thelandersson, Åsa Cider, Bengt Nellgård
    Abstract:

    BACKGROUND: Prone position has been used for several years to treat acute Lung Insufficiency, but in previous studies patients with unstable intracranial pressure (ICP) are mostly excluded. The aim of this study was to investigate if prone position is a safe and useful treatment in patients with reduced intracranial compliance. METHODS: A consecutive, prospective pilot study of 11 patients admitted to the neuro intensive care unit (NICU) due to traumatic brain injury or intracerebral haemorrhage. ICP, cerebral perfusion pressure (CPP), heart rate (HR), mean arterial blood pressure (MABP), arterial partial pressure of oxygen (PaO(2)), arterial partial pressure of carbon dioxide (PaCO(2)), arterial oxygen saturation (SaO(2)) and respiratory system compliance were measured before, three times during and two times after the patients were placed in the prone position. RESULTS: No significant changes were demonstrated in ICP, CPP or MABP. PaO(2) and SaO(2) were significantly increased in the prone position. HR was significantly increased in the prone position and after 10 min in the supine post-prone position and the respiratory system compliance was increased after 1 h in the supine post-prone position. CONCLUSION: Turning NICU patients from the supine to the prone position did not influence ICP, CPP or MABP, but significantly improved patient PaO(2), SaO(2) and respiratory system compliance.

Anneli Thelandersson - One of the best experts on this subject based on the ideXlab platform.

  • Prone position in mechanically ventilated patients with reduced intracranial compliance.
    Acta Anaesthesiologica Scandinavica, 2006
    Co-Authors: Anneli Thelandersson, Åsa Cider, Bengt Nellgård
    Abstract:

    BACKGROUND: Prone position has been used for several years to treat acute Lung Insufficiency, but in previous studies patients with unstable intracranial pressure (ICP) are mostly excluded. The aim of this study was to investigate if prone position is a safe and useful treatment in patients with reduced intracranial compliance. METHODS: A consecutive, prospective pilot study of 11 patients admitted to the neuro intensive care unit (NICU) due to traumatic brain injury or intracerebral haemorrhage. ICP, cerebral perfusion pressure (CPP), heart rate (HR), mean arterial blood pressure (MABP), arterial partial pressure of oxygen (PaO(2)), arterial partial pressure of carbon dioxide (PaCO(2)), arterial oxygen saturation (SaO(2)) and respiratory system compliance were measured before, three times during and two times after the patients were placed in the prone position. RESULTS: No significant changes were demonstrated in ICP, CPP or MABP. PaO(2) and SaO(2) were significantly increased in the prone position. HR was significantly increased in the prone position and after 10 min in the supine post-prone position and the respiratory system compliance was increased after 1 h in the supine post-prone position. CONCLUSION: Turning NICU patients from the supine to the prone position did not influence ICP, CPP or MABP, but significantly improved patient PaO(2), SaO(2) and respiratory system compliance.

  • Prone position in mechanically ventilated patients with reduced intracranial compliance.
    Acta Anaesthesiologica Scandinavica, 2006
    Co-Authors: Anneli Thelandersson, Åsa Cider, Bengt Nellgård
    Abstract:

    BACKGROUND: Prone position has been used for several years to treat acute Lung Insufficiency, but in previous studies patients with unstable intracranial pressure (ICP) are mostly excluded. The aim of this study was to investigate if prone position is a safe and useful treatment in patients with reduced intracranial compliance. METHODS: A consecutive, prospective pilot study of 11 patients admitted to the neuro intensive care unit (NICU) due to traumatic brain injury or intracerebral haemorrhage. ICP, cerebral perfusion pressure (CPP), heart rate (HR), mean arterial blood pressure (MABP), arterial partial pressure of oxygen (PaO(2)), arterial partial pressure of carbon dioxide (PaCO(2)), arterial oxygen saturation (SaO(2)) and respiratory system compliance were measured before, three times during and two times after the patients were placed in the prone position. RESULTS: No significant changes were demonstrated in ICP, CPP or MABP. PaO(2) and SaO(2) were significantly increased in the prone position. HR was significantly increased in the prone position and after 10 min in the supine post-prone position and the respiratory system compliance was increased after 1 h in the supine post-prone position. CONCLUSION: Turning NICU patients from the supine to the prone position did not influence ICP, CPP or MABP, but significantly improved patient PaO(2), SaO(2) and respiratory system compliance.

Sten G E Lindahl - One of the best experts on this subject based on the ideXlab platform.

