The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Edison Serrano - One of the best experts on this subject based on the ideXlab platform.
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responses in rainbow trout oncorhynchus mykiss to increasing dietary doses of Lupinine the main quinolizidine alkaloid found in yellow lupins lupinus luteus
Aquaculture, 2011Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Margareth Overland, Jon Ovrum Hansen, Liv Torunn MydlandAbstract:Abstract This experiment investigated the effect of increasing dietary doses of Lupinine, the main quinolizidine alkaloid in Lupinus luteus , on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout ( Oncorhynchus mykiss ). Duplicate groups of rainbow trout (initial body weight of 330 g) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg Lupinine kg −1 for 60 days. Feed intake and growth were reduced in response to dietary Lupinine, best fit by quadratic regression. Based on these results, the practical tolerance level of Lupinine, with regard to growth and feed intake, was ≤ 100 mg kg −1 feed. Carcass composition did not vary among treatments. Despite a depletion of glycogen and lipid stores in the hepatocytes, Lupinine did not induce any morphological changes in spleen, kidney, heart or intestinal tissues. These results indicate that the Lupinine possesses a strong anti-palatability effect, but does not appear to pose short-term health risks for rainbow trout.
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responses in rainbow trout oncorhynchus mykiss to increasing dietary dose of Lupinine alkaloid
Lupins for health and wealth. Proceedings of the 12th International Lupin Conference Fremantle Western Australia 14-18 September 2008, 2008Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Jon Ovrum Hansen, Thor Landsverk, Liv Torunn MydlandAbstract:Yellow lupin ( Lupinus luteus ) is a promising source of protein in feeds for carnivorous fish. However, the high content of alkaloids may limit its potential for use. Lupinine is the main quinolizidine alkaloid in several varieties of Lupinus luteus . It has been reported to be highly toxic for bacteria and invertebrates, however no information is available about the allelopathic effects of Lupinine on vertebrates. This study investigated the effect of increasing dietary doses of Lupinine on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout. Duplicate groups of rainbow trout (initial body weight of 0.3 kg) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg Lupinine/kg for 60 days. Results from this study show that feed intake and growth were linearly reduced in response to dietary Lupinine. Based on results obtained by additional analysis of variance, the practical tolerance levels of Lupinine with regard to growth and feed intake was up to 100 mg/kg feed. Carcass composition did not vary among treatment. Besides a depletion of glycogen and lipid stores in the hepatocytes, the dietary inclusion of Lupinine did not cause any morphological changes in kidney, heart or intestinal tissue. These results indicate that the Lupinine alkaloid possesses a strong anti-palatability effect, but does not pose an adverse short-term risk to the health of rainbow trout.
Liv Torunn Mydland - One of the best experts on this subject based on the ideXlab platform.
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responses in rainbow trout oncorhynchus mykiss to increasing dietary doses of Lupinine the main quinolizidine alkaloid found in yellow lupins lupinus luteus
Aquaculture, 2011Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Margareth Overland, Jon Ovrum Hansen, Liv Torunn MydlandAbstract:Abstract This experiment investigated the effect of increasing dietary doses of Lupinine, the main quinolizidine alkaloid in Lupinus luteus , on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout ( Oncorhynchus mykiss ). Duplicate groups of rainbow trout (initial body weight of 330 g) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg Lupinine kg −1 for 60 days. Feed intake and growth were reduced in response to dietary Lupinine, best fit by quadratic regression. Based on these results, the practical tolerance level of Lupinine, with regard to growth and feed intake, was ≤ 100 mg kg −1 feed. Carcass composition did not vary among treatments. Despite a depletion of glycogen and lipid stores in the hepatocytes, Lupinine did not induce any morphological changes in spleen, kidney, heart or intestinal tissues. These results indicate that the Lupinine possesses a strong anti-palatability effect, but does not appear to pose short-term health risks for rainbow trout.
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responses in rainbow trout oncorhynchus mykiss to increasing dietary dose of Lupinine alkaloid
Lupins for health and wealth. Proceedings of the 12th International Lupin Conference Fremantle Western Australia 14-18 September 2008, 2008Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Jon Ovrum Hansen, Thor Landsverk, Liv Torunn MydlandAbstract:Yellow lupin ( Lupinus luteus ) is a promising source of protein in feeds for carnivorous fish. However, the high content of alkaloids may limit its potential for use. Lupinine is the main quinolizidine alkaloid in several varieties of Lupinus luteus . It has been reported to be highly toxic for bacteria and invertebrates, however no information is available about the allelopathic effects of Lupinine on vertebrates. This study investigated the effect of increasing dietary doses of Lupinine on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout. Duplicate groups of rainbow trout (initial body weight of 0.3 kg) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg Lupinine/kg for 60 days. Results from this study show that feed intake and growth were linearly reduced in response to dietary Lupinine. Based on results obtained by additional analysis of variance, the practical tolerance levels of Lupinine with regard to growth and feed intake was up to 100 mg/kg feed. Carcass composition did not vary among treatment. Besides a depletion of glycogen and lipid stores in the hepatocytes, the dietary inclusion of Lupinine did not cause any morphological changes in kidney, heart or intestinal tissue. These results indicate that the Lupinine alkaloid possesses a strong anti-palatability effect, but does not pose an adverse short-term risk to the health of rainbow trout.
Jens-uwe Grabow - One of the best experts on this subject based on the ideXlab platform.
