The Experts below are selected from a list of 25512 Experts worldwide ranked by ideXlab platform
Sven Gläser - One of the best experts on this subject based on the ideXlab platform.
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static Lung Volumes and airway resistance reference values in healthy adults
Respirology, 2013Co-Authors: Beate Koch, Henry Völzke, Nele Friedrich, Rudolf A Jorres, Stefan B Felix, Ralf Ewert, C Schaper, Sven GläserAbstract:BACKGROUND AND OBJECTIVE: The assessment of static Lung Volumes and airway resistance is a frequently performed diagnostic procedure and considered as an important tool in medical surveillance to detect pulmonary diseases. The objectives of the study are to establish reference equations for body plethysmographic parameters in a representative adult population across a wide age range and to compare the normative values from this sample with previous ones. METHODS: Body plethysmography was applied in 1809 participants (885 males) of a cross-sectional, population-based survey (Study of Health in Pomerania). Individuals with cardiopulmonary disorders and/or a pack-year smoking history >10 years and participants with a body mass index >30 kg/m(2) were excluded. In total, 686 healthy individuals (275 males) aged 25-85 years were assessed. RESULTS: Prediction equations for both genders were established by quantile regression analysis taking into account the influence of age, height and weight. CONCLUSIONS: The study provides a novel set of prediction equations for static Lung Volumes and airway resistance obtained using body plethysmography. Compared with our findings, existing equations underestimated some normal values. The results emphasize the need for up-to-date reference equations.
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Airflow limitation, Lung Volumes and systemic inflammation in a general population
The European respiratory journal, 2011Co-Authors: Sven Gläser, Till Ittermann, Beate Koch, Henry Völzke, Henri Wallaschofski, Matthias Nauck, C. Warnke, Claus Vogelmeier, Holger Schulz, Stephan B. FelixAbstract:Although several levels of evidence have suggested an association between systemic inflammation and spirometric Lung Volumes, data addressing the potential interrelationship between airflow limitation and inflammatory markers are sparse and remain controversial. Potential associations between high-sensitivity C-reactive protein (hsCRP), fibrinogen and Lung function were investigated in 1,466 individuals aged 25–85 yrs, representing a general population. Within this cross-sectional population, data on body plethysmography, spirometry, helium dilution and diffusing capacity of the Lung for carbon monoxide ( D L,CO ) were analysed. After adjustment for potential confounding factors, such as smoking, obesity and cardiorespiratory fitness, there was an inverse association of hsCRP with forced expiratory and static Lung Volumes. In neither apparently healthy nor the entire population was inflammation associated with airflow limitation in central airways. In smokers only, higher hsCRP and fibrinogen were associated with an impaired D L,CO . This study shows that higher levels of hsCRP are associated with decreased Lung Volumes in a general population over a wide age range. A consistent interrelationship of central airflow limitation and inflammation was not verifiable. Smoking is related to an impaired D L,CO in association with an increase in systemic inflammation.
Henry Völzke - One of the best experts on this subject based on the ideXlab platform.
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static Lung Volumes and airway resistance reference values in healthy adults
Respirology, 2013Co-Authors: Beate Koch, Henry Völzke, Nele Friedrich, Rudolf A Jorres, Stefan B Felix, Ralf Ewert, C Schaper, Sven GläserAbstract:BACKGROUND AND OBJECTIVE: The assessment of static Lung Volumes and airway resistance is a frequently performed diagnostic procedure and considered as an important tool in medical surveillance to detect pulmonary diseases. The objectives of the study are to establish reference equations for body plethysmographic parameters in a representative adult population across a wide age range and to compare the normative values from this sample with previous ones. METHODS: Body plethysmography was applied in 1809 participants (885 males) of a cross-sectional, population-based survey (Study of Health in Pomerania). Individuals with cardiopulmonary disorders and/or a pack-year smoking history >10 years and participants with a body mass index >30 kg/m(2) were excluded. In total, 686 healthy individuals (275 males) aged 25-85 years were assessed. RESULTS: Prediction equations for both genders were established by quantile regression analysis taking into account the influence of age, height and weight. CONCLUSIONS: The study provides a novel set of prediction equations for static Lung Volumes and airway resistance obtained using body plethysmography. Compared with our findings, existing equations underestimated some normal values. The results emphasize the need for up-to-date reference equations.
