The Experts below are selected from a list of 5661 Experts worldwide ranked by ideXlab platform
Yuji Yasunaga - One of the best experts on this subject based on the ideXlab platform.
-
Intradural extramedullary mass formation in spinal cord Sarcoidosis: case report and literature review.
Spine, 2003Co-Authors: Takahiko Hamasaki, Masayuki Noda, Naosuke Kamei, Susumu Yamamoto, Mitsuo Ochi, Yuji YasunagaAbstract:Study Design. A case of myelopathy caused by intradural extramedullary spinal cord Sarcoidosis. Objectives. To report a rare case of mass formation in spinal cord Sarcoidosis and discuss the diagnostic approach and therapeutic management of this condition. Summary of Background Data. > Spinal cord Sarcoidosis is a rare condition that is difficult to diagnose, and intradural extramedullary mass formation is even rarer. Materials and Methods. A 42-year-old woman first noticed numbness in her fingers, and these symptoms gradually spread to her hands and feet. MRI revealed an intradural extramedullary mass, as confirmed by an isointensity T1 and low-intensity T2 signal, and also enhanced by Gd-DTPA. The authors suspected the mass to be a meningioma and performed surgery to resect it. Results. The mass was observed through the dura, and it was twined with the rootlet. After surgery, the patient experienced temporary paralysis of her right upper extremity, followed rapidly by almost complete neurologic recovery. Bilateral hilar lymphadenopathy was noted and this was diagnosed histologically as Lung Sarcoidosis. One year after surgery, a complete AV block occurred because of heart Sarcoidosis and a pacemaker was inserted. Conclusions. Spinal cord Sarcoidosis is rare disease and is difficult to diagnose, but when a mass is present in the spinal canal, it is important to remain open to the possibility of spinal cord Sarcoidosis. Besides if it is diagnosed as spinal cord Sarcoidosis, it is also important to remain systemic Sarcoidosis before, during, and after surgery to check general conditions and to guide appropriate treatment.
Jose C. Clemente - One of the best experts on this subject based on the ideXlab platform.
-
The Lung microbiota in early rheumatoid arthritis and autoimmunity
Microbiome, 2016Co-Authors: Jose U. Scher, Anders Eklund, Johan Grunewald, Vijay Joshua, Alejandro Artacho, Shahla Abdollahi-roodsaz, Johan Öckinger, Susanna Kullberg, Magnus Sköld, Jose C. ClementeAbstract:Background Airway abnormalities and Lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This suggests the possibility that the Lung could be a site of autoimmunity generation in RA, perhaps in response to microbiota changes. We therefore sought to test whether the RA Lung microbiome contains distinct taxonomic features associated with local and/or systemic autoimmunity. Methods 16S rRNA gene high-throughput sequencing was utilized to compare the bacterial community composition of bronchoalveolar lavage fluid (BAL) in patients with early, disease-modifying anti-rheumatic drugs (DMARD)-naïve RA, patients with Lung Sarcoidosis, and healthy control subjects. Samples were further assessed for the presence and levels of anti-citrullinated peptide antibodies (including fine specificities) in both BAL and serum. Results The BAL microbiota of RA patients was significantly less diverse and abundant when compared to healthy controls, but similar to Sarcoidosis patients. This distal airway dysbiosis was attributed to the reduced presence of several genus (i.e., Actynomyces and Burkhordelia ) as well as reported periodontopathic taxa, including Treponema , Prevotella , and Porphyromonas . While multiple clades correlated with local and systemic levels of autoantibodies, the genus Pseudonocardia and various related OTUs were the only taxa overrepresented in RA BAL and correlated with higher disease activity and erosions. Conclusions Distal airway dysbiosis is present in untreated early RA and similar to that detected in Sarcoidosis Lung inflammation. This community perturbation, which correlates with local and systemic autoimmune/inflammatory changes, may potentially drive initiation of RA in a proportion of cases.
-
The Lung microbiota in early rheumatoid arthritis and autoimmunity
Microbiome, 2016Co-Authors: Jose U. Scher, Anders Eklund, Johan Grunewald, Vijay Joshua, Alejandro Artacho, Shahla Abdollahi-roodsaz, Johan Öckinger, Susanna Kullberg, Magnus Sköld, Jose C. ClementeAbstract:Airway abnormalities and Lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This suggests the possibility that the Lung could be a site of autoimmunity generation in RA, perhaps in response to microbiota changes. We therefore sought to test whether the RA Lung microbiome contains distinct taxonomic features associated with local and/or systemic autoimmunity. 16S rRNA gene high-throughput sequencing was utilized to compare the bacterial community composition of bronchoalveolar lavage fluid (BAL) in patients with early, disease-modifying anti-rheumatic drugs (DMARD)-naive RA, patients with Lung Sarcoidosis, and healthy control subjects. Samples were further assessed for the presence and levels of anti-citrullinated peptide antibodies (including fine specificities) in both BAL and serum. The BAL microbiota of RA patients was significantly less diverse and abundant when compared to healthy controls, but similar to Sarcoidosis patients. This distal airway dysbiosis was attributed to the reduced presence of several genus (i.e., Actynomyces and Burkhordelia) as well as reported periodontopathic taxa, including Treponema, Prevotella, and Porphyromonas. While multiple clades correlated with local and systemic levels of autoantibodies, the genus Pseudonocardia and various related OTUs were the only taxa overrepresented in RA BAL and correlated with higher disease activity and erosions. Distal airway dysbiosis is present in untreated early RA and similar to that detected in Sarcoidosis Lung inflammation. This community perturbation, which correlates with local and systemic autoimmune/inflammatory changes, may potentially drive initiation of RA in a proportion of cases.