  • Regional differences in nitric oxide-mediated vasorelaxation in porcine pulmonary arteries.
    Acta anaesthesiologica Scandinavica, 2006
    Co-Authors: D. Rimeika, Sten G E Lindahl, N. P. Wiklund, C. U. Wiklund
    Abstract:

    Background:  Several previous investigations have shown improved oxygenation when ventilator-treated patients with acute Lung injury are turned prone. In a previous human study, we demonstrated higher Ca2+-dependent nitric oxide synthase (NOS) activity in dorsal than in ventral parts of the Lung. The current investigation was designed to determine whether Ca2+-dependent NOS activity was different in dorsal and ventral porcine Lung regions. In addition, possible differences in vascular responses to nitroprusside or secondary to acetylcholine- or bradykinin-stimulated NO production were studied in dorsal and ventral pulmonary arteries. Methods:  In the study, 20 pigs were used. Lung biopsies and pulmonary arterial rings were harvested from ventral and dorsal Lung regions. NOS activity was determined by citrulline assay in the presence and absence of the calcium chelator ethyleneglycol-bis(β-aminoethylether)-N,N′-tetraacetic acid (EDTA) to discriminate between Ca2+-dependent and Ca2+-independent NOS activity. In organ baths, in submaximally contracted arterial rings, vasorelaxation induced by acetylcholine, bradykinin and nitroprusside was measured. Results:  Ca2+-dependent NOS activity was higher in dorsal parts (87.2 ± 9.1 citrulline units) than in ventral parts (62.2 ± 10.1 citrulline units, P < 0.05) of porcine Lung. There was a greater relaxation in dorsal than in ventral pulmonary arterial rings induced by both acetylcholine and bradykinin. Nitroprusside relaxed both sites equally. Conclusions:  Our results show that endothelial-derived NO is an important factor influencing the differences between dorsal and ventral Lung regions in vasorelaxing activity in porcine pulmonary arteries. This finding provides an explanation for the improved oxygenation when patients with severe acute Lung Insufficiency are turned prone.

  • dramatic effect on oxygenation in patients with severe acute Lung Insufficiency treated in the prone position
    Critical Care Medicine, 1997
    Co-Authors: Margareta Mure, Claesroland Martling, Sten G E Lindahl
    Abstract:

    ObjectiveTo confirm the positive effect of prone positioning on oxygenation in patients with acute Lung Insufficiency.DesignClinical follow-up study.SettingThe intensive care unit at a tertiary care academic hospital.PatientsThirteen patients suffering from severe acute Lung Insufficiency caused by

Åsa Cider - One of the best experts on this subject based on the ideXlab platform.

  • Prone position in mechanically ventilated patients with reduced intracranial compliance.
    Acta Anaesthesiologica Scandinavica, 2006
    Co-Authors: Anneli Thelandersson, Åsa Cider, Bengt Nellgård
    Abstract:

    BACKGROUND: Prone position has been used for several years to treat acute Lung Insufficiency, but in previous studies patients with unstable intracranial pressure (ICP) are mostly excluded. The aim of this study was to investigate if prone position is a safe and useful treatment in patients with reduced intracranial compliance. METHODS: A consecutive, prospective pilot study of 11 patients admitted to the neuro intensive care unit (NICU) due to traumatic brain injury or intracerebral haemorrhage. ICP, cerebral perfusion pressure (CPP), heart rate (HR), mean arterial blood pressure (MABP), arterial partial pressure of oxygen (PaO(2)), arterial partial pressure of carbon dioxide (PaCO(2)), arterial oxygen saturation (SaO(2)) and respiratory system compliance were measured before, three times during and two times after the patients were placed in the prone position. RESULTS: No significant changes were demonstrated in ICP, CPP or MABP. PaO(2) and SaO(2) were significantly increased in the prone position. HR was significantly increased in the prone position and after 10 min in the supine post-prone position and the respiratory system compliance was increased after 1 h in the supine post-prone position. CONCLUSION: Turning NICU patients from the supine to the prone position did not influence ICP, CPP or MABP, but significantly improved patient PaO(2), SaO(2) and respiratory system compliance.

  • Prone position in mechanically ventilated patients with reduced intracranial compliance.
    Acta Anaesthesiologica Scandinavica, 2006
    Co-Authors: Anneli Thelandersson, Åsa Cider, Bengt Nellgård
    Abstract:

    BACKGROUND: Prone position has been used for several years to treat acute Lung Insufficiency, but in previous studies patients with unstable intracranial pressure (ICP) are mostly excluded. The aim of this study was to investigate if prone position is a safe and useful treatment in patients with reduced intracranial compliance. METHODS: A consecutive, prospective pilot study of 11 patients admitted to the neuro intensive care unit (NICU) due to traumatic brain injury or intracerebral haemorrhage. ICP, cerebral perfusion pressure (CPP), heart rate (HR), mean arterial blood pressure (MABP), arterial partial pressure of oxygen (PaO(2)), arterial partial pressure of carbon dioxide (PaCO(2)), arterial oxygen saturation (SaO(2)) and respiratory system compliance were measured before, three times during and two times after the patients were placed in the prone position. RESULTS: No significant changes were demonstrated in ICP, CPP or MABP. PaO(2) and SaO(2) were significantly increased in the prone position. HR was significantly increased in the prone position and after 10 min in the supine post-prone position and the respiratory system compliance was increased after 1 h in the supine post-prone position. CONCLUSION: Turning NICU patients from the supine to the prone position did not influence ICP, CPP or MABP, but significantly improved patient PaO(2), SaO(2) and respiratory system compliance.

Margareta Mure - One of the best experts on this subject based on the ideXlab platform.

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