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Periodontitis is related to Lung Volumes and airflow limitation- a cross-sectional study
The European respiratory journal, 2012Co-Authors: Birte Holtfreter, Till Ittermann, Henry Völzke, Stefanie Richter, Thomas Köcher, Marcus Dörr, Anne Obst, Christoph Schäper, Ulrich John, Peter MeiselAbstract:This study aimed to assess the potential association of periodontal diseases with Lung Volumes and airflow limitation in a general adult population. Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25–86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the Lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and Lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors. After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static Lung Volumes, airflow limitation and hyperinflation (p Periodontal disease was significantly associated with reduced Lung Volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases.
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Airflow limitation, Lung Volumes and systemic inflammation in a general population
The European respiratory journal, 2011Co-Authors: Sven Gläser, Till Ittermann, Beate Koch, Henry Völzke, Henri Wallaschofski, Matthias Nauck, C. Warnke, Claus Vogelmeier, Holger Schulz, Stephan B. FelixAbstract:Although several levels of evidence have suggested an association between systemic inflammation and spirometric Lung Volumes, data addressing the potential interrelationship between airflow limitation and inflammatory markers are sparse and remain controversial. Potential associations between high-sensitivity C-reactive protein (hsCRP), fibrinogen and Lung function were investigated in 1,466 individuals aged 25–85 yrs, representing a general population. Within this cross-sectional population, data on body plethysmography, spirometry, helium dilution and diffusing capacity of the Lung for carbon monoxide ( D L,CO ) were analysed. After adjustment for potential confounding factors, such as smoking, obesity and cardiorespiratory fitness, there was an inverse association of hsCRP with forced expiratory and static Lung Volumes. In neither apparently healthy nor the entire population was inflammation associated with airflow limitation in central airways. In smokers only, higher hsCRP and fibrinogen were associated with an impaired D L,CO . This study shows that higher levels of hsCRP are associated with decreased Lung Volumes in a general population over a wide age range. A consistent interrelationship of central airflow limitation and inflammation was not verifiable. Smoking is related to an impaired D L,CO in association with an increase in systemic inflammation.
J Clausen - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiology of changes in absolute Lung Volumes.
The European respiratory journal, 1998Co-Authors: E Bancalari, J ClausenAbstract:Changes in absolute Lung Volumes are common in Lung disease and result in significant impacts on gas exchange, respiratory muscle function, the sensation of dyspnoea, and limitations to maximal exercise. Though our knowledge regarding the magnitude and determinants of changes in Lung Volumes in health and disease has increased in the past 20 years, a number of important questions remain unanswered. Consideration of the limitations of specific methods for measuring Lung Volumes is essential when analysing published studies regarding absolute Lung Volumes in infants, children and adults. Though functional residual capacity is most commonly measured in children and adults with the subject awake and at rest, increasingly attention is being directed to making these measurements under clinically more relevant conditions (e.g. during exercise, sleep, anesthesia, or mechanical ventilation). The relationships between dynamic changes in functional residual capacity, flow limitation during tidal breaths, sensation of dyspnoea and exercise limitation are important to understand, and are the focus of current and future research. Improved understanding of these relationships may lead to improvements in therapy of patients with acute and chronic Lung disease and are likely to be particularly important for evaluating the efficacy of and optimal patient selection for new modes of therapy, such as Lung volume reduction surgery.