Kazuma Ohyashiki - One of the best experts on this subject based on the ideXlab platform.
-
A case of primary pulmonary cavitation with thin smooth walls in Sarcoidosis
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2004Co-Authors: Masafumi Misawa, Masahiro Aoshima, Kousuke Mizuno, Hitoshi Ohkubo, Yusuke Hakoda, Tsuyoshi Yoshida, Kazushige Minemura, Kenta Utsumi, Kazuma OhyashikiAbstract:A 27-year-old female was admitted to our hospital after a regular medical check revealed BHL and cavitation in the right upper Lung field on a chest radiograph. Ga scintigraphy showed abnormal uptake bilaterally in the mediastinal and hilar lymph nodes. We strongly suspected Lung Sarcoidosis, then performed TBLB and BAL. BAL fluid disclosed a high proportion of lymphocytes with a marked elevation of the CD4/CD8 ratio, compatible with Sarcoidosis. A TBLB specimen revealed non-caseating epithelioid cell granuloma compatible with a diagnosis of Lung Sarcoidosis. From the clinical and radiological observations, it was concluded that the cavitation in the present case was primary pulmonary cavitation in Sarcoidosis, as distinct from infection, malignancy, bulla or cystic bronchiectasis. Chest radiographs taken a half year after diagnosis showed reduction of the cavitary lesion and disappearance of BHL.
-
Direct demonstration of the productive capability of cytokines at the single cell level in Lung Sarcoidosis using multicolor cytometry.
Respiration; international review of thoracic diseases, 2002Co-Authors: Akira Kunisawa, Akira Nagate, Ikuma Kasuga, Yoshikazu Kawanishi, Hidekazu Tago, Kazuma OhyashikiAbstract:Background: Sarcoidosis is a chronic systemic disorder of unknown etiology characterized by noncaseating epithelioid cell granulomatous lesions, around which an increasing number of
-
A case of spinal Sarcoidosis complaining of chest and back pain as a first manifestation and mimicking syringomyelia on MRI
No to shinkei = Brain and nerve, 2002Co-Authors: Masafumi Misawa, Kazushige Minemura, Kenta Utsumi, Akira Nagate, Akira Kunisawa, Ikuma Kasuga, Kazuma OhyashikiAbstract:The patient was a 24-year-old female complaining of bell-shaped chest and back pain with visual disturbance. Chest X-ray showed bilateral hilar lymphadenopathy without the presence of pleural effusion. Bronchoalveolar fluid showed lymphocytosis with an elevated CD 4/CD 8 ratio. Transbronchial Lung biopsy demonstrated a non-caserous granulomatous lesion with an accumulation of epitheloid cells, suggesting Lung Sarcoidosis. No abnormality of electrocardiogram was detectable, and spinal tap for examination of chest and back pain demonstrated on elevated level of beta 2-microglobulin, and a normal angiotensin converting enzyme level. Spinal MRI showed a lineal lesion mimicking syringomyelia on T 2-weighted image. Steroid administration was started for the chest and back pain, since the spinal lesion was suspected due to spinal Sarcoidosis. All clinical and laboratory findings, without the presence of pleural effusion or cardiac fluid, supported the diagnosis of spinal Sarcoidosis causing chest and back pain. In the literature, patients with spinal Sarcoidosis manifesting chest and back pain and with a MRI finding mimicking syringomyelia have been rarely reported. This case might be important in considering spinal cord Sarcoidosis as a differential diagnosis of chest and back pain.
Takahiko Hamasaki - One of the best experts on this subject based on the ideXlab platform.
-
Intradural extramedullary mass formation in spinal cord Sarcoidosis: case report and literature review.