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rotational spectra of bicyclic decanes the trans conformation of Lupinine
Journal of Physical Chemistry A, 2013Co-Authors: Michaela K Jahn, Alberto Lesarri, Emilio J. Cocinero, David A Dewald, Montserrat Vallejolopez, Jens-uwe GrabowAbstract:The conformational and structural properties of the bicyclic quinolizidine alkaloid (−)-Lupinine have been investigated in a supersonic jet expansion using microwave spectroscopy. The rotational sp...
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Rotational Spectra of Bicyclic Decanes: The Trans Conformation of (−)-Lupinine
2013Co-Authors: Michaela K. Jahn, Alberto Lesarri, David Dewald, Montserrat Vallejo-lópez, Emilio J. Cocinero, Jens-uwe GrabowAbstract:The conformational and structural properties of the bicyclic quinolizidine alkaloid (−)-Lupinine have been investigated in a supersonic jet expansion using microwave spectroscopy. The rotational spectrum is consistent with a single dominant trans conformation within a double-chair skeleton, which is stabilized by more than 10.4 kJ mol–1 with respect to other conformations. In the isolated conditions of the jet, the hydroxy methyl side chain of the molecule locks in to form an intramolecular O–H···N hydrogen bond to the electron lone pair at the nitrogen atom. Accurate rotational constants, centrifugal distortion corrections, and 14N nuclear quadrupole coupling parameters are reported and compared to ab initio (MP2) and DFT (M06-2X) calculations. The stability of Lupinine is further compared computationally with epiLupinine and decaline in order to gauge the influence of intramolecular hydrogen bonding, absent in these molecules
Thorsten Bach - One of the best experts on this subject based on the ideXlab platform.
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enantioselective lewis acid catalysis of intramolecular enone 2 2 photocycloaddition reactions
ChemInform, 2014Co-Authors: Richard Brimioulle, Thorsten BachAbstract:The utilization of the products is demonstrated on the compound (VI) as chiral key intermediate for the synthesis of (+)-Lupinine (X) and (+)-thermopsine (XII).
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enantioselective lewis acid catalysis of intramolecular enone 2 2 photocycloaddition reactions
Science, 2013Co-Authors: Richard Brimioulle, Thorsten BachAbstract:Asymmetric catalysis of photochemical cycloadditions has been limited by the challenge of suppressing the unselective background reaction. Here, we report that the high cross-section ππ* transition of 5,6-dihydro-4-pyridones, a versatile class of enone substrates, undergoes a >50 nanometer (nm) bathochromic absorption shift upon Lewis acid coordination. Based on this observation, enantioselective intramolecular [2+2] photocycloaddition reactions (82 to 90% enantiomeric excess) were achieved with these substrates using 0.5 equivalents of a chiral Lewis acid upon irradiation at a wavelength of 366 nm. One of the products was applied as a key intermediate in the total synthesis of (+)-Lupinine and the formal synthesis of (+)-thermopsine. Several enones show similar bathochromic shifts in the presence of a Lewis acid, indicating that chiral Lewis acid catalysis may be a general approach toward enantioselective enone [2+2] photocycloadditions.
Trond Storebakken - One of the best experts on this subject based on the ideXlab platform.
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responses in rainbow trout oncorhynchus mykiss to increasing dietary doses of Lupinine the main quinolizidine alkaloid found in yellow lupins lupinus luteus
Aquaculture, 2011Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Margareth Overland, Jon Ovrum Hansen, Liv Torunn MydlandAbstract:Abstract This experiment investigated the effect of increasing dietary doses of Lupinine, the main quinolizidine alkaloid in Lupinus luteus , on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout ( Oncorhynchus mykiss ). Duplicate groups of rainbow trout (initial body weight of 330 g) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg Lupinine kg −1 for 60 days. Feed intake and growth were reduced in response to dietary Lupinine, best fit by quadratic regression. Based on these results, the practical tolerance level of Lupinine, with regard to growth and feed intake, was ≤ 100 mg kg −1 feed. Carcass composition did not vary among treatments. Despite a depletion of glycogen and lipid stores in the hepatocytes, Lupinine did not induce any morphological changes in spleen, kidney, heart or intestinal tissues. These results indicate that the Lupinine possesses a strong anti-palatability effect, but does not appear to pose short-term health risks for rainbow trout.
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responses in rainbow trout oncorhynchus mykiss to increasing dietary dose of Lupinine alkaloid
Lupins for health and wealth. Proceedings of the 12th International Lupin Conference Fremantle Western Australia 14-18 September 2008, 2008Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Jon Ovrum Hansen, Thor Landsverk, Liv Torunn MydlandAbstract:Yellow lupin ( Lupinus luteus ) is a promising source of protein in feeds for carnivorous fish. However, the high content of alkaloids may limit its potential for use. Lupinine is the main quinolizidine alkaloid in several varieties of Lupinus luteus . It has been reported to be highly toxic for bacteria and invertebrates, however no information is available about the allelopathic effects of Lupinine on vertebrates. This study investigated the effect of increasing dietary doses of Lupinine on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout. Duplicate groups of rainbow trout (initial body weight of 0.3 kg) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg Lupinine/kg for 60 days. Results from this study show that feed intake and growth were linearly reduced in response to dietary Lupinine. Based on results obtained by additional analysis of variance, the practical tolerance levels of Lupinine with regard to growth and feed intake was up to 100 mg/kg feed. Carcass composition did not vary among treatment. Besides a depletion of glycogen and lipid stores in the hepatocytes, the dietary inclusion of Lupinine did not cause any morphological changes in kidney, heart or intestinal tissue. These results indicate that the Lupinine alkaloid possesses a strong anti-palatability effect, but does not pose an adverse short-term risk to the health of rainbow trout.