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Measurement of absolute Lung Volumes by imaging techniques
The European respiratory journal, 1997Co-Authors: J ClausenAbstract:In this paper, the techniques available for estimating total Lung capacities from standard chest radiographs in children and infants as well as adults are reviewed. These techniques include manual measurements using ellipsoid and planimetry techniques as well as computerized systems. Techniques are also available for making radiographic Lung volume measurements from portable chest radiographs. There are inadequate data in the literature to support recommending one specific technique over another. Though measurements of Lung Volumes by radiographic, plethysmographic, gas dilution or washout techniques result in remarkably similar mean results when groups of normal subjects are tested, in patients with disease, the results of these different basic measurement techniques can differ significantly. Computed tomographic and magnetic resonance techniques can also be used to measure absolute Lung Volumes and offer the theoretical advantages that the results in individual subjects are less affected by variances of thoracic shape than are measurements made using conventional chest radiographs.
Beate Koch - One of the best experts on this subject based on the ideXlab platform.
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static Lung Volumes and airway resistance reference values in healthy adults
Respirology, 2013Co-Authors: Beate Koch, Henry Völzke, Nele Friedrich, Rudolf A Jorres, Stefan B Felix, Ralf Ewert, C Schaper, Sven GläserAbstract:BACKGROUND AND OBJECTIVE: The assessment of static Lung Volumes and airway resistance is a frequently performed diagnostic procedure and considered as an important tool in medical surveillance to detect pulmonary diseases. The objectives of the study are to establish reference equations for body plethysmographic parameters in a representative adult population across a wide age range and to compare the normative values from this sample with previous ones. METHODS: Body plethysmography was applied in 1809 participants (885 males) of a cross-sectional, population-based survey (Study of Health in Pomerania). Individuals with cardiopulmonary disorders and/or a pack-year smoking history >10 years and participants with a body mass index >30 kg/m(2) were excluded. In total, 686 healthy individuals (275 males) aged 25-85 years were assessed. RESULTS: Prediction equations for both genders were established by quantile regression analysis taking into account the influence of age, height and weight. CONCLUSIONS: The study provides a novel set of prediction equations for static Lung Volumes and airway resistance obtained using body plethysmography. Compared with our findings, existing equations underestimated some normal values. The results emphasize the need for up-to-date reference equations.
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Airflow limitation, Lung Volumes and systemic inflammation in a general population
The European respiratory journal, 2011Co-Authors: Sven Gläser, Till Ittermann, Beate Koch, Henry Völzke, Henri Wallaschofski, Matthias Nauck, C. Warnke, Claus Vogelmeier, Holger Schulz, Stephan B. FelixAbstract:Although several levels of evidence have suggested an association between systemic inflammation and spirometric Lung Volumes, data addressing the potential interrelationship between airflow limitation and inflammatory markers are sparse and remain controversial. Potential associations between high-sensitivity C-reactive protein (hsCRP), fibrinogen and Lung function were investigated in 1,466 individuals aged 25–85 yrs, representing a general population. Within this cross-sectional population, data on body plethysmography, spirometry, helium dilution and diffusing capacity of the Lung for carbon monoxide ( D L,CO ) were analysed. After adjustment for potential confounding factors, such as smoking, obesity and cardiorespiratory fitness, there was an inverse association of hsCRP with forced expiratory and static Lung Volumes. In neither apparently healthy nor the entire population was inflammation associated with airflow limitation in central airways. In smokers only, higher hsCRP and fibrinogen were associated with an impaired D L,CO . This study shows that higher levels of hsCRP are associated with decreased Lung Volumes in a general population over a wide age range. A consistent interrelationship of central airflow limitation and inflammation was not verifiable. Smoking is related to an impaired D L,CO in association with an increase in systemic inflammation.
Peter Meisel - One of the best experts on this subject based on the ideXlab platform.
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Periodontitis is related to Lung Volumes and airflow limitation- a cross-sectional study
The European respiratory journal, 2012Co-Authors: Birte Holtfreter, Till Ittermann, Henry Völzke, Stefanie Richter, Thomas Köcher, Marcus Dörr, Anne Obst, Christoph Schäper, Ulrich John, Peter MeiselAbstract:This study aimed to assess the potential association of periodontal diseases with Lung Volumes and airflow limitation in a general adult population. Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25–86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the Lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and Lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors. After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static Lung Volumes, airflow limitation and hyperinflation (p Periodontal disease was significantly associated with reduced Lung Volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases.
