The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
P Fabbri - One of the best experts on this subject based on the ideXlab platform.
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the composition of the Lupus Band Test lbt on the sun protected non lesional spnl skin in patients with cutaneous Lupus erythematosus cle
Lupus, 1999Co-Authors: C Cardinali, Marzia Caproni, P FabbriAbstract:The objective of this study was to analyse the different immunoreactants at the dermo-epidermal junction (DEJ) of patients with cutaneous Lupus erythematosus (CLE). Sun-protected non lesional (SPNL) skin biopsies from 65 patients with specific cutaneous manifestations of LE and from 18 patients with other dermatologic diseases were Tested using the direct immunofluorescence (DIF) technique. Nineteen out of 65 patients with CLE were affected by systemic LE (SLE). We used the conventional chi-squared Test to analyse statistical differences between CLE-SLE and CLE-non-SLE groups in the immunological composition of Lupus Band Test (LBT). C3 was the most common component while IgM were the most frequent immunoglobulins (Igs) of LBT in LE patients. No immunoreactants could be demonstrated at the DEJ in patients with other dermatologic diseases. No statistical differences could be found between CLE-SLE and CLE-non-SLE groups as regards the detection of the different immunoreactants at the DEJ. A positive LBT (ev...
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the utility of the Lupus Band Test on sun protected non lesional skin for the diagnosis of systemic Lupus erythematosus
Clinical and Experimental Rheumatology, 1999Co-Authors: C Cardinali, Marzia Caproni, P FabbriAbstract:OBJECTIVE: The sensitivity and specificity of the Lupus Band Test was evaluated, using three different criteria, on sun-protected non-lesional skin for the diagnosis of systemic Lupus erythematosus (SLE). In addition, the sensitivity and specificity of the Lupus Band Test was compared with those of other laboratory Tests used in the diagnosis of SLE. METHODS: Sun-protected non-lesional skin biopsies from 65 patients (F 50; M 15; mean age 41 yrs.) with specific cutaneous manifestations of Lupus erythematosus (LE) and from 18 patients with other dermatologic diseases (F 11, M 7; mean age 40 yrs.) were Tested using the direct immunofluorescent technique. RESULTS: The sensitivity and specificity of the Lupus Band Test was 10.5% and 97.8% respectively using the strict criterion of the presence of two different immunoreactants. The sensitivity and specificity were 52.6% and 69.5% respectively based on the presence of two different immunoreactants and were 78.9% and 47.8% based on the presence of only one immunoreactant. The highest sensitivity was found for ANA (100%). The specificity of all the laboratory abnormalities was particularly high, varying from 82.8% to 100%, except for ANA antibodies which showed a specificity of 65.2%. CONCLUSIONS: A positive Lupus Band Test on sun-protected non-lesional skin (even if showing the presence of only one immunoreactant at the dermo-epidermal junction) represents a useful and specific criterion for identifying patients with LE. However, this Test is not useful in distinguishing between cutaneous Lupus patients with systemic involvement and those without systemic involvement.
Gunnar N Westberg - One of the best experts on this subject based on the ideXlab platform.
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Lupus Band Test in uninvolved oral mucosa in systemic Lupus erythematosus
Acta Medica Scandinavica, 2009Co-Authors: Roland Jonsson, Gudrun Nyberg, Aud Kristenssonaas, Gunnar N WestbergAbstract:: In 42 patients with systemic Lupus erythematosus, clinically normal oral mucosa was investigated with direct immunofluorescence technique for the presence of immunoglobulins G, A and M and complement factor C3 in the mucosal basement membrane zone (the Lupus Band Test, LBT). Punch biopsies were performed in the posterior part of the hard palate (n = 39) or the lower labial mucosa (n = 3). The immunopathological observations were compared with clinical and serological data. The LBT was positive for IgM in 45% of the patients and trace amounts of IgM were found in another 19%. In 7 cases (17%) either IgG, IgA or C3 were found in addition to IgM and these patients all had a severe form of the disease, while the presence of IgM only was not correlated to clinical parameters.
C Cardinali - One of the best experts on this subject based on the ideXlab platform.
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the composition of the Lupus Band Test lbt on the sun protected non lesional spnl skin in patients with cutaneous Lupus erythematosus cle
Lupus, 1999Co-Authors: C Cardinali, Marzia Caproni, P FabbriAbstract:The objective of this study was to analyse the different immunoreactants at the dermo-epidermal junction (DEJ) of patients with cutaneous Lupus erythematosus (CLE). Sun-protected non lesional (SPNL) skin biopsies from 65 patients with specific cutaneous manifestations of LE and from 18 patients with other dermatologic diseases were Tested using the direct immunofluorescence (DIF) technique. Nineteen out of 65 patients with CLE were affected by systemic LE (SLE). We used the conventional chi-squared Test to analyse statistical differences between CLE-SLE and CLE-non-SLE groups in the immunological composition of Lupus Band Test (LBT). C3 was the most common component while IgM were the most frequent immunoglobulins (Igs) of LBT in LE patients. No immunoreactants could be demonstrated at the DEJ in patients with other dermatologic diseases. No statistical differences could be found between CLE-SLE and CLE-non-SLE groups as regards the detection of the different immunoreactants at the DEJ. A positive LBT (ev...