Spine, 2003Co-Authors: Takahiko Hamasaki, Masayuki Noda, Naosuke Kamei, Susumu Yamamoto, Mitsuo Ochi, Yuji YasunagaAbstract:Study Design. A case of myelopathy caused by intradural extramedullary spinal cord Sarcoidosis. Objectives. To report a rare case of mass formation in spinal cord Sarcoidosis and discuss the diagnostic approach and therapeutic management of this condition. Summary of Background Data. > Spinal cord Sarcoidosis is a rare condition that is difficult to diagnose, and intradural extramedullary mass formation is even rarer. Materials and Methods. A 42-year-old woman first noticed numbness in her fingers, and these symptoms gradually spread to her hands and feet. MRI revealed an intradural extramedullary mass, as confirmed by an isointensity T1 and low-intensity T2 signal, and also enhanced by Gd-DTPA. The authors suspected the mass to be a meningioma and performed surgery to resect it. Results. The mass was observed through the dura, and it was twined with the rootlet. After surgery, the patient experienced temporary paralysis of her right upper extremity, followed rapidly by almost complete neurologic recovery. Bilateral hilar lymphadenopathy was noted and this was diagnosed histologically as Lung Sarcoidosis. One year after surgery, a complete AV block occurred because of heart Sarcoidosis and a pacemaker was inserted. Conclusions. Spinal cord Sarcoidosis is rare disease and is difficult to diagnose, but when a mass is present in the spinal canal, it is important to remain open to the possibility of spinal cord Sarcoidosis. Besides if it is diagnosed as spinal cord Sarcoidosis, it is also important to remain systemic Sarcoidosis before, during, and after surgery to check general conditions and to guide appropriate treatment.
Jose U. Scher - One of the best experts on this subject based on the ideXlab platform.
-
The Lung microbiota in early rheumatoid arthritis and autoimmunity
Microbiome, 2016Co-Authors: Jose U. Scher, Anders Eklund, Johan Grunewald, Vijay Joshua, Alejandro Artacho, Shahla Abdollahi-roodsaz, Johan Öckinger, Susanna Kullberg, Magnus Sköld, Jose C. ClementeAbstract:Background Airway abnormalities and Lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This suggests the possibility that the Lung could be a site of autoimmunity generation in RA, perhaps in response to microbiota changes. We therefore sought to test whether the RA Lung microbiome contains distinct taxonomic features associated with local and/or systemic autoimmunity. Methods 16S rRNA gene high-throughput sequencing was utilized to compare the bacterial community composition of bronchoalveolar lavage fluid (BAL) in patients with early, disease-modifying anti-rheumatic drugs (DMARD)-naïve RA, patients with Lung Sarcoidosis, and healthy control subjects. Samples were further assessed for the presence and levels of anti-citrullinated peptide antibodies (including fine specificities) in both BAL and serum. Results The BAL microbiota of RA patients was significantly less diverse and abundant when compared to healthy controls, but similar to Sarcoidosis patients. This distal airway dysbiosis was attributed to the reduced presence of several genus (i.e., Actynomyces and Burkhordelia ) as well as reported periodontopathic taxa, including Treponema , Prevotella , and Porphyromonas . While multiple clades correlated with local and systemic levels of autoantibodies, the genus Pseudonocardia and various related OTUs were the only taxa overrepresented in RA BAL and correlated with higher disease activity and erosions. Conclusions Distal airway dysbiosis is present in untreated early RA and similar to that detected in Sarcoidosis Lung inflammation. This community perturbation, which correlates with local and systemic autoimmune/inflammatory changes, may potentially drive initiation of RA in a proportion of cases.
-
The Lung microbiota in early rheumatoid arthritis and autoimmunity
Microbiome, 2016Co-Authors: Jose U. Scher, Anders Eklund, Johan Grunewald, Vijay Joshua, Alejandro Artacho, Shahla Abdollahi-roodsaz, Johan Öckinger, Susanna Kullberg, Magnus Sköld, Jose C. ClementeAbstract:Airway abnormalities and Lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This suggests the possibility that the Lung could be a site of autoimmunity generation in RA, perhaps in response to microbiota changes. We therefore sought to test whether the RA Lung microbiome contains distinct taxonomic features associated with local and/or systemic autoimmunity. 16S rRNA gene high-throughput sequencing was utilized to compare the bacterial community composition of bronchoalveolar lavage fluid (BAL) in patients with early, disease-modifying anti-rheumatic drugs (DMARD)-naive RA, patients with Lung Sarcoidosis, and healthy control subjects. Samples were further assessed for the presence and levels of anti-citrullinated peptide antibodies (including fine specificities) in both BAL and serum. The BAL microbiota of RA patients was significantly less diverse and abundant when compared to healthy controls, but similar to Sarcoidosis patients. This distal airway dysbiosis was attributed to the reduced presence of several genus (i.e., Actynomyces and Burkhordelia) as well as reported periodontopathic taxa, including Treponema, Prevotella, and Porphyromonas. While multiple clades correlated with local and systemic levels of autoantibodies, the genus Pseudonocardia and various related OTUs were the only taxa overrepresented in RA BAL and correlated with higher disease activity and erosions. Distal airway dysbiosis is present in untreated early RA and similar to that detected in Sarcoidosis Lung inflammation. This community perturbation, which correlates with local and systemic autoimmune/inflammatory changes, may potentially drive initiation of RA in a proportion of cases.