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the utility of the Lupus Band Test on sun protected non lesional skin for the diagnosis of systemic Lupus erythematosus
Clinical and Experimental Rheumatology, 1999Co-Authors: C Cardinali, Marzia Caproni, P FabbriAbstract:OBJECTIVE: The sensitivity and specificity of the Lupus Band Test was evaluated, using three different criteria, on sun-protected non-lesional skin for the diagnosis of systemic Lupus erythematosus (SLE). In addition, the sensitivity and specificity of the Lupus Band Test was compared with those of other laboratory Tests used in the diagnosis of SLE. METHODS: Sun-protected non-lesional skin biopsies from 65 patients (F 50; M 15; mean age 41 yrs.) with specific cutaneous manifestations of Lupus erythematosus (LE) and from 18 patients with other dermatologic diseases (F 11, M 7; mean age 40 yrs.) were Tested using the direct immunofluorescent technique. RESULTS: The sensitivity and specificity of the Lupus Band Test was 10.5% and 97.8% respectively using the strict criterion of the presence of two different immunoreactants. The sensitivity and specificity were 52.6% and 69.5% respectively based on the presence of two different immunoreactants and were 78.9% and 47.8% based on the presence of only one immunoreactant. The highest sensitivity was found for ANA (100%). The specificity of all the laboratory abnormalities was particularly high, varying from 82.8% to 100%, except for ANA antibodies which showed a specificity of 65.2%. CONCLUSIONS: A positive Lupus Band Test on sun-protected non-lesional skin (even if showing the presence of only one immunoreactant at the dermo-epidermal junction) represents a useful and specific criterion for identifying patients with LE. However, this Test is not useful in distinguishing between cutaneous Lupus patients with systemic involvement and those without systemic involvement.
Marzia Caproni - One of the best experts on this subject based on the ideXlab platform.
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the composition of the Lupus Band Test lbt on the sun protected non lesional spnl skin in patients with cutaneous Lupus erythematosus cle
Lupus, 1999Co-Authors: C Cardinali, Marzia Caproni, P FabbriAbstract:The objective of this study was to analyse the different immunoreactants at the dermo-epidermal junction (DEJ) of patients with cutaneous Lupus erythematosus (CLE). Sun-protected non lesional (SPNL) skin biopsies from 65 patients with specific cutaneous manifestations of LE and from 18 patients with other dermatologic diseases were Tested using the direct immunofluorescence (DIF) technique. Nineteen out of 65 patients with CLE were affected by systemic LE (SLE). We used the conventional chi-squared Test to analyse statistical differences between CLE-SLE and CLE-non-SLE groups in the immunological composition of Lupus Band Test (LBT). C3 was the most common component while IgM were the most frequent immunoglobulins (Igs) of LBT in LE patients. No immunoreactants could be demonstrated at the DEJ in patients with other dermatologic diseases. No statistical differences could be found between CLE-SLE and CLE-non-SLE groups as regards the detection of the different immunoreactants at the DEJ. A positive LBT (ev...
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the utility of the Lupus Band Test on sun protected non lesional skin for the diagnosis of systemic Lupus erythematosus
Clinical and Experimental Rheumatology, 1999Co-Authors: C Cardinali, Marzia Caproni, P FabbriAbstract:OBJECTIVE: The sensitivity and specificity of the Lupus Band Test was evaluated, using three different criteria, on sun-protected non-lesional skin for the diagnosis of systemic Lupus erythematosus (SLE). In addition, the sensitivity and specificity of the Lupus Band Test was compared with those of other laboratory Tests used in the diagnosis of SLE. METHODS: Sun-protected non-lesional skin biopsies from 65 patients (F 50; M 15; mean age 41 yrs.) with specific cutaneous manifestations of Lupus erythematosus (LE) and from 18 patients with other dermatologic diseases (F 11, M 7; mean age 40 yrs.) were Tested using the direct immunofluorescent technique. RESULTS: The sensitivity and specificity of the Lupus Band Test was 10.5% and 97.8% respectively using the strict criterion of the presence of two different immunoreactants. The sensitivity and specificity were 52.6% and 69.5% respectively based on the presence of two different immunoreactants and were 78.9% and 47.8% based on the presence of only one immunoreactant. The highest sensitivity was found for ANA (100%). The specificity of all the laboratory abnormalities was particularly high, varying from 82.8% to 100%, except for ANA antibodies which showed a specificity of 65.2%. CONCLUSIONS: A positive Lupus Band Test on sun-protected non-lesional skin (even if showing the presence of only one immunoreactant at the dermo-epidermal junction) represents a useful and specific criterion for identifying patients with LE. However, this Test is not useful in distinguishing between cutaneous Lupus patients with systemic involvement and those without systemic involvement.
Roland Jonsson - One of the best experts on this subject based on the ideXlab platform.
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Lupus Band Test in uninvolved oral mucosa in systemic Lupus erythematosus
Acta Medica Scandinavica, 2009Co-Authors: Roland Jonsson, Gudrun Nyberg, Aud Kristenssonaas, Gunnar N WestbergAbstract:: In 42 patients with systemic Lupus erythematosus, clinically normal oral mucosa was investigated with direct immunofluorescence technique for the presence of immunoglobulins G, A and M and complement factor C3 in the mucosal basement membrane zone (the Lupus Band Test, LBT). Punch biopsies were performed in the posterior part of the hard palate (n = 39) or the lower labial mucosa (n = 3). The immunopathological observations were compared with clinical and serological data. The LBT was positive for IgM in 45% of the patients and trace amounts of IgM were found in another 19%. In 7 cases (17%) either IgG, IgA or C3 were found in addition to IgM and these patients all had a severe form of the disease, while the presence of IgM only was not correlated to clinical parameters.
